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| 1 | Radiofrequency ablation for early oesophageal squamous neoplasia:Outcomes form United Kingdom registry显示文摘AIM:To report outcomes on patients undergoing radiofrequency ablation(RFA)for early oesophageal squamous neoplasia from a National Registry.METHODS:A Prospective cohort study from 8 tertiary referral centres in the United Kingdom.Patients with squamous high grade dysplasia(HGD)and early squamous cell carcinoma(ESCC)confined to the mucosa were treated.Visible lesions were removed by endoscopic mucosal resection(EMR)before RFA.Following initial RFA treatment,patients were followed up 3monthly.Residual flat dysplasia was treated with RFA until complete reversal dysplasia(CR-D)was achieved or progression to invasive Squamous cell cancer defined as infiltration into the submucosa layer or beyond.The main outcome measures were CR-D at 12 mo from start of treatment,long term durability,progression to cancer and adverse events.RESULTS:Twenty patients with squamous HGD/ESCC completed treatment protocol.Five patients(25%)had EMR before starting RFA treatment.CR-D was 50%at12 mo with a median of 1 RFA treatment,mean 1.5(range 1-3).Two further patients achieved CR-D with repeat RFA after this time.Eighty per cent with CR-D remain dysplasia free at latest biopsy,with median follow up 24 mo(IQR 17-54).Six of 20 patients(30%)progressed to invasive cancer at 1 year.Four patients(20%)required endoscopic dilatations for symptomatic structuring after treatment.Two of these patients have required serial dilatations thereafter for symptomatic dysphagia with a median of 4 dilatations per patient.The other 2 patients required only a single dilatation to achieve an adequate symptomatic response.One patient developed cancer during follow up after end of treatment protocol.CONCLUSION:The role of RFA in these patients re-mains unclear.In our series 50%patients responded at12 mo.These figures are lower than limited published data. | Rehan J Haidry Mohammed A Butt Jason Dunn Matthew Banks Abhinav Gupta Howard Smart Pradeep Bhandari Lesley Ann Smith Robert Willert Grant Fullarton Morris John Massimo Di Pietro Ian Penman Marco Novelli Laurence B Lovat | 2013 | World Journal of Gastroenterology2013，19，36： | 7 |
| 2 | Psychosocial factors and their association with reflux oesophagitis,Barrett's oesophagus and oesophageal adenocarcinoma显示文摘AIM:To investigate the role of psychological characteristics as risk factors for oesophageal adenocarcinoma(OAC),as well as the reflux-mediated precursor pathway.METHODS:An all-Ireland population-based case-control study recruited 230 reflux oesophagitis(RO),224 Barrett's oesophagus(BO) and 227 OAC patients and 260 controls.Each case/control group completed measures of stress,depression,self-efficacy,self-esteem,repression and social support.A comparative analysis was undertaken using polytomous logistic regression adjusted for potential confounders.RESULTS:Compared to controls,OAC patients were almost half as likely to report high stress levels over their lifetime(P = 0.010,OR 0.51;95%CI:0.29-0.90)and 36% less likely to report having experienced depression(OR 0.64;95%CI:0.42-0.98).RO patients reported significantly higher stress than controls particularly during middle-and senior-years(P for trends < 0.001).RO patients were 37% less likely to report having been highly emotionally repressed(OR 0.63;95%CI:0.41-0.95).All case groups(OAC,RO and BO) were more likely than controls to report having had substantial amounts of social support(OR 2.84;95%CI:1.63-4.97;OR 1.97;95%CI:1.13-3.44 and OR 1.83;95%CI:1.03-3.24,respectively).CONCLUSION:The improved psychological profile of OAC patients may be explained by response shift.The role of psychological factors in the development of OAC requires further investigation. | Paul Denver Michael Donnelly Liam J Murray Lesley A Anderson | 2013 | World Journal of Gastroenterology2013，19，11： | 5 |
| 3 | Risk factors for Barrett’s oesophagus and oesophageal adenocarcinoma:Results from the FINBAR study显示文摘AIM:To investigate risk factors associated with Barrett's oesophagus and oesophageal adenocarcinoma.METHODS:This all-Ireland population-based case-control study recruited 224 Barrett's oesophagus patients,227 oesophageal adenocarcinoma patients and 260 controls.All participants underwent a structured interview with information obtained about potential lifestyle and environmental risk factors.RESULTS:Gastro-oesophageal reflux was associated with Barrett's [OR 12.0(95% CI 7.64-18.7)] and oesophageal adenocarcinoma [OR 3.48(95% CI 2.25-5.41)].Oesophageal adenocarcinoma patients were more likely than controls to be ex-or current smokers [OR 1.72(95% CI 1.06-2.81)and OR 4.84(95% CI 2.72-8.61)respectively] and to have a high body mass index [OR 2.69(95% CI 1.62-4.46)].No significant associations were observed between these risk factors and Barrett's oesophagus.Fruit but not vegetables were negatively associated with oesophageal adenocarcinoma [OR 0.50(95% CI 0.30-0.86)].CONCLUSION:A high body mass index,a diet low in fruit and cigarette smoking may be involved in the progression from Barrett's oesophagus to oesophageal adenocarcinoma. | Lesley A Anderson RG Peter Watson Seamus J Murphy Brian T Johnston Harry Comber Jim Mc Guigan John V Reynolds Liam J Murray | 2007 | World Journal of Gastroenterology2007，13，10： | 5 |
| 4 | Have patients with esophagitis got an increased risk of adenocarcinoma? Results from a population-based study显示文摘AIM: To examine an increased risk of esophageal adenocarcinoma is restricted to patients who develop Barrett's esophagus or whether esophagitis per se is a risk factor for adenocarcinoma.METHODS: A population-based cohort of patients with histological evidence of esophagitis without Barrett's esophagus was constructed using electronic pathology reports relating to all esophageal biopsies in Northern Ireland between 1993 and 1996. Person-years of followup and incident cases of esophageal cancer were calculated by linking the cohort to death files and the Northern Ireland Cancer Registry records. Standardized incidence ratios (SIR) were calculated for esophageal cancers (adenocarcinoma, squamous cell carcinoma (SCC), and histologically unspecified cancers).RESULTS: A total of 2 013 patients in the cohort provided 13 559 patient-years of follow-up (mean follow-up 6.7 years). None of the patients developed adenocarcinoma. Three patients developed SCC, and six developed histologically unspecified cancers. The SIR for all esophageal cancers and for SCC were 2.73 (95%CI 1.25-5.19) and 2.93 (95%CI 0.61-8.59), respectively. In a sensitivity analysis in which all unspecified esophageal cancers were treated as adenocarcinomas, the SIR for adenocarcinoma was 2.64 (0.97-5.75).CONCLUSION: The risk of adenocarcinoma is not elevated in patients with histological evidence of esophagitis without Barrett's esophagus; however, these patients may have a moderately increased risk of SCC.Further studies are required to confirm these findings,which suggest that Barrett's esophagus, not esophagitis,is the key precursor lesion in the development of adenocarcinoma. | Seamus J Murphy Lesley A Anderson Brian T Johnston Deirdre A Fitzpatrick Peter RG Watson Pauline Monaghan Liam J Murray | 2005 | World Journal of Gastroenterology2005，11，46： | 4 |
| 5 | Human cord blood-derived cells can differentiate into hepatocytes in the mouse liver with no evidence of cellular fusion显示文摘 | Philip N Newsome Ingolfur Johannessen Shelagh Boyle Evangelos Dalakas Karen A Mcaulay Kay Samuel Frances Rae Lesley Forrester Marc L Turner Peter C Hayes David J Harrison Wendy A Bickmore John N Plevris | 2003 | Gastroenterology2003，，7： | 2 |
| 6 | CD44 and its interaction with extracellular matrix显示文摘 | Lesley J Hyman R Kincade PW | 1993 | Adv Immunol1993，54，： | 1 |
| 7 | Poliovirus replicons encoding the B subunit of Helicobacter Pylori unrease elicit a Th1 associated immune response显示文摘 | Novak Lesley E | 1999 | Vaccine1999，17，： | 1 |
| 8 | Prevalence of chronic kidney disease in the united States显示文摘 | Coresh J Selvin E Lesley A | 2007 | JAMA2007，298，17： | 1 |
| 9 | Simultaneous nitrification and denitrification in aerobic chemostat cultures of Thiosphaera pantotropha 显示文摘 | Lesley A R Van Niel E W J Torremans R A M | 1998 | Appl Eviron Microbiol1998，54，： | 1 |
| 10 | A genetic study of inbreeding and of crossing inbred lines of peaches显示文摘 | Lesley J W | 1957 | Proc Amer Hort Scr1957，70，： | 1 |
| 11 | Consensus decision making in human crowds 显示文摘 | Johnr G Dyer Christos C Ioan-Nou Lesley J Morrell | 2008 | Animal behaviour2008，75，2： | 1 |
| 12 | 口腔癌患者体细胞线粒体基因突变分布、特点及突变热点探讨显示文摘目的近年研究已经发现线粒体DNA编码、氧化磷酸化和细胞ATP产生所需的多肽的表达改变是肿瘤细胞的常见特征,线粒体已涉及到细胞凋亡,也可能由于它对突变子的高度敏感性和DNA修复机制的缺陷而参与了肿瘤的发生过程.有研究显示沉溺于嚼槟榔伴用矿物粉的男性患者,在其后半生具有口腔癌发生的高度风险,癌发生率也有逐年增高的趋势. | 刘玲玲 谭端军 Lesley J Agress LJC Wong | 2002 | 中华老年多器官疾病杂志2002，1，1： | 1 |
| 13 | Recombinant Factor VIIa:a view of its use in congenital or acquired haemophilia and othee congenital bleeding disorders显示文摘 | Asif M Siddiqui A Lesley J | 2005 | Drugs2005，65，8： | 1 |
| 14 | Separation of high molecular weight sorghum procyanidins by HPLC显示文摘 | LESLEY J P LARRY G B | 1989 | J Agric Food Chem1989，37，： | 1 |
| 15 | Double origin of the posterior inferior cerebellar artery显示文摘 | Lesley W S Dalsania H J | 2004 | AJNR2004，25，3： | 1 |
| 16 | Hyaluronate can function as a cell adhesion molecule and C,D44 participates in hyaluronate recognition显示文摘 | Miyake BK Underhill CB Lesley J | 1990 | J Exp Med1990，172，： | 1 |
| 17 | BAI 3, CDX 2 and VIL 1: a panel of three antibodies to distinguish small cell from large cell neuroendocrine lung carcinomas显示文摘 | Muhammad F Bari Helen Brown Andrew G Nicholson Keith M Kerr John R Gosney William A Wallace Irshad Soomro Salli Muller Danielle Peat Jonathan D Moore Lesley A Ward Maxim B Freidin Eric Lim Manu Vatish David R J Snead | 2014 | Histopathology2014，，： | 1 |
| 18 | Habitat specificity, seed germination and experimental translocation of the endangered herb Brachycome muelleri (Asteraceae)显示文摘 | MANFRED J LESLEY P BIRGITTE S | 2004 | Biological Conservation2004，116，： | 1 |
| 19 | Thiosphaera Pantotropha gen nov sp nov, a Facultative Autotrophic Sulphur Bacterium显示文摘 | Lesley A Robertson L A Kuenen J G | 1983 | J Gen Microbiol1983，129，8： | 1 |
| 20 | Influence of HLA gene polymorphisms on susceptibility and outcome post infection with the SARS-CoV virus显示文摘Dear Editor,Severe Acute Respiratory Syndrome(SARS)has beendescribed as the first pandemic of the 21st century andbetween November 2002 and July 2003,over 8000 peo-ple were infected with the SARS-associated coronavirus(SARS-CoV).Polymorphisms in the human leukocyteantigen(HLA)system have been shown to influencesusceptibility to SARS-CoV but here we were unable | Fang Fang Yuan Zlatibor Velickovic Lesley J Ashton Wayne B Dyer Andrew F Geczy Heather Dunckley Garry W Lynch John S Sullivan | 2014 | Virologica Sinica2014，29，2： | 1 |
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