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| 1 | Interplay between nitric oxide and VIP in CCK-8-induced phasic contractile activity in the rabbit sphincter of Oddi显示文摘AIM: The sphincter of Oddi (SO) plays an important role in delivery of bile into the duodenum. To establish whether vasoactive intestinal polypeptide (VIP) and nitric oxide (NO) were involved in phasic contractile activity of the rabbit SO stimulated by cholecystokinin-octapeptide (CCK-8).METHODS: Isolated SO muscle rings were cleaned of fat and mounted horizontally on two small L-shaped hooksone of which was connected to a force transducer for the measurement of isometric tension. The experiments were carried out in a thermostatically controlled (37±0.2℃)organ bath (5 mL) containing Krebs solution. The organ fluid was gassed with 95% O2 and 50 mL/L CO2 to keep the pH at 7.40±0.05. Contractile responses to CCK-8 (1μmol/L) were evaluated in the presence and absence of N^G-nitro-L-arginine (LNNA), an inhibitor of NO synthase (100μmol/L), and (p-chloro-D-Phe^6-Leu^17)-VIP (VIPa,30μmol/L), a VIP receptor antagonist.RESULTS: CCK-8 stimulated the phasic activity of the SO.NO synthase inhibition increased the frequency and amplitude of contractions with a slight increase in developed tension.Pre-incubation with VIPa also attenuated this CCK-8 effect.The combined application of LNNA and VIPa abolished the phasic activity of the muscle rings with a marked increase in tension in response to CCK-8.CONCLUSION: VIP and NO together contribute to an increase in phasic activity of SO. | Attila Pálv(o|¨)lgyi Réka Sári József Németh Annamária Szabolcs István Nagy Péter Hegyi János Lonovics Zoltán Szilvássy | 2005 | World Journal of Gastroenterology2005，11，21： | 11 |
| 2 | Shear bond strength of composite resin cements to lithium disilicate ceramics显示文摘 | Kumbuloglu O Lassila LV User A | 2005 | J Oral Rehabil2005，32，2： | 1 |
| 3 | Lymph node pathol- ogy:Benign proliferative, lymphpma and metastatic dis- ease显示文摘 | Sakai O Curtin HD Romo LV | 2000 | Radiol Clin North Am2000，38，6： | 1 |
| 4 | Inhibitory effect of Pulsatilla chinensis polysaccharides on glioma显示文摘 | Zhou F Lv O Zheng Y | 2012 | Int J Biol Macromol2012，50，5： | 1 |
| 5 | Multiple positive solutions for the one-dimensional singular p-Laplaeian显示文摘 | H Sh Lv D O'Regan Ch K Zhong | 2002 | Appl Math Comput2002，133，23： | 1 |
| 6 | FRA 16 D common chro- mosomal fragile site oxido - reductase ( FOR/WWOX ) protects against the effects of ionizing radiation in Drosophila 显示文摘 | O Keefe LV Liu Y Perkins A | 2005 | Oncogene2005，24，： | 1 |
| 7 | Intrinsic connectivity be- tween the hippoeampus and posterormedial cortex predicts mem- ory performance in cognitively intact older individuals显示文摘 | Liang W Peter LV Kelly O'K | 2010 | Neu- rolmage2010，51，9： | 1 |
| 8 | , 2006 Decreased arginine and nitrite levels in nitrate reductase-deficient Arabidopsis thaliana plants impair nitric oxide synthesis and the hypersensitive response to Pseudomonas syringae 显示文摘 | Modolo LV Augusto O Almeida IMG | 2006 | Plant Science2006，171，： | 1 |
| 9 | Effect of mental arithmetic and verbal fluency on blood flow velocity in the middle cerebral arteries显示文摘 | Amrein I Pálv(o)lgyi L Debreczeni R | 2004 | Ideggyogy Sz2004，57，： | 1 |
| 10 | Progonostic impact of p53,C-erbB2 and epidermal growth factor receptor on head and neck carcinoma显示文摘 | Parise Junior O Carvalho LV Miguel RE | 2004 | Sao Paulo Med J2004，122，6： | 1 |
| 11 | Multiple positive solutions for the one-dimensional singular p-Laplacian显示文摘 | LV H S Donal O' Regan Zhong C K | 2002 | Applied Mathematics and Computation2002，133，： | 1 |
| 12 | Long-term risk factor con- trol after a cardiac rehabilitation programme显示文摘 | Toms LV O'Neill ME Gardner A | 2003 | Aust Crit Care2003，16，1： | 1 |
| 13 | Multiple Positive Solutions for the One-dimensional Singular p-Laplaeian显示文摘 | Lv H S Doaal O'Regan and Zhong C K | 2002 | Applied Mathematics and Computation2002，133，： | 1 |
| 14 | Human resources for the control of road traffic injury显示文摘 | Mock C Kobusingye O Anh LV | 2005 | Bulletin of World Health Organi- zation2005，83，4： | 1 |
| 15 | Lymph node pathology,Benign proliferative,lymphoma,and metastatic disease显示文摘 | Sakai O Curtin HD Romo LV | 2000 | Radiol Clin North Am2000，38，5： | 1 |
| 16 | Paradoxical functions of B7 : CD28 costimulation in a MHC class Ⅱ-mismatched cardiac trans- plant model 显示文摘 | Yang J Riella LV Boenisch O | 2009 | Am J Transplant2009，9，12： | 1 |
| 17 | Differential expression and parent of origin effect of the 5-HT2A receptor gene C102T poly- morphism:Analysis of suicidality in schizophrenia and bipolar disorder 显示文摘 | De LV Likhodi O Kennedy JL | 2007 | American Journal of Medical Genetics Part B:Neuropsychiatric Ge- netics2007，144，3： | 1 |
| 18 | Cytokines:abnormalities in major depression and implications for pharmacological treatment显示文摘 | O' Brien SM Scott LV Dinan TG | 2004 | Hum Psychopharmacol2004，19，6： | 1 |
| 19 | Conunon chromosomal fragile sites and cancer: Focus on FRAI6D 显示文摘 | O'Keefe LV Richards R1 | 2006 | Cancer Lett2006，232，1： | 1 |
| 20 | Lymph node pathology:benign proliferative,lymphoma,and metastatic disease显示文摘 | Sakai O Curtin HD Rona LV | 2000 | Radiol Clini North Am2000，38，5： | 1 |
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