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| 1 | Pain and chronic pancreatitis: A complex interplay of multiple mechanisms显示文摘Despite multiple theories on the pathogenesis of pain in chronic pancreatitis,no uniform and consistently successful treatment strategy exists and abdominal pain still remains the dominating symptom for most patients and a major challenge for clinicians.Traditional theories focussed on a mechanical cause of pain related to anatomical changes and evidence of increased ductal and interstitial pressures.These observations form the basis for surgical and endoscopic drainage procedures,but the outcome is variable and often unsatisfactory.This underscores the fact that other factors must contribute to pathogenesis of pain,and has shifted the focus towards a more complex neurobiological understanding of pain generation.Amongst other explanations for pain,experimental and human studies have provided evidence that pain perception at the peripheral level and central pain processing of the nociceptive information is altered in patients with chronic pancreatitis,and resembles that seen in neuropathic and chronic pain disorders.However,pain due to e.g.,complications to the disease and adverse effects to treatment must not be overlooked as an additional source of pain.This review outlines the current theories on pain generation in chronic pancreatitis which is crucial in order to understand the complexity and limitations of current therapeutic approaches.Furthermore,it may also serve as an inspiration for further research and development of methods that can evaluate the relative contribution and interplay of different pain mechanisms in the individual patients,before they are subjected to more or less empirical treatment. | Jakob Lykke Poulsen Sφren Schou Olesen Lasse Paludan Malver Jens Brφndum Frφkjr Asbjφrn Mohr Drewes | 2013 | World Journal of Gastroenterology2013，19，42： | 5 |
| 2 | Electron transport-linked ubiquinonedependent recycling of a-tocopherol inhibits autooxidation of mitochondrial membranes显示文摘 | Lass A Sohal R S | 1998 | Arch Biochem Biophys1998，352，： | 1 |
| 3 | Thermogravimetric analysis on the pyrolysis and combustion characteristics of mixed fuels of petroleum coke and coal显示文摘 | LASSE H S | 1996 | Fuel1996，75，1： | 1 |
| 4 | Applicability of an absolute quantitative procedure to monitor intra-lndividual bcr/abl transcript kinetics in clinical samples from chronic myelogenous leukemia patients 显示文摘 | Kreuzer KA Lass U Nagel S | 2000 | Int J Cancer2000，86，5： | 1 |
| 5 | Electron transport-linked ubiquinone-dependent recycling of alpha-tocopherol inhibits autooxidation of mitochondrial membranes显示文摘 | Lass A and Sohal R S | 1998 | Archives of Biochemistry and Biophysics1998，352，： | 1 |
| 6 | Three years experience with monopolar and bipolar radiofrequency ablation surgery in patients with permanent atrial fibrillation显示文摘 | Geidel S Ostermeyer J Lass M | 2005 | Eur J Cardiothorac Surg2005，27，2： | 1 |
| 7 | Determination of coenzyme Q in human tissue by electrical detector显示文摘 | Lass A Sohal R S | 2000 | Faseb J2000，14，1： | 1 |
| 8 | Public Acceptance of CCS System Elements: A Conjoint Measurement 显示文摘 | Lasse W Selma L O S Vivianne H M V | 2012 | International Journal of Greenhouse Gas Control2012，6，： | 1 |
| 9 | Lumiean regu- lates collagen fibril assembly: skin fragility and corneal opacity in the absence of lumican显示文摘 | Chakravarti S Magnuson T Lass JH | 1998 | J Cell Biol1998，141，5： | 1 |
| 10 | Early and late results of perma- nent atrial fibrillation ablation surgery in aortic valve and CABG pa- tients 显示文摘 | Geidel S Lass M Krause K | 2008 | Thorac Cardiovasc Surg2008，56，7： | 1 |
| 11 | Three years experience with monopolar and bipolar radiofrequency ablation surgery in patients with permanent atrial fibrillation显示文摘 | Geidel S Ostermeyer J Lass M | 2005 | Eur J Cardiothorac Surg2005，27，： | 1 |
| 12 | Mutation analysis of DKK1 and in vivo evidence of predominant p53-independent DKK1 function in gliomas显示文摘 | MUELLER W LASS U WELLMANN S | 2005 | Acta Neuropathologica2005，109，3： | 1 |
| 13 | Correlational study of speakers' heights, weights, body surface areas, and speaking fundamental frequencies 显示文摘 | Lass N J Brown W S | 1978 | J Acoust Soc Am1978，63，4： | 1 |
| 14 | Bacterial community composition during two consecutive NE Monsoon periods in theArabian Sea studied by denaturing gradient gel electrophoresis (DGGE) of rRNA genes显示文摘 | Lasse R Grieg F S Laura B F | 1999 | Deep-Sea Research Ⅱ1999，46，6： | 1 |
| 15 | Identification of the of Escherichia coli MG1655 and characterization of its Product显示文摘 | Thaller M C Sehippa S Bonei A gene(aPhA)encoding thee lass B acid | 1997 | FEMS Microbiol Lett1997，146，： | 1 |
| 16 | Regulation of endotoxin-induced keratitis by PEcAM-1, MIP-2, and toll-like receptor 4 显示文摘 | Khatri S Lass JH Heinzel FP | 2002 | Invest Ophthalmol Vis Sci2002，43，7： | 1 |
| 17 | Simhltaneous anion and cation mobility in polypyrrole 显示文摘 | Steen S Lasse B Kamal V etal | 2003 | Solid State Ionics2003，159，12： | 1 |
| 18 | Three years experienee with monopotar and bipolar radlofrqueney ablation surgery in patients with permanent atrial fibrillation 显示文摘 | Geidel S Ostermeyer J Lass M | 2005 | Ear J Cardiothorae Surg2005，27，2： | 1 |
| 19 | Simultaneous Anion and Cation Mobility in Polypyrrole显示文摘 | STEEN S LASSE B KAMAL V | 2003 | Solid State Lonics2003，159，12： | 1 |
| 20 | Mutation analysis of DKKI and in vivo evidence of predominant p53-independent DKKI function in gliomas显示文摘 | Mueller W Lass U Wellmann S | 2005 | Acta Neuropathol2005，109，3： | 1 |
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