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| 1 | 新疆西昆仑库地混杂带中基性火山岩构造环境分析显示文摘库地北一些克沟基性火山岩是西昆仑库地蛇绿岩的重要组成单元之一,而有关其形成的构造环境仍存在很多争议,由此影响了对该蛇绿岩性质、形成和演化方面的深入认识。笔者在野外对一些克沟基性火山岩地质剖面进行了详细的观察,在综合前人研究资料的基础上,利用地球化学(主量、微量及稀土元素)及Sm/Nd同位素分析等数据对其构造背景进行了多种手段相结合的判别和分析,确定其形成的构造环境为洋内弧,从而为进一步确定库地蛇绿岩的形成环境提供了新的佐证。 | 方爱民 李继亮 刘小汉 侯泉林 Lee Ik Jong 肖文交 俞良军 周辉 | 2003 | 岩石学报2003，19，3： | 21 |
| 2 | The hidden switches undertying RORα-mediated circuits that critically regulate uncontrolled cell proliferation显示文摘 | Dongkwan Shin Ik Soo Kim Ji Min Lee Sung-Young Shin Jong-Hoon Lee Sung Hee Baek Kwang-Hyun Cho | 2014 | Journal of Molecular Cell Biology2014，8，4： | 13 |
| 3 | Low grade gastric mucosa associated lymphoid tissue lymphoma:Treatment strategies based on 10 year follow-up显示文摘AIM:To deduce strategic guidelines of gastric mucosa associated lymphoid tissue lymphoma (MALTOMA) by evaluating the long-term outcome of patients in respect to various treatment modalities.METHODS:A total of 55 patients with MALTOMA from May 1992 to August 2002 were retrospectively reviewed.RESULTS: Complete remission was obtained in 24 (82.8%) of 29 patients treated with anti Helicobacter pylori(H pylori) regimen only. The duration to reach complete remission was 12 months (85 percentile, 2-33 months).Five patients showed complete remission with radiation therapy (26-86 months).Two of them were Hpyloritreatment failure cases.CONCLUSION: Hpylorieradication is an effective primary treatment option for low grade MALTOMA and radiation therapy could be considered in patients with no evidence of Hpyloninfection or who do not respond to Hpylorieradication therapy 12 months after successful eradication. | Sang Kil Lee Yong Chan Lee Jae Bock Chung Chae Yoon Chon Young Myoung Moon Jin Kyung Kang In-Suh Park Chang Ok Suh Woo Ik Yang | 2004 | World Journal of Gastroenterology2004，10，2： | 12 |
| 4 | Comparison of postpolypectomy bleeding between epinephrine and saline submucosal injection for large colon polyps by conventional polypectomy:A prospective randomized,multicenter study显示文摘AIM:To evaluate and compare the clinical outcomes of prophylactic submucosal saline-epinephrine injection and saline injection alone for large colon polyps by conventional polypectomy. METHODS:A prospective study was conducted from July 2003 to July 2004 at 11 tertiary endoscopic centers. Large colon polyps (> 10 mm in diameter) wererandomized to undergo endoscopic polypectomy with submucosal saline-epinephrine injection (epinephrine group) or normal saline injection (saline group). Endoscopic polypectomy was performed by the conventional snare method,and early (< 12 h) and late bleeding complications (12 h-30 d) were observed. RESULTS:A total of 561 polyps in 486 patients were resected by endoscopic polypectomy. Overall,bleeding complications occurred in 7.6% (37/486) of the patients,including 4.9% (12/244) in the epinephrine group,and 10.3% (25/242) in the saline group. Early and late postpolypectomy bleeding (PPB) occurred in 6.6% (32/486) and 1% (5/486) of the patients,respectively,including 4.5% (11/244),0.4% (1/244) in the epinephrine group,and 8.7% (21/242),1.7% (4/242) in the saline group. No significant differences in the rates of overall,early and late PPB were observed between the 2 groups. Multivariate stepwise logistic regression analysis revealed that large size (> 2 cm) and neoplastic polyps were independently and significantly associated with the presence of PPB. CONCLUSION:The prophylactic submucosal injection of diluted epinephrine does not appear to provide an additional advantage over the saline injection alone for the prevention of PPB. | Suck-Ho Lee Il-Kwun Chung Sun-Joo Kim Jin-Oh Kim Bong-Min Ko Won-Ho Kim Hyun-Soo Kim Dong-IL Park Hyo-Jong Kim Jeong-Sik Byeon Suk-Kyun Yang Byeong Ik Jang Sung-Ae Jung Yoon-Tae Jeen Jai-Hyun Choi Hwang Choi Dong-Soo Han Jae Suk Song | 2007 | World Journal of Gastroenterology2007，13，21： | 9 |
| 5 | Association between Helicobacter pylori status and metachronous gastric cancer after endoscopic resection显示文摘AIM To investigate the effect of Helicobacter pylori(H. pylori) status test and H. pylori eradication on the occurrence of metachronous gastric cancer(MGC) after endoscopic submucosal dissection(ESD) of early gastric cancer(EGC) and risk factors of MGC. METHODS The authors retrospectively reviewed the medical records of 433 patients(441 lesions) who underwent ESD for EGC from January 2005 to January 2015 in Yeungnam University Hospital. Patients were categorized into two groups; the H. pylori tested group(n = 257) and the H. pylori non-tested group(n = 176) based on performance of H. pylori status test after ESD of EGC. The H. pylori tested group was further categorized into three subgroups based on H. pylori status; the H. pylori-eradicated subgroup(n = 120), the H. pylori-persistent subgroup(n = 42), and the H. pylori-negative subgroup(n = 95). Incidences of MGC and risk factors of MGC were identified.RESULTS Median follow-up duration after ESD was 30.00 mo(range, 6-107 mo). Total 15 patients developed MGC during follow-up. MGC developed in 11 patients of the H. pylori tested group(7 in the H. pylori-negative subgroup, 3 in the H. pylori-eradicated subgroup, and 1 in the H. pylori-persistent subgroup) and 4 patients of the H. pylori non-tested group(P > 0.05). The risk factors of MGC were endoscopic mucosal atrophy in the H. pylori tested group and intestinal metaplasia in all patients. CONCLUSION H. pylori eradication and H. pylori status test seems to have no preventive effect on the development of MGC after ESD for EGC. The risk factors of MGC development were endoscopic mucosal atrophy in the H. pylori tested group alone and intestinal metaplasia in all patients. | Sung Bum Kim Si Hyung Lee Seung Il Bae Yo Han Jeong Se Hoon Sohn Kyeong Ok Kim Byung Ik Jang Tae Nyeun Kim | 2016 | World Journal of Gastroenterology2016，22，44： | 8 |
| 6 | Technical issues and new devices of ESD of early gastric cancer显示文摘Endoscopic submucosal dissection(ESD) is a highly refined technique compared to conventional endoscopic mucosal resection.It enables complete resection of early gastric cancer(EGC) which has no possibility of lymph node metastasis.Indication for ESD of EGC generally entails early gastric cancer confined to the mucosa with well differentiated histology,though there are clinically suitable expanded criteria.As ESD requires specific skill and expertise,endoscopists need to be familiarized with basic methods and the use of special devices.The essence of the technique is to dissect the submucosal layer with direct vision and maintain thecutting plane above the underlying proper muscle layer.Although there are some differences in the detailed technical aspect,the cardinal method of ESD is now well established and standardized.Furthermore,research and development of new ESD devices that render more efficient,safe ESD are still in progress to improve the overall result of ESD on early gastric cancer. | Wan Sik Lee Jin Woong Cho Young Dae Kim Kyu Jong Kim Byung Ik Jang | 2011 | World Journal of Gastroenterology2011，17，31： | 8 |
| 7 | Tailoring uniform γ-MnO2 nanosheets on highly conductive three-dimensional current collectors for high-performance supercapacitor electrodes显示文摘最近的努力集中了于制造和应用程序三维(3-D ) nanoarchitecture 电极,它能展出优秀电气化学的性能。此处,向设计和合成的新奇策略尺寸悦耳、厚度悦耳二维( 2-D ) MnO <潜水艇class=“ a-plus-plus ”> 2 nanosheets 在上高度传导性一个维( 1-D )脊梁数组被开发了经由一灵巧,一步舞提高了化学洗澡免职( ECBD )在低温度的方法( 50 湡睯物吗?? | Sangbaek Park Hyun-Woo Shim Chan Woo Lee Hee Jo Song Ik Jae Park Jae-Chan Kim Kug Sun Hong Dong-Wan Kim | 2015 | Nano Research2015，8，3： | 7 |
| 8 | Effect of angiotensin Ⅱ type 1 receptor blocker and angiotensin converting enzyme inhibitor on the intraocular growth factors and their receptors in streptozotocin-induced diabetic rats显示文摘AIM: To investigate the effect of angiotensinⅡ type 1 receptor blocker(ARB) and angiotensin converting enzyme inhibitor(ACEI) on intraocular growth factors and their receptors in streptozotocin-induced diabetic rats. METHODS: Forty Sprague-Dawley rats were divided into 4 groups: control, diabetes mellitus(DM), candesartantreated DM, and enalapril-treated DM(each group, n=10). After the induction of DM by streptozotocin, candesartan [ARB, 5 mg/(kg·d)] and enalapril [ACEI, 10 mg/(kg·d)] were administered to rats orally for 4wk. Vascular endothelial growth factor(VEGF) and angiotensin Ⅱ(Ang Ⅱ) concentrations in the vitreous were measured using enzyme-linked immunosorbent assays, and VEGF receptor 2 and angiotensin II type 1 receptor(AT1R) levels were assessed at week 4 by Western blotting. RESULTS: Vitreous Ang Ⅱ levels were significantly higher in the DM group and candesartan-treated DM group than in the control(P=0.04 and 0.005, respectively). Vitreous AT1R increased significantly in DM compared to the other three groups(P<0.007). Candesartan-treated DM rats showed higher vitreal AT1R concentration than the enalapril-treated DM group and control(P<0.001 and P=0.005, respectively). No difference in vitreous Ang Ⅱ and AT1R concentration was found between the enalapriltreated DM group and control. VEGF and its receptor were below the minimum detection limit in all 4 groups.CONCLUSION: Increased Ang Ⅱ and AT1R in the hyperglycemic state indicate activated the intraocular renin-angiotensin system, which is inhibited more effectively by systemic ACEI than systemic ARB. | Ik Soo Byon Dong Hyun Lee Eun Sook Jun Min Kyu Shin Sung Who Park Ji Eun Lee | 2017 | International Journal of Ophthalmology(English edition)2017，10，6： | 5 |
| 9 | Ce对铸造Mg-5Al-2Si合金中Mg2Si相改性及力学性能的影响显示文摘利用X射线衍射、光学显微镜和扫描电镜等分析测试手段,研究了不同Ce添加量对重力铸造Mg-5Al-2Si合金显微组织和力学性能的影响规律。结果表明,添加Ce以后,合金中主要存在α-Mg相、汉字状Mg2Si相、多边形Mg2Si相、细小的Al11Ce3和CeSi2相;稀土Ce的加入改变了合金中Mg2Si相的尺寸、形貌与分布;随着Ce含量增加,汉字状Mg2Si相的平均长度大幅度减小,共晶Mg2Si相的形貌由粗大的汉字状转变为多边形状;当Ce添加量为0.4%时,试验合金的力学性能达到最佳,而增加至0.8%时,合金的力学性能反而下降。拉伸断口形貌也揭示了合金的力学性能情况。因此,适当的Ce添加量(0.4%)可以有效地改性Mg2Si相,从而提高合金的强度和伸长率。 | 朱文杰 李德江 曾小勤 Seul Bi Lee Ik Min Park | 2019 | 铸造2019，68，7： | 5 |
| 10 | Significant risk and associated factors of active tuberculosis infection in Korean patients with inflammatory bowel disease using anti-TNF agents显示文摘AIM:To evaluate the incidence and risk factors of Korean tuberculosis(TB) infection in patients with inflammatory bowel disease(IBD) undergoing anti-TNF treatment.METHODS:The data of IBD patients treated with anti-TNFs in 13 tertiary referral hospitals located in the southeastern region of Korea were collected retrospectively.They failed to show response or were intolerant to conventional treatments,including steroids or immunomodulators.Screening measures for latent TB infection(LTBI)and the incidence and risk factors ofactive TB infection after treatment with anti-TNFs were identified.RESULTS:Overall,376 IBD patients treated with antiTNF agents were recruited(male 255,mean age of anti-TNF therapy 32.5±13.0 years);277 had Crohn’s disease,99 had ulcerative colitis,294 used infliximab,and 82 used adalimumab.Before anti-TNF treatment,screening tests for LTBI including an interferon gamma release assay or a tuberculin skin test were performed in 82.2%of patients.Thirty patients(8%)had LTBI.Sixteen cases of active TB infection including one TB-related mortality occurred during 801 personyears(PY)follow-up(1997.4 cases per 100000 PY)after anti-TNF treatment.LTBI(OR=5.76,95%CI:1.57-21.20,P=0.008)and WBC count<5000 mm3(OR=4.5,95%CI:1.51-13.44,P=0.007)during follow-up were identified as independently associated risk factors.CONCLUSION:Anti-TNFs significantly increase the risk of TB infection in Korean patients with IBD.The considerable burden of TB and marked immunosuppression might be attributed to this risk. | Eun Soo Kim Geun Am Song Kwang Bum Cho Kyung Sik Park Kyeong Ok Kim Byung Ik Jang Eun Young Kim Seong Woo Jeon Hyun Seok Lee Chang Heon Yang Yong Kook Lee Dong Wook Lee Sung Kook Kim Tae Oh Kim Jonghun Lee Hyung Wook Kim Sam Ryong Jee Seun Ja Park Hyun Jin Kim | 2015 | World Journal of Gastroenterology2015，21，11： | 5 |
| 11 | Cutaneous metastasis as an initial presentation of a non-functioning pancreatic neuroendocrine tumor显示文摘Non-functioning pancreatic neuroendocrine tumors(NF-PNETs) are rare tumors that account for 2% of all pancreatic malignancy.About 60% of NF-PNETs present distant metastases and usually hepatic metastases.However,cutaneous metastases are very rare.Herein,we report our experience with a 60-yearold male who visited our outpatient clinic with a mass on his left hip.An abdominal computerized tomography scan demonstrated not only a left hip mass and an enlarged left inguinal lymph node,but also a huge heterogeneous enhancing mass on the pancreas.Initially,we removed the metastatic lesions,which was a small cell neuroendocrine carcinoma with 50% of the Ki-67 index in the histopathological report.After 3 wk,we performed a total pancreatectomy and a total gastrectomy.Four weeks after the 1st operation,we detected a recurrence at the operative bed on his left hip,and subsequently removed the recurring mass.The patient was receiving chemotherapy based on etoposide and cisplatin treatment. | Woo Young Shin Keon Young Lee Seung Ik Ahn Shin-Young Park Keun-Myoung Park | 2015 | World Journal of Gastroenterology2015，21，33： | 4 |
| 12 | Goniosynechialysis for secondary angle closure glaucoma in a pseudophakic patient after vitrectomy and silicone oil injection显示文摘Dear Sir,Iam Jonghoon Shin,from the Department of Ophthalmology of Pusan National University Hospital,Busan,Korea.I write to present a patient with secondary angle closure glaucoma(SACG)after vitrectomy and silicone oil(SO)injection who was successfully treated | Jonghoon Shin Hyeshin Jeon Ik Soo Byon Ji-Woong Lee | 2014 | International Journal of Ophthalmology(English edition)2014，7，5： | 4 |
| 13 | Clinical significance of tumor-infiltrating lymphocytes for gastric cancer in the era of immunology显示文摘Immunotherapy has begun to revolutionize cancer treatment, by introducing therapies that target the host immune system instead of the tumor, therapies that possess unique adverse event profiles, and therapies that may cure certain types of cancer. The immune microenvironment of tumors is emerging as the most important means of understanding the relationship between a patient' immune system and their cancer, informing prognosis, and guiding immunotherapy, such as an antibody blockade of immune checkpoints. For some solid tumors, simple quantitation of lymphocyte infiltration would seem to have prognostic significance, suggesting that lymphocyte infiltration is not passive but may actively promote or inhibit tumor growth. For gastric cancers, several studies have provided strong evidence that immune cells contribute to determining prognosis. However, the exact role of immune cells in gastric cancer remains unclear. Therefore, this review focuses on the clinical significance of immune cells, especially tumor-infiltrating lymphocytes, in gastric cancer. | Byung Woog Kang Jong Gwang Kim In Hee Lee Han Ik Bae An Na Seo | 2017 | World Journal of Gastrointestinal Oncology2017，9，7： | 3 |
| 14 | Predictors of post-treatment stenosis in cervical esophageal cancer undergoing high-dose radiotherapy显示文摘AIM To evaluate toxicity and treatment outcome of highdose radiotherapy(RT) for cervical esophageal cancer(CEC).METHODS We reviewed a total of 62 consecutive patients who received definitive RT for stage Ⅰ to Ⅲ cervical esophageal cancer between 2001 and 2015. Patients who received < 45 Gy, treated for lesions below sternal notch, treated with palliative aim, treated with subsequent surgical resection, or diagnosed with synchronous hypopharyngeal cancer were excluded. Treatment failures were divided into local(occurring within the RT field), outfield-esophageal, and regional [occurring in regional lymph node(s)] failures. Factors predictive of esophageal stenosis requiring endoscopic dilation were analyzed.RESULTS Grade 1, 2, and 3 esophagitis occurred in 19(30.6%), 39(62.9%), and 4 patients(6.5%), respectively, without grade ≥ 4 toxicities. Sixteen patients(25.8%) developed post-RT stenosis, of which 7 cases(43.8%) were malignant. Four patients(6.5%) developed tracheoesophageal fistula(TEF), of which 3(75%) cases were malignant. Factors significantly correlated with post-RT stenosis were stage T3/4(P = 0.001), complete circumference involvement(P < 0.0001), stenosis at diagnosis(P = 0.024), and endoscopic complete response(P = 0.017) in univariate analysis, while complete circumference involvement was significant in multivariate analysis(P = 0.003). A higher dose(≥ 60 Gy) was not associated with occurrence of postRT stenosis or TEF. With a median follow-up of 24.3(range, 3.4-152) mo, the 2 y local control, outfield esophageal control, progression-free survival, and overall survival(OS) rates were 78.9%, 90.2%, 49.6%, and 57.3%, respectively. Factors significantly correlated with OS were complete circumference involvement(P = 0.023), stenosis at diagnosis(P < 0.0001), and occurrence of post-RT stenosis or TEF(P < 0.001) in univariate analysis, while stenosis at diagnosis(P = 0.004) and occurrence of post-RT stenosis or TEF(P = 0.023) were significant in multivariate analysis. CONCLUSION Chemoradiation for CEC was well tolerated, and a higher dose was not associated with stenosis. Patients with complete circumferential involvement require close follow-up. | Jun Won Kim Tae Hyung Kim Jie-Hyun Kim Ik Jae Lee | 2018 | World Journal of Gastroenterology2018，24，7： | 3 |
| 15 | Predictive risk factors of perforation in gastric endoscopic submucosal dissection for early gastric cancer: a large, multicenter study显示文摘 | Min Kim Seong Woo Jeon Kwang Bum Cho Kyung Sik Park Eun Soo Kim Chang Keun Park Hyang Eun Seo Yun Jin Chung Joong Goo Kwon Jin Tae Jung Eun Young Kim Byeong Ik Jang Si Hyung Lee Kyeong Ok Kim Chang Hun Yang | 2013 | Surgical Endoscopy2013，，4： | 3 |
| 16 | Systematic study of(MoTa)_(x)NbTiZr medium-and high-entropy alloys for biomedical implants-In vivo biocompatibility examination显示文摘In this study,the application of medium-and high-entropy(Mo Ta)_(x)Nb Ti Zr alloys in biomedical implants was systematically analyzed.The alloy with the best combination of mechanical properties was selected and characterized for in vitro and in vivo response for the first time to examine its biomedical properties.A logarithmic increase in the hardness and the yield strength was observed as a function of the Mo and Ta content.Alloys with up to 0.4 mol fraction of Mo and Ta showed a plastic strain of more than 30%under compression.The nanoindentation results showed that the addition of Mo and Ta increased the elastic modulus of the system linearly.It was surmised that the addition of Ta and Mo above a critical concentration(mole fraction=0.4)was unfavorable from a biomedical perspective as it increased the brittleness and elastic modulus and decreased the ductility of the system.Therefore,the(Mo Ta)_(0.2)Nb Ti Zr alloy is a potential structural material for biomedical implants because of its excellent strength and ductility.The developed alloy was investigated for its corrosion properties and compared with commercial biomedical alloys.Furthermore,the biocompatibility of the alloy was examined using an in vivo examination.The alloy was implanted in the skeletal muscles of mice for four weeks and the histology of the surrounding tissue was studied.The alloy exhibited strong passive behavior in a phosphate buffer solution and non-toxic soft tissue response. | Muhammad Akmal Ahtesham Hussain Muhammad Afzal Young Ik Lee Ho Jin Ryu | 2021 | Journal of Materials Science & Technology2021，，19： | 2 |
| 17 | New Discovery of the Early Cretaceous Volcanic Rocks on the Barton Peninsula,King George Island,Antarctica and Its Geological Significance显示文摘Ages determined with the 40Ar/39Ar isotopic system affirms the Early Cretaceous volcanic activity in the Barton Peninsula, King George Island, Antarctica. Two specimens of basaltic andesite collected from the lowermost volcanic sequence of the peninsula were irradiated and analyzed in different experiments, yielding an identical age spectrum, and two magmatic thermal events of the Early Cretaceous (120.4±1.6 Ma, 119±1 Ma) and Early Tertiary (5 3.1±1.5 Ma, 52±1 Ma) are distinguished. The former is interpreted to represent the primary cooling age of basaltic andesite, whereas the latter is the thermal reset age caused by the intrusion of granitic pluton. These new ages clearly indicate that volcanism was active during the Early Cretaceous on the Barton Peninsula and that intensive hy-drothermal alteration and mineralization of Mesozoic volcanic rocks resulted from Tertiary magmatism. | ZHENG Xiangshen SANG Haiqing QIU Ji LIU Jiaqi LEE Jong Ik KIM Hyeoncheol | 2000 | Acta Geologica Sinica(English Edition)2000，74，2： | 2 |
| 18 | The Effects of Aroma Acupuncture applied on Chronic Headache Patients显示文摘 | In Tae JUNG Su Yong KIM Doo Ik LEE Keon Sik KIM Jae Dong LEE Yun Ho LEE Do Young CHOI | 2005 | World Journal of Acupuncture-Moxibustion2005，15，3： | 2 |
| 19 | Clinical usefulness of 18F-FDG PET-CT for patients with gallbladder cancer and cholangiocarcinoma显示文摘 | Seung Won Lee Hong Joo Kim Jung Ho Park Dong Il Park Yong Kyun Cho Chong Il Sohn Woo Kyu Jeon Byung Ik Kim | 2010 | Journal of Gastroenterology2010，，5： | 2 |
| 20 | A follow-up of combined vaccination with plasmarived and recombinant hepatitis B vaccine in infants 显示文摘 | Lee Pi Noller Ik | 1995 | Vaccine1995，13，17： | 2 |
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