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| 1 | Viral hepatitis prevalence in patients with active and latent tuberculosis显示文摘AIM: To assess the prevalence of hepatitis B virus(HBV) and hepatitis C virus(HCV) infection and association with drug induced liver injury(DILI) in patients undergoing anti-tuberculosis(TB) therapy.METHODS: Four hundred and twenty nine patients with newly diagnosed TB- either active disease or latent infection- who were due to commence antiTB therapy between September 2008 and May 2011 were included. These patients were prospectively tested for serological markers of HBV, HCV and human immunodeficiency virus(HIV) infections- hepatitis B core antigen(HBc Ag), hepatitis B surface antigen(HBs Ag), hepatitis B e antigen, Ig G and Ig M antibody to HBc Ag(anti-HBc), HCV Ig G antibody and HIV antibody using a combination of enzyme-linked immunosorbent assay, Western blot assay and polymerase chain reaction techniques. Patients were reviewed at least monthly during the TB treatment initiation phase. Liver function tests were measured prior to commencement of antiTB therapy and 2-4 wk later. Liver function tests were also performed at any time the patient had significant nausea, vomiting, rash, or felt non-specifically unwell. Fisher's exact test was used to measure significance in comparisons of proportions between groups. A P value of less than 0.05 was considered statistically significant.RESULTS: Of the 429 patients, 270(62.9%) had active TB disease and 159(37.1%) had latent TB infection. 61(14.2%) patients had isolated anti-HBc positivity, 11(2.6%) were also HBs Ag positive and 7(1.6%) were HCV-antibody positive. 16/270 patients with active TB disease compared to 2/159 patients with latent TB infection had markers of chronic viral hepatitis(HBs Ag or HCV antibody positive; P = 0.023). Similarly the proportion of HBs Ag positive patients were significantly greater in the active vs latent TB infection group(10/43 vs 1/29, P = 0.04). The prevalence of chronic HBV or HCV was significantly higher than the estimated United Kingdom prevalence of 0.3% for each. We found no association between DILI and presence of serological markers of HBV or HCV. Three(5.3%) patients with serological markers of HBV or HCV infection had DILI compared to 25(9.5%) patients without; P = 0.04.CONCLUSION: Viral hepatitis screening should be considered in TB patients. DILI risk was not increased in patients with HBV/HCV. | Hesam Ahmadi Nooredinvand David W Connell Mahmoud Asgheddi Mohammed Abdullah Marie O'Donoghue Louise Campbell Melissa I Wickremasinghe Ajit Lalvani Onn Min Kon Shahid A Khan | 2015 | World Journal of Gastroenterology2015，21，29： | 7 |
| 2 | 生物素——抗结核药物新研究方向(英文)显示文摘耐药菌的出现对全球公共卫生构成了巨大的挑战,结核分枝杆菌(TB)是结核病的病原菌,是临床上最重要的病原体之一。新抗生素的研发用以治疗耐药性结核病已成为临床及公共卫生管理亟待解决的重要问题。生物素(维生素B7)在结核杆菌的代谢途径如脂肪酸合成和三羧酸循环中发挥重要作用,通过生物素蛋白连接酶连接活性辅助因子而被激活。生物素蛋白连接酶及其相关生物合成通路是微生物合成生物素过程中必不可或缺的关键分子,因而有可能成为新的药物靶点。遗传研究表明,结核杆菌需要由菌体进行生物素的全程合成,因此,生物素合成酶在在结核杆菌代谢过程中起着至关重要的作用,引起了抗结核药物研究者的高度重视。本文论述了结核杆菌生物素合成通路,并重点分析了生物素合成过程中可能成为药物靶点的关键酶,旨在为结核病的治疗提供新思路,具有重要的临床意义。 | THOMPSON Andrew P STERNICKI Louise M WEGENER Kate L 陆伟 竺丽梅 BOOKER Grant W POLYAK Steven W 李燕 | 2016 | 江苏预防医学2016，27，3： | 4 |
| 3 | 人体-座椅接触面测量参数的研究初探显示文摘文中介绍了一种集力、温度和湿度传感器信息的座椅舒适度检测系统。传感器的布放采用已发表文章中所介绍的布放方式:温度和湿度传感器分别放置在左、右腿和尾臀骨下方;4个力传感器分别放在左、右腿和左、右坐骨结节的下方。在进行人体实验前,对力、温度和湿度传感器的输出一致性进行了测试。测量数据显示:温度传感器标准方差为±0.2℃;湿度传感器标准方差为±0.3%,压力传感器标准方差为±0.09 V(其中加载负荷5 kg~15 kg,力传感器输出电压的变化为3.67~4.31 V),这表明所有的传感器具有一致的输出特性。在三天内,共有10人/次利用该检测系统对3种坐垫(泡沫、木质和压模坐垫)的舒适度进行了评估。为了避免次序效应对测量结果的影响,整个实验采用了拉丁方设计方法。通过将坐姿调整时间、最大温度和平均相对湿度与舒适度主观评测问卷进行对比分析,结果表明传感器的原始数据和相关参数的变化与人对座椅舒适度的主观评价之间存在一定的联系。 | 刘卓夫 罗中明 Vincenzo Cascioli Louise Mazzeo Andrewl Heusch Peter W M^c Carthy | 2011 | 仪表技术与传感器2011，，1： | 3 |
| 4 | Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study显示文摘 | Mark S Pearce Jane A Salotti Mark P Little Kieran McHugh Choonsik Lee Kwang Pyo Kim Nicola L Howe Cecile M Ronckers Preetha Rajaraman Alan W Craft Louise Parker Amy Berrington de González | 2012 | The Lancet . 2012 (9840)2012，，： | 3 |
| 5 | New exploration and understanding of traditional Chinese medicine 显示文摘 | Xutian S Zhang J Louise W | 2009 | The American journal of Chinese medicine2009，37，03： | 1 |
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| 7 | Trimalleolar Fractures显示文摘 | W C WARNER LOUIS A. FARBER | 1965 | Southern Medical Journal1965，，10： | 1 |
| 8 | Increasing incidence of thyroid cancer in the United States, 1973-2002显示文摘 | Louise D H Gilbert W | 2006 | Jama the Journal of the American Medical Association2006，295，18： | 1 |
| 9 | Sciurus vulgaris显示文摘 | Lurz P W W John G Louise M | 2005 | Mammalian Species2005，，769： | 1 |
| 10 | Profiling the Senior Traveler: An Australian Perspective显示文摘 | Louise H Carter R W Sherrie W Hein R | 2002 | Journal of Travel Research2002，41，8： | 1 |
| 11 | Nephrotic syndrome in children显示文摘 | Rachel L Louise W Nicholas JAW | 2010 | Paediatrics and Child Health2010，20，1： | 1 |
| 12 | Recent trends in the development of health management显示文摘 | Edinflond W Louis Y Ku Kfl I | | 0，，103： | 1 |
| 13 | Challenges to effective cancer control in China, India, and Russia显示文摘 | Paul E Goss Kathrin Strasser-Weippl Brittany L Lee-Bychkovsky Lei Fan Junjie Li Yanin Chavarri-Guerra Pedro E R Liedke C S Pramesh Tanja Badovinac-Crnjevic Yuri Sheikine Zhu Chen You-lin Qiao Zhiming Shao Yi-Long Wu Daiming Fan Louis W C Chow Jun Wang Qio | 2014 | Lancet Oncology2014，，5： | 1 |
| 14 | Cloning and characterization of Aplysia neutral endopeptidase,a metallo-endopeptidase involved in the extracellular metabolism of neuropeptides in Aplysia californica显示文摘 | Jacques P Z Louise W Wafa B | 1999 | The Journal of Neuroscience1999，19，11： | 1 |
| 15 | Characterizing the unfolded states of proteins using single-molecule FRET spectroscopy and molecular simulations显示文摘 | Merchant K A Best R B Louis J M Gopich I V Eaton W A | | 0，，： | 1 |
| 16 | Disease outbreak detection system using syndromic data in the greater Washington DC area 1 1 Information for the full text of this article is available via AJPM Online at www.ajpm-online.net.显示文摘 | Michael D Lewis Julie A Pavlin Jay L Mansfield Sheilah O’Brien Louis G Boomsma Yevgeniy Elbert Patrick W Kelley | 2002 | American Journal of Preventive Medicine2002，，3： | 1 |
| 17 | Nonfinancial Disclosures Across Anglo - American Countries显示文摘 | Sean W G Robb Louise E Single Marilyn T Zarzeski | 2001 | Journal of Iternational Accounting Auditing & Taxation2001，10，： | 1 |
| 18 | Chromatin-association of the polycomb group protein Bmi-1 is cell cycle-regulated and correlates with its phosphorylation status显示文摘 | Jan W Dieter S Louise A | 1999 | J Cell Science1999，112，： | 1 |
| 19 | Mechanism of adverse conditions cau-sing lack of flagella in Escherichia coli显示文摘 | Shi W Li C Louise C J | | 0，，08： | 1 |
| 20 | Synthesis and luminescent properties of sub-5-nm lanthanide oxides nanoparticles显示文摘 | Bazzi R Flores-Gonzalez M A Louis C Lebbou K Dujardin C Brenier A Zhang W Tillement O Bernstein E Perriat P | | 0，，0： | 1 |
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