维普中文期刊产品整合服务
464篇 您的检索式:作者名="Lacy S"
    题名 作者 年代 出处 被引量
1Adjuvant therapy sparing in rectal cancer achieving complete response after chemoradiation显示文摘AIM:To evaluate the long-term results of conventional chemoradiotherapy and laparoscopic mesorectal excision in rectal adenocarcinoma patients without adjuvant therapy.METHODS:Patients with biopsy-proven adenocarcinoma of the rectum staged cT3-T4 by endoscopic ultrasound or magnetic resonance imaging received neoadjuvant continuous infusion of 5-fluorouracil for five weeks and concomitant radiotherapy.Laparoscopic surgery was planned after 5-8 wk.Patients diagnosed with ypT0N0 stage cancer were not treated with adjuvant therapy according to the protocol.Patients with ypT1-2N0 or ypT3-4 or N+were offered 5-fluorouracil-based adjuvant treatment on an individual basis.An external cohort was used as a reference for the findings.RESULTS:One hundred and seventy six patients were treated with induction chemoradiotherapy and 170underwent total mesorectal excision.Cancer staging of ypT0N0 was achieved in 26/170(15.3%)patients.After a median follow-up of 58.3 mo,patients withypT0N0 had five-year disease-free and overall survival rates of 96%(95%CI:77-99)and 100%,respectively.We provide evidence about the natural history of patients with localized rectal cancer achieving a complete response after preoperative chemoradiation.The inherent good prognosis of these patients will have implications for clinical trial design and care of patients.CONCLUSION:Withholding adjuvant chemotherapy after complete response following standard neoadjuvant chemoradiotherapy and laparoscopic mesorectal excision might be safe within an experienced multidisciplinary team.Xabier García-Albéniz Rosa Gallego Ralf Dieter Hofheinz Gloria Fernández-Esparrach Juan Ramón Ayuso-Colella Josep Antoni Bombí Carles Conill Miriam Cuatrecasas Salvadora Delgado Angels Ginés Rosa Miquel Mario Pagés Estela Pineda Verónica Pereira Aarón Sosa Oscar Reig Iván Victoria Luis Feliz Antonio María de Lacy Antoni Castells Iris Burkholder Andreas Hochhaus Joan Maurel 2014World Journal of Gastroenterology2014,20,42:5
2Thermocapillary migration of bubbles and drops at moderate values of the Marangoni number in reduced gravity 显示文摘Balasubramaniam B Lacy C E Woniak G Subramanian R S 1996Phys Fluids1996,8,4:1
3Influence of temperature and moisture on growth and sporulation of Botrytis squamosa 显示文摘Alderman S C Lacy M L 1984Canadian Journal of Botany1984,62,12:1
4Engagement of two distinct binding domains on CCL17 is required for signaling through CCR4 and establishment of localized inflammatory conditions in the lung显示文摘Santulli-Marotto S Boakye K Lacy E 2013PLoS One2013,8,81:1
5Nonlinear dynamic analyses of an earth dam显示文摘Prevost J H Abdel-Ghaffar A M Lacy S J 1985Journal of Geotechnical Engineering1985,111,7:1
6Laparoscopyassisted colectomy versus open colectomy for treatment of non-metastatic colon cancer: a randomised trial 显示文摘Lacy AM Garcia Valdecasas JC Delgado S etal 2002Lancet2002,359,9325:1
7Laparoscopy-assisted colectomy versus open colectomy for treatment of nonmetastatic colon cancer:a randomised trial显示文摘Lacy AM García-Valdecasas JC Delgado S 0,,9325:1
8Serum uric acid:novel prognostic factor in primary systemic amyloidosis显示文摘Kumar S Dispenzieri A Lacy MQ 2008Mayo Clin Proc2008,83,3:1
9Laparoscopy assisted colectomy versus open colectomy for treatment of non-metastatic colon cancer: a randomised trial显示文摘Lacy AM Garcia-Valdecasas JC Delgado S 2002Lancet2002,359,9325:1
10Utilization of sugar cane bagasse hemicellulosic hydrolyzate by Pichia stipitis for the production of ethanol显示文摘Roberto I C Lacis L S Barbosa M F S 1991Proc Biochem1991,26,1:1
11Laparoscopy-assisted colectomy versus open colectomy for treatment of non-metastatic colon cancer:a randomized trial显示文摘Lacy A M Garcia-Valdecasas J C Delgado S 2002Lancet2002,359,9325:1
12Laparoscopy-assisted colectomy versus open colectomy for treatment of non-metastatic colon cancer:a randomised trial显示文摘Lacy AM Garcia-Valdecasas JC Delgado S 2002Lancet2002,359,9325:1
13Thalidomlde as initial therapy for earlystage myeloma显示文摘Rarjkumar S V Gertz M A Lacy M Q 2003Leukemia2003,17,5:1
14Minilaparoscopy-assis- ted transrectal low anterior resection (LAR) : a preliminary study 显示文摘Lacy AM Adelsdorfer C Delgado S 2013Surg Endosc2013,27,1:1
15Climate impact of increasing atmospheric carbon dioxide显示文摘Hansen J D Johnson A Lacis S 1981Science1981,213,4511:1
16Laparoscopy-assisted colectomy versus open colectomy for treatment of non-metastatic colon cancer:a randomised trial显示文摘Lacy AM Garcia-Valdecasas JC Delgado S 2002Lancet2002,359,9325:1
17Laparoscopy-assisted colectomy versus open colectomy for treatment of non-metastatic colon cancer:a randomised trial显示文摘Lacy AM García-Valdecasas JC Delgado S 2002Lancet2002,359,9325:1
18Laparoscopy-asssisted colectomy versus open colectomy for treatment of non-metastatic colon cancer:a randomized trial显示文摘Lacy AM Garcia-Valdecasas JC Delgado S 2002Lancet2002,359,9325:1
19Conjugated linoleic aoid is synthesized endogenously in lactating dairy cows by 9- desaturase显示文摘Griinari J M Corl B A Lacy S H 2000J Nutr2000,130,9:1
20The Bayesian Detection of Discontinuities in a Polynomial Regression and its Application to the Cycle Slip Problem显示文摘Lacy M C Reguzzoni M Fernando S 2008Journal of Geodesy2008,82,9:1
返回顶部 每页显示:
共24页 首页 上一页 第1页 下一页 末页 /24 跳转

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1 渝公网安备 50019002500403号 违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费