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| 1 | Effect of alcohol consumption on liver stiffness measured by transient elastography显示文摘AIM:To determine the evolution of transient elastography(TE) in patients with alcoholic liver disease according to alcohol cessation or continuation.METHODS:We retrospectively selected in our local database all patients who had two TE between June 2005 and November 2010 with chronic alcohol excessive consumption and excluded those with associated cause of liver disease.TE was performed at least one week apart by senior operator.TE examinations with less than ten successful measures or with an interquartile range above 30% were excluded.We retrospectively reviewed file of all patients to include only patient followed up by trained addictologist and for which definite information on alcohol consumption was available.Concomitant biological parameters [aspartate amino transferase(AST),alanine amino transferase and gamma-glutamyl transpeptidase(GGT)] within 4 wk of initial and final TE were recorded.Putative fibrosis score according to initial and final TE were determined with available cut-off for alcoholic liver disease and hepatitis C.Initial and final putative fibrosis score were compared according to alcohol consumption during follow-up.RESULTS:During the study period 572 patients had TE examination for alcoholic liver disease and 79 of them had at least two examinations.Thirty-seven patients met our criteria with a median follow-up of 32.5 wk.At the end of the study,13(35%) were abstinent,and 24(65%) relapsers.Eight patients had liver biopsy during follow-up.TE decreased significantly during follow-up in 85% of abstinent patients [median(range):-4.9(-6.1,-1.9)],leading to a modification of the putative fibrosis stage in 28%-71% of patient according to different cut-off value.In relapsers TE increased in 45% and decreased in 54% of patient.There was no statistical difference between initial and final TE in relapsers.In the overall population,using 22.6 kPa as cut-off for cirrhosis,4 patients had cirrhosis at initial TE and 3 patients had cirrhosis at final TE.Using 19.5 kPa as cut-off for cirrhosis,7 patients had cirrhosis at initial TE and 5 patients had cirrhosis at final TE.Using 12.5 kPa as cut-off for cirrhosis,16 patients had cirrhosis at initial TE and 15 patients had cirrhosis at final TE.Evolution of biological data was in accordance with the relapse or abstinent status:abstinence ratio(duration of abstinence/duration follow-up) was correlated with AST ratio(r =-0.465,P = 0.007) and GGT ratio(r =-0.662,P<0.0001).GGT was correlated with initial(r = 0.488,P = 0.002) and final TE(r = 0.49,P<0.005).Final TE was correlated with AST(r = 0.362,P<0.05).Correlation between TE ratio and AST ratio(r = 0.44,P = 0.01) revealed that TE varied proportionally to AST for all patients irrespective of their alcohol status.The same relationship was observed between TE ratio and GGT ratio(r = 0.65,P<0.0001).Evolution of TE was significantly correlated with the ratio of time of abstinence to observation time(r =-0.387,P = 0.016) and the evolution of liver enzymes.CONCLUSION:TE significantly decreased with abstinence.Results of TE in alcoholic liver disease cannot be interpreted without taking into account alcohol consumption and liver enzymes. | Edouard Bardou-Jacquet Ludivine Legros Draman Soro Marianne Latournerie Anne Guillygomarc'h Caroline Le Lan Pierre Brissot Dominique Guyader Romain Moirand | 2013 | World Journal of Gastroenterology2013，19，4： | 20 |
| 2 | “Smart”nanomaterials for cancer therapy显示文摘Recent development in nanotechnology has provided new tools for cancer therapy and diagnostics.Because of their small size,nanoscale devices readily interact with biomolecules both on the cell surface and inside the cell.Nanomaterials,such as fullerenes and their derivatives,are effective in terms of interactions with the immune system and have great potential as anticancer drugs.Comparatively,other nanomaterials are able to load active drugs to cancer cells by selectively using the unique tumor environment,such as their enhanced permeability,retention effect and the specific acidic microenvironment.Multifunctional and multiplexed nanoparticles,as the next generation of nanoparticles,are now being extensively investigated and are promising tools to achieve personalized and tailored cancer treatments. | LE GUYADER Laurent | 2010 | Science China Chemistry2010，53，11： | 4 |
| 3 | Insulin resistance–associated hepatic iron overload显示文摘 | Michel-Henry Mendler Bruno Turlin Romain Moirand Anne-Marie Jouanolle Thierry Sapey Dominique Guyader Jean-Yves le Gall Pierre Brissot Véronique David Yves Deugnier | 1999 | Gastroenterology1999，，5： | 2 |
| 4 | Noise Feedback Coding Revisited:Refurbished Legacy Codecs and New Coding Models显示文摘Noise feedback coding(NFC) has attracted renewed interest with the recent standardization of backward-compatible enhancements for ITU-T G.711 and G.722.It has also been revisited with the emergence of proprietary speech codecs,such as BV16,BV32,and SILK,that have structures different from CELP coding.In this article,we review NFC and describe a novel coding technique that optimally shapes coding noise in embedded pulse-code modulation(PCM) and embedded adaptive differential PCM(ADPCM).We describe how this new technique was incorporated into the recent ITU-T G.711.1,G.711 App.III,and G.722 Annex B(G.722B) speech-coding standards. | Stéphane Ragot Balázs Kvesi Alain Le Guyader | 2012 | ZTE Communications2012，10，2： | 2 |
| 5 | Self-repelling snakes for topology-preserving segmentation models显示文摘 | Le GUYADER C VESE L A | 2008 | IEEE Transactions on Image Processing2008，17，5： | 1 |
| 6 | Detection and quantification of noroviruses in shellfish显示文摘 | Le Guyader Francoise S Parnaudeau Sylvain Schaeffer Julien | 2009 | Appl Environ Microbiol2009，75，3： | 1 |
| 7 | Magnitude of rainfall on viral contamination of the marine environment during gastroenteritis epidemics in human coastal population 显示文摘 | MIOSSEC L LE GUYADER F HAUGARREAU L | 2000 | Rev Epidemiol Sante2000，48，： | 1 |
| 8 | A semiquantitative approach to estimate Norwalk-like virus contamination of oysters implicated in an outbreak 显示文摘 | LE GUYADER F S NEILL F H DUBOIS E | 2003 | Int J Food Microbiol2003，87，： | 1 |
| 9 | Inhibition of platelet GPⅡb-Ⅲa and P-selectin expression by aspirin is impaired by stress hyperglycemia显示文摘 | Le Guyader A Pacheco G Seaver N | 2009 | J Diabetes Complications2009，23，1： | 1 |
| 10 | Environmental con- ditions leading to shellfish contamination and related outbreaks 显示文摘 | Maalouf H Pommepuy M Le Guyader FOS | 2010 | Food and Environmental Virology2010，2，3： | 1 |
| 11 | Detection of hepatitis a virus, rotavirus, and enterovirus in naturally contaminated shellfish and sediment by reverse transeription-seminested PCR显示文摘 | Le GUYADER F DUBOIS E MENARD D | 1994 | Appl Environ Microbiol1994，60，： | 1 |
| 12 | Inhibition of platelet GPIIb-IIIa and P selectin expression by aspirin is impaired by stress hyperglycemia显示文摘 | Le Guyader A Pacheco G Seaver N | 2008 | J Di-abetes Complications2008，23，1： | 1 |
| 13 | Decreased Cardiovascular and Extrahepatic Cancer-Related Mortality In Treated Patients with Mild HFE Hemochromatosis显示文摘 | Edouard Bardou-Jacquet Jeff Morcet Ghislain Manet Fabrice Lainé Michèle Perrin Anne-Marie Jouanolle Dominique Guyader Romain Moirand Jean-Fran?ois Viel Yves Deugnier | 2014 | Journal of Hepatology2014，，： | 1 |
| 14 | Detection of human caliciviruses in fecal samples by RT-PCR 显示文摘 | ATMAR R L NEILL F H LE GUYADER F S | 2011 | Methods Mol Biol2011，665，： | 1 |
| 15 | A simple method for detection of major phenotypic abnormalities in myelodysplastic syndromes:expression of CD56 in CMML 显示文摘 | Laeronique-Gazaille C Chaury MP Le Guyader A | 2007 | Haematologica2007，92，6： | 1 |
| 16 | Self-repelling Snakes for Topology-preserving Segmentation Models显示文摘 | le Guyader C Vese L A | 2008 | IEEE Transactions on Image Processing2008，17，5： | 1 |
| 17 | Double-contrast radiological exploration ofthe major duodenal papilla显示文摘 | Blain F Le Guyader J Brousse A | 1980 | J Radiol1980，61，89： | 1 |
| 18 | A semiquantitative approach to estimate norwalk-like virus contamination of oysters implicated in an outbreak 显示文摘 | LE GUYADER F S NEILLB F H DUBOISC E | 2003 | International Journal of Food Microbiology2003，87，： | 1 |
| 19 | Self-repelling Snakes for Topology-preserving Segmentation Models 显示文摘 | Le Guyader C Vese L A | 2008 | IEEE Transactions on Image Processing2008，17，5： | 1 |
| 20 | Presence of a mitochondrialtype 70-kDa heat shock protein in Trichomonas vaginalis suggests a very early mitochondrial endosymbiosis in eukaryotes 显示文摘 | Germot A Philippe H Le Guyader H | 1996 | Proc Natl Acad Sci USA1996，93，14： | 1 |
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