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204篇 您的检索式：作者名="LEONI G"

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	题名	作者	年代	出处	被引量
1	Regulation of intestinal permeability: The role of proteases显示文摘The gastrointestinal barrier is-with approximately 400 m^2-the human body's largest surface separating the external environment from the internal milieu. This barrier serves a dual function: permitting the absorption of nutrients, water and electrolytes on the one hand, while limiting host contact with noxious luminal antigens on the other hand. To maintain this selective barrier, junction protein complexes seal the intercellular space between adjacent epithelial cells and regulate the paracellular transport. Increased intestinal permeability is associated with and suggested as a player in the pathophysiology of various gastrointestinal and extraintestinal diseases such as inflammatory bowel disease, celiac disease and type 1 diabetes. The gastrointestinal tract is exposed to high levels of endogenous and exogenous proteases, both in the lumen and in the mucosa. There is increasing evidence to suggest that a dysregulation of the protease/antiprotease balance in the gut contributes to epithelial damage and increased permeability. Excessive proteolysis leads to direct cleavage of intercellular junction proteins, or to opening of the junction proteins via activation of protease activated receptors. In addition, proteases regulate the activity and availability of cytokines and growth factors, which are also known modulators of intestinal permeability. This review aims at outlining the mechanisms by which proteases alter the intestinal permeability. More knowledge on the role of proteases in mucosal homeostasis and gastrointestinal barrier function will definitely contribute to the identification of new therapeutic targets for permeability-related diseases.	Hanne Van Spaendonk Hannah Ceuleers Leonie Witters Eveline Patteet Jurgen Joossens Koen Augustyns Anne-Marie Lambeir Ingrid De Meester Joris G De Man Benedicte Y De Winter	2017	World Journal of Gastroenterology2017，23，12：	6
2	The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines显示文摘	Leoni F Zaliani A Bertolini G Porro G Pagani P Pozzi P	2002	Proc Natl Acad Sci USA2002，99，：	1
3	MAISTAS:a tool for automatic structural evaluation of alternative splicing products显示文摘	Floris M Raimondo D Leoni G	2011	Bioinformatics2011，27，12：	1
4	The antitumor histone deacety-lase inhibitor suberoylanilide hydroxamic acid exhibits anti-in-flammatory properties via suppression of cytokines显示文摘	Leoni F Zaliani A Bertolini G Porro G Pagani P Pozzi P Dona G Fossati G Sozzani S* Azam T Bufler P Fantuzzi G Goncharov I Kim SH Pomerantz BJ Reznikov LL SiegmundB Dinarello CA Mascagni P	2002	ProcNatl Acad Sci USA2002，99，：	1
5	The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic in- flammation in vivo 显示文摘	LEONI F FOSSATI G LEWIS E C	2005	Molecular Medicine2005，11，123456789101112：	1
6	The use of tenax for the extraction of pesticides and polychlorinated biphenyls from water显示文摘	Puccetti G Colombo R J	1976	J Chromatogr1976，125，：	1
7	Genetic analysis of Cryptosporidium from 2414 humans with diarrhoea in England between 1985 and 2000显示文摘	LEONI F AMAR C NICHOLS G	2006	Journal of Medical Microbiology2006，55，：	1
8	BRAF V600E mutation analysis increases diagnostic accuracy for papillary thyroid carcinoma in fine- needle aspiration biopsies显示文摘	Zatelli MC Trasforini G Leoni S	2009	EurJ Endocrinol2009，161，3：	1
9	Genetic analysis of Cryptosporidium from 2414 humans with diarrhoea in England between 1985 and 2000显示文摘	Leoni F Amar C Nichols G	2006	J Med Microbiol2006，55，6：	1
10	Arsenic trioxide therapy for relapsed acute promyelocytic leukemia: a bridge to transplantation 显示文摘	Leoni F Gianfaldoni G Annunziata M Fanci R Ciol- li S Nozzoli C	2002	Haematologica2002，87，5：	1
11	The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits anti-inflammatory properties via suppression of cytokines显示文摘	Leoni F Zaliani A Bertolini G	2002	Proc Natl Acad Sci USA2002，99，5：	1
12	Simultaneous occurrence of chronic granulocytic leukemia and chronic lymphoid leukemia 显示文摘	LEONI F FERRINI P R CASTOLDI G L	1987	Haematologica1987，72，5：	1
13	Oocyte cryop-reservation and ovarin tissue banking显示文摘	Leoni G Boyliolo L	2001	Theriogenology2001，55，6：	1
14	Lhermitte's sign followingoxaliplatin-containing chemotherapy in a cisplatin-pretreated ovar-ian cancer patient显示文摘	Ciucci G De Giorgi U Leoni M	2003	Eur J Neurol2003，10，3：	1
15	Genetic analysis of Cryptosporidium from 2414 humans with diarrhoea in England between 1985 and 2000 显示文摘	Leoni F Amar C Nichols G	2006	J Med Microbiol2006，55，6：	1
16	Arsenic trioxide therapy for relapsed acute promyelocytic leukemia:a bridge to transplantation显示文摘	Leoni F Gianfaldoni G Annunziata M	2002	Haematologica2002，87，5：	1
17	Prospective, randomized comparison of deep or supperfcial cervieal plexus block for carotid eudarterectomy surrgery显示文摘	Leoni A Margrin S Mascotto G	1998	Anesthesiology1998，89，4：	1
18	Kinematic Bending Moments in Pile Foundations显示文摘	Dezi F Carbonari S Leoni G	2010	Soil Dynamics and Earthquake Engineer-ing2010，30，3：	1
19	BRAF V600E mutation analysis increases diagnostic accuracy for papillary thyroid carcinoma in fine-needle aspiration biopsies显示文摘	Zatelli MC Trasforini G Leoni S	2009	Eur J Endocrinol2009，161，3：	1
20	Ultrasound-guided liver resections for hepatocellular carcinoma显示文摘	Torzilli G Leoni P Gendarini A	2002	Hepatogastroenterology2002，49，43：	1

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