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| 1 | Sessile serrated adenomas:Demographic,endoscopic and pathological characteristics显示文摘AIM:To study the demographic and endoscopic characteristics of patients with sessile serrated adenoma(SSA) in a single center.METHODS:Patients with SSA were identified by review of the pathology database of Mayo Clinic Arizona from 2005 to 2007.A retrospective chart review was performed to extract data on demographics,polyp characteristics,presence of synchronous adenomatous polyps or cancer,polypectomy methods,and related complications.RESULTS:One hundred and seventy-one(2.9%) of all patients undergoing colonoscopy had a total of 226 SSAs.The mean(SE) size of the SSAs was 8.1(0.4) mm;42% of SSAs were ≤ 5 mm,and 69% were ≤ 9 mm.Fifty-one per cent of SSAs were located in the cecum or ascending colon.Approximately half of the patients had synchronous polyps of other histological types,including hyperplastic and adenomatous polyps.Synchronous adenocarcinoma was present in seven(4%) cases.Ninety-seven percent of polyps were removed by colonoscopy.CONCLUSION:Among patients with colon polyps,2.9% were found to have SSAs.Most of the SSAs were located in the right side and were safely managed by colonoscopy. | Suryakanth R Gurudu Russell I Heigh Giovanni De Petris Evelyn G Heigh Jonathan A Leighton Shabana F Pasha Isaac B Malagon Ananya Das | 2010 | World Journal of Gastroenterology2010，16，27： | 7 |
| 2 | Capsule endoscopy in suspected small bowel Crohn's disease:Economic impact of disease diagnosis and treatment显示文摘AIM: To model clinical and economic benef its of capsule endoscopy (CE) compared to ileo-colonoscopy and small bowel follow-through (SBFT) for evaluation of suspected Crohn’s disease (CD). METHODS: Using decision analytic modeling, total and yearly costs of diagnostic work-up for suspected CD were calculated, including procedure-related adverse events, hospitalizations, off ice visits, and medications. The model compared CE to SBFT following ileo-colonoscopy and secondarily compared CE to SBFT for initial evaluation. RESULTS: Aggregate charges for newly diagnosed, medically managed patients are approximately $8295. Patients requiring aggressive medical management costs are $29 508; requiring hospitalization, $49 074. At sensitivity > 98.7% and specifi city of > 86.4%, CE is less costly than SBFT. CONCLUSION: Costs of CE for diagnostic evaluationof suspected CD is comparable to SBFT and may be used immediately following ileo-colonoscopy. | Jonathan A Leighton Ian M Gralnek Randel E Richner Michael J Lacey Frank J Papatheofanis | 2009 | World Journal of Gastroenterology2009，15，45： | 5 |
| 3 | Nat Med:靶向两分子或有助于彻底治愈白血病显示文摘科学家在癌细胞内发现两个信号蛋白能够让癌细胞抵抗化疗。研究表明阻断这两种蛋白能够增强化疗对人类白血病小鼠模型的治疗效果。相关研究结果发表在国际学术期刊NatureMedicine上。研究人员发现在治疗中阻断c-Fos和Dusp1这两个蛋白能够治愈一些受激酶驱动且抵抗治疗的白血病和实体瘤。 | Meenu Kesarwani, Zachary Kincaid, Ahmed Gomaa, Erika Huber, Sara Rohrabaugh, Zain Siddiqui, Muhammad F Bouso, Kakajan Komurov, James C Mulloy, Jose A Cancelas, H Leighton Grimes Mohammad Azam Tahir Latif Ming Xu H Leighton Grimes Mohammad Azam | 2017 | 现代生物医学进展2017，17，17： | 4 |
| 4 | Guidelines for Conscious Sedation and Monitoring During Gastrointestinal Endoscopy显示文摘 | J.Patrick Waring Todd H Baron William K Hirota Jay L Goldstein Brian C Jacobson Jonathan A Leighton J.Shawn Mallery Douglas O Faigel | 2003 | Gastrointestinal Endoscopy2003，，3： | 1 |
| 5 | Effect of Channel Geometry on Solute Dispersion in Pressure-Driven Microfluidic Systems显示文摘 | Dutta D Ramachandran A Leighton D T | 2006 | Microfluid Nanofluid2006，2，： | 1 |
| 6 | ASGE guideline:the role of endoscopy in acute non-variceal upper-GI hemorrhage显示文摘 | Adler D G Leighton J A Davila R E | | 0，，04： | 1 |
| 7 | The shear-induced migration of particles in concentrated suspensions 显示文摘 | Leighton D T Aerivos A | 1987 | Journal of Fluid Mechanism1987，181，： | 1 |
| 8 | Double-balloon enteroscopy and capsule endoscopy have cmnparable diagnoslie yield in small-bowel dis- ease : a meta-analysis 显示文摘 | Pasha SF Leighton JA Das A | 2008 | Clin Gastroenterol Hepatol2008，6，6： | 1 |
| 9 | Anterior approachet and stabilization of the disrupted sacmiliac joint 显示文摘 | Simpson L A Waddell J P Leighton R K | 1987 | J Trauma1987，27，12： | 1 |
| 10 | A prospective study of the utility of abdominal radiographs after capsule endoscopy for the diagnosis of capsule retention 显示文摘 | Sachdev M S Leighton J A Fleischer D E | 2007 | Gastrointest Endosc2007，66，5： | 1 |
| 11 | Composition controlled spin polarization in Co1-x FexS2 alloys 显示文摘 | C Leighton M Manno A Cady J W Freeland L Wang K Umenoto R M Wentzcovitch T Y Chen C L Chien P L Kuhns M J R Hoch A P Reyes W G Moulton E D Dahlberg J Checkelsky J Eckert | 2007 | Journal of Physics : Condensed Matter2007，19，31： | 1 |
| 12 | The lift on a small sphere touching a plane in the presence of a simple shear flow 显示文摘 | LEIGHTON D ACRIVOS A | 1985 | Z Angew Math Phys1985，36，： | 1 |
| 13 | A meta - analysis of the yield of capsule endoscopy compared other diagnostic modalitie- sin patients with non--stficturing small bowel Crohn'S disease显示文摘 | Triester SL Leighton J A Leontiadis G I | 2006 | Am J Gastroenterol2006，101，95： | 1 |
| 14 | Crohn disease of the small bawel: preliminary comparison among CT enterography, capsule endoscopy, small-bowel follow-through, and ileoscopy显示文摘 | Hara A K Leighton J A Heigh R I | 2006 | Radiology2006，238，1： | 1 |
| 15 | Experimental hybridization in abalone显示文摘 | Leighton D L Lewis C A | 1982 | Int J Invertebr Reprod1982，5，5： | 1 |
| 16 | Advances in the treat,ment ofintracapsular hipfracturesinthe elderly显示文摘 | Leighton R K Schmidt A H Collier P | 2007 | Injury2007，38，3： | 1 |
| 17 | Small bowel: Preliminary comparison of capsule endoscopy with barium study and CT 显示文摘 | Hara A K Leighton J A Sharma V K | 2004 | Radiology2004，230，3： | 1 |
| 18 | Effect of parenteral opioid analgesia on the progress of labor: a meta-analysis显示文摘 | HALPERN SH LEIGHTON BL OHLSSON A | 1998 | JAMA1998，280，： | 1 |
| 19 | Effects of chronic administration of vanadate to the rat on the sensitivity of glycolysis and glycogen synthesis in skeletal muscle to insulin显示文摘 | CHALLISS R A LEIGHTON B LOZEMAN F J | 1987 | Biochem Pharmacol1987，36，3： | 1 |
| 20 | Small bowel:Preliminary comparison of capsule endoscopy with barium study and CT显示文摘 | Hara A K Leighton J A Sharma V K | 2004 | Radiology2004，230，3： | 1 |
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