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| 1 | Bipolar depression:a review of treatment options显示文摘Bipolar depression(BD-D)is both common and incredibly challenging to treat.Even treated individuals with BD-D experience depression approximately 19%of the time,and subsyndromal depression an additional 18%.This stands in clear contrast to the approximately 10%of time spent in hypomania and 1%of time spent in mania.Despite this high illness burden,there remain relatively few treatment options approved by the US Food and Drug Administration for BD-D.Of the approved medications,four are second-generation antipsychotics(SGAs)and one is an SGA combined with an antidepressant.However,particularly when used long-term,antipsychotics can pose a significant risk of adverse effects,raising the clinical conundrum of weighing the risks associated with longterm antipsychotic use versus the risk of relapse when patients are off medications.Here,we review commonly used treatments for BD-D,including antipsychotics,classic mood stabilisers,electroconvulsive therapy and psychotherapy.We then address the somewhat controversial topic of antidepressant use in BD-D.Finally,we summarise emerging treatment options and highlight ongoing clinical trials.We hope this review will help compare the risks and benefits of several common and novel options for the treatment of patients with BD-D.In doing so,we also hope this review will aid the individualised selection of treatments based on each patient’s history and treatment goals. | Kate Levenberg Zachary A Cordner | 2022 | General Psychiatry2022，35，4： | 2 |
| 2 | A method for the solution of certain non-linear problemsin least squares显示文摘 | | 1944 | Quart Appl Math1944，2，： | 1 |
| 3 | Endothelial cells derived from human embryonic stern cells 显示文摘 | Levenberg S Golub J S Amit M | 2002 | Proc Natl Acad Sci U S A2002，99，7： | 1 |
| 4 | A method for the solution of certain non-linear problems in least squares显示文摘 | Levenberg K | 1944 | Quart Appl Math1944，2，： | 1 |
| 5 | A method for the solution of certain nonlinear problems in least squares 显示文摘 | Levenberg K | 1944 | Quarterly of Applied Mathematics1944，，2： | 1 |
| 6 | Endothelial cells derived from human embryonic stem cells显示文摘 | Levenberg S Golub JS Amit M | 2002 | PNAS2002，99，7： | 1 |
| 7 | A method for the solution of certain non-linear problem in least squares 显示文摘 | Levenberg K | 1944 | Quarterly of Applied Mathematics1944，2，2： | 1 |
| 8 | Endothelial cells derived from human embryonic stem cells显示文摘 | Levenberg S Golub JS Amit M | 2002 | Proc Natl Acad Sci USA2002，99，： | 1 |
| 9 | A method for the solution of certain nonlinear problems in least squares 显示文摘 | Levenberg K | 1944 | Quart Appl Math1944，2，： | 1 |
| 10 | Differentiation of Human Embryonic Stem Cells on Three-Dimensional Polymer Scaffolds显示文摘 | Levenberg S | 2003 | Proc Natl Acad Sci USA2003，100，12： | 1 |
| 11 | A method for the solution of certainnonlinear problems in least squares 显示文摘 | Levenberg K | 1944 | QuarterlyJournal of Applied Mathematics1944，2，2： | 1 |
| 12 | Advances in Tissue Engineering显示文摘 | Levenberg S Langer R | 2004 | Curr Top Dev Biol2004，61，： | 1 |
| 13 | Endothelial cells derived from human embryonic stem cells显示文摘 | Levenberg S Golub JS Amit M | 2002 | Proc Natl Acad Sci USA2002，99，： | 1 |
| 14 | p27 is involved in N- cadherin-mediated contact inhibition of cell growth and S-phase entry显示文摘 | Levenberg S Yarden A Kam Z | 1999 | Oncogene1999，18，4： | 1 |
| 15 | Engineering vascularized skeletal muscle tissue显示文摘 | Levenberg S Rouwkema J Macdonald M | 2005 | Nat Biotechnol2005，23，7： | 1 |
| 16 | A method for the solution of certain problems in least squares显示文摘 | K Levenberg | 1944 | Quarterly Applied Mathematics1944，，2： | 1 |
| 17 | Endothelial cells derived from human embryonic stem cells显示文摘 | Levenberg S Golub J S Am it M | 2002 | Proc Natl Acad Sci USA2002，99，： | 1 |
| 18 | Endothelial cells derived from human embryonic stem cells显示文摘 | Levenberg S Golub JS Amit M | 2002 | Proc Natl Acad Sci U S A2002，99，7： | 1 |
| 19 | Integrating comprehensive adolescent preventive services into routine medicine care:rationale and approaches显示文摘 | Elster AB Levenberg P | 1997 | Pediatric Clinics of North America1997，44，6： | 1 |
| 20 | A method for the solution of certain problems in least squares 显示文摘 | Levenberg K | 1944 | Quarterly of Applied Mathematics1944，，2： | 1 |
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