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| 1 | Inflammatory status in chronic renal failure: The role of homocysteinemia and pro-inflammatory cytokines显示文摘AIM: To evaluate determinants of inflammatory markers in chronic renal failure patients according to the level of glomerular filtration rate. METHODS: One hundred fifty four patients(Age; 44 ± 06 years, male/female; 66/88) with chronic renal failure(CRF) were divided into 6 groups according to the National Kidney Foundation(NKF) classification. They included 28 primary stage renal failure patients(CRF 1), 28 moderate stage renal failure patients(CRF 2),28 severe stage renal failure patients(CRF 3), 18 endstage renal failure patients(CRF 4), 40 hemodialysis(HD) patients, and 12 peritoneal dialysis(PD) patients. Tumor necrosis factor-α(TNF-α), interleukin-1β(IL-1β), interleukin-6(IL-6) and C-reactive protein(CRP) were analyzed by immunosorbent assay kit(ELISA)(Cayman Chemical's ACETM EIA kit). Immunoassay methods were used for total homocysteine(tH cy)(fluorescence polarization immunoanalysis HPLC, Perkin Emer 200 series), transferrin(MININEPHTM human transferin kit: ZK070.R), ferritin(ADVIA Centaur) and fibrinogen analysis(ACL 200). Differences between groups were performed using SPSS 20.0 and data are expressed as the mean ± SD.RESULTS: Results showed that in comparison with CRF 1 group and other groups, TNF-α and IL-6 levels were respectively more elevated in HD(16.38 ± 5.52 pg/mL vs 0.39 ± 0.03 pg/mL, 11.05 ± 3.59 pg/mL vs 8.20 ± 0.22 pg/mL, P < 0.001) and PD(14.04 ± 3.40 pg/m L vs 0.39 ± 0.03 pg/m L, 10.15 ± 1.66 pg/m L vs 8.20 ± 0.22 pg/m L, P < 0.001). IL-1β levels were increased in HD(9.63 ± 3.50 pg/m L vs 3.24 ± 0.10 pg/mL, P < 0.001) and CRF 4(7.76 ± 0.66 pg/mL vs 3.24 ± 0.10 pg/m L, P < 0.001) patients than in CRF 1 and in the other groups. Plasma t Hcy levels were higher in HD(32.27 ± 12.08 μmol/L) and PD(28.37 ± 4.98 μmol/L) patients compared to the other groups of CRF(P < 0.001). The serum CRP level was significantly increased in HD(18.17 ± 6.38 mg/L) and PD(17.97 ± 4.85 mg/L) patients compared to the other groups of CRF patients(P < 0.001). The plasma fibrinogen level was more elevated in HD(6.86 ± 1.06 g/L) and CRF 4(6.05 ± 0.57 g/L) than in the other groups(P < 0.001). Furthermore; the ferritin level was higher in HD(169.90 ± 62.16 ng/m L) and PD(90.08 ± 22.09 ng/m L) patients compared to the other groups of CRF(P < 0.001). The serum transferrin value was significantly decreased especially in PD(1.78 ± 0.21 g/L) compared to the other groups(P < 0.001). We found a negative correlationbetween glomerular filtration rate(GFR), TNF-α levels(r =-0.75, P < 0.001), and t Hcy levels(r =-0.68, P < 0.001). We observed a positive correlation between GFR and transferrin levels(r = 0.60, P < 0.001). CONCLUSION: CRF was associated with elevated inflammatory markers. The inflammation was observed at the severe stage of CRF and increases with progression of renal failure. | Hadja Fatima Tbahriti Djamel Meknassi Rachid Moussaoui Amar Messaoudi Lakhdar Zemour Abbou Kaddous Malika Bouchenak Khedidja Mekki | 2013 | World Journal of Nephrology2013,2,2: | 32 |
| 2 | Static Analysis of Functionally Graded Sandwich Plates Using an Efficient and Simple Refined Theory显示文摘In this paper, a new displacement based high-order shear deformation theory is introduced for the static response of function-ally graded sandwich plate. Unlike any other theory, the number of unknown functions involved is only four, as against five in case of other shear deformation theories. The theory presented is variationally consistent, has strong similarity with classical plate theory in many aspects, does not require shear correction factor, and gives rise to transverse shear stress variation such that the transverse shear stresses vary parabolically across the thickness satisfying shear stress free surface conditions. Two common types of functionally graded sandwich plates, namely, the sandwich with functionally graded facesheet and homogeneous core and the sandwich with homogeneous facesheet and functionally graded core, are considered. Governing equations are derived from the principle of virtual displacements. The closed-form solution of a simply supported rectangular plate subjected to sinu-soidal loading has been obtained by using the Navier method. The validity of the present theory is investigated by comparing some of the present results with those of the classical, the first-order and the other higher-order theories. It can be concluded that the proposed theory is accurate and simple in solving the static bending behavior of functionally graded sandwich plates. | Hadj Henni ABDELAZIZ Hassen Ait ATMANE Ismail MECHAB Lakhdar BOUMIA Abdelouahed TOUNSI Adda Bedia El ABBAS | 2011 | Chinese Journal of Aeronautics2011,24,4: | 3 |
| 3 | Current systematic reviews and meta-analyses of COVID-19显示文摘BACKGROUND Coronavirus disease 2019(COVID-19)has left a significant impact on the world's health,economic and political systems;as of November 20,2020,more than 57 million people have been infected worldwide,with over 1.3 million deaths.While the global spotlight is currently focused on combating this pandemic through means ranging from finding a treatment among existing therapeutic agents to inventing a vaccine that can aid in halting the further loss of life.AIM To collect all systematic reviews and meta-analyses published related to COVID-19 to better identify available evidence,highlight gaps in knowledge,and elucidate further meta-analyses and umbrella reviews that are yet to be performed.METHODS We explored studies based on systematic reviews and meta-analyses with the keyterms,including severe acute respiratory syndrome(SARS),SARS virus,coronavirus disease,COVID-19,and SARS coronavirus-2.The included studies were extracted from Embase,Medline,and Cochrane databases.The publication timeframe of included studies ranged between January 01,2020,to October 30,2020.Studies that were published in languages other than English were not considered for this systematic review.The finalized full-text articles are freely accessible in the public domain.RESULTS Searching Embase,Medline,and Cochrane databases resulted in 1906,669,and 19 results,respectively,that comprised 2594 studies.515 duplicates were subsequently removed,leaving 2079 studies.The inclusion criteria were systematic reviews or meta-analyses.860 results were excluded for being a review article,scope review,rapid review,panel review,or guideline that produced a total of 1219 studies.After screening articles were categorized,the included articles were put into main groups of clinical presentation,epi-demiology,screening and diagnosis,severity assessment,special populations,and treatment.Subsequently,there was a second subclassification into the following groups:gastrointestinal,cardiovascular,neurological,stroke,thrombosis,anosmia and dysgeusia,ocular manifestations,nephrology,cutaneous manifestations,D-dimer,lymphocyte,anticoagulation,antivirals,convalescent plasma,immunosuppressants,corticosteroids,hydroxychloroquine,renin-angiotensin-aldosterone system,technology,diabetes mellitus,obesity,pregnancy,children,mental health,smoking,cancer,and transplant.CONCLUSION Among the included articles,it is clear that further research is needed regarding treatment options and vaccines.With more studies,data will be less heterogeneous,and statistical analysis can be better applied to provide more robust clinical evidence.This study was not designed to give recommendations regarding the management of COVID-19. | Mahmoud Nassar Nso Nso Mostafa Alfishawy Anastasia Novikov Salim Yaghi Luis Medina Bahtiyar Toz Sofia Lakhdar Zarwa Idrees Yungmin Kim Dawa Ongyal Gurung Raheel S Siddiqui David Zheng Mariam Agladze Vikram Sumbly Jasmine Sandhu Francisco Cuevas Castillo Nadya Chowdhury Ravali Kondaveeti Sakil Bhuiyan Laura Guzman Perez Riki Ranat Carlos Gonzalez Harangad Bhangoo John Williams Alaa Eldin Osman Joyce Kong Jonathan Ariyaratnam Mahmoud Mohamed Ismail Omran Mariely Lopez Akwe Nyabera Ian Landry Saba Iqbal Anoosh Zafar Gondal Sameen Hassan Ahmed Daoud Bahaaeldin Baraka Theo Trandafirescu Vincent Rizzo | 2021 | World Journal of Virology2021,10,4: | 2 |
| 4 | ABO incompatibility in renal transplantation显示文摘ABO blood group incompatibility(ABO-I)was historically considered an absolute contraindication to kidney transplantation due to the significant risk of acute antibody-mediated rejection and early graft loss.Nevertheless,the urge to minimize the gap between the candidates’number on the waitlist for kidney transplants and the available kidney donors encourage investigation into finding ways to use organs from ABO-I kidney donors,especially in the era of using more potent immunosuppression therapies.This review aims to discuss a general overview of ABO-I kidney transplantation and the different protocols adopted by some transplant centers to meaningfully overcome this barrier. | Mahmoud Mohamed Tara Sweeney Duaa Alkhader Mahmoud Nassar Ahmed Alqassieh Sofia Lakhdar Nso Nso Tibor Fulop Ahmed Daoud Karim M Soliman | 2021 | World Journal of Transplantation2021,11,9: | 2 |
| 5 | Methanation of carbon dioxide over preoxidized rhodium显示文摘 | Amariglio A Lakhdar M Amariglio H | 1983 | J Catal1983,81,: | 1 |
| 6 | Protocol for monitoring stanging crop in grasslangs using visual obstruction 显示文摘 | Lakhdar Benkobi Daniel W Uresk | 2000 | Journal of Raugeland Management2000,53,: | 1 |
| 7 | Evaluation of the effectiveness of a broadspectrum sunscreen in the prevention of chloasma in pregnant women 显示文摘 | Lakhdar H zouhair K Khadir K | 2007 | J Eur Acad Dermatol Venereol2007,21,6: | 1 |
| 8 | Six months training alone or combined with diet alters HOMA-AD,HOMA-IR and plasma and adipose tissue adiponectin in obese women显示文摘 | LAKHDAR N DENGUEZLI M ZAOUALI M | 2014 | Neuro Endocrinol Lett2014,35,5: | 1 |
| 9 | Correlation of EPHX1,GSTP1,GSTM1,and GSTT1 genetic polymorphisms with antioxidative stress markers in chronic obstructive pulmonary disease显示文摘 | LAKHDAR R DENDEN S MOUHAMED MH | 2011 | Exp Lung Res2011,,37: | 1 |
| 10 | Evaluation of the effectiveness of a broad-spectrum sunscreen in the prevention of chloasma in pregnant women显示文摘 | ZOUHAIR K KHADIR K | 2007 | JEADV2007,21,6: | 1 |
| 11 | Combined analysis of EPHX1,GSTP1,GSTM1 and GSTT1 gene polymorphisms in relation to chronic obstructive pulmonary disease risk and lung function impairment显示文摘 | LAKHDAR R DENDEN S KNANI J | 2011 | Dis Markers2011,30,5: | 1 |
| 12 | Experimental analysis of transformation plasticity 显示文摘 | Lakhdar Taleb Nathalie Cavallo Francois Waeekel | 2001 | International Journal of Plasticity2001,17,: | 1 |
| 13 | Effects of 5-years applica- tion of municipal solid waste compost on the distribution and mobility of heavy metals in a Tunisian calcareous soil显示文摘 | Aehiba W B Gabteni N Lakhdar A | 2009 | Agriculture Ecosystems and Environment2009,130,34: | 1 |
| 14 | Effectiveness of compost use in salt-affected soil 显示文摘 | Lakhdar A Rabhi M Ghnaya T | 2009 | Journal of Hazardous Materials2009,171,: | 1 |
| 15 | Update in chronic ob-structive Pulmonary disease: role of antioxidant and metabolizinggenepolymorphisms 显示文摘 | LAKHDAR R DENDEN S KASSAB A | 2011 | Exp Lung Res2011,37,6: | 1 |
| 16 | Effectiveness of com- post use in salt-affected soil 显示文摘 | Lakhdar A Rabhi M Ghnaya T | 2009 | Journal of Hazardous Materi-als2009,17,1: | 1 |
| 17 | Evaluation of the effectiveness of a broadspectrum sunscreen in the preven- tion of chloasma in pregnant women显示文摘 | Lakhdar H zouhair K Khadir K | 2007 | J Eur Acad Dermatol Venereol2007,21,6: | 1 |
| 18 | Combined analysis of EPHX1,GSTP1,GSTM1 and GSTT1 gene polymorphisms in relation to chronic obstructive pulmonary disease risk and lung function impairmen显示文摘 | Ramzi Lakhdar Sabri Denden Jalel Knani | 2011 | Disease Markers2011,30,5: | 1 |
| 19 | Evaluation of the effec-tiveness of a broad-spectrum sunscreen in the prevention of chloasmain pregnant women 显示文摘 | Lakhdar H Zouhair K Khadir K | 2007 | J Eur Acad Dermatol Venere2007,21,6: | 1 |
| 20 | Comparative cytotoxicity of low-and high-osmolar contrast media to human fibroblasts and rat mesangialcells in culture显示文摘 | Potier M Lagroye I Lakhdar B | 1997 | Invest Radiol1997,32,10: | 1 |