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| 1 | Features of extrahepatic metastasis after radiofrequency ablation for hepatocellular carcinoma显示文摘BACKGROUND Extrahepatic metastasis(EHM)of hepatocellular carcinoma(HCC)is associated with poor outcomes.However,the clinical features and risk factors of EHM of HCC after radiofrequency ablation(RFA)remain unclear.AIM To elucidate the characteristics and risk factors of EHM after RFA for HCC.METHODS From January 2008 to December 2017,we retrospectively enrolled 661 patients who underwent RFA as first-line treatment for HCC at 2 tertiary hospitals.The inclusion criteria were age≥18 years,a diagnosis of HCC,and treatment-naivety.Abdominal computed tomography(CT)or magnetic resonance imaging(MRI)and alpha-fetoprotein measurements were routinely performed at 1 mo after RFA and followed-up at intervals of 3-6 mo.Univariate analyses were performed using the chi-squared test or Student’s t-test,and univariate and multivariate analyses were performed via logistic regression,as appropriate.RESULTS EHM was diagnosed in 44 patients(6.7%)during a median follow-up period of 1204 days.The 10-year cumulative rate of HCC recurrence and EHM was 92.7%and 33.7%,respectively.Initial recurrence was most often intrahepatic,and the rate of extrahepatic recurrence at initial recurrence was only 1.2%.The median time to the diagnosis of EHM was 2.68 years,and 68.2%of patients developed EHM within 2 years of the first recurrence,regardless of recurrence-free survival and 75.0%of patients developed EHM within 5 years after first recurrence.EHM was mostly diagnosed via abdominal CT/MRI in 33(75.0%)and 38 of 44 patients(86.4%)with EHM had either positive abdominal CT scan results or serum AFP level elevation.In multivariate analysis,recurrence-free survival<2 years,ablation zone/tumor size<2,and alpha-fetoprotein level>400 IU/mL were associated with a high EHM risk.CONCLUSION EHM occurs following multiple intrahepatic recurrences after RFA and combined contrast-enhanced abdominal CT and serum AFP were useful for surveillance.Patients especially with high-risk factors require close follow-up for EHM. | Jae H Yoon Young J Goo Chae-Jun Lim Sung K Choi Sung B Cho Sang S Shin Chung H Jun | 2020 | World Journal of Gastroenterology2020，26，32： | 3 |
| 2 | A GA paradigm for learning fuzzy rules 显示文摘 | Lim M H Rahardja S Gwee B H | 1996 | Fuzzy Sets and Systems1996，72，2： | 2 |
| 3 | Coordination of differential effects of primary estrogen and catecholestrogen on two distinct targets mediates embryo implantation in the mouse显示文摘 | PARIA B C LIM H WANG X N | 1998 | Endocrinology1998，139，12： | 1 |
| 4 | Transpalatal advancement pharyngoplasty outcomes compared with uvulopalatopharygoplasty显示文摘 | WOODSON B T ROBINSON S LIM H J | 2005 | Otolaryngol Head NeckSurg2005，133，： | 1 |
| 5 | A GA paradigm for learning fuzzy rules显示文摘 | Lim M N Rahardjm S Gwee B H | 1996 | Fuzzy Systems1996，82，2： | 1 |
| 6 | Physical properties of gelidium corneum-gelatin blend films containing grapefruit seed extract or green tea extract and its application in the packaging of pork loins显示文摘 | HONG Y H LIM G O SONG K B | 2009 | Food Science2009，74，1： | 1 |
| 7 | Preparation of Ru thin film layer on Si and TaN/Si as diffusion barrier by plasma enhanced atomic layer deposition 显示文摘 | Choi B H Lim Y H Lee J H0 | 2010 | Microelec- tronie Engineering2010，87，： | 1 |
| 8 | Curcumin down -regulates the muhidrug- resistance mdrl b genc by inhibiting the PI3K/Akt/ NF kappa B pathway显示文摘 | CHOI B H KIM C G LIM Y | 2008 | Cancer Lett2008，259，： | 1 |
| 9 | Prediction of inverse covariance matrix( PICM ) sequences for STAP 显示文摘 | Lim C H Mulgrew B | 2006 | IEEE Signal Process Letters2006，15，4： | 1 |
| 10 | Gene induction by glycyrol to apoptosis through endonuclease G in tumor cells and prediction of oncogene function by microarray analysis显示文摘 | Lee S 0h H M Lim W B | 2008 | Anticancer Drugs2008，19，5： | 1 |
| 11 | Microstructure evolution and hardening behavior of 2024 aluminum alloy processed by severe plastic deformation 显示文摘 | Kang S B Lim C Y Kim H W | 2002 | Materials Science Forum2002，，2： | 1 |
| 12 | Biodegradablepolyester poly as a non-toxic gene carrier 显示文摘 | LIM Y B HANS O KONG H U | 2000 | Pharm Res2000，17，7： | 1 |
| 13 | A continuum model for size-dependent deformation of elastic films of nanoscale thickness显示文摘 | He L H Lim C W Wu B S | 2004 | International Journal of Solids and Structures2004，41，： | 1 |
| 14 | A modified ultrasonic linear motor显示文摘 | Zhai B Lim S P Lee K H | | 0，，03： | 1 |
| 15 | Formulation Method for Solid-to-beam Transition Finite Elements显示文摘 | Lim J K Song T H Seog B H | | 0，，11： | 1 |
| 16 | Sonographic findings of solid and papillary epitheal neoplasm of the pancreas 显示文摘 | Lee D H Yi B H Lim J W | 2001 | J Ultrsound Med2001，20，11： | 1 |
| 17 | Microwave dielectric properties of the (1-x)LaA103-xTiO2 system 显示文摘 | LIM D H KIM B H KIM T G | 1999 | Mater Res Bull1999，34，1011： | 1 |
| 18 | Korean Panic Disorder Severity Scale:construct Validity by Confirmatory factor analysis显示文摘 | Lim Y J Yu B H Kim J H | 2007 | Depression and Anxiety2007，24，： | 1 |
| 19 | Determination of black carbon by chemical oxidation and thermal treatment in recent marine and lake sediments and Cretaceous-Tertiary clays 显示文摘 | Lim B Cachier H | 1996 | Chemical Geology1996，131，1： | 1 |
| 20 | Discogenic lumbar pain: as- sociation with MR imaging and CT discography显示文摘 | Lim C H Jee W H Son B C | 2005 | Eur J Radiol2005，54，3： | 1 |
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