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| 1 | 肠道菌群促进血管紧张素Ⅱ诱导的高血压和血管功能障碍显示文摘肠道微生物对宿主生理反应及对免疫功能的发展来说必不可少。肠道菌群对血压和全身血管功能等这些由免疫细胞功能决定的生理过程的影响知之甚少。方法:与常规饲养的小鼠(conventionally raised rats,CONV-R)比较,未受任何细菌影响的无菌小鼠(GF)表现出较为严重的全身性辅助性T细胞1型滞后。 | 刘莉 叶鹏 Karbach SH Schnfelder T Brandao I Wilms E Hrmann N Jckel S Schüler R Finger S Knorr M Lagrange J Brandt M Waisman A Kossmann S Schüfer K Münzel T Reinhardt C Wenzel P | 2016 | 中华高血压杂志2016，24，10： | 5 |
| 2 | Increased syndecan-1 and glypican-3 predict poor perinatal outcome and treatment resistance in intrahepatic cholestasis显示文摘Background:Intrahepatic cholestasis of pregnancy(ICP)increases the risk of adverse pregnancy outcomes.This study aimed to explore the association between serum syndecan-1 and glypican-3 levels and the adverse perinatal outcome as well as the responses to the treatment of ursodeoxycholic acid(UDCA).Methods:This prospective,case control study included 88 pregnant women(44 women with ICP and 44 healthy controls).The primary end points were the perinatal outcome and the response to UDCA therapy.A logistic regression model was used to identify the independent risk factors of adverse pregnancy outcomes and reduced response to UDCA therapy.Results:Women with ICP had significantly higher serum syndecan-1(1.27±0.36 ng/m L vs.0.98±0.50 ng/m L;P=0.003),glypican-3(1.78±0.13 ng/m L vs.1.69±0.16 ng/m L;P=0.004),AST(128.59±1.44 vs.13.29±1.32 U/L;P<0.001),and ALT(129.84±1.53 vs.8.00±3.67 U/L;P<0.001)levels compared with the controls.The increased levels of syndecan-1(OR=4.715,95%CI:1.554–14.310;P=0.006),glypican-3(OR=8.465,95%CI:3.372–21.248;P=0.007),ALT(OR=1.382,95%CI:1.131–1.690;P=0.002),and postprandial bile acid(PBA)(OR=3.392,95%CI:1.003–12.869;P=0.026)were correlated to ICP.The adverse neonatal outcome was related to increased glypican-3(OR=4.275,95%CI:2.726–5.635;P=0.039),and PBA(OR=3.026,95%CI:1.069–13.569;P=0.037).Increases of syndecan-1(OR=7.464,95%CI:2.130–26.153,P=0.017)and glypican-3(OR=6.194,95%CI:2.951–13.002;P=0.025)were the risk factors of decreased response to UDCA treatment.Conclusion:Syndecan-1 and glypican-3 might be powerful determinants in predicting adverse perinatal outcome in patients with ICP,and they can be used to predict the response to the UDCA treatment. | Basak Gümüs Güler Sibel Ozler | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，3： | 3 |
| 3 | Nanocelluloses as innovative polymers in research and application显示文摘 | Klemm D Schumann D Kramer F He(B)ler N Hornung M Schmauder H P Marsch S | | 0，，09： | 1 |
| 4 | Point-of-care i-STAT cardiac troponin I for assessment of patients with symptoms suggestive of acute coronary syndrome显示文摘 | Apple F S Ler R Chung A Y | 2006 | Clin Chem2006，52，： | 1 |
| 5 | HDAC2 mediates therapeutic resistance of pancreatic cancer cells via the BH3-only protein NOXA显示文摘 | Fritsche P Seidler B Schüler S | 2009 | Gut2009，58，10： | 1 |
| 6 | The ecological importance of the Staphylococcus sciuri species group as a reservoir for resistance and virulence genes显示文摘 | Nemeghaire S Argudín MA Feβler AT | 2014 | Vet M icrobiol2014，171，34： | 1 |
| 7 | Sleeve gastrec- tomy as sole and definitive bariatric procedure:5-year for weight loss and gbrelin显示文摘 | Bohdjalian A Langer FB Shakeri-LeidenmhO ler S | 2010 | Obes Surg2010，20，5： | 1 |
| 8 | Time-of-flight optical ranging system based on time-correlated single-photon counting显示文摘 | S John Massa S Gerald Bul ler | | 0，，31： | 1 |
| 9 | Delayed storage and controlled atmosphere storage of nectar ines: two strategies to prevent woolliness显示文摘 | Zhou HongWei Lurie S Lers A | 2000 | Post harvest Biol Technol2000，18，： | 1 |
| 10 | Volume change during the formation of nanoporous gold by dealloying 显示文摘 | PARIDA S KRAMER S VOLKERT C A RI3SNER H ERLEBACHER J WEISSM(~LER J | 2006 | Physics Review Letters2006，97，03： | 1 |
| 11 | Investigation of wind shear coefficients and their effect on electrical energy generation显示文摘 | F?rt?n E Güler ? Akda? S A | 2011 | Applied Energy2011，88，11： | 1 |
| 12 | Maize HapMap2 identifies extant variation from a genome in flux 显示文摘 | Jer-Ming Chia Chi Song Peter J Bradbury Denise Cos- tich Natalia de Leon John Doebley Robert J Elshire Brandon Gaut Laura Geller Jeffrey C Glaubitz Michael Gore Kate E Guill Jim Holland Matthew B Hufford Jinsheng Lai Meng Li Xin Liu Yanli Lu Richard Mc- Combie Rebecca Nelson Jesse Poland Boddupalli M Prasanna Tanja Pyhajarvi Tingzhao Rong Rajandeep S Sekhon Qi Sun Maud I Tenaillon Feng Tian Jun Wang Xun Xu Zhiwu Zhang Shawn M Kaeppler Jef- frey Ross-lbarra Michael D McMullen Edward S Buck- ler Gengyun Zhang Yunbi Xu Doreen Ware | 2012 | Nat Genet2012，，44： | 1 |
| 13 | Direct Reprogramming of Fibroblasts into Neural Stem Cells by Defined Factors显示文摘 | Dong Wook Han Natalia Tapia Andreas Hermann Kathrin Hemmer Susanne H?ing Marcos J. Araúzo-Bravo Holm Zaehres Guangming Wu Stefan Frank S?ren Moritz Boris Greber Ji Hun Yang Hoon Taek Lee Jens C. Schwamborn Alexander Storch Hans R. Sch?ler | 2012 | Cell Stem Cell2012，，4： | 1 |
| 14 | Evaluation of serum anti-cardiolipin and oxidized low-density lipoprotein levels in chronic periodontitis patients with essential hypertension显示文摘 | Türko(g)lu O Bari (s) N Kütük(c)üler N | 2008 | J Periodontol2008，79，2： | 1 |
| 15 | Yin Yang 1 deficiency in skeletal muscle protects a- gainst rapamycin-induced diabetic-like symptoms through activation of insulin/IGF signaling 显示文摘 | BLATI'LER S M CUNNINGHAM J T VERDEGUER F | 2012 | Cell Metab2012，15，： | 1 |
| 16 | Plesovice zircon-A new natural reference material for U-Pb and Hf isotopic microanalysis显示文摘 | Sláma J Ko)(s)ler J Condon D J | | 0，，1： | 1 |
| 17 | Diffuse binding of Zn2+ to the denatured ensemble of Cu/Zn superoxide dismutase l显示文摘 | Szpryngiel S Oliveberg M M~ler L | 2015 | FEBSOpen /71'o72015，5，： | 1 |
| 18 | i PS cell derived neuronal cells for drug discovery显示文摘 | Heilker R Traub S Reinhardt P Sch?ler HR Sterneckert J | 2014 | Trends Pharmacol Sci2014，35，10： | 1 |
| 19 | Delayed storage and controlled atmosphere storage of nectarines: two strategies to prevent woolliness 显示文摘 | Zhou H W Lurie S Lers A | 2000 | Postharvest Biology Technology2000，18，2： | 1 |
| 20 | Synthesis of unsymmetrical 3, 4-diaryl-3-pyrrolin-2- ones utilizing pyrrole weinreb amides 显示文摘 | GREGER J G YOON-MII LER S J P BECHTOLD N R | 2011 | J Org Chem2011，76，20： | 1 |
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