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| 1 | Concurrent use of aromatase inhibitors and hypofractionated radiation therapy显示文摘AIM: To retrospectively assess the acute and long-term toxicity using aromatase inhibitors (AI) therapy concurrently with hypofractionated radiotherapy (HFRT) in breast cancer patients. METHODS: From November 1999 to October 2007, 66 patients were treated with breast HFRT and concurrent AI. In 63 patients (95.5%), HFRT delivered a total dose of 32.5 Gy to the whole breast within 5 wk (five fractions, one fraction per week). Other fractionations were chosen in three patients for the patients' personal convenience. A subsequent boost to the tumor bed was delivered in 35 patients (53.0%). Acute toxicities were scored according to the Common Toxicity Criteria for Adverse Events v3. Late toxicity was defined as any toxicity occurring more than 6 mo after completion of HFRT and was scored according to the Late Effects Normal Tissue Task Force-Subjective, Objective, Management and Analytic scale. RESULTS: At the end of the HFRT course, 19 patients (28.8%) had no irradiation-related toxicity. Acute grade 1-2 epithelitis was observed in 46 patients (69.7%). One grade 3 toxicity (1.5%) was observed. With a median follow-up of 34 mo (range: 12-94 mo), 31 patients (47%) had no toxicity, and 35 patients (53%) presented with grade 1-2 fibrosis. No grade 3 or greater delayed toxicity was observed. CONCLUSION: We found that AI was well tolerated when given concurrently with HFRT. All toxicities were mild to moderate, and no treatment disruption was necessary. Further prospective assessment is warranted. | Cyrus Chargari Pablo Castro-Pena Ivan Toledano Marc A Bollet Alexia Savignoni Paul Cottu Fatima Laki Franois Campana Patricia De Cremoux Alain Fourquet Youlia M Kirova | 2012 | World Journal of Radiology2012，4，7： | 2 |
| 2 | Sloshing effect on the dynamic behavior of horizontal cylindrical shells显示文摘 | Lakis A A Bursuc G Toorani M H | 2009 | Nuclear Engineering and Design2009，239，： | 1 |
| 3 | Effects of mustard sprouts and Allylisothiocyanate on benzo(a)pyrene-induced DNA damage in human-derived cells:a model study with the single cell gel electrophoresis/Hep G2 assay显示文摘 | Uhl M Laky B Lhoste E | | 0，，1： | 1 |
| 4 | Processing of beta-amyloid precursor-like protein-1 and-2 by gamma-secretase regulates transcription 显示文摘 | SCHEINFELD M H GHERSI E LAKY K | 2002 | J Biol Chem2002，277，44： | 1 |
| 5 | Hybrid method for vibration analysis of rectangular plates显示文摘 | Kerboua Y Lakis A A Thomas M | 2007 | Nuclear Engineering and Design2007，237，8： | 1 |
| 6 | Effects of mustard sprouts and allylisothiocyanate on benzo(a)pyrene-induced DNA damage in human-derived cells:a model study with the single cell gel electrophoresis/Hep G2 assay显示文摘 | Uhl M Laky B Lhoste E | 2003 | Teratog Carcinog Mutagen2003，1，： | 1 |
| 7 | A neurological study of hand function of hemiplegic children显示文摘 | Brown J K Van Rensburg F Lakie G W M | 1987 | Dev Med Child Neurol1987，29，3： | 1 |
| 8 | Three-dimensional Modeling of Curved Structures containing and/or Submerged in Fluid 显示文摘 | Esmailzadeh M Lakis A A | 2008 | Finite Elements in Analysis and Design2008，44，： | 1 |
| 9 | The passive, human calf muscles in relation to standing: the non-linear decrease from short range to long range stiffness显示文摘 | Loram ID Maganaris CN Lakie M | 2007 | Journal of Physi- ology2007，584，2： | 1 |
| 10 | Pretreatment malnutrition and quality of life-association with prolonged length of hospital stay among patients with gynecological cancer:a cohort study显示文摘 | Laky B Janda M Kondalsamy Chennakesavan S | 2010 | BMC Cancer2010，10，： | 1 |
| 11 | Three-dimensional modeling of cured structures containing and/or submerged influid 显示文摘 | Esmailzadeh M Lakis A A Thomas M | 2008 | Finite Elements in Analysis and Design2008，44，2： | 1 |
| 12 | Tremor and the anti-obesity BRL 26830A显示文摘 | Connacher AA Lakie M Powers N | 1990 | Br J Clin Pharmacol1990，30，4： | 1 |
| 13 | Comparison of dif- ferent nutritional assessments and body composition measurements in detecting malnutrition among gyneco- logic cancer patients显示文摘 | Laky B Janda M Cleghorn G | 2008 | Am J Clin Nutr2008，87，6： | 1 |
| 14 | Using short- time Fourier transforms in machinery fault diagnosis 显示文摘 | SAFIZADEH M S LAKIS A A THOMAS M | 2000 | In- ternational Journal of COMADEM2000，3，1： | 1 |
| 15 | Comparison of different no tritional assessments and body composition measurements in de tecting malnutrition among gynecologic cancer patients显示文摘 | Laky B Janda M Cleghorn G | 2008 | Am J Clin Nutr2008，87，6： | 1 |
| 16 | Effects of mustard sprouts and allylisothiocyanate on benzo ( a ) pyrene-induced DNA damage in human-derived cells: a model study with the single cell gel electrophoresis/HepG2 assay 显示文摘 | Uhl M Laky B Lhoste E | 2003 | Teratog Carcinog Mutagen2003，，1： | 1 |
| 17 | Operational modal analysis by updating autoregressive model显示文摘 | VU V H THOMAS M LAKIS A A | 2009 | Mech Systems & Signal Processing2009，25，3： | 1 |
| 18 | Vibration analysis of rectangular plates coupled with fluid 显示文摘 | Kerboua Y Lakis A A Thomas M | 2008 | Applied Mathe- matical Modelling2008，32，： | 1 |
| 19 | ARMA models for modal analysis: effect of model orders and sampling frequency显示文摘 | SMAIL M THOMAS M LAKIS A | 1999 | Mech Systems & Signal Processing1999，13，6： | 1 |
| 20 | Vibration analysis of rectangular plates coupled with fluid显示文摘 | KERBOUA Y LAKIS A A THOMAS M | 2008 | Applied Mathematical Modeling2008，32，12： | 1 |
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