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| 1 | Colonoscopy surveillance for high risk polyps does not always prevent colorectal cancer显示文摘AIM To determine the frequency and risk factors for colorectal cancer(CRC) development among individuals with resected advanced adenoma(AA)/traditional serrated adenoma(TSA)/advanced sessile serrated adenoma(ASSA). METHODS Data was collected from medical records of 14663 subjects found to have AA, TSA, or ASSA at screening or surveillance colonoscopy. Patients with inflammatory bowel disease or known genetic predisposition for CRC were excluded from the study. Factors associated with CRC developing after endoscopic management of high risk polyps were calculated in 4610 such patients who had at least one surveillance colonoscopy within 10 years following the original polypectomy of the incident advanced polyp. RESULTS84/4610(1.8%) patients developed CRC at the polypectomy site within a median of 4.2 years(mean 4.89 years), and 1.2%(54/4610) developed CRC in a region distinct from the AA/TSA/ASSA resection site within a median of 5.1 years(mean 6.67 years). Approximately, 30%(25/84) of patients who developed CRC at the AA/TSA/ASSA site and 27.8%(15/54) of patients who developed CRC at another site had colonoscopy at recommended surveillance intervals. Increasing age; polyp size; male sex; right-sided location; high degree of dysplasia; higher number of polyps resected; and piecemeal removal were associated with an increased risk for CRC developmentat the same site as the index polyp. Increasing age; right-sided location; higher number of polyps resected and sessile endoscopic appearance of the index AA/TSA/ASSA were significantly associated with an increased risk for CRC development at a different site. CONCLUSION Recognition that CRC may develop following AA/TSA/ASSA removal is one step toward improving our practice efficiency and preventing a portion of CRC related morbidity and mortality. | Mohamad A Mouchli Lidia Ouk Marianne R Scheitel Alisha P Chaudhry Donna Felmlee-Devine Diane E Grill Shahrooz Rashtak Panwen Wang Junwen Wang Rajeev Chaudhry Thomas C Smyrk Ann L Oberg Brooke R Druliner Lisa A Boardman | 2018 | World Journal of Gastroenterology2018，24，8： | 5 |
| 2 | Differential expression of components of the cardiomyocyte adrenomedullin/intermedin receptor system following blood pressure red-uction in Nodeificient hypertension显示文摘 | Abdelrahman A M David B Lisa R S | 2005 | JPET Fast Forward2005，12，3： | 1 |
| 3 | Inheritance of Cold Hardiness and Dehydrin Genes in Diploid Mapping Populations of Blueberry显示文摘 | GaneshRP Lisa J R Rajeev A | 2004 | Journal of Crop Improvement2004，10，12： | 1 |
| 4 | Solving Inductive Reasoning Problems in Mathematics: Not-so-Trivial Pursuit 显示文摘 | Lisa A Haverty Kenneth R Koedinger David Klahr | 2000 | Cognitive Science2000，，24： | 1 |
| 5 | 9-Tetrahydrocannabinol suppresses vomiting behavior and Fos expression in both acute and delayed phases of cisplatin-incluced emesis in the least shrew 显示文摘 | Andrew P R Lisa G Nissar A D | 2009 | Behavioural Brain Research2009，196，： | 1 |
| 6 | Severe recurrent ureteral stricture: the combined use of an anterograde and retrograde approach in the prone split-leg position without X-rays显示文摘 | Cossu F M De Lisa A | 1997 | Eur Urol1997，31，2： | 1 |
| 7 | A two-phase study evaluating the relationship between Thimerosal-containing vaccine administration and the risk for an autism spectrum disorder diagnosis in the United States显示文摘Background:Autism spectrum disorder(ASD)is defined by standardized criteria of qualitative impairments in social interaction,qualitative impairments in communication,and restricted and stereotyped patterns of behavior,interests,and activities.A significant number of children diagnosed with ASD suffer a loss of previously-acquired skills,which is suggestive of neurodegeneration or a type of progressive encephalopathy with an etiological pathogenic basis occurring after birth.To date,the etiology of ASD remains under debate,however,many studies suggest toxicity,especially from mercury(Hg),in individuals diagnosed with an ASD.The present study evaluated concerns about the toxic effects of organic-Hg exposure from Thimerosal(49.55%Hg by weight)in childhood vaccines by conducting a two-phased(hypothesis generating/hypothesis testing)study with documented exposure to varying levels of Thimerosal from vaccinations.Methods:A hypothesis generating cohort study was undertaken to evaluate the relationship between exposure to organic-Hg from a Thimerosal-containing Diphtheria-Tetanus-acellular-Pertussis(DTaP)vaccine in comparison to a Thimerosal-free DTaP vaccine administered,from 1998 through 2000,for the risk of ASD as reported in the Vaccine Adverse Event Reporting System(VAERS)database(phase I).A hypothesis testing case–control study was undertaken to evaluate the relationship between organic-Hg exposure from Thimerosal-containing hepatitis B vaccines administered at specific intervals in the first six months of life among cases diagnosed with an ASD and controls born between 1991 through 1999 in the Vaccine Safety Datalink(VSD)database(phase II).Results:In phase I,it was observed that there was a significantly increased risk ratio for the incidence of ASD reported following the Thimerosal-containing DTaP vaccine in comparison to the Thimerosal-free DTaP vaccine.In phase II,it was observed that cases diagnosed with an ASD were significantly more likely than controls to receive increased organic-Hg from Thimerosal-containing hepatitis B vaccine administered within the first,second,and sixth month of life.Conclusions:Routine childhood vaccination is an important public health tool to reduce the morbidity and mortality associated with infectious diseases,but the present study provides new epidemiological evidence supporting an association between increasing organic-Hg exposure from Thimerosal-containing childhood vaccines and the subsequent risk of an ASD diagnosis. | David A Geier Brian S Hooker Janet K Kern Paul G King Lisa K Sykes Mark R Geier | 2013 | Translational Neurodegeneration2013，2，1： | 1 |
| 8 | Cardiac UCP2 expression and myocardial oxidative metabolism during acute septic shock in the rat显示文摘 | Michael J Jeffrey A Lisa R | 2003 | Shock2003，19，6： | 1 |
| 9 | Regulation of the synthesis and activity of ammonia monooxygenase in nigrosomonas europaea by altering pH to affect NH3 acailability显示文摘 | Lisa Y S Daniel J A Michael R H | 1997 | Applied and Environmental Microbiology1997，63，11： | 1 |
| 10 | Temporal lobe deficits murderers 显示文摘 | Lisa M Gatzke--Kopp M A Adrian R | 2001 | Neuropsychiatry Clin Neurosci2001，13，： | 1 |
| 11 | Catalytic Pyrolysis of Pine Over HZSM-5 with Different Binders 显示文摘 | lisa K French R J Orton K A | 2016 | Topics inCatalysis2016，59，： | 1 |
| 12 | Monitoring organichlorines with semi-permeable membrane devices (SPMDs) and mussels (Mytilus edulis) in Corio Bay,Victoria,Australia显示文摘 | HARRY F P BRUCE J R LISA A J | 1995 | Marine Pollution Bulletin1995，30，8： | 1 |
| 13 | Cardiac UCP2 expression and myocardial oxidative metabolism during acute septic shock in the rat显示文摘 | Michael J Jeffrey A Lisa R | | 0，，06： | 1 |
| 14 | Heparin stimulates production of bFGF and TGF-beta 1 by human normal, keloid, and fetal dermal fibroblasts显示文摘 | Lisa A Carroll R James K | 2003 | Med Sci Monit2003，9，3： | 1 |
| 15 | Meta -Analysis: Surgical Treatment of Obesity 显示文摘 | Melinda A Maggard Lisa R | 2005 | Ann Intern Med2005，142，： | 1 |
| 16 | Greenhouse gas emissions from heavy-duty vehicles显示文摘 | Lisa A G Greg R Deborah R | 2008 | Atmospheric Environment2008，42，19： | 1 |
| 17 | Performance optimization using template mapping for datapath intensive high-level synthesis显示文摘 | Miguel R Corazao Marwan A Khalaf Lisa MGuerra | 1996 | IEEE Transactions on Computer-Aided Design of Intergrated Circuits and Systems1996，15，8： | 1 |
| 18 | Quantitative falls risk estimation through multi-sensor assessment of standing balance显示文摘 | Barry R Greene Denise McGrath Lorcan Walsh Emer P Doheny David McKeown Chiara Garattini Clodagh Cunningham Lisa Crosby Brian Caulfield Rose A Kenny | 2012 | Physiological Measurement2012，，12： | 1 |
| 19 | Flight con- nections and their impacts on delay propagation显示文摘 | PAUL T R LISA A S LEONARD A W | 2003 | Digital Avionics Systems Conference2003，5，1： | 1 |
| 20 | Syntheses and stnactures of anomeric quaternary ammonium β-ghwo- sides and comments on the anomeric C--N bond lengths显示文摘 | Lisa Iddon Ryan A Bragg John R Hm'ding | 2009 | Tetrahedron2009，65，32： | 1 |
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