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| 1 | Drug resistance and new therapies in colorectal cancer显示文摘Colorectal cancer(CRC) is often diagnosed at an advanced stage when tumor cell dissemination has taken place. Chemo-and targeted therapies provide only a limited increase of overall survival for these patients. The major reason for clinical outcome finds its origin in therapy resistance. Escape mechanisms to both chemo-and targeted therapy remain the main culprits. Here, we evaluate major resistant mechanisms and elaborate on potential new therapies. Amongst promising therapies is α-amanitin antibodydrug conjugate targeting hemizygous p53 loss. It becomes clear that a dynamic interaction with the tumor microenvironment exists and that this dictates therapeutic outcome. In addition, CRC displays a limited response to checkpoint inhibitors, as only a minority of patients with microsatellite instable high tumors is susceptible. In this review, we highlight new developments with clinical potentials to augment responses to checkpoint inhibitors. | Kevin Van der Jeught Han-Chen Xu Yu-Jing Li Xiong-Bin Lu Guang Ji | 2018 | World Journal of Gastroenterology2018，24，34： | 21 |
| 2 | A review of soil heavy metal pollution from mines in China: Pollution and health risk assessment显示文摘 | Zhiyuan Li Zongwei Ma Tsering Jan van der Kuijp Zengwei Yuan Lei Huang | 2014 | Science of the Total Environment2014，，： | 7 |
| 3 | Genotype and Planting Density Effects on Rooting Traits and Yield in Cotton (Gossypium hirsutum L,)显示文摘植物的根密度分发是在植物之间的竞争的主要指示物并且从土壤决定资源俘获。这个实验在 Anyang 在 2005 被进行,在黄河区域定位了,河南省省,中国。栽培变种被选择的三朵棉花(Gossypium hirsutum L.) :混合 Bt 栽培变种 CRI46,常规 Bt 栽培变种 CRI44 和 CRI45。六种密度被设计,从象表面区域,直径和长度那样的 1.5 ~ 12.0 个 plants/m2Root 参数被使用 DT 扫描图象分析方法分析。根长度密度(RLD ) ,根一般水准直径和根区域索引(RAI ) ,根表面区域每统一陆地区域,被学习。结果显示出那 RLD, RAI 在遗传型之间不同;更高显著地有的混合 CRI46 (P < 0.05 ) RLD 和 RAI 比常规栽培变种珍视特别在低种的密度下面,混合 CRI46 的不到 3.0 plants/m2The 根区域索引(RAI ) 在 flowering 阶段比 CRI44 和 CRI45 高是 61% 。RLD 和 RAI 也是显著地不同的(P= 0.000 ) 在种密度之间。RAI 的深度分发证明在增加,种密度 RAI 在在 50 厘米下面的土壤层是逐渐地分布式的。混合 CRI46 的 RAI 为所有种的密度,比另外的栽培变种显然高在 flowering 和圆蒴阶段期间。混血儿在阻止根的早熟的老朽的根维护有一个强壮的优点,这被结束。混合 CRI46 的根直径比 6.0 个 plants/m2Good 协会在不同阶段在产量和 RAI 之间被发现的在种低的密度有一条遗传上更高的根直径。种密度的最佳为混血儿为常规栽培变种和约 4.05.0 plants/m2 从 4.50 plants/m2 到 6.75 plants/m2。 | Li-Zhen Zhang Bao-Guo Li Gen-Tu Yan Wopke van der Werf JHJ Spiertz Si-Ping Zhang | 2006 | Journal of Integrative Plant Biology2006，48，11： | 5 |
| 4 | The First Quantitative Slip-Rate Estimated Along the Ashikule Fault at the Western Segment of the Altyn Tagh Fault System显示文摘As one of the longest strike-slip fault in Asia,the Altyn Tagh Fault(ATF)defines the northern boundary of the Tibetan Plateau and plays a significant role inaccommodating the deformation resulting from the IndiaAsia convergence.Slip-rate and seismic behavior of the fault are critical to understand the present-day | PAN Jiawei LI Haibing VAN DER WOERD Jerome SUN Zhiming SI Jialiang PEI Junling WU Fuyao CHEVALIER Marie-Luce | 2015 | Acta Geologica Sinica(English Edition)2015，89，6： | 5 |
| 5 | Antibiotic Treatment Drives the Diversification of the Human Gut Resistome显示文摘Despite the documented antibiotic-induced disruption of the gut microbiota, the impact of antibiotic intake on strain-level dynamics, evolution of resistance genes, and factors influencing resistance dissemination potential remains poorly understood. To address this gap we analyzed public metagenomic datasets from 24 antibiotic treated subjects and controls, combined with an in-depth prospective functional study with two subjects investigating the bacterial community dynamics based on cultivation-dependent and independent methods. We observed that shortterm antibiotic treatment shifted and diversified the resistome composition, increased the average copy number of antibiotic resistance genes, and altered the dominant strain genotypes in an individual-specific manner. More than 30% of the resistance genes underwent strong differentiation at the single nucleotide level during antibiotic treatment. We found that the increased potential for horizontal gene transfer, due to antibiotic administration, was ~3-fold stronger in the differentiated resistance genes than the non-differentiated ones. This study highlights how antibiotic treatment has individualized impacts on the resistome and strain level composition, and drives the adaptive evolution of the gut microbiota. | Jun Li Elizabeth A.Rettedal Eric van der Helm Mostafa Ellabaan Gianni Panagiotou Morten O.A.Sommer | 2019 | Genomics, Proteomics & Bioinformatics2019，17，1： | 4 |
| 6 | Light interception and utilization in relay intercrops of wheat and cotton显示文摘 | L. Zhang W. van der Werf L. Bastiaans S. Zhang B. Li J.H.J. Spiertz | 2008 | Field Crops Research2008，，1： | 4 |
| 7 | Comparative studies on fouling of homogeneous anion exchange membranes by different structured organics in electrodialysis显示文摘Five negatively charged organic compounds with different structures, sodium methane sulfonate(MS), sodium benzene sulfonate(BS), sodium 6-hydroxynaphthalene-2-sulfonate(NSS), sodium dodecyl sulfate(SDS), and sodium dodecyl benzene sulfonate(SDBS), were used to examine the fouling of an anion exchange membrane(AEM) in electrodialysis(ED),to explore the effect of molecular characteristics on the fouling behavior on the AEM and changes in the surface and electrochemical properties of the AEM. Results indicated that the fouling degree of the AEM by the different organics followed the order:SDBS > SDS > NSS > BS > MS. SDBS and SDS formed a dense fouling layer on the surface of the AEM, which was the main factor in the much more severe membrane fouling, and completely restricted the transmembrane ion migration. The other three organics caused fouling of the AEM by adsorption on the surface and/or accumulation in the interlayer of the AEM, and exhibited almost no influence on the transmembrane ion migration. It was also concluded that the organics with benzene rings caused more severe fouling of the AEM due to the stronger affinity interaction and steric effect between the organics and the AEM compared with organics with aliphatic chains. | Zhijuan Zhao Shaoyuan Shi Hongbin Cao Yujiao Li Bart Van der Bruggen | 2019 | Journal of Environmental Sciences2019，31，3： | 4 |
| 8 | Perspectives of CRISPR/Cas-mediated cisengineering in horticulture:unlocking the neglected potential for crop improvement显示文摘Directed breeding of horticultural crops is essential for increasing yield,nutritional content,and consumer-valued characteristics such as shape and color of the produce.However,limited genetic diversity restricts the amount of crop improvement that can be achieved through conventional breeding approaches.Natural genetic changes in cisregulatory regions of genes play important roles in shaping phenotypic diversity by altering their expression.Utilization of CRISPR/Cas editing in crop species can accelerate crop improvement through the introduction of genetic variation in a targeted manner.The advent of CRISPR/Cas-mediated cis-regulatory region engineering(cis-engineering)provides a more refined method for modulating gene expression and creating phenotypic diversity to benefit crop improvement.Here,we focus on the current applications of CRISPR/Cas-mediated cis-engineering in horticultural crops.We describe strategies and limitations for its use in crop improvement,including de novo cis-regulatory element(CRE)discovery,precise genome editing,and transgene-free genome editing.In addition,we discuss the challenges and prospects regarding current technologies and achievements.CRISPR/Cas-mediated cis-engineering is a critical tool for generating horticultural crops that are better able to adapt to climate change and providing food for an increasing world population. | Qiang Li Manoj Sapkota Esther van der Knaap | 2020 | Horticulture Research2020，7，1： | 3 |
| 9 | COMPARING PERFORMANCE OF CROP SPECIES MIXTURES AND PURE STANDS显示文摘Intercropping is the planned cultivation of species mixtures on agricultural land.Intercropping has many attributes that make it attractive for developing a more sustainable agriculture,such as high yield,high resource use efficiency,lower input requirements,natural suppression of pests,pathogens and weeds,and building a soil with more organic carbon and nitrogen.Information is needed which species combinations perform best under different circumstances and which management is suitable to bring out the best from intercropping in a given production situation.The literature is replete with case studies on intercropping from across the globe,but evidence synthesis is needed to make this information accessible.Meta-analysis requires a careful choice of metric that is appropriate for answering the question at hand,and which lends itself for a robust meta-analysis.This paper reviews some metrics that may be used in the quantitative synthesis of literature data on intercropping. | Wopke VAN DER WERF Lizhen ZHANG Chunjie LI Ping CHEN Chen FENG Zhan XU Chaochun ZHANG Chunfeng GU Lammert BASTIAANS David MAKOWSKI TjeerdJan STOMPH | 2021 | Frontiers of Agricultural Science and Engineering2021，8，3： | 2 |
| 10 | Growth, yield and quality of wheat and cotton in relay strip intercropping systems显示文摘 | L. Zhang W. van der Werf S. Zhang B. Li J.H.J. Spiertz | 2007 | Field Crops Research2007，，3： | 2 |
| 11 | Oxidation-induced crack healing in Ti 3 AlC 2 ceramics显示文摘 | G.M. Song Y.T. Pei W.G. Sloof S.B. Li J.Th.M. De Hosson S. van der Zwaag | 2007 | Scripta Materialia2007，，1： | 2 |
| 12 | Computer simulation of W-C-Co-V system diffusion couples显示文摘Diffusion couples,WC/Co-1at.%C,V8C7/Co,and WC/Co-0.3wt.%V8C7 were constructed and annealed at tem-peratures ranging from 1100 to 1300°C. The concentration profile of V and W atoms in these couples were measured by EPMA. Aided by Thermo-calc & DICTRA software package,the concentration profiles of W and V in established diffu-sion couples were calculated by the moving boundary model according to revised dynamic parameters and MOB database,respectively. Then the concentration profile of W in Co binder during sintering WC-Co cemented carbide was simulated by the Cell model. It can provide reference for composition and sintering process design of cemented carbides with high per-formance. Meanwhile,the validity of revised dynamic parameters of the W-C-Co-V system is verified by the comparison of experimental and simulated results. | HE Yanlin LI Lin HUANG Shuigen Jef Vleugels Omer Van der Biest | 2007 | Rare Metals2007，26，5： | 2 |
| 13 | Efficient photon coupling from a diamond nitrogen vacancy center by integration with silica fiber显示文摘A central goal in quantum information science is to efficiently interface photons with single optical modes for quantum networking and distributed quantum computing.Here,we introduce and experimentally demonstrate a compact and efficient method for the low-loss coupling of a solid-state qubit,the nitrogen vacancy(NV)center in diamond,with a single-mode optical fiber.In this approach,single-mode tapered diamond waveguides containing exactly one high quality NV memory are selected and integrated on tapered silica fibers.Numerical optimization of an adiabatic coupler indicates that near-unity-efficiency photon transfer is possible between the two modes.Experimentally,we find an overall collection efficiency between 16%and 37%and estimate a single photon count rate at saturation above 700 kHz.This integrated system enables robust,alignment-free,and efficient interfacing of single-mode optical fibers with single photon emitters and quantum memories in solids. | Rishi N Patel Tim Schröder Noel Wan Luozhou Li Sara L Mouradian Edward H Chen Dirk R Englund | 2016 | Light(Science & Applications)2016，5，1： | 2 |
| 14 | Post-hepatectomy liver regeneration in the context of bile acid homeostasis and the gut-liver signaling axis显示文摘Background:Liver regeneration following partial hepatectomy(PHx)is a complicated process involving multiple organs and several types of signaling networks.The bile acid-activated metabolic pathways occupy an auxiliary yet important chapter in the entire biochemical story.PHx is characterized by rapid but transient bile acid overload in the liver,which constitutes the first wave of proliferative signaling in the remnant hepatocytes.Bile acids trigger hepatocyte proliferation through activation of several nuclear receptors.Following biliary passage into the intestines,enterocytes reabsorb the bile acids,which results in the activation of farnesoid X receptor(FXR),the consequent excretion of fibroblast growth factor(FGF)19/FGF15,and its release into the enterohepatic circulation.FGF19/FGF15 subsequently binds to its cognate receptor,fibroblast growth factor receptor 4(FGFR4)complexed withβ-klotho,on the hepatocyte membrane,which initiates the second wave of proliferative signaling.Because some bile acids are toxic,the remnant hepatocytes must resolve the potentially detrimental state of bile acid excess.Therefore,the hepatocytes orchestrate a bile acid detoxification and elimination response as a protective mechanism in concurrence with the proliferative signaling.The response in part results in the excretion of(biotransformed)bile acids into the canalicular system,causing the bile acids to end up in the intestines.Relevance for patients:Recently,FXR agonists have been shown to promote regeneration via the gut-liver axis.This type of pharmacological intervention may prove beneficial for patients with hepatobiliary tumors undergoing PHx.In light of these developments,the review provides an in-depth account of the pathways that underlie post-PHx liver regeneration in the context of bile acid homeostasis in the liver and the gut-liver signaling axis. | Lianne de Haan Sarah Jvan der Lely Anne-Loes K.Warps Quincy Hofsink Pim B.Olthof Mark J.de Keijzer Daniel A.Lionarons Lionel Mendes-Dias Bote G.Bruinsma Korkut Uygun Hartmut Jaeschke Geoffrey C.Farrell Narci Teoh Rowan Fvan Golen Tiangang Li Michal Heger | 2018 | Journal of Clinical & Translational Research2018，4，1： | 2 |
| 15 | Inverse reliability problem 显示文摘 | DER Kiureghian ZHANG Y LI C C | 1994 | ASCE Journal of Engineering Mechanics1994，120，5： | 1 |
| 16 | Biological performance of uncoated and octacalcium phosphate-coated Ti6Al4V显示文摘 | HABIBOVIC P LI J van der VALK C M | 2005 | Biomaterials2005，26，1： | 1 |
| 17 | Rapid induction of multiple resistance mechanisms in Aspergillus fumigatus during az- ole therapy: a case study and review of the literature显示文摘 | Camps SM van der Linden JW Li Y | 2012 | Antimi- crob Agents Chemother2012，56，1： | 1 |
| 18 | Temporal correlation of blood scattering signals in vivo from radiofrequency intravascular ultrasound 显示文摘 | Li W van der Steen A F W Lancee C T | 1996 | Ultrasound Med Biology1996，22，5： | 1 |
| 19 | Crosslinked collagen/chitosan matrix for artificial livers显示文摘 | X.H. Wang D.P. Li W.J. Wang Q.L. Feng F.Z. Cui Y.X. Xu X.H. Song Mark van der Werf | 2003 | Biomaterials2003，，19： | 1 |
| 20 | Magnetostratigraphicdating of river terraces:Rapid and intermittent incision by theYellow River of the northeast margin of the Tibetan Plateauduring the Quaternary显示文摘 | Li J J Fang X M Van Der Voo R | 1997 | Journal of Geophysical Research1997，105，10： | 1 |
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