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| 1 | Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial显示文摘 | Axel Grothey Eric Van Cutsem Alberto Sobrero Salvatore Siena Alfredo Falcone Marc Ychou Yves Humblet Olivier Bouché Laurent Mineur Carlo Barone Antoine Adenis Josep Tabernero Takayuki Yoshino Heinz-Josef Lenz Richard M Goldberg Daniel J Sargent Frank Ciho | 2012 | The Lancet2012，，： | 10 |
| 2 | Acute necrotizing pancreatitis as fi rst manifestation of primary hyperparathyroidism显示文摘We report the case of a female patient with severe acute necrotizing pancreatitis associated with hypercalcemia as first manifestation of primary hyperparathyroidism caused by a benign parathyroid adenoma.Initially the acute pancreatitis was treated conservatively.The patient subsequently underwent surgical resection of the parathyroid adenoma and surgical clearance of a large infected pancreatic pseudocyst.Although the association of parathyroid adenoma-induced hypercalcemia and acute pancreatitis is a known medical entity,it is very uncommon.The pathophysiology of hypercalcemia-induced acute pancreatitis is therefore not well known,although some mechanisms have been proposed.It is important to treat the provoking factor.Therefore,the cause of hypercalcemia should be identif ied early.Surgical resection of the parathyroid adenoma is the ultimate therapy. | Jeroen I Lenz Jimmy M Jacobs Bart Op de Beeck Ivan A Huyghe Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，23： | 9 |
| 3 | Assessment of stricturing Crohn's disease:Current clinicalpractice and future avenues显示文摘Crohn's disease(CD) is a chronic remittent idiopathic disease. Although the early phase of the disease is commonly characterized by inflammation-driven symptoms, such as diarrhea, the frequency of fibrostenotic complications in patients with CD increases over the long-term course of the disease. This review presents the current diagnostic options for assessing CD-associated strictures. In addition to the endoscopic evaluation of CD strictures, this review summarizes the currently available imaging modalities, including ultrasound and cross-sectional imaging techniques. In addition to stricture detection, differentiating between the primarily inflammatory strictures and the predominantly fibrotic ones is essential for selecting the appropriate treatment strategy(anti-inflammatory medical treatment vs endoscopical or surgical approaches). Therefore, recent imaging advances, such as contrast-enhanced ultrasound and ultrasound elastography, contribute to the development of noninvasive non-radiating imaging of CD-associated strictures. Finally, novel magnetic resonance imaging techniques, such as diffusion-weighted, motility and magnetization transfer imaging, as well as 18F-FDG PET/CT, molecular imaging approaches and biomarkers, are critically reviewed with regard to their potential role in assessing stricturing CD. | Dominik Bettenworth Tobias M Nowacki Friederike Cordes Boris Buerke Frank Lenze | 2016 | World Journal of Gastroenterology2016，22，3： | 4 |
| 4 | Detection and characterization of murine colitis and carcinogenesis by molecularly targeted contrast-enhanced ultrasound显示文摘AIM To study mucosal addressin cellular adhesion molecule-1(MAd CAM-1) and vascular endothelial growth factor(VEGF)-targeted contrast enhanced ultrasound(CEUS) for the assessment of murine colitis and carcinogenesis. METHODS C57BL/6 mice were challenged with 3% dextran sodium-sulfate(DSS) for three, six or nine days to study the development of acute colitis. Ultrasound was performed with and without the addition of unspecific contrast agents. MAd CAM-1-targeted contrast agent was used to detect and quantify MAd CAM-1 expression. Inflammatory driven colorectal azoxymethane(AOM)/DSS-induced carcinogenesis was examined on day 42 and 84 using VEGF-targeted contrast agent. Highly specific tissue echogenicity was quantified using specialized software. Sonographic findings were correlated to tissue staining, western blot analysis and immunohistochemistry to quantify the degree of inflammation and stage of carcinogenesis. RESULTS Native ultrasound detected increased general bowel wall thickening that correlated with more progressed and more severe DSS-colitis(healthy mice: 0.3 mm ± 0.03 vs six days DSS: 0.5 mm ± 0.2 vs nine days DSS: 0.6 mm ± 0.2, P < 0.05). Moreover, these sonographic findings correlated well with clinical parameters such as weight loss(r2 = 0.74) and histological damage(r2 = 0.86)(P < 0.01). In acute DSS-induced murine colitis, CEUS targeted against MAd CAM-1 detected and differentiated stages of mild, moderate and severe colitis via calculation of mean pixel contrast intensity in decibel(9.6 d B ± 1.6 vs 12.9 d B ± 1.4 vs 18 d B ± 3.33, P < 0.05). Employing the AOM/DSSinduced carcinogenesis model, tumor development was monitored by CEUS targeted against VEGF and detected a significantly increased echogenicity in tumors as compared to adjacent healthy mucosa(healthy mucosa, 1.6 d B ± 1.4 vs 42 d, 18.2 d B ± 3.3 vs 84 d, 18.6 d B ± 4.9, P < 0.01). Tissue echogenicity strongly correlated with histological analysis and immunohistochemistry findings(VEGF-positive cells in 10 high power fields of healthy mucosa: 1 ± 1.2 vs 42 d after DSS start: 2.4 ± 1.6 vs 84 d after DSS start: 3.5 ± 1.3, P < 0.01). CONCLUSION Molecularly targeted CEUS is a highly specific and noninvasive imaging modality, which characterizes murine intestinal inflammation and carcinogenesis in vivo. | Markus Brückner Jan Heidemann Tobias M Nowacki Friederike Cordes Jorg Stypmann Philipp Lenz Faekah Gohar Andreas Lügering Dominik Bettenworth | 2017 | World Journal of Gastroenterology2017，23，16： | 4 |
| 5 | An integrated metabonomic investigation of acetaminophen toxicity in the mouse using NMR spectroscopy 显示文摘 | Coen M Lenz E M Nicholson J K | 2003 | Chem Res Toxicol2003，16，3： | 1 |
| 6 | CsrA and three redundant small RNAs regulate quorum sensing in Vibrio cholerae显示文摘 | Lenz D H Miller M B ZhuJ | 2005 | Mol Microbiol2005，58，4： | 1 |
| 7 | Analytical Strategies in Metabonomics 显示文摘 | Lenz E M Wilson I D | 2007 | J Proteome Res2007，6，2： | 1 |
| 8 | Analytical strategies in metabonomics 显示文摘 | LENZ E M WILSON I D | 2007 | J Pl-oteorne Res2007，6，2： | 1 |
| 9 | Exhaustive exercise-induced tissue hypoxia does not change endothelin and big endothelin plasma levels in normal volunteers 显示文摘 | Lenz T Nadansky M Gossmann J | 1998 | Am J Hypertens1998，11，81： | 1 |
| 10 | The grothendieck group of a cluster category显示文摘 | Barot M Kussin D Lenzing H | 2008 | J Pure Applied Algebra2008，212，： | 1 |
| 11 | The holm oak leaf proteome : ana- lytical and biological variability in the protein expression level as-sessed by 2 - DE and protein identification tandem mass spectrometry de novo sequencing and sequence similarity searching 显示文摘 | Jorge I Navarro R M Lenz C | 2005 | Pro- teomics2005，5，1： | 1 |
| 12 | Aggressive lymphomas显示文摘 | LENZ G STAUDT L M | 2010 | N Engl J Med2010，362，15： | 1 |
| 13 | The pittsburgh rehabilitation participation scale:reliability and validity of a clinician-rated measure of participation in acute rehabilitation显示文摘 | Lenze E Munin M Quear T | 2004 | Arch Phys Med Rehabil2004，85，： | 1 |
| 14 | Variation in the holm oak leaf proteome at different plant developmental stages, between provenances and in response to drought stress 显示文摘 | Jorge I Navarro R M Lenz C | 2006 | Proteomics2006，6，： | 1 |
| 15 | Novel approaches to treatment of advanced colorectal cancer with anti-EGFR monoclonal antibodies显示文摘 | Zhang W Gordon M Lenz HJ | 2006 | Ann Med2006，38，8： | 1 |
| 16 | Ex vivo evaluation of the polymerization temperatures during cement augmentation of proxi- mal femoral nail antirotation blades 显示文摘 | FLIRI L LENZ M BOGER A et la | 2012 | J Trauma Acute Care Surg2012，72，4： | 1 |
| 17 | Fruit Photosynthesis显示文摘 | Blank M Lenz F | 1989 | Plant Cell and Environments1989，12，： | 1 |
| 18 | Early consolidation by myeloablative radiochemotherapy followed by autologous stem cell transplantation in first remission significantly prolongs progression-free survival in mantle-cell lymphoma:results of a prospective randomized trial of the European MCL Network显示文摘 | Dreyling M Lenz G Hoster E | 2005 | Blood2005，105，： | 1 |
| 19 | 显示文摘 | LENZ E M WILSON I D | 2007 | Journal of Proteome Research2007，6，2： | 1 |
| 20 | Case retrieval nets:basic ideas and extensions显示文摘 | LENZ M BURKHARD H D | 1996 | Knowledge and Information Systems1996，1137，： | 1 |
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