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| 1 | Molecular dissection of plant height QTLs using recombinant inbred lines from hybrids between common wheat (Triticum aestivum L.) and spelt wheat (Triticum spelta L.)显示文摘In wheat, plant height is an important agronomic trait, and a number of quantitative trait loci (QTLs) controlling plant height have been located. In this study, using the conditional and unconditional QTL mapping methods, combined with data from five different growth stages over two years of field trials, the developmental behavior for plant height in wheat was dissected. Nine unconditional QTLs and 8 conditional QTLs were identified, of which 6 were detected by both methods. None of the 11 QTLs was detected at all of the 5 investigated developmental stages, but 7 QTLs were detected at certain stages in both years. Further analysis identified 9 unconditional QTLs at different stages, which could explain the phenotypic variation from 4.81% to 17.35%. It was noteworthy that one major QTL designated QHt-4B-2, which was located on chromosome 4B, was detected on May 18 and 25 in both years, and its genetic contributions to plant height ranged from 13.42% to 16.13%. Moreover, of the 8 conditional QTLs identified, six were detected in both years, in the order of QHt-3B→QHt-4B-1→QHt-4B-2→QHt-4D→QHt-5A and QHt-2B expressed at the same developmental stage. The results indicate that QTL expression during plant height development is selective and in a temporal order. | LIU Gang XU ShengBao NI ZhongFu XIE ChaoJie QIN DanDan LI Jing LU LaHu ZHANG JinPing PENG HuiRu SUN QiXin | 2011 | Chinese Science Bulletin2011，56，18： | 6 |
| 2 | Genomic and genic sequence variation in synthetic hexaploid wheat (AABBDD) as compared to their parental species显示文摘In order to understand the genomic changes during the evolution of hexaploid wheat, two sets of synthetic hexaploid wheat from hybridization between maternal tetraploid wheat (AABB) and paternal diploid goat grass (DD) were used for DNA-AFLP and single strand conformation polymorphism (SSCP) analysis to determine the genomic and genic variation in the synthetic hexaploid wheat. Results indicated that more DNA sequences from paternal diploid species were eliminated in the synthetic hexaploid wheat than from maternal tetraploid wheat, suggesting that genome from parental species of lower ploidity tends to be eliminated preferentially. However, sequence variation detected by SSCP procedure was much lower than those detected by DNA-AFLP, which indicated that much less variation in the genic regions occurred in the synthetic hexaploid wheat, and sequence variations detected by DNA-AFLP could be derived mostly from non-coding regions and repetitive sequences. Our results also indicated that sequence variation in 4 genes can be detected in hybrid F1, which suggested that this type of sequence variation could be resulted from distant hybridization. It was interesting to note that 3 out of the 4 genes were mapped and clustered on the long arm of chromosome 2D, which indicated that variation in genic sequences in synthetic hexaploid wheat might not be a randomized process. | Lihong Nie Zongfu Han Lahu Lu Yingyin Yao Qixin Sun Zhongfu Ni | 2008 | Progress in Natural Science:Materials International2008，18，5： | 4 |
| 3 | Orientation-dependent and sequence-specific expansions of CTG/CAG trinueleotide repeats in Saccharomyces cerevisiae 显示文摘 | MMiret JJ Pessoa-Brandao L Lahue RS | 1998 | PNAS1998，95，12： | 1 |
| 4 | Mismatch repair in replication fideli- ty,genetic recombination, and cancer biology显示文摘 | Modrich P Lahue R | 1996 | Annu Rev Biochem1996，，65： | 1 |
| 5 | DNA mismatch correction in a defined system显示文摘 | Lahue R S Au K G Modrich P | 1989 | Science1989，245，4914： | 1 |
| 6 | Mismatch repair in replication fidelity,genetic recombination,and cancer biology显示文摘 | Modrich P Lahue R | 1996 | Annu Rev Biochem1996，65，： | 1 |
| 7 | The emerging infectious chal- lenge of Clostridium difficile-associated disease in Massachusetts hospital:clinical and economic consequences显示文摘 | Brien JA Lahue BJ CaroJJ | 2007 | Infect Control Hosp Epidemiol2007，28，： | 1 |
| 8 | Treatment of un- ruptured intracranial aneurysms:a nationwide assessment of effectiveness 显示文摘 | Higashida RT Lahue BJ Torbey MT et a/ | 2007 | Am J Neuroradiol2007，28，1： | 1 |
| 9 | Impact of early-season thrips management on reducing the risks of spotted wilt virus and suppressing aphid populations in flue-cured tobacco显示文摘 | Mc Pherson R M Stephenson M G Lahue S S | 2005 | Journal of economic entomology2005，98，1： | 1 |
| 10 | DNA mismatch correction in adefined system 显示文摘 | LAHUE R S AU K G MODRICH P | 1989 | Science1989，245，： | 1 |
| 11 | Mammary tumor heterogeneity in the expansion of myeloid- derived suppressor cells显示文摘 | DONKOR M K LAHUE E HOKE T A | 2009 | Int Immunopharmacol2009，9，78： | 1 |
| 12 | Treatment of unruptured in- tracranial aneurysms: a nationwide assessment of effec- tiveness显示文摘 | Higashida R T Lahue B J Torbey M T Hopkins L N Leip E Hanley D F | 2007 | AJNR Am J Neuroradiol2007，28，： | 1 |
| 13 | Effect of fluvoxamine on the phamacokinectics of roflumilast and roflumilast N-oxide显示文摘 | yon RICHTER O LAHU G HUENNEMEYER A | 2007 | Clin Phamacokinet2007，46，7： | 1 |
| 14 | High absolute bioavailability of the new oral phosphodiesterase-4 inhibitor roflumilast显示文摘 | Bethke TD Lahu G | 2011 | Int J Clin Pharmacol Ther2011，49，1： | 1 |
| 15 | Population pharmacokinetic modelling of roflumilast and roflumilast N-Oxide by total phosphodiesterase 4 inhibitory activity and development of a population pharmacodynamic adverse event model 显示文摘 | Lahu G H0nnemeyer A Diletti E | 2010 | Clin Pharmacokinet2010，49，9： | 1 |
| 16 | Steady-state pharmacokinetics of roflumilast and roflumilast N-oxide in patients with mild and moderate liver cirrhosis 显示文摘 | Hermann R Nassr N Lahu G | 2007 | Clin Pharmacokinet2007，46，5： | 1 |
| 17 | Effect of repeated dose of erythromycin on the pharmacokinetics of roflumilast and roflumilast N-oxide 显示文摘 | Lahu G Httnnemeyer A Herzog R | 2009 | Int J Clin Pharmacol Ther2009，47，7： | 1 |
| 18 | Pivotal role of an aliphatic side chain in the development of an HDM2 inhibitor 显示文摘 | Ma Y Lahue BR Gibeau CR | 2014 | ACSMed ChemLett2014，5，5： | 1 |
| 19 | Mismatch repair in replication fidelity- genetic recombination, and cancer biology显示文摘 | Modrich P Lahue R | 1996 | Annu Rev Biochem1996，65，： | 1 |
| 20 | High absolute bioavailability of the new oral phosphodiesterase-4 inhibitor roflumilast显示文摘 | BETHKE T D LAHU G | 2011 | Int J Clin Pharmacol Ther2011，49，1： | 1 |
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