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| 1 | Oxidative stress and extracellular matrices after hepatectomy and liver transplantation in rats显示文摘AIM:To investigate oxidative stress(OS)-mediated damage and the behavior of extracellular matrices in various rat models because shear stress with portal hypertension and cold ischemia/warm reperfusion injury trigger the liver regeneration cascade after surgery. These injuries also cause fatal liver damage.METHODS: Rats were divided into four groups according to the surgery performed: control; hepatectomy with 40% liver remnant(60% hepatectomy); orthotopic liver transplantation(OLT) with whole liver graft(100% OLT); and split OLT(SOLT) with 40% graft(40% SOLT). Survival was evaluated. Blood and liver samples were collected at 6 h after surgery. Biochemical and histopathological examinations were performed. OSinduced damage, 4-hydroxynonenal, ataxia-telangiectasia mutated kinase, histone H2AX, phosphatidylinositol 3-kinase(PI3K) and Akt were evaluated by western blotting. Behavior of extracellular matrices, matrix metalloproteinase(MMP)-9, MMP-2, tissue inhibitor of metalloproteinase(TIMP)-1 and TIMP-2 were also evaluated by western blotting and zymography. RESULTS: Although 100% OLT survived, 60% hepatectomy and 40% SOLT showed poor survival. Histopathological, immunohistological, biochemical and protein assays revealed that 60% hepatectomy, 100% OLT and 40% SOLT showed liver damage. PI3K and Akt were decreased in 60% hepatectomy and 40% SOLT. For protein expression, 40% SOLT showed differences in MMP-9, MMP-2 and TIMP-2. TIMP-1 showed differences in 60% hepatectomy and 40% SOLT. For protein activity, MMP-9 demonstrated significant differences in 60% hepatectomy, 100% OLT and 40% SOLT. CONCLUSION: Under conditions with an insufficient liver remnant, prevention of OS-induced damage via the Akt/PI3K pathway may be key to improve the postoperative course. MMP-9 may be also a therapeutic target after surgery. | Tomohide Hori Shinji Uemoto Feng Chen Lindsay B Gardner Ann-Marie T Baine Toshiyuki Hata Takayuki Kogure Justin H Nguyen | 2014 | World Journal of Hepatology2014，6，2： | 7 |
| 2 | Simple and reproducible hepatectomy in the mouse using the clip technique显示文摘AIM: To investigate the reliability of massive hepatectomy models by using clip techniques. METHODS: We analyzed anatomical findings in 100 mice following massive hepatectomy induced by liver reduction > 70%. The impact of various factors in the different models was also analyzed, including learning curves, operative time, survival curves, and histopathological findings.RESULTS: According to anatomical results, models with 75%, 80%, and 90% hepatectomy produced massive hepatectomy. Learning curves and operative times were most optimal with the clip technique. Each hepatectomy performed using the clip technique produced a reasonable survival curve, and there were no differences in histopathological findings between the suture and clip techniques. CONCLUSION: Massive hepatectomy by the clip technique is simple and can provide reliable and relevant data. | Tomohide Hori Norifumi Ohashi Feng Chen Ann-Marie T Baine Lindsay B Gardner Toshiyuki Hata Shinji Uemoto Justin H Nguyen | 2012 | World Journal of Gastroenterology2012，18，22： | 4 |
| 3 | Variations in Wool Growth with Nutrient Supply in Northern China显示文摘Field studies on essessment of nutritional status of the grazing sheep were carried out in each of the three major grassland regions, the eastern Inner Mongolia and beyond grassland, the Inner Mongolia - Ningxia - Gansu grassland and the Xinjiang grassland, in northern China. The results obtained showed that the wool production of fine wool sheep in these regions varied between regions and seasons, with similar seasonal patterns in all regions and that reducing the seasonal variations in nutrient supply would enhance wool production substantially. Nutritional limitations to wool growth of the grazing sheep in these regions were suggested, those were: the shortage of protein supply in winter and early spring; the poor quality of much of the pasture and the hay used as supplements, the low energy intake during winter which probably necessitated the use of body stores to maintain body temperature. | D X Lu,Iner(Mongolia Academy of Animal Sciences.Hohhot City.Inner Mongolia Autgolia Autonmous Region.PRC)Z C Feng,(Mongolia Academy of Animal Sciences.Hohhot City.Inner Mongolia Autgolia Autonmous Region.PRC)H R Wang,(Mongolia Academy of Animal Sciences.Hohhot City.Inner Mongolia Autgolia Autonmous Region.PRC)R Z Yang,(Xinjiang Institute of Animal Science.Xinjiang Academy of Animal Science.Yiu Hou Road.Urumqi.Xinjiang Uygur Autonomous Region PRC)C T Ma,(Chinese Academy of Agricultural Sciences.Lanzhou.Gansu.PRC)D B Purser,(CSIRO Division of Animal Production.Laboratory for Rural Research.Private Bag.P.O.Wembley.Western Australia 6014)J R Lindsay(CSIRO Division of Animal Production.Laboratory for Rural Research.Private Bag.P.O.Wembley.Western Australia 6014)D W Peter(CSIRO Division of Animal Production.Laboratory for Rural Research.Private Bag.P.O.Wembley.Western Australia 6014) | 1997 | 畜牧与饲料科学1997，22，S1： | 3 |
| 4 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 5 | A new Lagrangian model of Arctic sea ice显示文摘 | LINDSAY R W STERN H L | 2004 | Journal of Physical Oceanography2004，34，： | 1 |
| 6 | Delayed eosinophil apoptosis in asthma显示文摘 | Kankaanranta H Lindsay M A Giembyez M A | 2000 | Allergy Clin Immuno12000，106，1： | 1 |
| 7 | Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent显示文摘 | Sedlak J R Lindsay H | 1968 | Analytical Biochemistry1968，25，： | 1 |
| 8 | The gene for toxic shock toxinis carryed by a family of mmobile pathogenicity islands in Staphyloccus aureus显示文摘 | Lindsay J A Ruzin A Ross H F | 1998 | Mol Microbiol1998，29，： | 1 |
| 9 | Canadian study of health and aging 显示文摘 | Eastwood R Nobbs H Lindsay J | 1992 | Dementia and Geriatric Cognitive Disorders1992，3，4： | 1 |
| 10 | The utility of MPEG-7 systems in audio-visual applications with multiple streams显示文摘 | Lopes R J Lindsay A T David H | 2003 | IEEE Transactions on Circuits and Systems for Video Technology2003，13，1： | 1 |
| 11 | BDNF and NT-3 rescue sensory but not motoneurones following axotomy in the neonate显示文摘 | Eriksson NP Lindsay RM Aldskogius H | 1994 | Neuroreport1994，5，： | 1 |
| 12 | Selective blockade of the capsaicin receptor TRPV1 attenuates bone cancer pain 显示文摘 | Ghilardi JR Rohrich H Lindsay TH | 2005 | J Neurosci2005，25，12： | 1 |
| 13 | Effects of daily treatment with parathyroid hormone on bone microarchitecture and turnover in patients with osteoporosis:a paired biopsy study显示文摘 | Dempster DW Cosman F Kurland ES Zhou H Nieves J Woelfert L Shane E Plavetic K Muller R Bilezikian J Lindsay R | | 0，，10： | 1 |
| 14 | The RADARSAT geophysical processor system: quality of sea ice trajectory and deformation estimates显示文摘 | Lindsay W Stern R H L | 2003 | Journal of Atmospheric and Oceanic Technology2003，20，9： | 1 |
| 15 | The gene for toxic shock toxin is carried by a family of mobile pathogenicity islands in Staphylococcus aureus显示文摘 | LINDSAY J A RUZIN A ROSS H F | 1998 | Molecular Microbiology1998，29，2： | 1 |
| 16 | Teriparatide for osteoporosis: importance of the full course 显示文摘 | LINDSAY R KREGE J H MARIN F | 2016 | Osteopo- ros lnt2016，27，8： | 1 |
| 17 | Electroless Plating Fundamentals and Applications显示文摘 | Lindsay J H | 1993 | Plating & Surface Finishing1993，80，6： | 1 |
| 18 | Synthesis and the preliminary analysis of block copolymers of 3,3′-bis(azidomethyl)-oxetane and 3-nitratomethyl-3- methyloxetane 显示文摘 | Talukder M A H Lindsay G A | 1990 | Journal of Polymer Science Part A: Polymer Chemistry1990，28，9： | 1 |
| 19 | Selective blockade of the capsaicin receptor TRPV1 attenuates bone cancer pain 显示文摘 | Ghilardi JR Rohrich H Lindsay TH | 2005 | J Neurosci2005，25，12： | 1 |
| 20 | In defense of the Internet:The relationship between Internet communication and depression,loneliness,self-esteem,and perceived social support显示文摘 | Lindsay H G Larry M | 2002 | Cyber Psychology and Behavior2002，5，2： | 1 |
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