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| 1 | Modified joint probabilistic data association with classification-aided for multitarget tracking显示文摘Joint probabilistic data association is an effective method for tracking multiple targets in clutter, but only the target kinematic information is used in measure-to-track association. If the kinematic likelihoods are similar for different closely spaced targets, there is ambiguity in using the kinematic information alone; the cor-rect association probability will decrease in conventional joint probabilistic data association algorithm and track coalescence will occur easily. A modified algorithm of joint probabilistic data association with classification-aided is presented, which avoids track coalescence when tracking multiple neighboring targets. Firstly, an identification matrix is defined, which is used to simplify validation matrix to decrease computational complexity. Then, target class information is integrated into the data association process. Performance comparisons with and without the use of class information in JPDA are presented on multiple closely spaced maneuvering targets tracking problem. Simulation results quantify the benefits of classification-aided JPDA for improved multiple targets tracking, espe-cially in the presence of association uncertainty in the kinematic measurement and target maneuvering. Simulation results indicate that the algorithm is valid. | Ba Hongxin Cao Lei He Xinyi Cheng Qun | 2008 | Journal of Systems Engineering and Electronics2008，19，3： | 8 |
| 2 | Famitinib versus placebo in the treatment of refractory metastatic colorectal cancer:a multicenter,randomized,double-blinded,placebo-controlled,phaseⅡclinical trial显示文摘Background: Metastatic colorectal cancer(mCRC) patients with progressive disease after all available standard therapies need new medication for further treatment. Famitinib is a small-molecule multikinase inhibitor, with promising anticancer activities. This multicenter, randomized, double-blinded, placebo-controlled, phase II clinical trial was designed to evaluate the safety and efficacy of famitinib in mCRC.Methods: Famitinib or placebo was administered orally once daily. The primary endpoint was progression-free survival(PFS). Secondary endpoints included objective response rate(ORR), disease control rate(DCR), overall survival(OS), quality-of-life(QoL), and safety.Results: Between July 18,2012 and Jan 22,2014, a total of 167 patients were screened, and 154 patients were randomized in a 2:1 ratio to receive either famitinib(n = 99) or placebo(n = 55). The median PFS was 2.8 and 1.5 months in the famitinib and placebo groups(hazard ratio = 0.60,95% confidence interval = 0.41-0.86, P = 0.004). The DCR was 59.8% and 31.4%(P = 0.002) and the ORR was 2.2% and 0.0%(P = 0.540) in the famitinib and placebo groups,respectively. The most frequent grade 3-4 adverse events were hypertension(11.1%), hand-foot syndrome(10.1%),thrombocytopenia(10.1%) and neutropenia(9.1%). Serious adverse events occurred in 11(11.1%) patients in the famitinib group and 5(9.1%) in the placebo group(P = 0.788). The median OS of the famitinib and placebo groups was 7.4 and 7.2 months(P = 0.657).Conclusion: Famitinib prolonged PFS in refractory mCRC patients with acceptable tolerability.Trial registration This study was registered on ClinicalTrials.gov(NCT01762293) and was orally presented in the 2015 ASCO-Gastrointestinal | Rui-Hua Xu Lin Shen Ke-Ming Wang Gang Wu Chun-Mei Shi Ke-Feng Ding Li-Zhu Lin Jin-Wan Wang Jian-Ping Xiong Chang-Ping Wu Jin Li Yun-Peng Liu Dong Wang Yi Ba Jue-Ping Feng Yu-Xian Bai Jing-Wang Bi Li-Wen Ma Jian Lei Qing Yang Hao Yu | 2017 | Chinese Journal of Cancer2017，36，12： | 4 |
| 3 | Hundred-Joule-level,nanosecond-pulse Nd:glass laser system with high spatiotemporal beam quality显示文摘A 100-J-level Nd:glass laser system in nanosecond-scale pulse width has been constructed to perform as a standard source of high-fluence-laser science experiments. The laser system, operating with typical pulse durations of 3–5 ns and beam diameter 60 mm, employs a sequence of successive rod amplifiers to achieve 100-J-level energy at 1053 nm at3 ns. The frequency conversion can provide energy of 50-J level at 351 nm. In addition to the high stability of the energy output, the most valuable of the laser system is the high spatiotemporal beam quality of the output, which contains the uniform square pulse waveform, the uniform flat-top spatial fluence distribution and the uniform flat-top wavefront. | Sensen Li Yulei Wang Zhiwei Lu Lei Ding Yi Chen Pengyuan Du Dexin Ba Zhenxing Zheng Xin Wang Hang Yuan Chengyu Zhu Weiming He Dianyang Lin Yongkang Dong Dengwang Zhou Zhenxu Bai Zhaohong Liu Can Cui | 2016 | High Power Laser Science and Engineering2016，4，1： | 3 |
| 4 | G-protein-coupled receptors act via protein kinase C and Src to regulate NMDA receptors显示文摘 | Lu WY Xiong ZG Lei S Orser BA Dudek E Browning MD | 1999 | Nat Neurosci1999，2，4： | 1 |
| 5 | Polymorphisms in CYP2R1 Gene Associated with Serum Vitamin D Levels and Status in a Chinese Rural Population显示文摘Vitamin D, a fat-soluble vitamin and endocrine horm one, and it impacts various bone and extra-bone health, such as osteoporosis, diabetes, and cancer. The main circulating form of vitamin D is 25-hydroxyvitamin D [25(OH)D] and it is a useful clinical biomarker of vitamin D status. The Institute of Medicine (IOM) defines as vitamin D deficiency (VDD) when serum 25(OH)D concentration is less than 20 ng/mL⑴.Worldwide, VDD is recognized as a severe public health problem. In 2007, Holick estimated that globally over one billion people suffered from VDD or vitamin D insufficiency (VDI). In China, it has bee n reported that the prevale nee of VDD ranged from 38.8% to 91.2% in different regions. | WANG Yan HAN Han WANG Jun SHEN Fang YU Fei WANG Ling YU Song Cheng ZHANG Dong Dong SUN Hua Lei XUE Yuan BA Yue WANG Chong Jian LI Wen Jie | 2019 | Biomedical and Environmental Sciences2019，32，7： | 1 |
| 6 | Cleavage of interferon regulatory factor 7 by enterovirus 71 3C suppresses cellular responses 显示文摘 | Lei XB Xiao X Xue Q Jin Q He BA | 2013 | J Virol2013，87，3： | 1 |
| 7 | Further characterization of endometrial integrins during the menstrual cycle and in pregnancy显示文摘 | Lessey BA Lei Ying Castelbaum Arthur J | 1994 | Fertil Steril1994，62，3： | 1 |
| 8 | Changes in axial length following trabeculectomy and glaucoma drainage device surgery 显示文摘 | Francis BA Wang M Lei H | 2005 | Br J Ophthalmol2005，89，1： | 1 |
| 9 | Study on immobilization of lipase onto magnetic microspheres with epoxy groups显示文摘 | Lin Lei Yongxiao Ba Yanfeng Li | 2009 | Journal of Magnetism and Magnetic Materials2009，321，4： | 1 |
| 10 | Dominance of HIV-1 Subtype CRF01_ AE in Sexually Acquired Cases Leads to a New Epidemic in Yunnan Province of China显示文摘 | Zhang Yong’Lu Lin Ba Lei | 2006 | PLOS Med2006，3，11： | 1 |
| 11 | Enterovirus 71 3C inhibits cytokine expression through cleavage of the TAK1/ TAB1/TAB2/TAB3 complex 显示文摘 | Lei XB Han N Xiao X Jin Q He BA | 2014 | J Virol2014，88，17： | 1 |
| 12 | Changes in axial length following trabeculectomy and glauco- ma drainage device surgery显示文摘 | Francis BA Wang M Lei H LT Du Minckler DS Green RL | 2005 | Br J Ophthalmol2005，89，1： | 1 |
| 13 | A Study of the Probe Effect on the Apparent Image of Biological Atomic Force Microscopy显示文摘The probe effect on the apparent image of biological atomic force microscopy was explored in this study, and the potential of AFM in conformational study of gene related biological processes was illustrated by the specific nanostructural information of a new antitumor drug binding to DNA. | Xue Mei WANG Lei QIN Long BA Zu Hong LU | 2001 | Chinese Chemical Letters2001，12，12： | 1 |
| 14 | Digital health communities:the effect of their motivation mechanisms显示文摘 | SULIN BA LEI WANG | 2013 | Decision Support Systems2013，55，： | 1 |
| 15 | Com- petitive relationships between two contrasting but coexisting grasses显示文摘 | Ba Lei Wang De-li Hodgkinson K C | 2006 | Plant Ecology2006，183，1： | 1 |
| 16 | Digital health communities:the effect of their motivation mechanisms显示文摘 | SULIN BA LEI WANG | 2013 | Decision Support Systems2013，55，： | 1 |
| 17 | Polypoidal choroidal vasculopathy in Caucasians显示文摘 | Lafaut BA Leys AM Snyers B | 2000 | Graefes Arch Clin Exp Ophthalmol2000，238，9： | 1 |
| 18 | Interactions between herbivory and resource availability on grazing tolerance of Leymus chinensis显示文摘 | Gao Ying Wang De-li Ba Lei | | 0，，： | 1 |
| 19 | Furthercharacterization of endomet rialint egrins during the menstrual cycleand in pregnancy 显示文摘 | Lessey BA Lei Ying Castelbaum Arthur J | 1994 | Fertil Steril1994，62，3： | 1 |
| 20 | Polypoidal choroidal vasculopathy in Caucasians 显示文摘 | Lafaut BA Leys AM Snyers B | 2000 | Graefe'' s Arch Clin Exp Ophthalmol2000，238，： | 1 |
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