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| 1 | An acorn squash (Cucurbita pepo ssp. ovifera) fruit and seed transcriptome as a resource for the study of fruit traits in Cucurbita显示文摘Acorn squash(Cucurbita pepo)is an iconic fall vegetable in the United States,known for its unique fruit shape and also prized for its culinary properties.Little is known about the metabolism that underlies the development of fruit quality attributes such as color,sweetness,texture and nutritional qualities in acorn squash,or any other winter squash grown worldwide.To provide insight into winter squash fruit and seed development and add to the genomic resources in the Cucurbita genus,RNA sequencing was used to generate an acorn squash fruit and seed transcriptome from the cultivar Sweet REBA at critical points throughout fruit development.141838600 high-quality paired-end Illumina reads were assembled into 55949 unigenes.85%of unigenes with predicted open reading frames had homology with previously identified genes and over 62%could be functionally annotated.Comparison with the watermelon and cucumber genomes provided confirmation that the unigenes are full-length and comprehensive,covering an average of 90%of the coding sequence of their homologs and 72%of the cucumber and watermelon exomes.Key candidate genes associated with carotenoid and carbohydrate metabolism were identified toward a resource for winter squash fruit quality trait dissection.This transcriptome represents a major advance in C.pepo genomics,providing significant new sequence information and revealing the repertoire of genes expressed throughout winter squash fruit and seed development.Future studies on the genetic basis of fruit quality and future breeding efforts will be enhanced by tools and insights developed from this resource. | Lindsay E Wyatt Susan R Strickler Lukas A Mueller Michael Mazourek | 2015 | Horticulture Research2015，2，1： | 11 |
| 2 | Comparative analysis of Cucurbita pepo metabolism throughout fruit development in acorn squash and oilseed pumpkin显示文摘Both the fruit mesocarp and the seeds of winter squash can be used for consumption,although the focus of breeding efforts varies by cultivar.Cultivars bred for fruit consumption are selected for fruit mesocarp quality traits such as carotenoid content,percent dry matter,and percent soluble solids,while these traits are essentially ignored in oilseed pumpkins.To compare fruit development in these two types of squash,we sequenced the fruit transcriptome of two cultivars bred for different purposes:an acorn squash,‘Sweet REBA’,and an oilseed pumpkin,‘Lady Godiva’.Putative metabolic pathways were developed for carotenoid,starch,and sucrose synthesis in winter squash fruit and squash homologs were identified for each of the structural genes in the pathways.Gene expression,especially of known rate-limiting and branch point genes,corresponded with metabolite accumulation both across development and between the two cultivars.Thus,developmental regulation of metabolite genes is an important factor in winter squash fruit quality. | Lindsay E Wyatt Susan R Strickler Lukas A Mueller Michael Mazourek | 2016 | Horticulture Research2016，3，1： | 7 |
| 3 | Chemotherapy options in elderly and frail patients with metastatic colorectal cancer (MRC FOCUS2): an open-label, randomised factorial trial显示文摘 | Matthew T Seymour Lindsay C Thompson Harpreet S Wasan Gary Middleton Alison E Brewster Stephen F Shepherd M Sinead O’Mahony Timothy S Maughan Mahesh Parmar Ruth E Langley | 2011 | The Lancet2011，，9779： | 2 |
| 4 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 5 | Cholesterol-induced caveolin targeting to lipid droplets in adipocytes:a role for caveolar endocytosis显示文摘 | Le Lay S Hajduch E Lindsay M R | 2006 | Traffic2006，7，5： | 1 |
| 6 | Percutaneous coronary intervention-associated nephropathy foreshadows increased risk of lateadverse events in patients with normal baseline serum creatinine显示文摘 | LINDSAY J APPLE S PINNOW E E | 2003 | Catheter Cardiovasc Interv2003，59，3： | 1 |
| 7 | The competence of top team members: A frame-work for successful performance 显示文摘 | Thompson J E Stuart R Lindsay P R | 1996 | Journal of Managerial Psychology1996，11，3： | 1 |
| 8 | Modeling radiation pneumo nitis risk with clinical,dosimetric, and spatial parameters显示文摘 | Hope A J Lindsay P E EI Naqa I | 2006 | Int J Ra diat Oncol Biol Phys2006，65，1： | 1 |
| 9 | Dynamics of urban growth in Washington DC metropolitan area from landsat observations 显示文摘 | Masek J G Lindsay F E Goward S N | 2000 | International Journal of Remote Sensing2000，21，18： | 1 |
| 10 | Effects of daily treatment with parathyroid hormone on bone microarchitecture and turnover in patients with osteoporosis:a paired biopsy study显示文摘 | Dempster DW Cosman F Kurland ES Zhou H Nieves J Woelfert L Shane E Plavetic K Muller R Bilezikian J Lindsay R | | 0，，10： | 1 |
| 11 | Velo-cardio-facial syndrome associated with chromosome 22 deletions encompassing the Di George locus显示文摘 | Scambler P J Kelly D Lindsay E | 1992 | Lancet1992，，339： | 1 |
| 12 | Dynamics of ur- ban growth in the Washington D C metropolitanarea, 1973-1996, from Landsat observation 显示文摘 | Masek J G Lindsay F E Goward S N | 2000 | Internation- al Journal of Remote Sensing2000，21，18： | 1 |
| 13 | Infection after colorectal surgery : a randomized trial of prophylaxis with piperacillin versus sulbactam/ piperacillin显示文摘 | Stewart E Taylor W Lindsay G | 1995 | J Hosp Inf1995，29，： | 1 |
| 14 | microRNA and the immune response显示文摘 | Tsitsiou E Lindsay MA | 2009 | Curr Opin Pharmacol2009，9，4： | 1 |
| 15 | Analysis of aggregation response in Trogoderma grablumlarvae显示文摘 | Nara J M Lindsay R C Burkholder W E | 1981 | J Agri Food Chem1981，29，： | 1 |
| 16 | Limitations of the Knee Society Score in evaluating outcomes following revision total knee arthroplasty显示文摘 | Ghanem E Pawasarat I Lindsay A | 2010 | J Bone Joint Surg Am2010，92，14： | 1 |
| 17 | Second European ev- idence-based consensus on the diagnosis and management of ulcerative colitis:current management显示文摘 | Dignass A Lindsay J O Sturm A e t al | 2012 | J Crohns Coli- tis2012，6，10： | 1 |
| 18 | Use of the Tobit model in contingent valuation: Experimental evidence from the Pemige- wasset Wilderness Area显示文摘 | Halstead J M Lindsay B E Brown C M | 1991 | Journal of Environmental Manage- ment1991，33，1： | 1 |
| 19 | Hepatic mast cells in rats infected with Taeniataeniaeformis显示文摘 | Lindsay M C Williams J E | 1985 | parasit1985，15，： | 1 |
| 20 | Thermoelasticity显示文摘 | Green A E Lindsay K A | 1972 | Journal of Elasticity1972，2，1： | 1 |
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