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| 1 | Endothelial cells modified by adenovirus vector containing nine copies hypoxia response elements and human vascular endothelial growth factor as the novel seed cells for bone tissue engineering显示文摘Vascularization 在为骨头织物工程的新治疗学的策略的发展期间是热点之一,它能减轻 hypoxic 情形并且阻止移植失败。脉管的 endothelial 生长因素(VEGF ) 基因 transfection 使用 recombinant 侵入人体气管粘膜的病菌(广告) 向量能有效地支持 angiogenesis,但是 VEGF 的不受管束的长期的连续表示带安全担心。这里,我们构造了包含 HRE 倡导者和 hVEGF165 基因的九个拷贝的 recombinant 广告向量,它保存了组织缺氧可诱导的 factor-1/hypoxia 反应元素(HIF-1/HRE ) 的氧敏感。在进人的脐的静脉 endothelial 房间(HUVEC ) 的 transfection 以后, hVEGF165 mRNA 和蛋白质层次响应组织缺氧是高得多的,作为分别地由 RT-PCR 和 ELISA 揭示了。而且, Ad-9HRE-hVEGF165 向量有效地在 hypoxic 条件下面支持了增长,移植和 HUVEC 的试管形成。因此,我们相信 Ad-9HRE-hVEGF165 向量能贡献 vascularization 的规定,哪个可以在骨头织物工程期间为 hVEGF165 的表达式的更好的控制提供一条新途径(吗?作者 2017。代表生物化学和房间生物学的研究所由牛津大学出版社出版了,为生物科学的上海研究所,中国科学院。版权所有。为权限,请发邮件:journals.permissions@oup.com。) | Xiaobin Song Liang Shi Lamei Chen Xinyu Liu Xun Qu Ketao Wang Fengcai Wei | 2017 | Acta Biochimica et Biophysica Sinica2017，49，11： | 5 |
| 2 | Analysis of the influence of groundwater and the stress regime on bolt behaviour in underground coal mines显示文摘The service failure of rock bolts and cable bolts are frequently reported issues in underground coal mines. Whilst numerous experimental investigations concerned with the service failure of bolts have been conducted, numerical modelling offers an alternative approach in evaluating the factors contributing to service failures of bolts in underground mines. In this study, analysis of the influence of groundwater and tensile stress on bolts in underground coal mines was studied through the numerical modelling of a grouted bolt in the immediate roadway roof. Bolt tensile stress and groundwater dripping rates in the immediate roadway roof were analysed using a package based on finite element method to assess the effect of coal roof thickness and claystone bands, as main contributors of known service failures of bolts in roadways of underground coal mines. Increasing coal roof thickness was found to increase bolt dripping rates. Probable location of stress corrosion cracking (SCC) occurrence was established through examining the shift and increase in maximum bolt tensile stress that was exhibited along the bolt length with increasing coal roof thickness. Claystone bands situated at the top and centre horizon of a grouted bolt produced lower bolt dripping rates compared with scenarios with no claystone bands. Intersecting claystone bands at the centre horizon of a bolt for a fully grouted bolt could increase the likelihood of SCC corrosion and bolt failure by contributing to microbial corrosion processes and grout fracturing by tensile stress. This study improves the understanding the bolt failure associated with the presence of groundwater and changing stress environments, which in turn is imperative in formulating strategies to mitigate support element failures and improve the ground support viability. | Jack A.Smith Hamed Lamei Ramandi Chengguo Zhang Wendy Timms | 2019 | International Journal of Coal Science & Technology2019，6，2： | 5 |
| 3 | KRAS mutation:from undruggable to druggable in cancer显示文摘Cancer is the leading cause of death worldwide,and its treatment and outcomes have been dramatically revolutionised by targeted therapies.As the most frequently mutated oncogene,Kirsten rat sarcoma viral oncogene homologue(KRAS)has attracted substantial attention.The understanding of KRAS is constantly being updated by numerous studies on KRAS in the initiation and progression of cancer diseases.However,KRAS has been deemed a challenging therapeutic target,even“undruggable”,after drugtargeting efforts over the past four decades.Recently,there have been surprising advances in directly targeted drugs for KRAS,especially in KRAS(G12C)inhibitors,such as AMG510(sotorasib)and MRTX849(adagrasib),which have obtained encouraging results in clinical trials.Excitingly,AMG510 was the first drug-targeting KRAS(G12C)to be approved for clinical use this year.This review summarises the most recent understanding of fundamental aspects of KRAS,the relationship between the KRAS mutations and tumour immune evasion,and new progress in targeting KRAS,particularly KRAS(G12C).Moreover,the possible mechanisms of resistance to KRAS(G12C)inhibitors and possible combination therapies are summarised,with a view to providing the best regimen for individualised treatment with KRAS(G12C)inhibitors and achieving truly precise treatment. | Lamei Huang Zhixing Guo Fang Wang Liwu Fu | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 5 |
| 4 | Genetic Analysis of FBXO2, FBXO6, FBXO12, and FBXO41 Variants in Han Chinese Patients with Sporadic Parkinson's Disease显示文摘Parkinson's disease(PD) is the second most common neurodegenerative disorder and has an elusive etiology. It is likely multifactorial, and genetic defects contribute to its pathogenesis. At least 25 genetic loci and20 monogenic genes have been identified in monogenic PD. Recessive F-box protein 7 gene(FBXO7) mutations reportedly cause hereditary parkinsonism. To explore the roles of four paralogs(FBXO2, FBXO6, FBXO12, and FBXO41) in PD development, their variants(rs9614,rs28924120, rs6442117, and rs61733550, respectively)were analyzed in 502 Han Chinese patients with PD and556 age, gender, and ethnicity-matched normal participants in China's Mainland. Statistically significant differences in genotypic and allelic frequencies were detected only in the FBXO2 variant rs9614(P = 0.001 and 0.023, respectively;odds ratio 0.819, 95% confidence interval 0.690–0.973)between patients and controls. These results suggest that the FBXO2 variant rs9614 C allele may decrease the PD risk in mainland Han Chinese and may be a biomarker for PD. | Lamei Yuan Zhi Song Xiong Deng Zhijian Yang Yan Yang Yi Guo Hongwei Lu Hao Deng | 2017 | Neuroscience Bulletin2017，33，5： | 4 |
| 5 | Diketene-based neat four-component synthesis of the dihydropyrimidinones and dihydropyridine backbones using silica sulfuric acid(SSA)显示文摘Heterocyclic skeleton building blocks to afford dihydropyrimidinones and dihydropyridines based on neat adducts of diketene,alcohols and aldehydes via silica sulfuric acid(SSA) catalyzed ring opening of diketene in four-component Biginelli-type and Hantzsch-type reactions are presented. | Sadegh Rostamnia Kamran Lamei | 2012 | Chinese Chemical Letters2012，23，8： | 4 |
| 6 | Structural design and parameter determination for fluted-roller fertilizer applicator显示文摘The instability of the motion layer of fertilizer particle influences the precision and the accuracy of the amount of fertilizer application in the working process of fluted-roller fertilizer applicator.The characteristics of the motion layer were investigated,and a systematic scheme was proposed for designing the structures of fertilizer-filling cavity,fertilizer-filling surface and fertilizer-delivery cavity.The key parameters of the structure were studied by discrete element method.It was figured out that to ensure the smooth operation of fertilizer applicator,the fertilizer-filling angle was 105°,fertilizer-contact angle should be large than 100°,and the fertilizer-resistance angle should be smaller than 35°.Moreover,the stability of fertilizer motion morphology was investigated to verify the design.The results showed that when the roll rotational speed was larger than 120 deg/s,compared with the conventional design the CV of the amount of fertilizer application was reduced from 1.5%-3.5%to 0.5%-1.0%,and the accuracy of the fertilizer discharge was improved with the square of the correlation coefficient between the amount of fertilizer application and the roll rotational speed was larger than 0.999.It was deduced from the results that the precision and accuracy of the amount of fertilizer application are improved via eliminating the driving layer and enhancing the stable filling and conveying of the forced layer. | Shan Zeng Yipeng Tan Yu Wang Xiwen Luo Lamei Yao Dengpan Huang Zewen Mo | 2020 | International Journal of Agricultural and Biological Engineering2020，13，2： | 4 |
| 7 | Interaction between source rock and evaporite:A case study of natural gas generation in the northern Dongying Depression显示文摘It is well known that oil generated from source rocks of saline-lake facies is characteristic of low Pr/Ph ratio and high contents of gammacerane.The authors found that gas generated from the same source rocks was high in benzene and cyclohexane contents and had light carbon isotope compositions.In this study,a series of thermal simulations of gas generations on source rock with/without evaporites(such as carbonate,gypsum,and sodium chlorite,respectively),were conducted.It was found that the gypsum played an important role on the catalyzsis of gas generation in the thermal simulations.Compositions of the gaseous hydrocarbons generated from source rocks with evaporites are very similar to those of natural gases discovered from northern Dongying Depression.Meanwhile,in the thermal simulations,it was found that the carbon isotopic compositions of gaseous hydrocarbons generated from source rocks with evaporites are lighter than those of the gases from source rocks without evaporites.Therefore,it is concluded that natural gases discovered from northern Dongying Depression are the product of interaction between source rocks and evaporites(especially gypsum) of the saline facies. | JIN Qiang WANG Juan SONG Guoqi WANG Li LIN Lamei BAI Shengpin | 2010 | Chinese Journal Of Geochemistry2010，29，1： | 3 |
| 8 | Decreased expression of GLUT4 in male CG- IUGR rats may play a vital role in their increased susceptibility to diabetes mellitus in adulthood显示文摘 | Chang Duan Min Liu Haiyan Xu Weiwei Tang Jiayun Liu Lamei Hou Lijuan Li | 2016 | Acta Biochimica et Biophysica Sinica2016，48，10： | 3 |
| 9 | Single-atom cobalt nanozymes promote spinal cord injury recovery by anti-oxidation and neuroprotection显示文摘Oxidative stress and inflammation are central pathophysiological processes in a traumatic spinal cord injury(SCI).Antioxidant therapies that reduce the reactive oxygen and nitrogen species(RONS)overgeneration and inflammation are proved promising for improving the outcomes.However,efficient and long-lasting antioxidant therapy to eliminate multiple RONS with effective neuroprotection remains challenging.Here,a single-atom cobalt nanozyme(Co-SAzyme)with a hollow structure was reported to reduce the RONS and inflammation in the secondary injury of SCI.Among SAzymes featuring different single metal-N sites(e.g.,Mn,Fe,Co,Ni,and Cu),this Co-SAzyme showed a versatile property to eliminate hydrogen peroxide(H_(2)O_(2)),superoxide anion(O_(2)·^(-)),hydroxyl radical(·OH),nitric oxide(·NO),and peroxynitrite(ONOO^(-))that overexpressed in the early stage of SCI.The porous hollow structure also allowed the encapsulation and sustained release of minocycline for neuroprotection in synergy.In vitro results showed that the Co-SAzyme reduced the apoptosis and pro-inflammatory cytokine levels of microglial cells under oxidative stress.In addition,the Co-SAzyme combined with minocycline achieved remarkable improved functional recovery and neural repairs in the SCI-rat model. | Yuxing Jiang Hongtao Rong Yifan Wang Shange Liu Peng Xu Zhen Luo Lamei Guo Tao Zhu(✉) Hongpan Rong Dingsheng Wang Jiatao Zhang Yu Yi Hao Wang | 2023 | Nano Research2023，16，7： | 2 |
| 10 | Human umbilical cord mesenchymal stem cells for psoriasis:a phase 1/2a,single-arm study显示文摘Psoriasis is a common,chronic immune-mediated systemic disease that had no effective and durable treatment.Mesenchymal stem cells(MSCs)have immunomodulatory properties.Therefore,we performed a phase 1/2a,single-arm clinical trial to evaluate the safety and efficacy of human umbilical cord-derived MSCs(UMSCs)in the treatment of psoriasis and to preliminarily explore the possible mechanisms.Seventeen patients with psoriasis were enrolled and received UMsC infusions.Adverse events,laboratory parameters,PASl,and PGA were analyzed.We did not observe obvious side effects during the treatment and 6-month follow-up.A total of 47.1%(8/17)of the psoriasis patients had at least 40%improvement in the PASl score,and 17.6%(3/17)had no sign of disease or minimal disease based on the PGA score.And the efficiency was 25%(2/8)for males and 66.7%(6/9)for females.After UMSC transplantation(UMSCT),the frequencies of Tregs and CD4^(+)memory T cells were significantly increased,and the frequencies of T helper(Th)17 and CD4^(+)naive T cells were significantly decreased in peripheral blood(PB)of psoriasis patients.And all responders showed significant increases in Tregs and CD4^(+)memory T cells,and significant decreases in Th17 cells and serum IL-17 level after UMsCT.And baseline level of Tregs in responders were significantly lower than those in nonresponders.In conclusion,allogeneic UMSCT is safe and partially effective in psoriasis patients,and level of Tregs may be used as a potent biomarker to predict the clinical efficacy of UMSCT.Trial registration Clinical Trials NCT03765957. | Lamei Cheng Siqi Wang Cong Peng Xiao Zou Chao Yang Hua Mei Chuang Li Xian Su Na Xiao Qi Ouyang Mi Zhang Qiaolin Wang Yan Luo Minxue Shen Qun Qin Honglin Wang Wu Zhu Guangxiu Lu Ge Lin Yehong Kuang Xiang Chen | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 2 |
| 11 | 热膜耦合海水淡化实验研究显示文摘以热法海水淡化浓盐水及原海水作为原料水,采用中空纤维反渗透膜进行了将近2个月的实验研究。实验结果表明,砂过滤器过滤速度及反冲洗、絮凝剂投加量对砂过滤器出水SDI值有较大影响。砂过滤器对浊度具有较好去除效果,但不能有效去除影响RO膜性能的热法海水淡化消泡剂(聚丙二醇)等物质。在整个实验期间,RO膜产水电导率为100~250μS/cm,RO膜脱盐率>99.55%;浓盐水实验阶段RO膜进水压力明显高于混合水实验阶段,分别为5.8~6.1 MPa、5.0~5.3MPa。并对热膜耦合海水淡化实际工程实施中应注意的问题提出建议。 | 唐智新 吴礼云 梁红英 吴刚 李强 孙雪 Xue Lamei | 2018 | 冶金动力2018，，1： | 2 |
| 12 | Carboxypeptidase-mediated metabolism of calcitonin gene-related peptide in human gingival crevicular fluid-a role in periodontal inflammation显示文摘 | Salmon AL Lamey PJ | 2000 | J Clin Periodontol2000，27，7： | 1 |
| 13 | Shear bond strength and residual adhesive after orthodontic bracket debonding 显示文摘 | Al Shamsi A Cunningham JL Lamey PJ | 2006 | Angle Orthod2006，76，4： | 1 |
| 14 | Using Co - Boiling Method to Separate the Mixture of Meth- yl Naphthalene and Quinolin 显示文摘 | Lamey S C | 1974 | Separation Science1974，9，5： | 1 |
| 15 | Autosomal recessive be-strophinopathy associated with angle-closure glaucoma显示文摘 | Crowley C Paterson R Lamey T | 2014 | Documenta Ophthalmologica2014，129，1： | 1 |
| 16 | Etalerability and presenting symptoms in burning mouth syndrome 显示文摘 | Lamey PJ Freeman R Eddie SA | 2005 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2005，99，1： | 1 |
| 17 | Fertilizer, manure and compost effects on weed growth and competition with winter wheat in western Canada显示文摘 | BLACKSHAW R E MOLNAR L J LAMEY F J | 2005 | Crop Protection2005，24，： | 1 |
| 18 | Aluminous cements containing magnesium aluminate spinel from Egyptian dolomite 显示文摘 | NAGY M A EL-HEMALY S A S LAMEY G G | 2001 | Ceram Int2001，27，： | 1 |
| 19 | Recurrent aph- thous ulceration and food senskivity显示文摘 | Nolan A Lamey PJ Miligan KA | 1991 | J Oral Pathol Med1991，20，10： | 1 |
| 20 | Carriage of Candida species in the oral cavity in diabetic patients: Relationship to glycaemic control显示文摘 | Fisher BM Lamey PJ Samaranayake LP | 1987 | J Oral Pathol1987，16，5： | 1 |
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