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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Third-generation nephrectomy by natural orifice transluminal endoscopic surgery显示文摘 | Lima E Rolanda C Pego J M Henriques-Coelho T Silva D Osorio L | 2007 | J Urol2007，178，： | 1 |
| 3 | Sponta neous formation of travelling localized structures and their asymptotic behaviours in binary fluid convection 显示文摘 | WATANABE T LIMA M NISHIURA Y | 2012 | Journal of Fluid Mechanics2012，712，： | 1 |
| 4 | Armillaria paulensis : a new South American species 显示文摘 | Lima M L Asai T Capelari M | 2008 | Mycological Research2008，112，： | 1 |
| 5 | Validation of a matrix solid phase dispersion (MSPD) technique for determination of pesticides in lyophilized eggs of the chicken Gallus gallus domesticus显示文摘 | dos Reis Souza M K Moreira C O de Lima T G | 2013 | Microchem J2013，110，： | 1 |
| 6 | Characterization of fly ash from bio and municipal waste显示文摘 | Lima A T Ottosen L M Pedersen A J | 2008 | Biomass & Bioenergy2008，32，3： | 1 |
| 7 | Immobilization of heavy metal ions by broiler litter-derived bioehars in water and soil显示文摘 | Uchimiya M Lima I M Klasson K T | 2010 | Joumal of Agrieultural and Food Chemistry2010，58，9： | 1 |
| 8 | IgG fe receptors provide an alternative infection route for murine gamma-herpesvirus-68显示文摘 | Rosa G T Gillet L Smith C M de Lima B D Stevenson P G | 2007 | PLoS ONE2007，2，： | 1 |
| 9 | Genotype- environment interaction in wood basic density of Eucalyptus clones 显示文摘 | LIMA J T BREESE M C CAHALAN C M | 2000 | Wood Science and Technology2000，34，3： | 1 |
| 10 | Ovarian tissue collection for cryopreservation in pediatric age: laparoscopic technical tips 显示文摘 | Lima M Gargano T Fabbri R | 2014 | J Pediatr Adolesc Gynecol2014，27，2： | 1 |
| 11 | Rice bran stabilization and rice bran oil extraction using ohmic heating显示文摘 | LAKKAKULA N R LIMA M WALKER T | 2004 | Bioresource Technology2004，92，： | 1 |
| 12 | Immobilization of Heavy Metal Ions (Cu Ⅱ, Cd Ⅱ, Ni Ⅱ, and Pb Ⅱ )by Broiler Litter-Derived Biochars in Water and Soil 显示文摘 | Uchimiya M Lima I M Klasson K T | 2010 | Journal of Agricultural and Food Chemistry2010，58，9： | 1 |
| 13 | Influence of aerobic training on cardiovascular and metabolic parameters in ederly hypertensive women 显示文摘 | Braz N F Carneiro M V Oliveira-Ferreira F Arrieiro A N Amorim F T Lima M M | 2012 | Int J Prev Med2012，3，： | 1 |
| 14 | Voltammetric performance and application of a sensor for sodium ions constructed with layered birnessitetype manganese oxide显示文摘 | Martinez M T Lima A S Bocchi N | 2009 | Talanta2009，80，2： | 1 |
| 15 | Liquid - liquid extraction of proteases from fermented broth by PEG/citrate aqueous two-phase system 显示文摘 | Porto T S Silva G M M Porto C S Cavalcanti M T H Neto B B Lima F J L Converti A Porto A L F Pessoa J A | 2008 | Chemical Engineering and Processing2008，47，4： | 1 |
| 16 | Purification, partial characterization, and covalent immobilization?stabilization of an extracellular o-umylase from Aspergillus niveus显示文摘 | Silva T M de Lima Damcsio A R Maller A | 2013 | Folia Microbiologica2013，，3： | 1 |
| 17 | Population structure and reproductive dynamics of Octopus insularis (Cephalopoda: Octopodidae) in a coastal reef environment along northeastern Brazil 显示文摘 | LIMA F D LEITE T S HAIMOVICI M | 2014 | Fisheries Research2014，，152： | 1 |
| 18 | Immobilization of heavy metal ions ( Cu- Ⅱ , Cd- Ⅱ , Ni-Ⅱ , and Pb- Ⅱ ) by broiler litter-derived biochars in water and soil显示文摘 | UCHIMIYA M LIMA I M KLASSON K T | 2010 | Journal of Agricultural and Food Chemistry2010，58，9： | 1 |
| 19 | Character- ization of narrow micropores in almond shell biochars by nitrogen, carbon dioxide, and hydrogen adsorption 显示文摘 | KLASSON K T UCHIMIYA M LIMA I M | 2015 | Industrial Crops and Products2015，67，： | 1 |
| 20 | Pharmacokinetics of once-daily IV busulfan as part of pretransplantation preparative regimens : a comparison with an every 6-hour dosing schefule显示文摘 | MADDEN T DE LIMA M THAPAR N | 2007 | Biol Blood Marrow Transplant2007，13，1： | 1 |
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