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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Evidence for a 15; 17translocation in every patient with acute promyelmytic leukemia显示文摘 | LARSON R A KONDO K VARDIMAN J W BUTLER A E GOLOMB H M ROWLEY J D | 1984 | Am J Med1984，76，5： | 1 |
| 3 | A practical approach to guide clinicians in the evaluation of male patients with breast masses 显示文摘 | Hines S L Tan W Larson J M | 2008 | Geriatrics2008，63，6： | 1 |
| 4 | Management strategies to decrease calf death losses in beef herds显示文摘 | LARSON R L TYLER J W SCHULTZ L G | 2004 | J Am Vet Med Assoc2004，224，1： | 1 |
| 5 | Rebound of five one-dimensionally compressed unsaturated granular soils显示文摘 | STONE J A LARSON W E | 1980 | Soil Science Society of America Journal1980，44，4： | 1 |
| 6 | Relationships between spa- tial environmental heterogeneity and plant species diversity on a limestone pavement 显示文摘 | LUNDHOLM J T LARSON D W | 2003 | Ecography2003，26，6： | 1 |
| 7 | Atomic force microscopy and direct surface force measurements 显示文摘 | RALSTON J LARSON I RUTLAND M W | 2005 | Pure and Applied Chemistry2005，77，12： | 1 |
| 8 | Endothelial EphA receptor stimulation increases lung vascular permeability显示文摘 | Larson J Schomberg S Schroeder W | 2008 | Am J Physiol Lung Cell Mol Physiol2008，295，3： | 1 |
| 9 | NCSOIL, a model of nitrogen and carbon transformation in soil: Description, calibration, and behavior显示文摘 | Moiina j A E Clapp C E Shaffer M J Chichester F W Larson W E | 1983 | Soil Science Society of America Journal1983，47，1： | 1 |
| 10 | The threat of soil erosion to long-term crop production显示文摘 | Larson W E Pierce F J Dowdy R H | 1983 | Science1983，219，9： | 1 |
| 11 | Productivity of soils: assessing long term changes due to erosion' s long term effects显示文摘 | PIERCE F J LARSON W E DOWDY R H | 1983 | Journal of Soil and Water Conservation1983，38，： | 1 |
| 12 | Grain boundary segregation in boron added interstitial free steels studied by 3-dimensional atom probe 显示文摘 | Seto K Larson D J Warren P J Smith G D W | 1999 | Set Mater1999，40，： | 1 |
| 13 | The dynamics of soil quality as a measure of sustainable management显示文摘 | Larson W E Pierce F J | 1994 | 35:37-511994，35，： | 1 |
| 14 | Factors influencing seed germination in Carex scoparia Sehk显示文摘 | Larson J L Stearns F W | 1990 | Wetlands1990，10，： | 1 |
| 15 | Conservation and Enhancement of Soil Quality 显示文摘 | Larson W E Pierce F J | 1994 | IBSRAUM Proc1994，12，： | 1 |
| 16 | Three-dimensional X-ray structural microscopy with submicrometre resolution 显示文摘 | LARSON B C YANG W ICE G E BUDAI J D TISCHLER J Z | 2002 | Nature2002，415，6874： | 1 |
| 17 | Crystallization kinetics of ammonium suLphate显示文摘 | LARSON M A MULLIN J W | 1983 | Journal of Crystal Growth1983，8，10： | 1 |
| 18 | The dynamics of soil quality as measure of sustainable management显示文摘 | Larson W E Pierce F J | 1994 | Soil Science Society of America Journal1994，，2： | 1 |
| 19 | Periplasmic glycerophosphodiester phosphodiesterase of Escherich- ia coli, a new enzyme of the glp regulon 显示文摘 | LARSON T J EHRMANN M BOOS W | 1983 | The Jour- nal of Biological Chemistry1983，258，9： | 1 |
| 20 | Experimental model for a seismic landmine detection system 显示文摘 | Scott W R Martin J S Larson G | 2001 | IEEE Trans Geosci Remote Sens2001，39，： | 1 |
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