|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | In vivo radiometric analysis of glucose uptake and distribution in mouse bone显示文摘Bone formation and remodeling occurs throughout life and requires the sustained activity of osteoblasts and osteoclasts,particularly during periods of rapid bone growth.Despite increasing evidence linking bone cell activity to global energy homeostasis,little is known about the relative energy requirements or substrate utilization of bone cells.In these studies,we measured the uptake and distribution of glucose in the skeleton in vivo using positron-emitting^(18)F-fluorodeoxyglucose([^(18)F]-FDG) and non-invasive,high-resolution positron emission tomography/computed tomography(PET/CT) imaging and ex vivo autoradiography.Assessment of [^(18)F]-FDG uptake demonstrated that relative to other tissues bone accumulated a significant fraction of the total dose of the glucose analog.Skeletal accumulation was greatest in young mice undergoing the rapid bone formation that characterizes early development.PET/CT imaging revealed that [^(18)F]-FDG uptake was greatest in the epiphyseal and metaphyseal regions of long bones,which accords with the increased osteoblast numbers and activity at this skeletal site.Insulin administration significantly increased skeletal accumulation of [^(18)F]-FDG,while uptake was reduced in mice lacking the insulin receptor specifically in osteoblasts or fed a high-fat diet.Our results indicated that the skeleton is a site of significant glucose uptake and that its consumption by bone cells is subject to regulation by insulin and disturbances in whole-body metabolism. | Meredith L Zoch Diane S Abou Thomas L Clemens Daniel LJ Thorek Ryan C Riddle | 2016 | Bone Research2016，4，1： | 9 |
| 2 | 限制卡路里摄入可抑制大鼠促进动脉衰老的炎症反应,保持年轻的表型显示文摘老化呈指数性增加典型心血管病的发病率和死亡率,这主要是由于动脉壁内分子、细胞和组织水平的动脉促炎变化。动物实验中,大鼠的卡路里限制(calorie restriction,CR)改善了动脉功能并延长了健康跨度和寿命。然而,CR如何影响大鼠动脉壁内分子,细胞和组织表型促炎变化仍有待阐明。该文选取随意喂食的344只年轻(6个月大)和老(24个月大)的Fischer大鼠,获取主动脉;另外选取1组在1个月大时开始只维持40%CR。 | 刘青 叶鹏 Wang MY Zhang L Zhu WQ Zhang J Kim SH Wang YS Ni L Telljohann R Monticone RE McGraw K Liu LJ Rafael de Cabo Lakatta EG | 2018 | 中华高血压杂志2018，26，11： | 3 |
| 3 | 中年直立性低血压和晕倒的风险显示文摘每年有1/3老年人晕倒。直立性低血压(orthostatic hypotension,OH)被认为是晕倒的重要危险因素之一,但先前对此研究的结论并不一致。 | Juraschek SP Daya N Appel LJ Miller ER Windham BG Pompeii L Griswold ME Kucharska-Newton A Selvin E 陈云 叶鹏 | 2017 | 中华高血压杂志2017，25，10： | 3 |
| 4 | A novel model of venous thrombosis in the vena cava of rabbits 显示文摘 | Chi L Saganek LJ Rogers KL | 1998 | J Pharmacol Toxicol Methods1998，39，4： | 2 |
| 5 | 育龄期妊娠和非妊娠女性的初次脑卒中发生率比较:以英国人口为基础的队列研究显示文摘与相似年龄的非妊娠女性相比,妊娠女性的脑卒中风险可能增加,但这种风险的严重程度和影响时机尚不清楚。该研究调查了育龄女性初次发生脑卒中事件的风险,并比较了在妊娠期间与产后早期与平时的风险差异。 | 刘莉 叶鹏 Ban L Sprigg N Abdul Sultan A Nelson-Piercy C Bath PM Ludvigsson JF Stephansson O Tata LJ | 2017 | 中华高血压杂志2017，25，5： | 2 |
| 6 | 强化降压对高血压患者左心室肥厚的影响显示文摘目前尚不清楚超出推荐值的强化降压是否更能降低高血压患者的左心室肥厚(left ventricular hypertrophy,LVH)发生风险,以及LVH风险降低能否解释强化降压的益处。Soliman等纳入收缩压干预试验(systolic blood pressure intervention,SPRINT)中患有高血压但无糖尿病的8164例受试者(平均年龄67.9岁,女性35.3%,31.2%为非洲裔), | 刘莉 叶鹏 Soliman EZ Ambrosius WT Cushman WC Zhang ZM Bates JT Neyra JA Carson TY Tamariz L Ghazi L Cho ME Shapiro BP He J Fine LJ Lewis CE SPRINT Research Study Group | 2017 | 中华高血压杂志2017，25，6： | 2 |
| 7 | Antioxidant and pancreas-protective effect of aucubin on rats with streptozotocin-induced diabetes 显示文摘 | Jin L Xue HY Jin LJ | 2008 | Eur J Pharmacol2008，582，13： | 1 |
| 8 | Ginkgo biloba extract (Egb761)protects human low density lipoproteins against oxidative modification mediated by copper显示文摘 | Droy-Lefaix MT Packer L | 1995 | Biochem Biophy Res Commun1995，212，： | 1 |
| 9 | Value of serum glycated albumin and high-sensitivity C-reactive protein levels in the prediction of presence of coronary artery disease in patients with type 2 diabetes显示文摘 | Pu LJ Lu L Xu XW | 2006 | Cardiovasc Diabetol2006，20，5： | 1 |
| 10 | Invasive Lobular carcinoma of the breast:Mammographic characteristics and computer-aided detection显示文摘 | Evans WP Warren Burhenne LJ Lanrie L | 2002 | Radiology2002，225，1： | 1 |
| 11 | Rat Strains Differ in Susceptibility to Urinary Tract Infection and Struvite Ureaplasma parvum-Induced Urinary Tract Infection and Struvite Stone Formation显示文摘 | Reyes L Reinhard M O'Donell LJ | 2006 | Infection and immunity2006，74，12： | 1 |
| 12 | A new class of bivariate copulas显示文摘 | Jos~ Antonio R L Manuel lJ F | 2004 | Statistics & Probability Letters2004，66，： | 1 |
| 13 | Dietary supplements and mortality rate in older women: the Iowa women's health study 显示文摘 | Mursu l Rohien K Haraack LJ | 2011 | Archives of Internal Medicine2011，171，18： | 1 |
| 14 | Serum advancedglycationendproducts and receptors as prognostic biomarkers indiabeticundergoingcoronaryarterystentimplantation显示文摘 | Shen Y Pu LJ Lu L etal | 2012 | CanJCardiol2012，28，6： | 1 |
| 15 | Energy Absorbed by Longitudinally Splitting a Tibialis Anterior Allograft:Implications for Double-Bundle Anterior Cruciate Ligament Reconstruction显示文摘 | Clark L Howard C Bisso LJ | 2010 | The Journal of Arthroscopic&Related Surgery2010，26，9： | 1 |
| 16 | Bicuspid aortic valve is herilable显示文摘 | Cripe L Andelfinger G Martin LJ | 2004 | J Am Coll Cardiol2004，44，1： | 1 |
| 17 | A potent and selective endogenous agonist for the mu-opiate receptor显示文摘 | Zadina JE Hackler L Ge LJ | 1997 | Nature1997，386，： | 1 |
| 18 | Hydroxytyrosol protects against oxidative damage by simultaneous activation of mitochondrial biogenesis and phase II detoxifying enzyme systems in retinal pigment epithelial cells 显示文摘 | Zhu L Shen WL Sun LJ | 2010 | J Nutr Biochem2010，21，： | 1 |
| 19 | Meat flavor volatiles: a review of the composition, techniques of analysis, and sensory evaluation显示文摘 | SHAHIDI F RUBIN LJ D'SOUZA L A | 1986 | Critical Reviews in Food Science and Nutrition1986，24，2： | 1 |
| 20 | Epidemiological benefits of more-effective tuberculosis vaccines,drugs,and diagnostics显示文摘 | Abu-Raddad LJ Sabatelli L Achterberg JT | | 0，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员