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| 1 | Analysis of risk factors for postoperative pancreatic fistula following pancreaticoduodenectomy显示文摘AIM:To explore the morbidity and risk factors of postoperative pancreatic fistula(POPF)following pancreaticoduodenectomy.METHODS:The data from 196 consecutive patients who underwent pancreaticoduodenectomy,performed by different surgeons,in the General Hospital of the People’s Liberation Army between January 1st,2013and December 31st,2013 were retrospectively collected for analysis.The diagnoses of POPF and clinically relevant(CR)-POPF following pancreaticoduodenectomy were judged strictly by the International Study Group on Pancreatic Fistula Definition.Univariate analysis was performed to analyze the following factors:patient age,sex,body mass index(BMI),hypertension,diabetes mellitus,serum CA19-9 level,history of jaundice,serum albumin level,blood loss volume,pancreatic duct diameter,pylorus preserving pancreaticoduodenectomy,pancreatic drainage and pancreaticojejunostomy.Multivariate logistic regression analysis was used to determine the main independent risk factors for POPF.RESULTS:POPF occurred in 126(64.3%)of the patients,and the incidence of CR-POPF was 32.7%(64/196).Patient characteristics of age,sex,BMI,hypertension,diabetes mellitus,serum CA19-9 level,history of jaundice,serum albumin level,blood loss volume,pylorus preserving pancreaticoduodenectomy and pancreaticojejunostomy showed no statistical difference related to the morbidity of POPF or CR-POPF.Pancreatic duct diameter was found to be significantly correlated with POPF rates by univariate analysis and multivariate regression analysis,with a pancreatic duct diameter≤3 mm being an independent risk factor for POPF(OR=0.291;P=0.000)and CR-POPF(OR=0.399;P=0.004).The CR-POPF rate was higher in patients without external pancreatic stenting,which was found to be an independent risk factor for CR-POPF(OR=0.394;P=0.012).Among the entire patient series,there were three postoperative deaths,giving a total mortality rate of 1.5%(3/196),and the mortality associated with pancreatic fistula was 2.4%(3/126).CONCLUSION:A pancreatic duct diameter≤3 mm is an independent risk factor for POPF.External stent drainage of pancreatic secretion may reduce CR-POPF mortality and POPF severity. | Qi-Yu Liu Wen-Zhi Zhang Hong-Tian Xia Jian-Jun Leng Tao Wan Bin Liang Tao Yang Jia-Hong Dong | 2014 | World Journal of Gastroenterology2014，20，46： | 32 |
| 2 | Theory and experimental verification of valveless piezoelectric pump with rotatable unsymmetrical slopes显示文摘A valveless piezoelectric pump with rotatable unsymmetrical slopes is developed in this research.It has the following features:The pump integrates driving and transporting,and it can mix different fluids while transporting them.In this paper,firstly,the design of the valveless piezoelectric pump with rotatable unsymmetrical slopes was proposed,and the single-direction flow principle was explained.Then,the fluid mechanics model of the valveless piezoelectric pump with rotatable unsymmetrical slopes was established.Meanwhile,the numerical simulation of the pump was performed.Finally,the experiments on relationship between the rotation angles of the slope and the flow rates were conducted.The experimental results showed that the maximum flow was 32.32 mL min 1.The maximum relative error between the theoretical results and the experimental ones was 14.59%.For the relationship between rotation angles and flow ratio of two inlets,the relative error between the experimental and theoretical maxima was 3.75%.Thus,the experiments proved the feasibility of the pump design and verified the theory. | ZHANG JianHui XIA QiXiao HUANG Yi LENG XueFei HUANG Jun ZHAO ChunSheng | 2011 | Science China(Technological Sciences)2011，54，11： | 7 |
| 3 | A LC-ESI-MS method for the simultaneous determination of madecassoside and its metabolite madecassic acid in rat plasma: comparison pharmacokinetics in normal and collagen-induced arthritic rats显示文摘To develop a simple and highly sensitive high performance liquid chromatography with electrospray ionization mass spectrometric(LC-ESI-MS) method for the simultaneous determination of madecassoside and its major metabolite madecassic acid in rat plasma, and compare the pharmacokinetics of the two compounds in normal and collagen-induced arthritis(CIA) rats. Glycyrrhetinic acid was used as the internal standard(IS). Chromatographic separation was accomplished on an Inertsil ODS-3 column, using a gradient elution with the mobile phase composed of acetonitrile and water acidified with 0.1%(V/V) formic acid. Detection was achieved by ESI-MS under the negative selected ion monitoring(SIM) mode. In normal and CIA rats, madecassoside(30 mg·kg-1) was orally administered for 21 consecutive days from the day of arthritis onset. For madecassoside, the linear range was 10–1 000 ng·mL-1 with the square regression coefficient(r) of 0.998 9, while for madecassic acid, the linear range was 10–500 ng·mL-1 with the square regression coefficient(r) of 0.996 1. The lower limit of quantification was 10 ng·mL-1 for both analytes. The intra- and inter-day precision ranged from 1.78% to 13.42% for madecassoside and 2.30% to 14.90% for madecassic acid, and the accuracy was between –0.95% and 6.30% for madecassoside and between –1.48% and 5.34% for madecassic acid. The average recoveries of madecassoside, madecassic acid and IS from spiked plasma samples were > 81%. The developed method was successfully applied to the pharmacokinetic study of madecassoside and madecassic acid in rats after an oral administration of madecassoside. During initial 7 days of dosing, the cmax and AUC of madecassoside were greatly decreased and Vd/F was markedly increased in CIA rats, and no significant difference was observed on the first day of dosing. In contrast, the T1/2, cmax and AUC of madecassic acid were significantly increased, and Ke of madecassic acid was greatly decreased in CIA rats compared with normal rats. Along with repeated administration of madecassoside, the differences of pharmacokinetic parameters of both madecassoside and madecassic acid between CIA and normal rats gradually subsided. The pharmacokinetic characteristics of both madecassoside and madecassic acid in rats were significantly altered by arthritis status, and the differences of pharmacokinetic parameters between arthritis and normal rats coincide with the severity of arthritis. | WANG Ting LENG Dan-Dan GAO Fei-Fei JIANG Chun-Jie XIA Yu-Feng DAI Yue | 2014 | Chinese Journal of Natural Medicines2014，12，12： | 5 |
| 4 | Polypropylene non-woven supported fibronectin molecular imprinted calcium alginate/polyacrylamide hydrogel film for cell adhesion显示文摘Fibronectin(FN) imprinted polypropylene(PP) non-woven supported calcium alginate/polyacrylamide hydrogel film(PP-s-CA/PAM MIP) was prepared using non-woven PP fiber as matrix, FN as template molecule, sodium alginate(SA) and acrylamide(AM) as functional monomers, via UV radiation-reduced polymerization. The PP-s-CA/PAM MIP exhibited an obvious improvement in terms of adsorption capacity for FN compared with non-imprinted polymer(NIP). The PP-s-CA/PAM MIP was successfully used for the culture of mouse fibroblast cells(L929) and the results showed that PP-s-CA/PAM MIP exhibited better cell adherence performance than the NIP did. | Dun-Wan Zhu Zhuo Chen Kong-Yin Zhao Bo-Hong Kan Lan-Xia Liu Xia Dong Hai Wang Chao Zhang Xi-Gang Leng Lin-Hua Zhang | 2015 | Chinese Chemical Letters2015，26，6： | 4 |
| 5 | CYP1A1 Ile462Val polymorphism contributes to colorectal cancer risk:A meta-analysis显示文摘AIM:To study the relation between CYP1A1 Ile462Val polymorphism and colorectal cancer risk by meta-analysis. METHODS:A meta-analysis was performed to investigate the relation between CYP1A1 Ile462Val polymorphism and colorectal cancer risk by reviewing the related studies until September 2010.Data were extracted and analyzed.Crude odds ratio(OR) with 95% confidence interval(CI) was used to assess the strength of relation between CYP1A1 Ile462Val polymorphism and colorectal cancer risk. RESULTS:Thirteen published case-control studies including 5336 cases and 6226 controls were acquired. The pooled OR with 95%CI indicated that CYP1A1 Ile462Val polymorphism was significantly related with colorectal cancer risk(Val/Val vs Ile/Ile:OR=1.47,95%CI:1.16-1.86,P=0.002;dominant model:OR= 1.33,95%CI:1.01-1.75,P=0.04;recessive model:OR=1.49,95%CI:1.18-1.88,P=0.0009) .Subgroup ethnicity analysis showed that CYP1A1 Ile462Val polymorphism was also significantly related with colorectal cancer risk in Europeans(Ile/Val vs Ile/Ile:OR=1.22,95%CI:1.05-1.42,P=0.008;dominant model:OR= 1.24,95%CI:1.07-1.43,P=0.004) and Asians(Val/ Val vs Ile/Ile:OR=1.40,95%CI:1.07-1.82,P=0.01;recessive model:OR=1.46,95%CI:1.12-1.89,P= 0.005) . CONCLUSION:CYP1A1 Ile462Val may be an increased risk factor for colorectal cancer. | Jian-Qiang Jin Yuan-Yuan Hu Yu-Ming Niu Gong-Li Yang Yu-Yu Wu Wei-Dong Leng Ling-Yun Xia | 2011 | World Journal of Gastroenterology2011，17，2： | 4 |
| 6 | Remodeling of skin nerve fibers during burn wound healing显示文摘Burn wound healing involves a complex sequence of processes.Recent studies have revealed that skin reinnervation may have an impact on physiological wound repair.Few studies have addressed the process of reinnervation and morphological changes in regenerated nerve fibers.The regeneration of neurites during full-thickness burn wound healing was determined by immunofluorescent staining using an anti-neurofilament protein monoclonal antibody,and three-dimensional morphology was observed under a laser scanning confocal microscope.Morphology and the volume fraction of collagen and nerve fibers were measured.Skin reinnervation increased during wound healing,peaked during the proliferative scar stage,and then decreased to lower levels during the maturation period.The results from the skin nerve fibers correlated with those from collagen using semi-quantitative analysis.Disintegration and fragmentation were observed frequently in samples from the proliferative stage,and seldom occurred during the maturation stage.There was a remodeling process of regenerated nerve fibers during wound healing,which comprised changed innervation density and topical morphology.The mechanism of remodeling for nerve fibers requires further investigation. | Yongqiang Feng Xia Li Rui Zhang Yu Liu Tingting Leng Yibing Wang | 2010 | Neural Regeneration Research2010，5，19： | 4 |
| 7 | The Pathogenesis and Treatment of COVID-19:A System Review显示文摘INTRODUCTION After the outbreak of severe acute respiratory syndrome(SARS)and Middle East respiratory syndrome(MERS),it was difficult to imagine the recurrence of a virus that can spread worldwide in less than two decades.However,it did.In December of 2019,this virus called severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)was associated with the emergence of pneumonia cases of unknown etiology in Wuhan,Hubei Province. | JI Ye Long WU Yang QIU Zhen MING Hao ZHANG Yi ZHANG Ai Ning LENG Yan XIA Zhong Yuan | 2021 | Biomedical and Environmental Sciences2021，34，1： | 3 |
| 8 | Role of perceived family support in psychological distress for pregnant women during the COVID-19 pandemic显示文摘BACKGROUND The coronavirus disease 2019(COVID-19)pandemic has caused major public panic in China.Pregnant women may be more vulnerable to stress,which may cause them to have psychological problems.AIM To explore the effects of perceived family support on psychological distress in pregnant women during the COVID-19 pandemic.METHODS A total of 2232 subjects were recruited from three cities in China.Through the online surveys,information on demographic data and health status during pregnancy were collected.Insomnia severity index,generalized anxiety disorder 7-item scale,patient health questionnaire-9,somatization subscale of the symptom check list 90 scale,and posttraumatic stress disorder checklist were used to assess the psychological distress.RESULTS A total of 1015(45.4%)women reported having at least one psychological distress.The women who reported having inadequate family support were more likely to suffer from multiple psychological distress(≥2 psychological distress)than women who received adequate family support.Among the women who reported less family support,41.8%reported depression,31.1%reported anxiety,8.2%reported insomnia,13.3%reported somatization and 8.9%reported posttraumatic stress disorder(PTSD),which were significantly higher than those who received strong family support.Perceived family support level was negatively correlated with depressive symptoms(r=-0.118,P<0.001),anxiety symptoms(r=-0.111,P<0.001),and PTSD symptoms(r=-0.155,P<0.001).CONCLUSION Family support plays an important part on pregnant women’s mental health during the COVID-19 pandemic.Better family support can help improve the mental health of pregnant women. | Yan-Ni Wang Zhao-Jing Yuan Wan-Chun Leng Lu-Yao Xia Ruo-Xi Wang Ze-Zhi Li Yong-Jie Zhou Xiang-Yang Zhang | 2021 | World Journal of Psychiatry2021，11，7： | 3 |
| 9 | Impact of Chronic Stress on Attention Control:Evidence from Behavioral and Event-Related Potential Analyses显示文摘Chronic stress affects brain function,so assessing its hazards is important for mental health.To overcome the limitations of behavioral data,we combined behavioral and event-related potentials(ERPs)in an attention network task.This task allowed us to differentiate between three specific aspects of attention:alerting,orienting,and execution.Forty-one participants under chronic stress and 31 non-stressed participants were enrolled.On the performance level,the chronically stressed group showed a significantly slower task response and lower accuracy.Concerning ERP measures,smaller cue-N1,cueN2,and larger cue-P3 amplitudes were found in the stressed group,indicating that this group was less able to assign attention to effective information,i.e.,they made inefficient use of cues and had difficulty in maintaining alerting.In addition,the stressed group showed larger target-N2 amplitudes,indicating that this group needed to allocate more cognitive resources to deal with the conflict targets task.Subgroup analysis revealed lower target-P3 amplitudes in the stressed than in the non-stressed group.Group differences associated with the attention networks were found at the ERP level.In the stressed group,excessive depletion of resources led to changes in attention control.In this study,we examined the effects of chronic stress on individual executive function from a neurological perspective.The results may benefit the development of interventions to improve executive function in chronically stressed individuals. | Qingjin Liu Yong Liu Xuechen Leng Jinfeng Han Feng Xia Hong Chen | 2020 | Neuroscience Bulletin2020，36，11： | 3 |
| 10 | Synthesis of N-methylene phosphonic chitosan(NMPCS)and its potential as gene carder显示文摘N-Methylene phosphoulc chitosan (NMPCS),an amphiphilic macromolecule with powerful chelating ability of Ca^(2+) ions,was synthesized and characterized.The physicochemical properties of NMPCS and the interactions between NMPCS and plasmid DNA were investigated by FTIR,^(13)C NMR,X-ray,agarose gel electrophorcsis retardation assay,atomic force microscopy (AFM) and circular dichroism (CD).The results suggest that at charge ratio 2:1 or above,DNA could be completely entrapped and spherical complexes with mean size of 80-210 nm were formed.Taking HeLa as host cell,luciferase expression mediated by NMPCS improved about 100 times compared to the expression mediated by chitosan. | Dun Wan Zhu Jin Gen Bo Hai Ling Zhang Wen Guang Liu Xi Gang Leng Cun Xian Song Yu Ji Yin Li Ping Song Lan Xia Liu Lin Mei Xiu Lan Li Yang Zhang Kang De Yao | 2007 | Chinese Chemical Letters2007，18，11： | 3 |
| 11 | Insights into summertime haze pollution events over Shanghai based on online water-soluble ionic composition of aerosols显示文摘 | Huanhuan Du Lingdong Kong Tiantao Cheng Jianmin Chen Jianfei Du Ling Li Xiangao Xia Chunpeng Leng Guanghan Huang | 2011 | Atmospheric Environment2011，，29： | 2 |
| 12 | Study on the PTX Parameters and Fractal Characteristics of Ore-Forming Fluids in the East Ore Section of the Pulang Copper Deposit,Southwest China显示文摘In this paper,the east ore section of the Pulang porphyry copper deposit is selected as the research object.The micro-thermometer and laser Raman spectroscopic technique are utilized to study the parameters of ore-forming fluids such as pressure,temperature,and compositions.In the meantime,the fractal models,including the perimeter-area(P-A)model and number-size(N-S)model,are introduced to quantify the shape of fluid inclusions,and distinguish the stages of ore-forming fluids,respectively.The results show that the types of fluid inclusions are diversified,namely two-phase liquid-rich type,two-phase vapor-rich type,three-phase CO2-rich type,three-phase halite-bearing type and pure liquid type.The fluids of main mineralization stage are characterized by medium-high temperature(170.2–421.4°C),medium-high salinity(9.3 wt.%–33.3 wt.%),and low density(0.73–1.06 g/cm3).With the migration and evolution,the temperature,salinity,and pressure of ore-forming fluids gradually decrease,while the density of fluids increases.The liquid-phase compositions mainly include H2O,and the vapor-phase compositions consist of H2O,CH4,N2,and CO2,indicating the characteristics of reducing fluids and the mixing of atmospheric precipitation.In general,the characteristics of ore-forming fluids in the east ore section are similar to those of the first mining area,suggesting that the ore-forming fluids in the east ore section may not migrate from the first mining area.And the east ore section may be a relatively independent metallogenic system.Moreover,the fractal analysis results demonstrate that the shape of fluid inclusions formed in the same hydrothermal activity features self-similarity.The DAPvalues of fluid inclusions in B veins,ED veins,andD veins are 1.04,1.06 and 1.10,respectively,showing a gradually increasing trend from the main stage to the late stage of mineralization.Meanwhile,the shape of fluid inclusions ranging from B veins to D veins becomes increasingly irregular.It also reveals that the homogenization temperature satisfies fractal distribution with four scale-invariant intervals,suggesting that all B veins,ED veins,and D veins have experienced at least four hydrothermal activities.Compared with histogram,the N-S fractal model is able to describe the distribution characteristics of the ore-forming fluids’homogenization temperature more precisely.Therefore,it presents a potential tool for the stage division of ore-forming fluids.This research provides information about the characteristics of ore-forming fluids in the east ore section of the Pulang porphyry copper deposit,which is beneficial for further exploration in this region,and the extension of the application of fractal models in the study of fluid inclusions.However,further testing of fractal models on the fluid inclusion study is warranted to fully determine the universality. | Qinglin Xia Tongfei Li Li Kang Shuai Leng Xiaochen Wang | 2021 | Journal of Earth Science2021，32，2： | 2 |
| 13 | Kruppel-like factor 4 acts as an oncogene in colon cancer stem cell-enriched spheroid cells显示文摘 | Leng Z Tao K Xia Q | 2013 | PLo S One2013，8，56： | 1 |
| 14 | A projection neural network and its application to constrained optimization problems显示文摘 | Xia Y S Leng H Wang J | 2002 | IEEE Trans on Circuits and Systems2002，49，4： | 1 |
| 15 | Krfippel-like factor 4 acts as an oncogene in colon cancer stem cell-enriched spheroid cells 显示文摘 | LENG Z TAO K XIA Q et d | 2013 | PLoS One2013，8，56： | 1 |
| 16 | Evaluation of the efficacy of an attenuated live vaccine against highly pathogenic porcine reproductive and respiratory syndrome virus in young pigs显示文摘 | Leng X Li Z Xia M | 2012 | Clin Vaccine Immunol2012，1，： | 1 |
| 17 | Evaluation of the efficacy of an at tenuated live vaccine against highly pathogenic porcine reproduc- tive and respiratory syndrome virus in young pigs显示文摘 | Leng X Li Z Xia M | 2012 | Clin Vac- cine Immunol2012，19，8： | 1 |
| 18 | Radiotherapy for gastric cancer: a systematic review and meta-analysis显示文摘 | Xiaohui Pang Wanqing Wei Weibing Leng Qi Chen Hongwei Xia Liu Chen Ronghui Li | 2014 | Tumor Biology2014，，： | 1 |
| 19 | Mutations in the genome of the highly pathogenic porcine reproductive and respiratory syndrome virus potentially related to attenuation显示文摘 | Leng X1 Li Z Xia M | 2012 | Vet Microbiol2012，157，12： | 1 |
| 20 | Mutations in the genome of the highly pathogenic porcine reproductive and respiratory syndrome virus po- tentially related to attenuation 显示文摘 | LENG X LI Z XIA M | 2012 | Vet Microbiol2012，157，12： | 1 |
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