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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 3 | Autophagy regulates adipose mass and differentiation in mice显示文摘 | Singh Rajat Xiang Youqing Wang Yongjun Baikati Kiran Cuervo Ana Maria Luu Yen K Tang Yan Pessin Jeffrey E Schwartz Gary J Czaja Mark J | 2009 | Journal of Clinical Investigation2009，，11： | 2 |
| 4 | Male breast cancer 15 years after allogeneic hematopoietic cell transplantation including total body irradiation for recurrent acute lymphoblastic leukemia显示文摘 | Lowe T Luu T Shen J | 2008 | Onkologie2008，31，5： | 1 |
| 5 | Photosensitive rash due to the epidermal growth factor receptor erlotinib 显示文摘 | Luu M Lai SE Patel J | 2007 | Photodermatol Photoimmunol Photomed2007，23，1： | 1 |
| 6 | Review:microbial mechanisms of accessing insoluble Fe( III) as an energy source显示文摘 | Luu Y-S Ramsay J A | 2003 | World Journal of Microbiology & Biotechnology2003，19，： | 1 |
| 7 | Optimization by direct search and systematic reduction of the size of search region显示文摘 | LUUS R JAAKOLA T H I J | 1973 | AICHE1973，19，3： | 1 |
| 8 | Toxicogenomics of A375 hunmn malignant melanoma cells treated with arbutin 显示文摘 | CHENG S K LUU R H SHEU J N | 2007 | Journal of Biomedical Science2007，14，1： | 1 |
| 9 | An orthotopic model of human osteosarcoma growth and spontaneous puhnonary metastasis 显示文摘 | Luu H H Kang Q Park J K | 2005 | Clin Exp Metastasis2005，22，4： | 1 |
| 10 | The adsorption of microcystin-LR by natural clay particles 显示文摘 | Morris R J Williams D E Luu He A | 2000 | Toxicon2000，38，2： | 1 |
| 11 | Effects of sulfide inclusion on hydrogen transport in steels显示文摘 | Luu W C Wu J K | 1995 | Mater Lett1995，24，6： | 1 |
| 12 | Modeling of army research laboratory EMP simulators显示文摘 | Miletta J R Chase R J Luu B B | 1993 | IEEE Trans on Nuclear Science1993，40，6： | 1 |
| 13 | Effects of sildenafil citrate (Viagra) on choroidal congestion显示文摘 | McCulley T J Luu J K Marmor M F | 2002 | Ophtha1 mologica2002，216，： | 1 |
| 14 | The adsorption of microcystin-LR by natural clay particles显示文摘 | MORRIS R J WILLIAMS D E LUU H A | 2000 | Toxicon2000，38，2： | 1 |
| 15 | Polycarbonate bottle use and urinary bisphenol A concentrations 显示文摘 | CARWILE J L LUU H T BASSETT L S | 2009 | Environ Health Perspect2009，117，9： | 1 |
| 16 | Saturation effects in heterodyne detection with Geiger-mode InGaAs avalanche photodiode detector arrays 显示文摘 | J X Luu L A Jiang | 2006 | ApplOpt2006，45，16： | 1 |
| 17 | A phase II trial of vorinostat (suberoylanilide hydroxamic acid) in metastatic breast cancer: a California Cancer Consortium study 显示文摘 | LUU T H MORGAN R J LEONG L | 2008 | Clin Cancer Res2008，14，21： | 1 |
| 18 | A non-isotopic probe-hybridization assay for residual DNA in biopharmaceuticals显示文摘 | Riggin A Luu V T Lobdell J K | 1997 | J Pharm Biomed Anal1997，16，： | 1 |
| 19 | Allelopathic effects of tall fescue on birdsfoot trefoil as influenced by N fertilization and seasonal changes显示文摘 | Luu K T Matches A G Peters E J | 1982 | Agronomy Journal1982，74，5： | 1 |
| 20 | Design of a Satellite Cluster System in Distributed Simulation显示文摘 | Lee J S Luu T | 2005 | Simulation2005，81，1： | 1 |
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