|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | 妊娠期肝内胆汁淤积症女性使用熊去氧胆酸治疗与安慰剂比较:一项随机对照试验显示文摘【据《Lancet》2019 年9 月报道】题:妊娠期肝内胆汁淤积症女性使用熊去氧胆酸治疗与安慰剂比较:一项随机对照试验(作者Chappell LC 等)妊娠期肝内胆汁淤积症的特征是产妇瘙痒和血清胆汁酸浓度升高,与死产、早产和新生儿入院率增加有关。熊去氧胆酸是被广泛应用的治疗方法,但是没有充分的证据基础。 | 刘宇维 牛俊奇 CHAPPELL LC BELL JL SMITH A | 2020 | 临床肝胆病杂志2020，36，2： | 6 |
| 3 | Cognitive disorder and dementia in type 2 diabetes mellitus显示文摘Insulin,a key pleiotropic hormone,regulates metabolism through several signaling pathways in target tissues including skeletal muscle,liver,and brain.In the brain,insulin modulates learning and memory,and impaired insulin signaling is associated with metabolic dysregulation and neurodegenerative diseases.At the receptor level,in aging and Alzheimer’s disease(AD)models,the amount of insulin receptors and their functions are decreased.Clinical and animal model studies suggest that memory improvements are due to changes in insulin levels.Furthermore,diabetes mellitus(DM)and insulin resistance are associated with age-related cognitive decline,increased levels ofβ-amyloid peptide,phosphorylation of tau protein;oxidative stress,pro-inflammatory cytokine production and dyslipidemia. Recent evidence shows that deleting brain insulin receptors leads to mildobesity and insulin resistance without influencing brain size and apoptosis development.Conversely, deleting insulin-like growth factor 1 receptor (IGF-1R) affects brain size anddevelopment, and contributes to behavior changes. Insulin is synthesized locally in the brain andis released from the neurons. Here, we reviewed proposed pathophysiological hypotheses toexplain increased risk of dementia in the presence of DM. Regardless of the exact sequence ofevents leading to neurodegeneration, there is strong evidence that mitochondrial dysfunctionplays a key role in AD and DM. A triple transgenic mouse model of AD showed mitochondrialdysfunction, oxidative stress, and loss of synaptic integrity. These alterations are comparable tothose induced in wild-type mice treated with sucrose, which is consistent with the proposal thatmitochondrial alterations are associated with DM and contribute to AD development. Alterationsin insulin/IGF-1 signaling in DM could lead to mitochondrial dysfunction and low antioxidantcapacity of the cell. Thus, insulin/IGF-1 signaling is important for increased neural processing andsystemic metabolism, and could be a specific target for therapeutic strategies to decreasealterations associated with age-related cognitive decline. | Genaro G Ortiz Miguel Huerta Héctor A González-Usigli Erandis D Torres-Sánchez Daniela LC Delgado-Lara Fermín P Pacheco-Moisés Mario A Mireles-Ramírez Blanca MG Torres-Mendoza Roxana I Moreno-Cih Irma E Velázquez-Brizuela | 2022 | World Journal of Diabetes2022，13，4： | 2 |
| 4 | Misdiagnosis of tuberculosis and the clinical relevance of nontuberculous mycobacteria in Zambia显示文摘Objective:To determine the accuracy of TB diagnosis of TB in Zambia in the era of increasing HIV prevalence.Methods:Sputum of the clinically diagnosed TB cases was additionally subjected to liquid culture and molecular identification.This study distinguished between TB cases confirmed by positive Mycobacterium tuberculosis(M.tuberculosis) cultures and mycobacterial disease caused by non-tuberculous mycobacteria(NTM).Results:Only 49% of the 173 presumptively diagnosed TB cases was M.tuberculosis cultured,while in 13% (22) cases,a combination of M.tuberculosis and NTM was found.In 18% of the patients only NTM were cultured.In 28% ,no mycobacteria was cultivable.HIV positive status was correlated with the isolation of NTM(P<0.05).Conclusions:The diagnosis of tuberculosis based on symptoms, sputum smear and/or chest X-ray leads to significant numbers of false-positive TB cases in Zambia,most likely due to the increased prevalence of HIV.The role of NTM in tuberculosislike disease also seems relevant to the false diagnosis of TB in Zambia. | Patricia CAM Buijtels Michael D Iseman Shelagh Parkinson Cas S de Graaff Henri A Verbrugh Pieter LC Petit Dick van Soolingen | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，5： | 2 |
| 5 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 6 | 老年女性蔬菜硝酸盐的摄入与颈动脉粥样硬化和缺血性脑血管病的相关性显示文摘膳食硝酸盐的短期增加可通过形成一氧化氮和其他氮氧化物来改善血管健康。其是否可降低长期血管疾病风险尚未得到验证,为了明确这一点,Bondonno教授团队调查了植物来源的硝酸盐摄入与老年女性颈总动脉内膜中层厚度(common carotid artery intimamedia thickness,CCA-IMT)、斑块严重程度和缺血性脑血管疾病事件的关系(n=1226),方法:纳入研究对象,确定基线时(1998年)的蔬菜硝酸盐摄入量、生活方式因素和心血管病危险因素。 | 刘莉 叶鹏 Bondonno CP Blekkenhorst LC Prince RL Ivey KL Lewis JR Devine A Woodman RJ Lundberg JO Croft KD Thompson PL Hodgson JM | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 7 | 熊去氧胆酸与安慰剂对妊娠肝内胆汁淤积症治疗的比较:一项随机对照试验显示文摘【据《Lancet》2019年9月报道】题:熊去氧胆酸与安慰剂对妊娠肝内胆汁淤积症治疗的比较:一项随机对照试验(作者Chappell LC等)妊娠期肝内胆汁淤积症以产妇瘙痒和血清胆汁酸浓度升高为特征,与死产、早产和新生儿入院率增加有关。熊去氧胆酸作为一种治疗方法被广泛应用,但缺乏足够的证据基础。该研究旨在评估熊去氧胆酸是否可降低妊娠肝内胆汁淤积症患者的围产期不良后果。 | 陈林 李婉玉 CHAPPELL LC BELL JL SMITH A | 2020 | 临床肝胆病杂志2020，36，3： | 2 |
| 8 | Prospective evaluation of pain and analgesic use following major elective intracranial surgery显示文摘 | Gottschalk A Berkow LC Stevens RD | 2007 | J Neurosurg2007，106，2： | 1 |
| 9 | Decreased incidence of prostate cancer with selenium supplementation:results of a double-blind cancer prevention trial显示文摘 | Dalkin B Krongrad A | 1998 | Br J Urol1998，81，5： | 1 |
| 10 | Variants in inflammationgenes and the risk of biliary tract cancers and stones:a population-based study in China显示文摘 | Hsing AW Sakoda LC Rashid A | 2008 | Cancer Res2008，68，15： | 1 |
| 11 | Impairment of alveolar macrophage phagocytosis by ultrafine particles显示文摘 | Renwick LC Donaldson K Clouter A | 2001 | Toxicology and Applied Pharmacology2001，172，： | 1 |
| 12 | Oral cancer plasma tumor marker identified with bead-based affinity-fractionated proteomic technology 显示文摘 | Cheng A J Chen LC Chien KY | 2005 | Clin Chem2005，51，： | 1 |
| 13 | Probabilistic lifetime-oriented multiobjective optimi- zation of bridge maintenance: single maintenance type 显示文摘 | NEVES LC FRANGOPOL D M PETCHERDCHOO A | 2006 | Journal of Structural Engineering2006，132，6： | 1 |
| 14 | National survey of physicians' perception of the cause, complications, and management of gastroparesis显示文摘 | Briley LC Harrell SP Woosley A | 2011 | South Med J2011，104，6： | 1 |
| 15 | Robot-assisted radical cystectomy with intracorporeal urinary diversion in patients with transitional cell carcinoma of the bladder显示文摘 | Jonsson MN Adding LC Hosseini A | 2011 | Eur Urol2011，60，5： | 1 |
| 16 | Color duplex ultrasonography is insensitive for the detection of endoleak after aortic endografting:A systematic review显示文摘 | Ashoke R Brown LC Rodway A | | 0，，： | 1 |
| 17 | Prophylactic antibiotics for mesh inguinal hernioplasty:a meta-analysis显示文摘 | Sanabria A Domínguez LC Valdivieso E | | 0，，03： | 1 |
| 18 | Review of tech- nologies for oil and gas produced water treatment显示文摘 | Razi AF Pendashteh A Abdullah LC etal | 2009 | Journal of Hazardous Materials2009，170，23： | 1 |
| 19 | Expression of transcription factor AML-2 (RUNX3, CBF (alpha)-3) is induced by Epstein-Barr virus EBNA-2 and correlates with the B-cell activation phenotype 显示文摘 | Spender LC Comish GH Sullivan A | 2002 | J Virol2002，76，10： | 1 |
| 20 | Successful treatment of neuropathies,in patients with diabetes mellitus显示文摘 | Krendel D A Costigan DA Hopkins LC | 1995 | Arch Neurol1995，52，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员