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| 1 | Saccharomyces cerevisiae CNCM I-3856 in irritable bowel syndrome: An individual subject meta-analysis显示文摘AIM To confirm previous conclusions on Saccharomyces cerevisiae(S. cerevisiae) CNCM I-3856 for irritable bowel syndrome(IBS) management.METHODS An individual patient data meta-analysis was performed on two randomized clinical trials studying the effect of S. cerevisiae CNCM I-3856 supplementation on gastrointestinal(GI) symptoms in IBS subjects. A total of 579 IBS subjects were included. Outcomes were the daily Likert scale scores of abdominal pain/discomfort and bloating [area under the curve(AUC) and weekly means], responder status, and bowel movements(stool frequency and consistency). Statistical analyses were conducted in Intent to Treat(ITT) population, IBS-C subjects and IBS-C subjects with an abdominal pain/discomfort score higher than or equal to 2 at baseline('IBS-C ≥ 2 subpopulation').RESULTS S. cerevisiae CNCM I-3856 significantly improved abdominal pain/discomfort and bloating during the second month of supplementation [AUC(W5-W8)]with improvement up to the minimal clinically relevant threshold of 10%: a 12.3% reduction of abdominal pain/discomfort in the ITT population compared to the Placebo group(P = 0.0134) has been observed. In the IBS-C ≥ 2 subpopulation, there were a 13.1% reduction of abdominal pain/discomfort and a 14.9% reduction of bloating compared to the Placebo group(P = 0.0194 and P = 0.0145, respectively). GI symptoms significantly decreased during supplementation but no statistical differences were reported between groups at the end of the supplementation period. Responder status was defined as a subject who experienced a decrease of 1 arbitrary unit(a.u.) or 50% of the abdominal discomfort score from baseline for at least 2 wk out of the last 4 wk of the study. A significant difference between groups was reported in the ITT population, when considering the first definition: subjects in the Active group had 1.510 higher odds to be a responder(reduction of 1 a.u. of abdominal pain/discomfort) compared with subjects in the Placebo group(P = 0.0240). At the end of supplementation period, stool consistency in the Active group of the ITT population was significantly improved and classified as 'normal' compared to Placebo(respectively 3.13 ± 1.197 a.u. vs 2.58 ± 1.020 a.u., P = 0.0003). Similar results were seen in the IBS-C ≥ 2 subpopulation(Active group: 3.14 ± 1.219 a.u. vs Placebo group: 2.59 ± 1.017 a.u., P = 0.0009).CONCLUSION This meta-analysis supports previous data linking S. cerevisiae I-3856 and improvement of GI symptoms, in IBS overall population and in the IBS-C and IBS-C ≥ 2 subpopulations. | Amélie Cayzeele-Decherf Fanny Pélerin Sébastien Leuillet Benoit Douillard Béatrice Housez Murielle Cazaubiel Gunnard K Jacobson Peter Jüsten Pierre Desreumaux | 2017 | World Journal of Gastroenterology2017，23，2： | 2 |
| 2 | Expression of inhibitor-of - apoptosis protein family members in malignant mesothelioma显示文摘 | Kleinberg L Lie A K Florenes V A | 2007 | Human Pathology2007，38，7： | 1 |
| 3 | Human papillomavirus infection as a risk factor for squamous-cell carcinoma of the head and neck显示文摘 | Mork J Lie A K Glattre E | | 0，，15： | 1 |
| 4 | Fine grid tidal modeling of the Yellow and East China Seas显示文摘 | KANG S K LEE S R LIE H J | 1998 | Continental Shelf Research1998，18，： | 1 |
| 5 | Modeling and mesh generation of weld profile in tubular Y-joint 显示文摘 | Lie S T Lee C K Wong S M | 2001 | Journal of Constructional Steel Research Elsevier2001，57，5： | 1 |
| 6 | Sleep disordered breathing and hypertension: does self-reported sleepiness modify the association? 显示文摘 | Kapur K Resnick liE Gotflieb DJ | 2008 | Sleep2008，31，8： | 1 |
| 7 | Quantificatian of PoIyma BK Vimria in hemorrhagic cystitis complieaing bone marrow transplantation显示文摘 | Leun g A Y Suan CK Lie A K | 2001 | Blood2001，98，6： | 1 |
| 8 | Strontium ranelate - induced toxic epidermal necrolysis in a patient with post-menopausal osteoporosis 显示文摘 | Lee H Y Lie D Lira K S | 2009 | Osteoporos Int2009，20，1： | 1 |
| 9 | Transgenic human fetal fibroblasts as feeder layer for human embryonic stem cell lineage selection显示文摘 | Sidhu K S Lie K H Tuch B E | 2006 | Stem Cells Dev2006，15，5： | 1 |
| 10 | Modal analysis of measurements from a large-scale VIV model test of a riser in linearly sheared flow 显示文摘 | Lie H Kaasen K E | 2006 | Journal of Fluids and Structures2006，22，4： | 1 |
| 11 | Adverse effects of delayed treat- ment for perforated peptic ulcer显示文摘 | Svanes C Lie RT Svanes K | 1994 | Ann Surg1994，220，2： | 1 |
| 12 | Modelling and mesh generation of weld profile in tubular Y-joint显示文摘 | Lie S T Lee C K Wong S M | 2001 | Journal of Constructional Steel Research2001，57，5： | 1 |
| 13 | Shared patron显示文摘 | Davis K Jin Lie Neely C | 2012 | Serials Review2012，38，3： | 1 |
| 14 | Fast computation of multiphase flow in porous media by implicit discontinuous Galerkin schemes with optimal ordering of elements显示文摘 | NATVIG J LIE K | 2008 | Journal of Computational Physics2008，227，10： | 1 |
| 15 | Adverse effects of delayed tre-atment rotated pepticulcer显示文摘 | Lie RT Svanes K | 1994 | Ann Sarg1994，220，2： | 1 |
| 16 | Fire resistance of steel columns filled with bar-reinforced concrete显示文摘 | Lie T T Kodur V K R | 1996 | Journal of Structural Engineering1996，122，1： | 1 |
| 17 | Fire resistance of steel columns filled with bar-reinforced concrete 显示文摘 | LIE T T KODUR V K R | 1996 | Journal of Structural En- gineering ASCE1996，122，1： | 1 |
| 18 | Cell-based tissue engineering for the intervertebral disc:in vitro studies of human disc cell gene expression and matrix production within selected cell carriers显示文摘 | Gruber liE Leslie K Ingram J | 2004 | Spine J2004，4，1： | 1 |
| 19 | Fire resistance of circular steel columns filled with fibre-reinforced concrete 显示文摘 | KODUR V K R LIE T T | 1996 | Journal of Structural Engineering ASCE1996，122，7： | 1 |
| 20 | Folic acid supplements and risk of facial clefts :national population based case-control study显示文摘 | Wilcox AJ Lie RT Solvoll K | 2007 | BMJ2007，334，7591： | 1 |
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