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178篇 您的检索式:作者名="LEACH E"
    题名 作者 年代 出处 被引量
1Pancreatic cancer显示文摘Theresa Pluth Yeo Ralph H Hruban Steven D Leach Robb E Wilentz Taylor A Sohn Scott E Kern Christine A Iacobuzio-Donahue Anirban Maitra Michael Goggins Marcia I Canto Ross A Abrams Daniel Laheru Elizabeth M Jaffee Manuel Hidalgo Charles J Yeo 2002Current Problems in Cancer2002,,4:2
2向在人的察觉到钙的受体的 allosteric 药的结构的理解显示文摘allosterically 指向人的察觉到钙的受体(CaSR ) 的药有实质的治疗学的潜力,但是当前被限制。给 CaSR 的高分辨率的结构的缺席,我们把 mutagenesis 与一条新奇分析途径并且开发 “ 的分子的建模相结合; enriched”为在 Ca 2+ 在 CaSRs 7 transmembrane (7TM ) 以内的 o 和 allosteric 调节的人领域。修改多重有约束力的地点以适应在结构上的一个扩大的洞多样的 ligands 被识别。Phenylalkylamines 绑在与通常认为的 Ca 2+ o -binding 地点并且向一个细胞外的门厅延长。相反,在结构上和 pharmacologically 不同的 AC-265347 在 7TM 领域以内更深绑。而且,不同氨基酸网络被发现调停由不同调节的人的 cooperativity。这些调查结果可以与不同、潜在地偏导小径的药理学效果便于 allosteric 调节的人的合理设计。Katie Leach Karen J Gregory Irina Kufareva Elham Khajehali Anna E Cook Ruben Abagyan Arthur D Conigrave Patrick M Sexton Arthur Christopoulos 2016Cell Research2016,26,5:2
3Developmental regulation of respiratory activity in pea leaves 显示文摘Lennon A M Pratt J Leach G e al 1995Plant Physiol1995,107,:1
4Laminar sheet flow显示文摘Horton R E Leach H R Vliet V R 1934Transactions of the American Geophysical Union1934,15,2:1
5The worldwide obesity epidemic 显示文摘Jame PT Leach R Kalamare E 2001Obes Res2001,9,:1
6Natural variation in the essential oil content of Melaleuca alternifolia Cheel (Myrtaceae)显示文摘Homer L E Leach D N Lea D 2000Biochemical Systematics and Ecology2000,28,:1
7On the nature and pattern of neurocognitive function in major depressive disorder显示文摘ZAKZANIS K K LEACH L KAPLAN E 1998Neuropsychiatry Neuropsychol Behav Neurol1998,11,3:1
8Molecular and proteomic an- alyses highlight the importance of ubiquitination for the stress re- sistance, metabolic adaptation, morphogenetic regulation and vir- ulence of Candida albicans 显示文摘Leach MD Stead DA Argo E 2011Mol Microbiol2011,79,6:1
9Effects of high plant populations on the growth and yield of winter oilseed rape(Brassica napus)显示文摘LEACH J E STEVENSON H J RAINBOW A J 1999Journal of Agricultural Science1999,132,2:1
10Laminar sheet- flow 显示文摘Horton Robert E Leach H R Van Vliet Richard 1934Transactions American Geophysical Union1934,1,2:1
11Comparison between capillary electrophoresis and HPLC-FL for oehratoxin A quantification in wine显示文摘Gonzdlez-Penas E Leache C Lopez de Cerain A 2006Food Chemistry2006,97,:1
12Tibial Dyschondroplasia 40Y ears Later显示文摘Leach R M J Monsonego-Oman E 2007Poultry Science2007,8610,:1
13Cadmium and the food chain:The effect of dietary cadmium on tissue composition in chicks and laying hens显示文摘LEACH R WANG K W BAKER D E 1979Nutrition1979,109,:1
14Tibial dyschondropla- sia 40 years later显示文摘Leach R Monsonego- Oman E 2007Poultry Science2007,86,10:1
15Extended mean values显示文摘LEACH E B SHOLANDER M C 1978Amer Math Monthly1978,85,:1
16Nitrogen control in domestic wastewater:rapid infiltration systems显示文摘LEACH L E ENFIELD C G 1983Journal of Water Pollution Control Federation1983,55,:1
17Laminar sheet flow显示文摘Horton R E leach H R Van VIiet R 1934Transactions of the American Geophysical Union1934,15,2:1
18Changes in the plasma membrane distribution of rice phospholipase D druing resistantions with Xanthomonas oryzae pvoryzae显示文摘Young S Wang X M Leach J E 1996Plant Cell1996,8,:1
19Laminar sheet flow显示文摘Horton R E Leach H R Van V R 1934Transactions of the America Geophysical Union1934,15,2:1
20Nitrogen control in domestic wastewater:rapid infiltration systems显示文摘Leach L E Enfield C G 1983Journal of Water Pollution Control Federation1983,55,:1
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