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| 1 | Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer显示文摘Inflammatory bowel diseases are characterised by inflammation that compromises the integrity of the epithelial barrier. The intestinal epithelium is not only a static barrier but has evolved complex mechanisms to control and regulate bacterial interactions with the mucosal surface. Apical tight junction proteins are critical in the maintenance of epithelial barrier function and control of paracellular permeability. The characterisation of alterations in tight junction proteins as key players in epithelial barrier function in inflammatory bowel diseases is rapidly enhancing our understanding of critical mechanisms in disease pathogenesis as well as novel therapeutic opportunities. Here we give an overview of recent literature focusing on the role of tight junction proteins, in particular claudins, in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer. | Jonathan Landy Emma Ronde Nick English Sue K Clark Ailsa L Hart Stella C Knight Paul J Ciclitira Hafid Omar Al-Hassi | 2016 | World Journal of Gastroenterology2016，22，11： | 39 |
| 2 | Perfect metamaterial absorber显示文摘 | Landy N I Sajuyigbe S Mock J J | | Physical Review Letters0，，： | 3 |
| 3 | A comparison of the relative efficiency of ICSI and extended culture with epididymal sperm versus testicular sperm in patients with obstructive azoospermia显示文摘This is a retrospective cohort study comparing blastocyst transfer outcomes following intracytoplasmic sperm injection utilizing epididymal versus testicular sperm for men with obstructive azoospermia.All cases at a single center between 2012 and 2016 were included.Operative approach was selected at the surgeon’s discretion and included microepididymal sperm aspiration or testicular sperm extraction.Blastocyst culture was exclusively utilized prior to transfer.The primary outcome was live birth rate.Secondary outcomes included fertilization rate,blastulation rate,euploidy rate,and implantation rate.A mixed effects model was performed.Seventy-six microepididymal sperm aspiration cases and 93 testicular sperm extraction cases were analyzed.The live birth rate was equivalent(48.6%vs 50.5%,P=0.77).However,on mixed effects model,epididymal sperm resulted in a greater likelihood of fertilization(adjusted OR:1.37,95%CI:1.05–1.81,P=0.02)and produced a higher blastulation rate(adjusted OR:1.41,95%CI:1.1–1.85,P=0.01).As a result,the epididymal sperm group had more supernumerary blastocysts available(4.3 vs 3,P<0.05).The euploidy rate was no different.Pregnancy rates were no different through the first transfer cycle.However,intracytoplasmic sperm injection following microepididymal sperm aspiration resulted in a greater number of usable blastocysts per patient.Thus,the true benefit of epididymal sperm may only be demonstrated via a comparison of cumulative pregnancy rates after multiple transfers from one cohort. | Scott J Morin Brent M Hanson Caroline R Juneau Shelby A Neal Jessica N Landis Richard T Scott Jr James M Hotaling | 2020 | Asian Journal of Andrology2020，22，2： | 2 |
| 4 | Leukocyte and Bacterial Counts Do Not Correlate With Severity of Symptoms in Men With Chronic Prostatitis: The National Institutes of Health Chronic Prostatitis Cohort Study显示文摘 | Anthony J. Schaeffer Jill S. Knauss J. Richard Landis Kathleen J. Propert Richard B. Alexander Mark S. Litwin J. Curtis Nickel Michael P. O’leary Robert B. Nadler Michel A. Pontari Daniel A. Shoskes Scott I. Zeitlin Jackson E. Fowler Carissa A. Mazurick J | 2002 | The Journal of Urology2002，，3： | 2 |
| 5 | Biomarker-guided sequential targeted therapies to overcome therapy resistance in rapidly evolving highly aggressive mammary tumors显示文摘组合指向的治疗在由堵住治疗癌症是更有效的绕过机制或导致的合成致命性。然而,他们的临床的申请被抵抗和毒性妨碍。遇见这重要挑战,我们用 ErbB2-overexpressing/PTEN-low 开发了并且测试各种各样的指向的治疗的指导 biomarker 的顺序的应用程序的一个新奇概念,高度好攻击的乳癌作为我们的模型。惊人地,从遗传上设计的鼠标与 intratumoral 异质从病人和乳房的肿瘤在两 PTEN-low/trastuzumab-resistant 乳癌支撑了 ErbB2 和下游的小径驱动器 trastuzumab 抵抗的激活。尽管 lapatinib 开始禁止了 trastuzumab 抵抗的鼠标肿瘤,肿瘤由激活表明由量的蛋白质数组出现的网络的 PI3K/mTOR 绕过抑制。有趣地,小径也是的 mTOR 的激活在 neoadjuvant 观察了表明 lapatinib 抵抗的对待 lapatinib 的病人。Trastuzumab + lapatinib 抵抗被一个 PI3K/mTOR 双 kinase 禁止者(BEZ235 ) 的顺序的申请有效地没有重要毒性克服。然而,我们的 p-RTK 数组分析证明 BEZ235 治疗在遗传上设计的老鼠肿瘤导致了增加的 ErbB2 表示和 phosphorylation,导致 BEZ235 抵抗并且在 3-D,然而并非 2-D,文化。机械学地,我们作为 BEZ235 抵抗的新奇机制识别了 ErbB2 蛋白质稳定和激活,它被随后的治疗与 lapatinib + BEZ235 联合颠倒。显著地, biomarker 指导的指向的治疗的这个顺序的应用程序在很快发展加倍的抵抗的肿瘤改变忍受极其好攻击的肿瘤的鼠标的寿命。使用的这条根本上新奇的途径有效地在一个顺序的顺序罐头指向了治疗目标和改编在在治疗期间发展抵抗的癌症的发信号的网络。 | Ozgur Sahin Qingfei Wang Samuel W Brady Kenneth Ellis Hai Wang Chia-Chi Chang Qingling Zhang Preety Priya Rui Zhu Stephen T Wong Melissa D Landis William J Muller Francisco J Esteva Jenny Chang Dihua Yu | 2014 | Cell Research2014，24，5： | 2 |
| 6 | Demographic and clinical characteristics of men with chronic prostatitis:the national institutes of health chronic prostatitis cohort study显示文摘 | Schaeffer A J Landis J R Knauss | 2002 | J Urol2002，168，： | 1 |
| 7 | Design Considerations and a Suggested Approach for Regional and Comparative Ecological Risk Assessment显示文摘 | Landis W G Wiegers J A | 1997 | Human and Ecolog- ical Risk Assessment1997，3，3： | 1 |
| 8 | Pain,psy-chological variables,sleep quality,and natural killercell activity in midlife women with and without fibro-myalgia显示文摘 | LANDIS C A LENTZ M J TSUJI J | 2004 | Brain Behav Immun2004，18，： | 1 |
| 9 | The Measurement of Observer Agreement for Gategorical data显示文摘 | Landis J R Koch G G | 1977 | Bio metrics1977，33，： | 1 |
| 10 | Use of enzyme penicillin acylase in selective amidation/amide hydrolysis to resolve ethyl 3-amino-4-pentynoate isomers显示文摘 | Topgi R S Ng J S Landis B | 1999 | Bioorganic & Medicinal Chemistry1999，7，10： | 1 |
| 11 | A constitutive model for ferroelectric polycrystals 显示文摘 | HUBER J E FLECK N A LANDIS C M | 1999 | J Mmech Phys Solids1999，47，： | 1 |
| 12 | Cognitive changes at high altitude in healthy climbers and in climbers developing acute mountain sickness显示文摘 | M Landis T Casey J | 1991 | Aviat Space Environ Med1991，62，4： | 1 |
| 13 | Leukocyte and bacterial counts do not correlate with severity of symptoms in men with chronic prostatitis,the National Institutes of Health Chronic Prostatitis Cohort Study显示文摘 | Schacffer A J Knauss J S Landis J R | 2002 | J Urol2002，168，3： | 1 |
| 14 | Twenty years of the Bay Area rapid transit sys- tem: Land-use and development impacts显示文摘 | Cevero R Landis J | 1997 | Transportation Re- search Part A1997，31，4： | 1 |
| 15 | Predictors of quality of lifeand pain in chronic prostatitis/chronic pelvic pain syndrome : findingsfrom the National Institutes of Health Chronic Prostatitis Cohort Study显示文摘 | Tripp DA Curtis Nickel J Landis JR | 2004 | BJU International2004，94，： | 1 |
| 16 | The measurement of observer a-greement for categorical data显示文摘 | LANDIS J R KOCH G G | 1977 | Biometrics1977，33，1： | 1 |
| 17 | Design considerations and a suggested approach for regional and comparative ecological risk assessment显示文摘 | LANDIS W G WIEGERS J A | 1997 | Human and Ecological Risk Assessment1997，3，3： | 1 |
| 18 | Perfect metamaterial absorber显示文摘 | Landy N I Sajuyigbe S Mock J J | | 0，，20： | 1 |
| 19 | Opinion: can the pharmaceutical industry reduce attrition rate?显示文摘 | KOLA I LANDIS J | 2004 | Nature Rev2004，3，8： | 1 |
| 20 | Twenty Years of the Bay Area Rapid Transit System:Land Use and Development Impacts显示文摘 | Cervero R Landis J | 1997 | Transportation Research Part A:Policy and Practice1997，31，4： | 1 |
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