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| 1 | 中年成人平均动脉压的体位改变与动脉硬度的关系:Framingham心脏研究显示文摘Torjesen A, Cooper LL, Rong J, Larson MG, Hamburg NM, Levy D, Benjamin EJ, Vasan RS, Mitchell GF. Relations of arterial stiffness with postural change in mean arterial pressure in middle-aged adults:the Framingham heart study. Hyperten- sion,2017,69(4) :685-690.站立位血压稳定调节受损可导致不良结果,包括跌倒、晕厥和定向障碍。平均动脉压(meanarterialpressure,MAP)通常在站立位时增加,然而,站立位MAP增加不足或减少可能导致脑灌注减少。已有研究报道,在动脉硬度增加的老年人中存在体位性低血压,年轻至中年人MAP的体位性改变与动脉硬度的相关性尚未阐明。该研究分析了Framingham心脏研究第3代队列中的受试者3205人(女性1693人,占53%)的直立性血压反应和全面血液动力学数据。 | Torjesen A Cooper LL Rong J Larson MG Hamburg NM Levy D Benjamin EJ Vasan RS Mitchell GF 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，3： | 5 |
| 2 | Cytokines in the BALB/c mouse testis in various conditions显示文摘To investigate whether testosterone, estrogens, vasectomy, experimental cryptorchidism, varicocele or aging would induce changes in the cytokine environment of the mouse testis. Methods: In adult male BALB/c mice,testosterone implants, estradiol benzoate, vasectomy, unilateral cryptorchidism, unilateral varicocele were adminis tered/performed. The mice were followed up for different periods of time and were then sacrificed with testes incised for examination. The control mice received the vehicle or sham-operation. Results: IL-10 was present in Leydig cells of nearly every testis and IL-10 + macrophages in 39% of testes. IL-6 was found in the testes of intact adult mice, mice treated with testosterone for 70 days, cryptorchid testes and sham-operated testes. Conclusion: Results suggest that IL-10 might be involved in the generation of the immunologically privileged microenvironment in the testis. | E.Verjnkorva M.Martikainen P.Pllnen | 2001 | Asian Journal of Andrology2001，3，1： | 4 |
| 3 | CD99and CD 106(VCAM-1)in human testis显示文摘Aim:The expression of the cytokines Il-2,IL-6,IL-10,IFN-γ and TNF-α and the adhesion proteins CD99 and CD106 was studied in the human testis at the protein level.Methods:The expression of the cytokines and the adhesion proteins was assessed using immunohistochemistry and immunoblotting.Results:None of the cytokines studied was present in the human testis,but CD99 and CD106(VCAM-1) strongly were expressed in all the testes investigated.CD99 was present in the interstitial tissue of the human testis as well as in the Sertoli cells.The identity of the CD99+ interstitial cells is unclear.CD106(VCAM-1) was present in Leydig cells as well as the basal parts of the Sertoli cells in the seminiferous tubules.In immunoblotting,CD99 was demonstrated at molecular ratios of 46-57(kD).This is a novel isoform of the molecule.Conclusion:The human testis produces both CD99 and CD106 and as CD106 mediates cell binding to lymphocytes,it is possible that the human Leydig cells adhere to lymphocytes like the rodent Leydig cells. | E. Verjnkorva M. Laato P. Pllnen | 2002 | Asian Journal of Andrology2002，4，4： | 3 |
| 4 | Superior LSPR substrates based on electromagnetic decoupling for on-a-chip high-throughput label-free biosensing显示文摘Localized surface plasmon resonance(LSPR)biosensing based on supported metal nanoparticles offers unparalleled possibilities for high-end miniaturization,multiplexing and high-throughput label-free molecular interaction analysis in real time when integrated within an opto-fluidic environment.However,such LSPR-sensing devices typically contain extremely large regions of dielectric materials that are open to molecular adsorption,which must be carefully blocked to avoid compromising the device readings.To address this issue,we made the support essentially invisible to the LSPR by carefully removing the dielectric material overlapping with the localized plasmonic fields through optimized wet-etching.The resulting LSPR substrate,which consists of gold nanodisks centered on narrow SiO2 pillars,exhibits markedly reduced vulnerability to nonspecific substrate adsorption,thus allowing,in an ideal case,the implementation of thicker and more efficient passivation layers.We demonstrate that this approach is effective and fully compatible with state-of-the-art multiplexed real-time biosensing technology and thus represents the ideal substrate design for high-throughput label-free biosensing systems with minimal sample consumption. | Srdjan S Aćimović Hana Šípová Gustav Emilsson Andreas B Dahlin Tomasz J Antosiewicz Mikael Käll | 2017 | Light(Science & Applications)2017，6，1： | 3 |
| 5 | Efficacy and safety of sitagliptin when added to insulin therapy in patients with type 2 diabetes显示文摘 | T.Vilsb?ll J.Rosenstock H.Yki‐J?rvinen W. T.Cefalu Y.Chen E.Luo B.Musser P. J.Andryuk Y.Ling K. D.Kaufman J. M.Amatruda S. S.Engel L.Katz | 2009 | Diabetes Obesity and Metabolism2009，，2： | 2 |
| 6 | Plasma MMP 9 and MMP-2 following acute myocardial infarction in man: correlation with echocardiographic and neurohumoral parameters of left ventricular dysfunction 显示文摘 | Squire IB Evans J Ng LL | 2004 | J Card Fail2004，10，4： | 1 |
| 7 | Ribavirin plus interferon versus interferon for chronic hepatitis C显示文摘 | Brok J Gruud LL Gruud C | 2010 | Cochrane Database Syst Rev2010，，00： | 1 |
| 8 | Role for gammaaminobutyric acid in selective vulnerability in gerbils显示文摘 | Lust WD Ricci A J | 1989 | Stroke1989，20，： | 1 |
| 9 | Systemic lidocaine for neuropathic pain relief显示文摘 | Chen LL | 2000 | Pain2000，87，1： | 1 |
| 10 | Neuroendocrine gastric carcino- ma expressing somatostain: a highly malignant, rare tumor 显示文摘 | Waisberg J de Matos LL Pezzolo S | 2006 | World J Gastroentero12006，12，24： | 1 |
| 11 | Phase I and phar-macologic study of OSI -774, an epidermal growth factor receptor tyrosine kinase inibitor, in patients with advanced solid malignancies显示文摘 | Hidalgo M Siu LL Nemunaitis J | 2001 | J Clin Oncol2001，19，： | 1 |
| 12 | LCRGI suppresses tumor growth in vivo by liposome-mediated gene transfer 显示文摘 | Ll Y J ZHANG X P CHEN Z C | 2002 | Chin J Cancer Res2002，14，2： | 1 |
| 13 | Cytoskeleton of hippocampal neurons as a target for valproic acid in an experimental model of depression 显示文摘 | Ferrero A J Cereseto M Sifonios LL | 2007 | Prog Neuropsychopharmacol Biol Psychiatry2007，31，7： | 1 |
| 14 | Bacteriostatic action of a no- vel four-component bioactive glass 显示文摘 | Bellantone M Coleman N J Hench LL | 2000 | J Biomed Mater Res2000，51，3： | 1 |
| 15 | Modulation of serum follicle-stimulating hormone bioactivity and isoform distribution by estrogenic steroids in normal women and in gonadal dysgenesis显示文摘 | Padmanabhan V Lang LL Sonstein J | 1988 | J Clin Endocrinol Metab1988，67，： | 1 |
| 16 | Im- munoregulatory molecules during pregnancy and at birth显示文摘 | POWER LL POPPLEWELL E J HOLLOWAY JA | 2002 | J Re- prod Immnnol2002，56，2： | 1 |
| 17 | Plasma N-terminal pro-brain natri- uretic peptide in type 1 diabetic patients with and without diabetic ne- phropathy显示文摘 | Siebenhofer A Ng LL Plank J | 2003 | Diabet Med2003，20，7： | 1 |
| 18 | Long-term follow-up outcomeofpa- tients undergoing radiofrequency ablation founresectablehepatocel- lular carcinoma显示文摘 | Machi J Bueno RS Wong LL | 2012 | World J Surg2012，29，11： | 1 |
| 19 | Methionine metabolismin human pregnancy 显示文摘 | Dasarathy J Gruca LL Bennett C | 2010 | Am J Clin Nutr2010，91，2： | 1 |
| 20 | Continuity of Care in Intensive Care Units: A Cluster-Randomized Trial of Intensivist Staffing 显示文摘 | ll NA Wolf KM Hammersley J | 2011 | Am J Reapir Crit Care Med2011，184，7： | 1 |
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