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| 1 | Experimental evidence on the immunopathogenesis of primary biliary cirrhosis显示文摘Primary biliary cirrhosis(PBC)is a chronic cholestatic liver disease for which an autoimmune pathogenesis is supported by clinical and experimental data,including the presence of autoantibodies and autoreactive T cells.The etiology remains to be determined,yet data suggest that both a susceptible genetic background and unknown environmental factors determine disease onset.Multiple infectious and chemical candidates have been proposed to trigger the disease in a genetically susceptible host,mostly by molecular mimicry.Most recently,several murine models have been reported,including genetically determined models as well as models induced by immunization with xenobiotics and bacteria. | Carlo Selmi Francesca Meda Anaid Kasangian Pietro Invernizzi Zhigang Tian Zhexiong Lian Mauro Podda M Eric Gershwin | 2010 | Cellular & Molecular Immunology2010，7，1： | 14 |
| 2 | Failure of hepatocyte marker-expressing hematopoietic progenitor cells to efficiently convert into hepatocytes in vitro显示文摘 | Lian G Wang C Teng C Zhang C Du L Zhong Q Miao C Ding M Deng H | 2006 | 中国生物学文摘2006，20，5： | 11 |
| 3 | 肝癌乙型肝炎病毒X抗原相关基因的克隆显示文摘目的 观察HepG2细胞因乙型肝炎病毒X抗原 (HBx)转染导致的基因表达差异。 方法①用逆转录病毒感染的方法建立表达乙型肝炎病毒X抗原 (HepG2X)及氯霉素乙酰转移酶 (HepG2Cat)的细胞模型。②用抑制差减杂交的方法做HepG2X和对照细胞 (HepG2Cat)的cDNA文库差示筛选。③用3 2 P随机引物标记法标记探针做NorthernBlot杂交及地高辛缺口翻译标记法做原位分子杂交以筛选基因探针。结果 经cDNA文库差减杂交及抑制性PCR扩增共得到 10个cDNA探针 ,其中 8个被HBx所启动 ,2个因HBx而表达下降。经检测 ,这些基因在HepG2X和对照细胞中的表达均有差异。在被HBx所抑制的 2个差示表达基因中 ,1个与人的蛋白翻译起始因子同源 ,同时发现 ,此基因在正常组织中表达较强 ,而在肿瘤组织中表达被抑制。结论 HBx能够改变宿主细胞的基因表达 。 | 刘杰 LIAN Zhaorui PAN Jinbo Clayton M 胡家露 朱明华 窦科峰 丁杰 吴开春 樊代明 Feitelson M | 2000 | 中华消化杂志2000，20，3： | 7 |
| 4 | 成年大鼠睾丸经EDs处理后再生睾丸间质细胞基因图谱的改变显示文摘成年睾丸间质细胞(ALC)是睾丸中产生雄激素的唯一内分泌细胞,只占有睾丸细胞的1%-5%。大鼠睾丸中的睾丸间质细胞被EDs去除后能够再生。本研究中,我们主要研究了大鼠睾丸经EDS处理后睾丸间质细胞再生及基因的变化图谱。EDS处理后7、21、35、90天后分析血清中睾酮、睾丸基因图谱和一些类固醇生成相关的蛋白变化情况。EDS处理后第7天睾丸中睾酮水平几乎检测不到,然后开始恢复。处理后7天,81个基因下调2倍或者更多,其中48个基因检测不到,包括类固醇合成通路中的蛋白Star、Scarbl、Cypllal、Cypl7al、Hsd3bl、CyplblICyp2al。这些基因在21天开始表达增多,到90天已经完全恢复到正常水平。89个基因上调2倍或者更高,nPkib。这些上调的基因到90天恢复正常;其中Cyp2al直到35天才开始恢复,表明这个基因只在成年睾丸间质细胞中表达,不在前体细胞中表达。qPCR,Westernblot、半定量免疫组织染色检测了随机抽取的基因和蛋白确认其变化情况。 | Yu-Fei Zhang Kai-Ming Yuan Yong Liang Yan-Hui Chu Qing-Quan Lian Yu-Fei Ge Wei Zhen Chantal M Sottas Zhi-Jian Su Ren-Shan Ge | 2015 | Asian Journal of Andrology2015，17，2： | 5 |
| 5 | Ultrafast synthesis and sintering of materials in a single running experiment approach by using electric fields显示文摘Processing of materials in the form of ceramics normally involves several steps including calcination at a relatively low temperature for synthesis of the end-product powder and sintering at a high temperature for densification.The work we have been developing introduces a novel approach enabling synthesis plus sintering of materials in a single running experiment by using electric fields,ending with dense ceramics that display grains noticeably finer than in conventional processing.This new paradigm is fully illustrated with experiments conducted on amorphous CaCu3Ti4O12 precursor powder,shown to experience,on heating,crystallization through intermediate phases,followed by chemical reaction leading to synthesis of the end-product powder,plus densification depending on field adjustment.The processing time and furnace temperature are considerably reduced,demonstrating that enhanced synthesis and sintering rates applied under field input.Similar results found in Bi2/3Cu3Ti4O12are also shown.The different factors that may contribute to this unique scenario,including Joule heating,defect generation,and reduction of free energy for nuclei formation promoted by the applied field,are briefly discussed.Overall,the findings we bring here are exclusive as they show an exploitable way that allows rapid processing of materials with good control over particle and grain coarsening. | Lílian M.JESUS Ronaldo S.SILVA Jean-Claude M’PEKO | 2019 | Journal of Advanced Ceramics2019，8，2： | 2 |
| 6 | Effect of light emitting diodes on morphogenesis and growth of bulblets of Lilium in vitro显示文摘 | Lian M L Piao X C Paek K Y | 2003 | Scientia Horticulturae2003，44，1： | 1 |
| 7 | Estrogen receptor alpha genotype is associated with a reduced prevalence of radiographic hip osteoarthritis in elderly Caucasian women1显示文摘 | LIAN K LUI L ZMUDA J M | 2007 | Osteoarthrtis Cartilage2007，15，8： | 1 |
| 8 | Discrete particle simulation ofagglomerate impact coalescence 显示文摘 | Lian G Thomtont C Adams M J | 1998 | Chemical Engineering Science(S0009-2509)1998，53，19： | 1 |
| 9 | Effects of light emitting diodes on the in vitro induction and growth of bulhlets of Liliurn oriental hybrid Pesaro 显示文摘 | Lian M L Murthy H N Pack K Y | 2002 | Scientia Horticulturae2002，94，3： | 1 |
| 10 | Setup ad- justment of multiple lots using a sequential monte carlo meth- od显示文摘 | LIAN Z COLSIMO B M DEL CASTILLO E | 2006 | Technometries2006，48，3： | 1 |
| 11 | The effect of UV ozone treatment on poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate)显示文摘 | Helander M G Wang Z B Greiner M T Liu Z W Lian K Lu Z H | | 0，，17： | 1 |
| 12 | Appl Surf Sci显示文摘 | Chen X M Li G Y Lian J S | 2008 | 255(5): 23222008，255，5： | 1 |
| 13 | Feasibility,efficacy and safety of tyrosine kinase inhibitor treatment in hemodialyzed patients with renal cell cancer: 10 years of experience显示文摘 | CZARNECKA AM KAWECK1 M LIAN F | 2015 | Future Oncol2015，11，16： | 1 |
| 14 | Biofuels and implications for agricultural water use:blue impacts of green energy显示文摘 | Giordano M Lian Y | 2008 | Water Policy2008，10，1： | 1 |
| 15 | 显示文摘 | Fan X M Lian J S | 2005 | Applied Surface Science2005，239，： | 1 |
| 16 | A field study of the thermal environment in residential buildings in Harbin显示文摘 | WANG Z J WANG G LIAN L M | 2003 | ASHRAE Transactions2003，109，2： | 1 |
| 17 | Cholinergie agunists inhibit HMGB1 release and improve survival in experimental sepsis 显示文摘 | Wang H Lian H Ochani M | 2004 | Nat Med2004，10，11： | 1 |
| 18 | Overexpressing glutamine synthetase gene modifies nitrogen metabolism and abiotic steress responses in rice 显示文摘 | Cai H G Zhong Y Xiao J H Li X /-I Zhang Q F Lian X M | 2009 | Plant Cell Reports2009，28，3： | 1 |
| 19 | Biochemical and immunologic effects of rituximab in patients with primary bili- ary cirrhosis and an incomplete response to ursodeoxycholic acid显示文摘 | TSUDA M MORITOKI Y LIAN ZX | 2012 | Hepatology2012，55，2： | 1 |
| 20 | High immunogenic enterovirus 71 strain and its production using serum-free microcarrier Vero cell culture显示文摘 | Liu C C Lian W C Butler M | 2007 | Vaccine2007，25，： | 1 |
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