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| 1 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 2 | Role of functional imaging in the development and refinement of invasive neuromodulation for psychiatric disorders显示文摘Deep brain stimulation(DBS) is emerging as a pow-erful tool for the alleviation of targeted symptoms in treatment-resistant neuropsychiatric disorders. Despite the expanding use of neuropsychiatric DBS, the mecha-nisms responsible for its effects are only starting to be elucidated. Several modalities such as quantitative elec-troencephalography as well a intraoperative recordings have been utilized to attempt to understand the under-pinnings of this new treatment modality, but functional imaging appears to offer several unique advantages. Functional imaging techniques like positron emission tomography, single photon emission computed tomog-raphy and functional magnetic resonance imaging have been used to examine the effects of focal DBS on activ-ity in a distributed neural network. These investigations are critical for advancing the field of invasive neuro-modulation in a safe and effective manner, particularly in terms of defining the neuroanatomical targets and refining the stimulation protocols. The purpose of this review is to summarize the current functional neuroim-aging findings from neuropsychiatric DBS implantation for three disorders: treatment-resistant depression, obsessive-compulsive disorder, and Tourette syndrome. All of the major targets will be discussed(Nucleus ac-cumbens, anterior limb of internal capsule, subcallosal cingulate, Subthalamic nucleus, Centromedial nucleus of the thalamus-Parafasicular complex, frontal pole, and dorsolateral prefrontal cortex). We will also address some apparent inconsistencies within this literature, and suggest potential future directions for this promis-ing area. | Nolan R Williams Joseph J Taylor Kayla Lamb Colleen A Hanlon E Baron Short Mark S George | 2014 | World Journal of Radiology2014，6，10： | 6 |
| 3 | Reversal of established CD4+ type 2 T helper-mediated allergic airway inflammation and eosinophilia by therapeutic treatment with DNA vaccines limits progression towards chronic intlammation and remodeling显示文摘 | Jarman E Lamb JR | 2004 | Immunology2004，112，4： | 1 |
| 4 | Synthesis of Nanostruc- tured Titania Powders via Hydrolysis of Titanium Isoprop- oxide in Supercritical Carbon Dioxide 显示文摘 | STALLLINGS W E LAMB H H | 2003 | Langmuir2003，19，7： | 1 |
| 5 | Toxic effects of cupric,chromate and chromicions on biological oxidation显示文摘 | Lamb A5Tollefson E L | 1973 | Water Res1973，7，5： | 1 |
| 6 | Sap flow and water transfer in the Garonne River riparian woodland, France: first results on poplar and willow显示文摘 | Lambs L Muller E | 2002 | Annual of Forest Science2002，59，3： | 1 |
| 7 | Alliance competence,resources,and alliance success:Conceptualization,measurement,and initial test显示文摘 | LAMBE C J SPEKMAN R E HUNT S D | 2002 | Academy of Marketing Science2002，30，2： | 1 |
| 8 | Alliance Competence, Resources, and Alliance Success: Conceptualization, Measurement, and Initial Test显示文摘 | Lambe C J Spekman R E Hunt S D | 2002 | Journal of the Academy of Marketing Science2002，30，2： | 1 |
| 9 | P-V-T properties of fluids in the system H20CO2q-NaCI: New graphical presentation and implications for fluid inclusion studies显示文摘 | BROWN P E LAMB W M | 1989 | Geochimiea et CosmoehimieaActa1989，53，6： | 1 |
| 10 | Heat and water vapor transport in fabrics under ventilated conditions 显示文摘 | LAMB George E R | 1992 | Journal of Textile Research1992，62，7： | 1 |
| 11 | Effect of surface stones on erosion, evaporation, soil temperature, and soil moisture 显示文摘 | LAMB J and CHAPMAN J E | 1943 | Journal of the American Society of Agronomy1943，35，： | 1 |
| 12 | Electrocardiographic findings in 122,043 individuals显示文摘 | HISS R G LAMB L E | 1962 | Circulation1962，25，： | 1 |
| 13 | MicroRNA expression profiles classify human cancers显示文摘 | LU J Getz G Miska EA Alvarez-Saavedra E Lamb J Peck D Sweet-Cordero A Ebert BL Mak RH Ferrando AA | | 0，，： | 1 |
| 14 | Sap flow and water transfer in the Garonne River riparian woodland, France: first results on poplar and willow 显示文摘 | Lambs L Muller E | 2002 | Annual of Forest Science2002，59，： | 1 |
| 15 | Cryopreservation of embryos and ova显示文摘 | Friedler S Giudice L C Lamb E J | 1988 | Fertil Sertil1988，49，： | 1 |
| 16 | An integrative genomics approach to infer causal associations between gene expression and disease显示文摘 | Schadt E E Lamb J Yang X | 2005 | Nat Genet2005，37，7： | 1 |
| 17 | Alliance compe tence, resources, and alliance success: Conceptualization, measurement, and initial test显示文摘 | Lambe C J Spekman R E Hunt S D | 2002 | Journal of the Academy Of Marketing Science2002，30，2： | 1 |
| 18 | Bringing emerging technologies to market: does academic research promote commercial exploration and exploitation 显示文摘 | TEGARDEN L F LAMB W B HATFIELD D E | 2012 | Engineering Management IEEE Transactions2012，59，4： | 1 |
| 19 | Modeling and monitoring land-cover change processes in tropical regions显示文摘 | Lamb in E | 1997 | Progress in physical Geography1997，21，3： | 1 |
| 20 | Analysis of reelin as a candidate gene for autism 显示文摘 | Bonora E Beyer K S Lamb J A | 2003 | Mol Psychiatry2003，8，10： | 1 |
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