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| 1 | Albuminuria as a marker of arterial stiffness in chronic kidney disease patients显示文摘AIM:To access the association between albuminuria levels and arterial stiffness in non-diabetic patients with hypertension and chronic kidney disease(CKD) stages 1-2,treated with renin angiotensin blockade agents plus other hypertensive drugs when needed.METHODS:One hundred fifteen patients [median age 52 years(68% males)] were consequently enrolled in the study.For each patient,we recorded gender,age,body mass index(BMI),peripheral systolic blood pressure(p SBP),peripheral diastolic blood pressure,peripheral pulse pressure,central systolic blood pressure(c SBP),central diastolic blood pressure(c DBP),central pulse pressure(c PP),hematocrit,hemoglobin,hs CRP,total cholesterol triglycerides,high-density lipoprotein-C,low-density lipoprotein-C,calcium,phosphorus,parathormone,and albumin,as well as 24 h urine albumin excretion.According to 24-h urine albumin collection,patients were then classified as those with moderately increased albuminuria(formerly called macroalbuminuria)(≤ 300 mg/d) and those with severely increased albuminuria(formerly called macroaluminuria(> 300 mg/d).We considered aortic stiffness(AS) indices [carotid femoral pulse wave velocity(PWVc-f) and augmentation index(AIx)] as primary outcomes ofthe study.We explored potential correlations between severely increased albuminuria and AS indices using a multiple linear regression model.RESULTS:Fifty-eight patients were included in the moderately increased albuminuria group and 57 in the severely increased albuminuria.Blood pressure measurements of the study population were 138 ± 14/82 ± 1.3 mm Hg(systolic/diastolic).There were no significant differences in age,sex,and BP measurements between the two groups.Patients with severely increased albuminuria had higher PWV and AIx than patients with moderately increased albuminuria(P < 0.02,P < 0.004,respectively).In addition these patients exhibited higher BMI(P < 0.03),hs CRP(P < 0.001),and fibrinogen levels(P < 0.02) compared to patients with moderately increased albuminuria.In multivariate linear regression analysis,severely increased albuminuria(β = 1.038,P < 0.010) p SBP(β = 0.028,P < 0.034) and Ht(β = 0.171,P = 0.001) remained independent determinants of the increased PWVc-f.Similarly,severely increased albuminuria(β = 4.385,P < 0.012),c SBP(β = 0.242,P < 0.001),c PP(β = 0.147,P < 0.01) and Ht levels(β = 0.591,P < 0.013) remained independent determinants of increased AIx.CONCLUSION:These findings demonstrate an independent association between AS indices and severely increased albuminuria in non-diabetic,hypertensive patients with CKD stages 1-2 treated with renin angiotensin aldosterone system blockers. | Rigas G Kalaitzidis Despina P Karasavvidou Athina Tatsioni Kosmas Pappas Giorgos Katatsis Angelos Liontos Moses S Elisaf | 2015 | World Journal of Nephrology2015，4，3： | 5 |
| 2 | Attainment of multifactorial treatment targets among the elderly in a lipid clinic显示文摘ObjectiveTo 检验目标成就类脂化合物阴沉, antihypertensive 和 antidiabetic 治疗在在在 Greece.MethodsThis 的一所大学医院的一个专家背景老是包括连续题目 ≥ 的回顾的研究;65 岁(n = 465 ) 与后续 ≥3 年。低密度的脂蛋白胆固醇( LDL-C ),血压( BP )和 glycated 血红素( HbA1c )目标成就根据心病学/欧洲人动脉粥样硬化社会( ESC/EAS )的欧洲社会被记录,为糖尿病( EASD ) guidelines.ResultsThe LDL-C 目标的学习的高血压( ESH ) /ESC 和欧洲协会的欧洲社会被27%很高、高、中等的风险病人,48%和62%分别地达到。更高完成的那些收到的 statin + ezetimibe 与那些收到的 statin monotherapy 相比 LDL-C 目标成就评价(48% 对 33% , P <0.05 ) 。糖尿病的题目, 71% 有 BP <140/85 mmHg,当没有糖尿病, 78% 那些有 BP < 时;140/90 mmHg。非糖尿病的个人(86%) 的一个更高的比例有 BP <150/90 mmHg。另外,有糖尿病的那些的一个更高的比例有 HbA1c <8% 而非 <7%(88% 和 47% ,分别地) 。笔记,从三个非糖尿病的个人的几乎一个和从十个糖尿病的个人的一个在一所大学医院,在非最优的 LDL-C 的老遗体的一个高比例, BP 和 HbA1c 层次的一个专家背景完成了所有三治疗 targets.ConclusionsEven。药联合的使用能改进 multifactorial 治疗目标成就,当不太严格的目标能更容易在这张人口被完成时。 | Fotios Barkas Evangelos Liberopoulos Eleftherios Klouras Angelos Liontos Moses Elisaf | 2015 | Journal of Geriatric Cardiology2015，12，3： | 5 |
| 3 | Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer显示文摘 | Velimezi G Liontos M Vougas K | 2013 | Nat Cell Biol2013，15，8： | 1 |
| 4 | Mutant p53 enhances nuclear factor kappaB activation by tumor necrosis factor alpha in cancer ceils 显示文摘 | Weisz L Damalas A Liontos M | 2007 | Cancer Res2007，67，6： | 1 |
| 5 | Transformational Leadership显示文摘 | Lynn Balster Liontos | 1992 | ERIC Digest1992，，： | 1 |
| 6 | Increased expres- sion of bFGF is associated with carotid atherosclerotic plaques instability engaging the NF-kappaB pathway 显示文摘 | Sigala F Savvari P Liontos M et ai | 2010 | J Cell Mol Med2010，14，9： | 1 |
| 7 | SRC - induced disas- sembly of adherens junctions requires localized phosphorylation and degradation of the rac activator tiaml 显示文摘 | Woodcock SA Rooney C Liontos M | 2009 | Mol Cell2009，33，5： | 1 |
| 8 | Factors contribu- ting to inappropriate ordering of tests in an academic medical department and the effect of an educational feedback strategy 显示文摘 | Miyakis S Karamanof G Liontos M | 2006 | Postgrad Med J2006，82，974： | 1 |
| 9 | Angiogenesis-related pathways in the pathogenesis of ovarian cancer 显示文摘 | Gavalas NG Liontos M Trachana SP | 2013 | Int J Mol Sci2013，14，8： | 1 |
| 10 | Oncogene-induced senescence is part of the tumorigenes is barrier imposed by DNA damage checkpoints显示文摘 | Bartkova J Rezaei N Liontos M | 2006 | Nature2006，444，7119： | 1 |
| 11 | Oncogene - induced senescence is part eft the tumorigenesis barrier imposed by DNA damage checkpoints 显示文摘 | Bartkova J Rezaei N Liontos M | 2006 | Nature2006，444，7119： | 1 |
| 12 | Increased expres- sion of bFGF is associated with carotid atherosclerotic plaques instability engaging the NF-kappa B pathway显示文摘 | Sigala F Savvari P Liontos M | 2010 | J Cell Mol Med2010，14，9： | 1 |
| 13 | Oneogeneinduced senescence is part of thetumorigenesis barrier im posed by DNA damage checkpoints 显示文摘 | BARTKOVA J REZAEI N LIONTOS M | 2006 | Nature2006，444，30： | 1 |
| 14 | Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints显示文摘 | Bartkova J Rezaei N Liontos M | 2006 | Nature2006，444，7119： | 1 |
| 15 | Increased expression of bFGF is associated with carotid atherosclerotic plaques in stability engaging the NF-kappaB pathway 显示文摘 | Sigala F Savvari P Liontos M | 2010 | J Cell Molecul Med2010，14，9： | 1 |
| 16 | Increased expression of bFGF isassociated with carotid atherosclerotic plaques instability engaging theNF-kappaB pathway显示文摘 | Sigala F Savvari P Liontos M | 2010 | J Cell Mol Med2010，14，9： | 1 |
| 17 | Increased expression ofbFGF is associated with carotid atherosclerotic plaques instabilityengaging the NF kappa B pathway显示文摘 | Sigala FV Savvari P Liontos M | 2010 | J Cell Mol Med2010，14，9： | 1 |
| 18 | Mutant p53 enhancesnuclear factor kappaB activation by tumor necrosis factor alpha inCancer cells显示文摘 | Weisz L Damalas A Liontos M | 2007 | Cancer Res2007，67，6： | 1 |
| 19 | Increased expression of bFGF is associated with carotid atherosclerotic plaques instability engaging the NF-kappaB pathway显示文摘 | Sigala F Savvari P Liontos M | 2010 | J Cell Mol Med2010，14，9： | 1 |
| 20 | Oncogene - induced se- nescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints 显示文摘 | Bartkova J Rezaei N Liontos M | 2006 | Nature2006，444，7119： | 1 |
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