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| 1 | 改善高血压患者的药物依从性:一项随机研究显示文摘治疗高血压和血脂异常能显著降低心血管事件和脑卒中风险,但服用降压药和降脂药的依从性差及没有持续性的现象仍很常见。数十年来已经对改善药物依从性的干预措施进行了较深入研究,即使采用了复杂的干预措施,其作用也很有限。一个可能的解释是不依从性受多因素影响。目前药物依从性研究的范围应倾向于个体化的治疗策略,而不是标准化干预,例如临床药师干预着重于关注患者药物相关问题和依从性行为。 | Hedegaard U Kjeldsen LJ Pottegard A Henriksen JE Lambrechtsen J Hangaard J Hallas J | 2015 | 中华高血压杂志2015，23，12： | 15 |
| 2 | Immune responses against SARS-coronavirus nucleocapsid protein induced by DNA vaccine显示文摘 | Zhao P Cao J Zhao LJ Ke JS Pan W Ren H Yu JG Qi ZT | 2005 | 第二军医大学学报2005，26，10： | 12 |
| 3 | Arteriovenous fistulas and digital hypoperfusion ischemic syndrome in patients on hemodialysis显示文摘AIM: To determine survival parameters as well as characteristics of patients with this syndrome. METHODS: The investigation was conducted over a period of eight years, as a prospective, non-randomized, clinical study which included 204 patients, treated by chronic hemodialysis. Most patients received hemodialysis 12 h per week. As vascular access for hemodialysis all subjects had an arteriovenous fistulae. Based on surveys the respondents were divided into groups of patients with and without digital hypoperfusion ischemic syndrome. Gender, demographic and anthropometric characteristics, together with comorbidity and certain habits, were recorded. During this period 34.8% patients died.RESULTS: Patients with digital hypoperfusion ischemic syndrome were older than those without ischemia(P = 0.01). Hemodialysis treatment lasted significantly longer in the patients with digital hypoperfusion ischemic syndrome(P = 0.02). The incidence of cardiovascular disease(P < 0.001) and diabetes mellitus(P = 0.01), as well as blood flow through the arteriovenous fistula(P = 0.036), were higher in patients with digital hypoperfusion ischemic syndrome. Statistically significant differences also existed in relation to oxygen saturation(P = 0.04). Predictive parameters of survival for patients with digital hypoperfusion ischemic syndrome were: adequacy of hemodialysis(B =-3.604, P < 0.001), hypertension(B =-0.920, P = 0.018), smoking(B =-0.901, P = 0.049), diabetes mellitus(B = 1.227, P = 0.005), erythropoietin therapy(B = 1.274, P = 0.002) and hemodiafiltration(B =-1.242, P = 0.033). KaplanMeier survival analysis indicated that subjects with and without digital hypoperfusion ischemic syndrome differed regarding the length of survival(P < 0.001), i.e., patients with confirmed digital hypoperfusion ischemic syndrome died earlier.CONCLUSION: Survival was significantly longer in the patients without digital hypoperfusion ischemic syndrome. | Radojica V Stolic Goran Z Trajkovic Dijana J Miric Bojana Kisic Zorana Djordje Goran Lj Azanjac Marijana S Stanojevic Dragica Z Stolic | 2013 | World Journal of Nephrology2013，2，2： | 8 |
| 4 | Small interfering RNA inhibits SARS-CoV nucleocapsid gene expression in cultured cells and mouse muscles显示文摘 | Zhao P Qin ZL Ke JS Lu Y Liu M Pan W Zhao LJ Cao J Qi ZT | 2005 | 第二军医大学学报2005，26，10： | 4 |
| 5 | 限制卡路里摄入可抑制大鼠促进动脉衰老的炎症反应,保持年轻的表型显示文摘老化呈指数性增加典型心血管病的发病率和死亡率,这主要是由于动脉壁内分子、细胞和组织水平的动脉促炎变化。动物实验中,大鼠的卡路里限制(calorie restriction,CR)改善了动脉功能并延长了健康跨度和寿命。然而,CR如何影响大鼠动脉壁内分子,细胞和组织表型促炎变化仍有待阐明。该文选取随意喂食的344只年轻(6个月大)和老(24个月大)的Fischer大鼠,获取主动脉;另外选取1组在1个月大时开始只维持40%CR。 | 刘青 叶鹏 Wang MY Zhang L Zhu WQ Zhang J Kim SH Wang YS Ni L Telljohann R Monticone RE McGraw K Liu LJ Rafael de Cabo Lakatta EG | 2018 | 中华高血压杂志2018，26，11： | 3 |
| 6 | 相对于男性,女性进行冠状动脉造影产生的额外的心血管病风险与严重受损的冠状动脉血流储备,而非阻塞性疾病相关显示文摘与男性相比,女性的心血管病死亡率更高,但是阻塞性冠状动脉疾病(coronary artery disease,CAD)在女性中不太普遍。冠状动脉血流储备(coronary flow reserve,CFR)是大、小血管CAD和心肌缺血的综合测量指标,可识别出具有心血管病死亡风险的患者,但其在临床实践中不是常规测量的指标。该研究试图调查性别、CFR和血管造影CAD严重程度对不良心血管事件的影响。 | 刘莉 叶鹏 Taqueti VR Shaw LJ Cook NR Murthy VL Shah NR Foster CR Hainer J Blankstein R Dorbala S Di Carli MF | 2016 | 中华高血压杂志2016，24，11： | 2 |
| 7 | 体位性低血压的危险因素:老年男女存在差异显示文摘体位性低血压(orthostatic hypotension,OH)一般发生在站立后调节血压水平的机制发生变化以后。目前尚不清楚不同性别间OH的发生率和危险因素有何不同。本文旨在调查老年人OH患病率和危险因素的性别差异。方法:纳入来自委内瑞拉马拉开波老龄化研究的882名参与者。从仰卧位到站立位3 min后,收缩压持续下降≥20和(或)舒张压持续下降≥10 mm Hg(1 mm Hg=0.133 kPa)定义为OH。考虑到性别的交互作用和性别分层,研究者采用多因素Logistic回归模型评估男、女OH危险因素的相关性。 | Méndez AS Melgarejo JD Mena LJ Chávez CA González AC Boggia J Terwilliger JD Lee JH Maestre GE 陈云 叶鹏 | 2019 | 中华高血压杂志2019，27，6： | 2 |
| 8 | Matrix metalloproteinase inhibitors:present achievements and future prospects显示文摘 | Denis LJ Verweij J | | 0，，： | 2 |
| 9 | 强化降压对高血压患者左心室肥厚的影响显示文摘目前尚不清楚超出推荐值的强化降压是否更能降低高血压患者的左心室肥厚(left ventricular hypertrophy,LVH)发生风险,以及LVH风险降低能否解释强化降压的益处。Soliman等纳入收缩压干预试验(systolic blood pressure intervention,SPRINT)中患有高血压但无糖尿病的8164例受试者(平均年龄67.9岁,女性35.3%,31.2%为非洲裔), | 刘莉 叶鹏 Soliman EZ Ambrosius WT Cushman WC Zhang ZM Bates JT Neyra JA Carson TY Tamariz L Ghazi L Cho ME Shapiro BP He J Fine LJ Lewis CE SPRINT Research Study Group | 2017 | 中华高血压杂志2017，25，6： | 2 |
| 10 | Diffusion weighted magnetic resonance imaging in acute 显示文摘 | Van Everdingen K J Van der ground T Kappelle LJ | 2007 | Stroke2007，29，： | 1 |
| 11 | Tendons:High-fieldstrength, surface coil MR imaging 显示文摘 | Beltran J Noto AM Herman LJ | 1987 | Radiology1987，162，3： | 1 |
| 12 | Dose conformity of gamma knife radiosurgery and risk factors for complications显示文摘 | Nakamura J Verhey LJ Smith V | 2001 | Int J Radiat Oncol Biol Phys2001，51，5： | 1 |
| 13 | Quantitative continuous EEG for detecting delayed cerebral ischemia in patients with poor-grade subarachnoid hemorrhage显示文摘 | Claassen J Hirsch LJ Kreiter KT | 2004 | Clin Neurophysiol2004，115，： | 1 |
| 14 | Definition of microRNAs that repress expression of the tumor suppressor gene FOXOI in endometrial cancer显示文摘 | Myatt SS Wang J Monteiro LJ | 2010 | Cancer Res2010，70，1： | 1 |
| 15 | Transient receptor potential chan- nels in cardiovascular function and disease 显示文摘 | Inoue R Jensen LJ Shi J | 2006 | Circ Res2006，99，： | 1 |
| 16 | Treatment ofrefractory status epilepticus with pentobarbital,propofol,ormidazolam:a systematic review显示文摘 | Claassen J Hirsch LJ Emerson RG | 2002 | Epilepsia2002，43，2： | 1 |
| 17 | Impact of sodium and uhrafihration profiling on hemodialysis- related symptoms 显示文摘 | Oliver M J Edwards LJ Churchill DN | 2001 | J Am Soc Nephrol2001，12，1： | 1 |
| 18 | The influence of the refrigerant charge on the function of small refrigeration appliances 显示文摘 | Kuijpers LJ M Janssen M J P | 1988 | ASHRAE Transactions1988，94，2： | 1 |
| 19 | Opacification and border delineati on improvement in patients with suboptimal endocardial definition in routine echocardiography: Results of the phase Ⅲ Albunes multicenter trial显示文摘 | Crouse LJ Cheirif J Hanly DE | 1993 | JACC1993，22，3： | 1 |
| 20 | Antidepressam-like effects of neurokinin receptor antagonists in the forced swim test in the rat显示文摘 | DABLEH LJ YASHPAL K ROCHFORD J | 2005 | Eur J Pharmacol2005，507，13： | 1 |
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