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| 1 | 螺内酯与可乐定作为难治性高血压第4种治疗药物的比较:难治性高血压的最佳治疗随机研究显示文摘该研究旨在通过一个多中心随机试验对作为难治性高血压患者的第4种治疗药物的螺内酯与可乐定进行比较。采用药丸计数评估药物治疗依从性。难治性高血压患者(定义为包括1种利尿剂在内的3种药物治疗12周,诊室及动态血压监测血压仍未控制)随机给予螺内酯(12.5~50 mg/d)或可乐定(0.1~0.3mg,2次/d)继续治疗12周。 | Krieger EM Drager LF Giorgi DMA Pereira AC Barreto-Filho JAS Nogueira AR Mill JG Lotufo PA Amodeo C Batista MC Bodanese LC Carvalho ACC Castro I Chaves H Costa EAS Feitosa GS Franco RJS Fuchs FD Guimarāes AC Jardim PC Machado CA Magalhāes ME Mion D Jr Nascimento RM Nobre F Nóbrega AC Ribeiro ALP Rodrigues-Sobrinho CR Sanjuliani AF Teixeira MDCB Krieger JE ReHOT Investigators 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，3： | 7 |
| 2 | Cognitive disorder and dementia in type 2 diabetes mellitus显示文摘Insulin,a key pleiotropic hormone,regulates metabolism through several signaling pathways in target tissues including skeletal muscle,liver,and brain.In the brain,insulin modulates learning and memory,and impaired insulin signaling is associated with metabolic dysregulation and neurodegenerative diseases.At the receptor level,in aging and Alzheimer’s disease(AD)models,the amount of insulin receptors and their functions are decreased.Clinical and animal model studies suggest that memory improvements are due to changes in insulin levels.Furthermore,diabetes mellitus(DM)and insulin resistance are associated with age-related cognitive decline,increased levels ofβ-amyloid peptide,phosphorylation of tau protein;oxidative stress,pro-inflammatory cytokine production and dyslipidemia. Recent evidence shows that deleting brain insulin receptors leads to mildobesity and insulin resistance without influencing brain size and apoptosis development.Conversely, deleting insulin-like growth factor 1 receptor (IGF-1R) affects brain size anddevelopment, and contributes to behavior changes. Insulin is synthesized locally in the brain andis released from the neurons. Here, we reviewed proposed pathophysiological hypotheses toexplain increased risk of dementia in the presence of DM. Regardless of the exact sequence ofevents leading to neurodegeneration, there is strong evidence that mitochondrial dysfunctionplays a key role in AD and DM. A triple transgenic mouse model of AD showed mitochondrialdysfunction, oxidative stress, and loss of synaptic integrity. These alterations are comparable tothose induced in wild-type mice treated with sucrose, which is consistent with the proposal thatmitochondrial alterations are associated with DM and contribute to AD development. Alterationsin insulin/IGF-1 signaling in DM could lead to mitochondrial dysfunction and low antioxidantcapacity of the cell. Thus, insulin/IGF-1 signaling is important for increased neural processing andsystemic metabolism, and could be a specific target for therapeutic strategies to decreasealterations associated with age-related cognitive decline. | Genaro G Ortiz Miguel Huerta Héctor A González-Usigli Erandis D Torres-Sánchez Daniela LC Delgado-Lara Fermín P Pacheco-Moisés Mario A Mireles-Ramírez Blanca MG Torres-Mendoza Roxana I Moreno-Cih Irma E Velázquez-Brizuela | 2022 | World Journal of Diabetes2022，13，4： | 2 |
| 3 | Urinary TWEAK and the activity of lupus nephritis显示文摘 | Schwartz N Su L Burkly LC | 2006 | J Autoimmun2006，27，4： | 1 |
| 4 | Psoriasis is characterized by accumulation of immunostimulatory and Thl/Thl7 cell-polarizing myeloid dendritic ceils 显示文摘 | Zaba LC Fuentes-Duculan J Eungdamrong N J | 2008 | J Invest Dermatol2008，129，1： | 1 |
| 5 | Cytochrome P450 1B1 is overexpressed and regulated by hypomethylation in prostate cancer显示文摘 | Tokizane T Shiina H Igawa M Enokida H Urakami S Kawakami T Ogishima T Okino ST Li LC Tanaka Y Nonomura N Okuyama A Dahiya R | 2005 | Clin Cancer Res2005，11，16： | 1 |
| 6 | Import of adenovi- rus DNA involves the nuclear pore complex receptor CAN/Nu- p214 and histone HI显示文摘 | Trotman LC Mosberger N Fornerod M | 2001 | Nat Cell Biol2001，3，12： | 1 |
| 7 | Toll-like receptor I variations influence susceptibility and im- mune response to Mycobacterium tuberculosis显示文摘 | DITTRICH N BEHROCAL-ALMANZA LC THADA S | 2015 | Tuberculosis (Edinb)2015，95，3： | 1 |
| 8 | Interaction of the Bovine Papillomavirus E2 Protein with Brd4 Tethers the Viral DNA to Host Mitotic Chromosomes显示文摘 | You J Jennie LC Akiko N | 2004 | Cell2004，117，： | 1 |
| 9 | Clinical outcome observation of preoperative concurrent ehemoradiotherapy/radiothcrapy alone in 174 Chinese patients with local advanced cervical earcinoma显示文摘 | Wei LC Wang N Shi M | 2013 | Onco Targets Ther2013，6，： | 1 |
| 10 | Persistence ectopic pregnancy after liner salpingotomy:a non-predictable complication to conservative surgery for tubal gestation显示文摘 | Otto LC Lisbeth N Nannie B | 2002 | Acta Obstet Gynecol Scand2002，81，11： | 1 |
| 11 | Antivirai effectsof interferon-β are enhanced in the absence of the translational suppressor 4E-BP1 in myocarditis induced by Coxsackievirus B3 显示文摘 | Burke JD Sonenberg N Platanias LC | 2011 | Antivir Ther2011，16，4： | 1 |
| 12 | Clinical value of lung cancer tumormarker显示文摘 | Qi LC Gao N Han ZG | 2007 | Chin J Lab Diagn2007，10，7： | 1 |
| 13 | Resection of the embryologically defined uterovaginal (Mtillerian) compartment and pelvic control in patients with cervical cancer: a prospective analysis显示文摘 | Hockel M Horn LC Manthey N | 2009 | Lancet Oncol2009，10，7： | 1 |
| 14 | Prevalence andimpact of primary dysmenorrhea among Mexican high school students显示文摘 | Ortiz MI Rangel-Flores E Carrillo-Alarcón LC | 2009 | Int J Gynaecol Obstet2009，107，3： | 1 |
| 15 | OX40 (CD 134 ) and OX40 ligand interaction plays an adjuvant role during in vivo Th2 responses 显示文摘 | Isbii N Ndhlovu LC Murata K | 2003 | Eur J Immunol2003，33，： | 1 |
| 16 | Monocyte chemoattractant protein-1 levels in patients with glomerular disease 显示文摘 | Rovin BH Doe N Tan LC | 1996 | Am J Kudbey Dis1996，27，5： | 1 |
| 17 | Intermittent hypoxia causes insulin resistance in lean mice independent of autonomic activity显示文摘 | Iiyori N Alonso LC Li J | 2007 | Am J Respir Crit Care Med2007，175，8： | 1 |
| 18 | Intermittent hypoxia causes insulin resistance in lean mice independent of autonomic activity显示文摘 | Iiyori N Alonso LC Li J | 2007 | Am J Respir Crit Care Med2007，175，8： | 1 |
| 19 | OX40(CD134) and OX40 ligand interaction plays an adjuvant role during in vivo Th2 responses 显示文摘 | Ishii N Ndhlovu LC Murata K | 2003 | Eur J Immunol2003，33，9： | 1 |
| 20 | Current concepts in glucocorticoid resistance显示文摘 | Yang N Ray DW Matthews LC | 2012 | Steroids2012，77，： | 1 |
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