|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Vesicular carriers containing phenylethyl resorcinol for topical delivery system; liposomes, transfersomes and invasomes显示文摘Topical administration of phenylethyl resorcinol(PR) has attracted much attention as skin lightening agent with potent anti-tyrosinase activity. Two novel types of elastic carriers were developed to overcome the limitation of PR as topical delivery by increasing the solubility, stability and decreasing skin irritation compared to conventional liposomes. In addition, it also promotes skin penetration of PR to reach deep skin layer at the target site. The lead formulations were obtained from the invasomes containing 1%(w/v) d-limonene mixed with 10%(v/v) absolute ethanol as the skin enhancer, and transfersomes containing 15%(w/w) sodium deoxycholate(SDC) as edge activator. All formulations gave a vesicle size < 500 nm, polydispersity index(PDI) < 0.3, high zeta potential, entrapment efficiency > 50%, and good stability on storage at 30 °C at 75% RH for 4 months. Transfersomes have a lower degree of deformability(6.63%) than invasomes(25.26%). In contrast, the liposomes as rigid vesicles do not show a deformable property. This characteristic affects the skin permeation, and thus, transfersomes with high elastic property provided a significantly higher cumulative amount, steady state flux( J ss) and permeability coefficient( K p) compared to other formulations. However, in vitro PR accumulation in full-thickness newborn pig skin demonstrated that the application of elastic carrier formulations gave significantly higher accumulation than liposomes, and gave anti-tyrosinase activity up to 80%. These results are straightforwardly related to the results of cellular level study. Transfersomes and invasomes showed higher tyrosinase inhibition activity and melanin content reduction when compared to liposomes in B16 melanoma cells. In addition, acute irritation test in rabbits confirmed that these formulations are safe for skin application. Therefore, elastic vesicle carriers have theefficiency to deliver PR into the deep skin in both quantity and effectiveness which are better than conventional liposomes and appropriate for a skin lightening product. | Thanaporn Amnuaikit Tunyaluk Limsuwan Pasarat Khongkow Prapaporna Boonme | 2018 | Asian Journal of Pharmaceutical Sciences2018，13，5： | 5 |
| 2 | 饲料中添加强化爱渔灵对凡纳滨对虾生长、存活及免疫指标以及攻毒实验的影响显示文摘在实验室条件下研究了强化爱渔灵对凡纳滨对虾(Litopenaeus vannamei)生长、存活和免疫反应的影响。生长实验设计了三种颗粒饲料,分别添加不同含量的强化爱渔灵(0%、0.05%和0.1%),每个处理有6个重复,每个重复对应1个鱼缸,其中有25尾虾。生长实验进行60d,期间每天投喂实验饲料4次,日投饵率为3%。实验结果表明,生长实验40d后,0.1%强化爱渔灵组虾体重(16.76±1.33)g,显著高于0.05%强化爱渔灵组(15.84±0.99)g和对照组(15.40±1.19)g的体重(P<0.05)。两个实验组之间成活率(97.18%~97.60%)没有显著差异,但显著高于对照组的成活率(83.20%)(P<0.05)。通过总血细胞计数(THC)、吞噬百分率、酚氧化酶活力以及杀菌活性等评价了各处理组虾的免疫力。结果表明,0.1%添加组的THC值和吞噬百分率以及酚氧化酶活性显著高于0.05%添加组和对照组。0.1%添加组和0.05%添加组杀菌活性的血清稀释度为1:16,而对照组为1:8。生长实验60d后,对各处理组的虾肌肉注射哈维病毒,两个实验组均未发现死亡率,而对照组的死亡率达43.33%。同时,用白斑综合症病毒感染虾,两个强化爱渔灵添加组在感染7d后的死亡率达到100%,而对照组的死亡率在6d内就达到100%。各处理组虾在感染黄头病毒后的死亡率结果与白斑综合征病毒感染实验结果类似。本研究表明,在饲料中添加0.1%强化爱渔灵可显著改善凡纳滨对虾的生长、成活率以及免疫力。 | Chalor Limsuwan Niti Chuchird Watchariya Purivirojkul Phanwalai Jantarapan 谭青松 | 2009 | 饲料工业2009，30，10： | 3 |
| 3 | Aerosolized iloprost for postoperative pulmonary hypertensive crisis in children with congenital heart disease 显示文摘 | Limsuwan A Wanitkul S Khosithset A | 2008 | Int J Cardiol2008，129，3： | 1 |
| 4 | Aerosolized iloprost for postoperative pulmonary hypertensive crisis in children with congenital heart disease 显示文摘 | Limsuwan A Wanitkul S Khosithset A | 2008 | Int J Cardiol2008，129，3： | 1 |
| 5 | Compositional changesof enamel and dentine after Er:YAG iaser irradiation显示文摘 | Choeysuppaket A Pokaipisit A Limsuwan P | 2010 | Adv Ma-ter Res2010，93，1： | 1 |
| 6 | Aerosolized Iloprost for pulmonary vasoreactivity testing in children with long-standing pulmonary hypertension related to congenital heart disease 显示文摘 | LIMSUWAN A KHOSITHSETH A WANICHKUL S | 2009 | Catheter Cardiovasc Interv2009，73，1： | 1 |
| 7 | Rhodomyr- tone: A new candidate as natural antibacterial drug from Rhodomyrtus tomentosa显示文摘 | Limsuwan S Trip EN Kouwen TRHM | 2009 | Phytomedicine2009，16，67： | 1 |
| 8 | Preparation and application of high near - infrared re- flective green pigment for ceramic tile roofs 显示文摘 | THONGKANLUANG T LIMSUWAN P RAKKWAMSUK P | 2011 | Interna- tional Journal of Applied Ceramie Technology2011，8，6： | 1 |
| 9 | Inhibitory effects of active compounds frompunica granatumpericarp on verocytotoxin by enetrohaemorrhagic escherichia coli O157:H7显示文摘 | VORAVUTHIKUNCHAI S P SRIRIRAK T LIMSUWAN S | 2005 | J Health Sci2005，51，5： | 1 |
| 10 | Temperature effects on freshwater snail shells: Pomacea canaliculata Lamarck as investigated by XRD, EDX, SEM and FTIR teehniques显示文摘 | Udomkan N Limsuwan P | 2008 | Materials Science and Engineering C2008，28，： | 1 |
| 11 | Inhibition of K^+ channel activity in human pulmonary, artery smooth muscle cells by serum from patients with pulmonary hypertension secondary to congenital heart disease 显示文摘 | LIMSUWAN A PLATOSHYN O YU Y | 2001 | Pediatr Res2001，50，1： | 1 |
| 12 | Intestinal synthesis and di- etary nonessentiality of vitamin B12 for tilapia nilotica 显示文摘 | LOVELL R T LIMSUWAN T | 1982 | Transactions of the American Fisheries Society1982，111，4： | 1 |
| 13 | Properties and photocatalysis of nanostructured titania prepared by sol-gel method for solar hydrogen production显示文摘 | Undom Tipparach Pichet Limsuwan | 2010 | Adv Mater2010，9394，4： | 1 |
| 14 | Aerosolized ilo- prost for pulmonary vasoreactivity testing in children with long-stand- ing pulmonary hypertension related to congenital heart disease 显示文摘 | Limsuwan A Khosithseth A Wanichkul S | 2009 | Catheter Cardiovasc Interv2009，73，1： | 1 |
| 15 | Rhodomyrtone: a new candidate as natural antibacterial drug from Rhodomyrtus tomentosa 显示文摘 | Limsuwan S Trip E N Kouwen T R | 2009 | Phytomedicine2009，16，67： | 1 |
| 16 | Aerosolized iloprost for pul- monary vasoreactivity testing in children with long-standing pulmonary hyperten- sion related to congenital heart disease显示文摘 | Limsuwan A Khosithseth A Wanichkul S | 2009 | Catheter Cardiovasc Interv2009，73，： | 1 |
| 17 | Intestinal synthesis and absorption of vitamin B12 in channel catfish显示文摘 | Limsuwan T Lovell R T | 1981 | The Joumal of nutrition1981，111，12： | 1 |
| 18 | Growth of silver nanoparticles by DC magnetron sputtering显示文摘 | ASANITHI P CHAIYAKUN S LIMSUWAN P | 2012 | Journal of Nanomaterials2012，2012，8： | 1 |
| 19 | Idiopathic muscle necrosis in the freshwater prawn , Macrobrachium rosenbergii, cultured in Thailand显示文摘 | NASH G CHINABUT S LIMSUWAN C | 1987 | Journal of Fish Diseases1987，10，2： | 1 |
| 20 | Penetration studies of prop-oxur and phoxim from eggshell into whole egg after experimental exposureand application in henhouses显示文摘 | LIMSUWAN S TANSAKUL N NAU H | 2007 | J Agric Food Chem2007，55，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员