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| 1 | Ron receptor-dependent gene regulation in a mouse model of endotoxin-induced acute liver failure显示文摘BACKGROUND:Prior experimentation has shown that loss of the tyrosine kinase(TK) signaling domain of the Ron receptor leads to marked hepatocyte protection in a model of lipopolysaccharideinduced acute liver failure(ALF) in D-galactosamine(GalN)sensitized mice.The aim of this study was to identify the role of Ron in the regulation of hepatic gene expression.METHODS:Microarray analyses were performed on liver RNA isolated sequentially from wild-type(WT) and TK-/mice during the progression of ALF.Gene array data were validated using Western and immunohistochemistry analyses as well as with ex vivo culture systems.RESULTS:At baseline,101 genes were differentially expressed between WT and TK-/-livers,which regulate processes involved in hypoxia,proliferation,apoptosis and metabolism.One hour after ALF induction,WT livers exhibited increased cytokine expression compared to TK-/-livers,and after 4 hours,an induction of suppressor of cytokine signaling(SOCS) genes as well as JAK-STAT pathway activation were prominent in TK-/livers compared to controls.CONCLUSION:Our studies suggest a novel hepato-protective mechanism in Ron TK-/-mice wherein increased and sustained SOCS production and JAK-STAT activation in the hepatocyte may inhibit the destructive proinflammatory milieu and promote survival factors which blunt hepatic death and the ensuing development of ALF. | Rishikesh M Kulkarni Louis W Kutcher William D Stuart Daniel J Carson Mike A Leonis Susan E Waltz | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，4： | 3 |
| 2 | MAISTAS:a tool for automatic structural evaluation of alternative splicing products显示文摘 | Floris M Raimondo D Leoni G | 2011 | Bioinformatics2011，27，12： | 1 |
| 3 | p-tert-Butylealix arene 显示文摘 | Gutsche C D Dhawan B Leonis M Stewart D | 1990 | Org Synth1990，，68： | 1 |
| 4 | Implantable cardioverter-defibrillator therapy for prevention of sudden death in patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia 显示文摘 | CORRADO D LEONI L LINK MS et a1 | 2003 | Circulation2003，108，： | 1 |
| 5 | P-tert-Butylcalix arene Preparation 显示文摘 | Gutsche C D Dhawan B Leonis M Stewart D | 1990 | Organic Syntheses1990，68，： | 1 |
| 6 | Three-dimensional electroanatomic voltage mapping increases accuracy of diagnosing arrhythmogenic right ventricular cardiomyopathy/dysplasia 显示文摘 | Corrado D Basso C Leoni L | 2005 | Circulation2005，111，： | 1 |
| 7 | Differentiation of Caco-2 cells requires both transcriptional and post-translational down-regulation of nyc 显示文摘 | LEONI B D NATOLI M NARDELLA M | 2012 | Differentiation2012，83，3： | 1 |
| 8 | Root canal morphology of the mesiobuccal root of maxillary first molars:A micro-computed tomographic analysis 显示文摘 | Somma F Leoni D Plotino G | 2009 | Int Endod J2009，422，： | 1 |
| 9 | Connective tissue growth factor : structure- function relationships of a mosaic, muhifunctional protein 显示文摘 | de WINTER P LEONI P ABRAHAM D | 2008 | Growth Factors2008，26，2： | 1 |
| 10 | Heme biosythesis in Rhizobium 显示文摘 | LEONY S A DITTA G S HELINSKI D R | 1982 | J Biol Chem1982，257，： | 1 |
| 11 | Free-radical copolymerization of styrene and m -isopropenyl- a,ar - dimethylbenzyl msoeyanate studied by ^1H-NMR kinetic experiments显示文摘 | Leonie B Christopher B K Thomas P D | 2002 | J Polym Sci: Part A: Polym Chem2002，40，： | 1 |
| 12 | Vitrification devices affect structural and molecular status of in vitro matured ovine oocytes显示文摘 | Leoni GG Bebbere D | 2007 | Mol Reprod2007，74，10： | 1 |
| 13 | Connective tissue growth factor:structure-function relationships of a mosaic,multifunctional protein显示文摘 | De Winter P Leoni P Abraham D | 2008 | Growth Factors2008，26，2： | 1 |
| 14 | Kinetic investigation on the smouldering combustion ofboreal peat 显示文摘 | Cancellieri D Leroy-Cancellieri V Leoni E | 2012 | Fuel2012，93，： | 1 |
| 15 | The effect of MgAl2O4 on the formation kinetics of Al2TiO5 from Al2O3 and TiO2 fine powders显示文摘 | BUSCAGLIA V ALCAZZI M D LEONI M | 1996 | Mater Sci1996，31，： | 1 |
| 16 | A new reporter cell line to monitor HIV infection and drug susceptibility in vitro显示文摘 | Gervaix A Wet D Leoni LM | 1997 | Proc Natl Acad Sci USA1997，94，： | 1 |
| 17 | Effect of different whole body hyperthemie sessions on the heat shock response in mice liver and brain显示文摘 | Leoni S Brambilla D Risuleo G | 2000 | Mol Cell Biochem2000，204，12： | 1 |
| 18 | Effect of vitrification solutions and cooling upon in vitro matured prepubertal ovine oocytes 显示文摘 | Suecu S Leoni G Bebbere D | 2007 | Theriogenology2007，68，： | 1 |
| 19 | Implantable cardioverter-defibrillator therapy for prevention of sudden deah in patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia显示文摘 | Corrado D Leoni L Link MS | 2003 | Circulation2003，108，25： | 1 |
| 20 | Gene expression analysis of osteoblastic ceils contacted by orthopedic implant particles 显示文摘 | Pioletti DP Leoni L Genini D | 2002 | J Biomed Mater Res2002，61，3： | 1 |
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