|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | MicroRNAs and liver cancer associated with iron overload:Therapeutic targets unravelled显示文摘Primary liver cancer is a global disease that is on the increase.Hepatocellular carcinoma(HCC)accounts for most primary liver cancers and has a notably low survival rate,largely attributable to late diagnosis,resistance to treatment,tumour recurrence and metastasis.MicroRNAs(miRNAs/miRs)are regulatory RNAs that modulate protein synthesis.miRNAs are involved in several biological and pathological processes including the development and progression of HCC.Given the poor outcomes with current HCC treatments,miRNAs represent an important new target for therapeutic intervention.Several studies have demonstrated their role in HCC development and progression.While many risk factors underlie the development of HCC,one process commonly altered is iron homeostasis.Iron overload occurs in several liver diseases associated with the development of HCC including Hepatitis C infection and the importance of miRNAs in iron homeostasis and hepatic iron overload is well characterised.Aberrant miRNA expression in hepatic fibrosis and injury response have been reported,as have dysregulated miRNA expression patterns affecting cell cycle progression,evasion of apoptosis,invasion and metastasis.In2009,miR-26a delivery was shown to prevent HCC progression,highlighting its therapeutic potential.Several studies have since investigated the clinical potential of other miRNAs with one drug,Miravirsen,currently in phaseⅡclinical trials.miRNAs also have potential as biomarkers for the diagnosis of HCC and to evaluate treatment efficacy.Ongoing studies and clinical trials suggest miRNA-based treatments and diagnostic methods will have novel clinical applications for HCC in the coming years,yielding improved HCC survival rates and patient outcomes. | Catherine M Greene Robert B Varley Matthew W Lawless | 2013 | World Journal of Gastroenterology2013，19，32： | 5 |
| 2 | Piston-cylinder work producing expansion device in a transcritical carbon dioxide cycle: experimental investigation 显示文摘 | BAEK J S GROLL E A LAWLESS P B | 2005 | International Journal of Refrigeration2005，28，2： | 1 |
| 3 | Temperature threshold for burn injury:an oximeter safetystudy显示文摘 | GREENHALGH D G LAWLESS M B CHEW B B | 2004 | The Journal of Burn Care amp Rehabilitation2004，25，5： | 1 |
| 4 | Rotor wake variabilityin a multistage compressor显示文摘 | Key N L Lawless P B Sanford F | 2010 | Journal of Propulsion andPower2010，26，2： | 1 |
| 5 | Vane clocking in athree-stage compressor: frequency domain data analysis显示文摘 | Key N L Lawless P B Sanford F | 2009 | Journal of Propulsion and Power2009，25，5： | 1 |
| 6 | Temperature threshold for burn injury: an oximeter safetystudy显示文摘 | Greenhalgh D G Lawless M B Chew B B | 2004 | J Burn Care Rehabil2004，25，5： | 1 |
| 7 | Particle Image Velocity Investigation of a High Speed Centrifugal Compressor Diffuser: Spanwise and Loading Variations显示文摘 | Cukurel B Lawless PB Fleeter S | 2010 | Journal of Turbomachinery2010，132，2： | 1 |
| 8 | High-speed centrifugal compressor instabilities during speed Transients显示文摘 | William C Oakes Patrick B Lawless Sanford Fleeter | 2004 | Journal of Aerospace Engineering2004，17，3： | 1 |
| 9 | Pistoneyl- inder work producing expansion device in a transcritical carbon dioxide cycle: part I experimental investiga- tion 显示文摘 | BAEK J S GROLL E A LAWLESS P B | 2005 | International Journal of Refrigeration2005，28，2： | 1 |
| 10 | Pistoncyl- inder work producing expansion device in a transcritical carbon dioxide cycle: part II theoretical model 显示文摘 | BAEK J S GROLL E A LAWLESS P B | 2005 | International Journal of Refrigeration2005，28，2： | 1 |
| 11 | A comparison of the labeled magnitude(LAM)scale,an 11-point category scale and the traditional 9-point hedonic scale显示文摘 | LAWLESS H T POPPER R KROLL B J | 2010 | Food Quality and Preference2010，21，1： | 1 |
| 12 | Interactions of astringent substances显示文摘 | Lawless H T Corrigan C J Lee C B | 1994 | Chemical Senses1994，19，2： | 1 |
| 13 | Piston cylinder work producing expansion device in a tran- scritical carbon dioxide cycle: part I experimental investigation显示文摘 | BAEK J S GROLL E A LAWLESS P B | 2005 | International Journal of Refrigera tion2005，28，2： | 1 |
| 14 | Off-design transonic ro- tor-inlet guide vane unsteady aerodynamic interactions显示文摘 | Papalia J Lawless P B Fleeter S | 2005 | Journal of Propulsion and Power2005，21，4： | 1 |
| 15 | Rotor wake variability in a multistage compressor显示文摘 | Key N L Lawless P B Fleeter S | 2010 | Journal of Propulsion and Power2010，26，2： | 1 |
| 16 | Time-course of astringent materials 显示文摘 | Lee C B Lawless H T | 1991 | Chem Senses1991，16，： | 1 |
| 17 | Particle image velocity investigation of a high speed centrifugal compressor diffuser: spanwise and loading variations显示文摘 | Cukurel-B Lawless P B Fleeter S | 2010 | Journal of Turbomachinery2010，132，2： | 1 |
| 18 | Legacy information systems: issues and directions 显示文摘 | BISBAL J LAWLESS D WU B | 1999 | IEEE Software1999，16，5： | 1 |
| 19 | Piston-cylinder work producing expansion device in a transcritical carbon dioxide cycle (Part I): Experimental investigation显示文摘 | Baek J S Groll E A Lawless P B | 2005 | International Journal of Refrigeration2005，28，： | 1 |
| 20 | An experimental study of vane clocking effects on embedded compressor stage performance显示文摘 | Key N L Lawless P B Fleeter S | | 0，，01： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员