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| 1 | Effects of HBV gene variations on disease development and antiviral therapy for patients with chronic hepatitis B显示文摘Viral variation may change pathogenicity, escape immunity, lead to persistence infection, and cause drug resistance against antiviral therapy. This study was undertaken to investigate the effects of HBV gene variation on the progression of disease and on the efficacy of antiviral therapy for patients with chronic hepatitis B(CHB). METHODS:Hepatitis B virus (HBV) gene mutational sites were detected using gene chip in selected hepatitis B patients. RESULTS:In the patients HBeAg did not show serologic conversion or HBeAg(-)/anti-HBe(+), but their HBV DNA remained positive 24 weeks after α-interferon therapy, which was associated with mutations of nt1896, nt1814, nt1762 and nt1764. In the patients, that HBV DNA levels decreased or were undetectable, but rebounded later after antiviral therapy by lamivudine was associated with mutations of aa528 and(or) aa552(i.e.YMDD mutation), which resulted in lamivudine-resistance. YMDD mutation was prone to occur 52 weeks after lamivudine therapy in some chronic hepatitis B patients (26.4%). Nt1896 mutation was common in most chronic hepatitis B patients (68.5%). Chronic severe hepatitis, cirrhosis, and primary liver carcinoma were related to the mutations of nt1896, nt1762 and nt1764. CONCLUSIONS:HBV gene mutations could aggravate patient’s condition and affect the efficacy of antiviral therapy. The regular detection of HBV gene mutation is helpful for identification of disease prognosis and adjustment of therapeutic strategy. | Shenzhen Eastlake Hospital, Shenzhen 518020, China (Chen JY) and National Key Laboratory of Virology (Wuhan University) Department of Infectious Diseases, Renmin Hospital, Wuhan University, Wuhan 430060, China(Wang LW, Sun XM and Gong ZJ) | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 8 |
| 2 | 血清ALT水平影响非创伤性常规指数诊断乙型肝炎相关肝硬化的准确性显示文摘【据Joural of Viral Hepatitis 2020年8月报道】题:血清ALT水平影响非创伤性常规指数诊断乙型肝炎相关肝硬化的准确性(作者Chen YP等)研究表明,FIB-4及APRI等常规指数诊断慢性乙型肝炎肝硬化、显著肝纤维化在不同研究中存在差异。近期,研究者们也先后提出了多项新的常规指数,包括红细胞体积分布宽度-血小板比值(RPR)、谷氨酰转肽酶-血小板比值(GPR)及简易肝纤维化指数(eLIFT)。为评估ALT水平对这些常规指数诊断表现的影响,1005例慢性乙型肝炎患者被纳入回顾性分析,这些患者均已接受肝活检及常规血液检查。在该研究中,似然比10、0.1的对应值分别被确定为确认诊断、排除诊断界值。 | 林小钰 陈永鹏 CHEN YP HUANG LW LIN XY | 2020 | 临床肝胆病杂志2020，36，9： | 7 |
| 3 | A chemical index of weather-ing without effect of wind sorting: Fe/Mg ratios in the acid-insoluble phases of loess deposits显示文摘Chemical analysis of acid-insoluble fractions in loess and paleosols shows that concentrations of Fe and Mg were under control of wind sorting and post-depositional weathering-pedogenesis. The former caused Fe and Mg concentrated in the finer grain-size fractions, displaying synchronous variations, while the latter made Fe and Mg separated, leading to Fe retained in the weathered section and Mg leached out. Therefore, Fe/Mg ratios in the acid insoluble fraction of loess and paleosols can eliminate the effect of wind sorting and serve as an excellent proxy record on intensity of weathering-pedogenesis. Based on calculation, leaching percentage of Mg in the paleosol S1 from the Luochuan, Xifeng and Huanxian sections is 15%, 11% and 2%, respectively, and on average 9% for the paleosols S2—S14 from the Luochuan section, with the highest value amounting to 22% in S5-1, suggesting the strongest weathering-pedogenesis. | Liu, LW Chen, J Wang, HT Chen, Y | 2001 | Chinese Science Bulletin2001，46，16： | 5 |
| 4 | Bench-to-bedside review: Apoptosis/programmed cell death triggeres by traumatic brain injury 显示文摘 | Zhang X Chen Y Jenkins LW | 2005 | Cfit Care2005，9，1： | 1 |
| 5 | Assessment of uterine receptivity by the endometrial sube-ndometrial blood flow distribution pattern in women undergoing in vitro fertilization-embryo transfer显示文摘 | Chien LW Au HK Chen PL | 2002 | Fertil Steril2002，78，2： | 1 |
| 6 | Single nucleotide polymorphism of rs430397 in the fifth intron of GRP78 gene and clinical relevance of primary hepatocellular carcinoma in Han chinese:risk and prognosis显示文摘 | Zhu X Chen MS Tian LW | | 0，，： | 1 |
| 7 | Co-localization of NMDA receptors and AMPA receptors in the neurons of vestibular nuclei of rats 显示文摘 | Chen LW Yung KK Chan YS | 2000 | Brain Res2000，884，12： | 1 |
| 8 | Splenic tumor:a clinicopathological study显示文摘 | Chen LW Chien RN Yen CL | 2004 | Int J Pract2004，58，10： | 1 |
| 9 | Quantitative study of the coexpression of Fos and N-methyl-D aspartate (NMDA) receptor subunits in otolith-related vestibular nuclear neurons of rats 显示文摘 | Chen LW Lai CH Law HY | 2003 | J Comp Neurol2003，460，2： | 1 |
| 10 | High glucose impairs endothelium-dependen! relaxation in rabbit aorta显示文摘 | GUO X LIU WL CHEN LW | 2000 | Acta Pharmacol Sin2000，21，2： | 1 |
| 11 | Fas/FasL pathway-mediated alveolar macrophage apoptosis involved in human silicosis显示文摘 | Yao SQ Rojanasakul LW Chen ZY | 2011 | Apoptosis2011，16，12： | 1 |
| 12 | Assessment of uterine receptivityby the endometrial-subendometrial blood flow distribution pattern inwomen undergoing in vitro fertilization embryo transfer显示文摘 | CHIEN LW AU HK CHEN PL | 2002 | Fertil Steril2002，78，2： | 1 |
| 13 | Assessment of uterine receptivity by the endometrial-subendometrial blood flow distribution pattern in women undergoing in vitro fertilization-embryo transfer显示文摘 | Chien LW Au HK Chen PL | 2002 | Fertil Steril2002，78，2： | 1 |
| 14 | Reduced FHIT expression in cervical carcinoma: correlation with tumor progression and poor prognosis 显示文摘 | Huang LW Chao SL Chen TJ | 2003 | Gynecol Oncol2003，90，2： | 1 |
| 15 | Total aortic arch reconstruction with open placement of triple-branched stent graft for acute type A dissection 显示文摘 | Chen LW Dai XF Zhang GC | 2010 | J Thorac Cardiovasc Surg2010，139，6： | 1 |
| 16 | Open-branched stent graft placement makes total arch replacement easier for acute type a aortic dissection显示文摘 | Chen LW Dai XF Yang GF | 2010 | Ann Thorac Surg2010，89，5： | 1 |
| 17 | Neuroprotective and anti-in- flammatory activities of atorvastatin in a rat ehronic constriction injury model显示文摘 | Chu LW Chen JY Yu KL | 2012 | Int J Immunopathol Pharmacol2012，25，1： | 1 |
| 18 | Assessment of uterine re- ceptivity by the endometrial subendometrial blood flow distri bution pattern in women undergoing in vitro fertilization em bryo transfer 显示文摘 | Chien LW Au HK Chen PL | | Fertil Sterih 201 I0，78，2： | 1 |
| 19 | Extensive primary repair of the thoracic aorta in acute type a aortic dissection by means of ascending aorta replacement combined with open placement of triple-branched stent graft: early results 显示文摘 | Chen LW Dai XF Lu L | 2010 | Circulation2010，122，14： | 1 |
| 20 | Localization of nerve growth factor, neurotrophin-3, and glial cell line-derived neu- rotrophic factor in nestin-expressing reactive astrocytes in the cau-date-putamen of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine- treated C57/B1 mice 显示文摘 | Chen LW Zhang JP Kwok-Yan Shum D | 2006 | J Comp Neurol2006，497，： | 1 |
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