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| 1 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 2 | Critical review of health effects of soyabean phyto-oestrogens in post-menopausal women显示文摘 | Cassidy A Albertazzi P Lise Nielsen I | 2006 | Proc Nutr Soc2006，65，1： | 1 |
| 3 | Renoprotective effects of angiotensin Ⅱ receptor blockade in type Ⅰ diabetic patients with diabetic nephropathy显示文摘 | Steen A Lise T Peter R | 2000 | Kidney Int2000，57，： | 1 |
| 4 | Individual serum lev- els of anti-mtillerian hormone in healthy girls persist through childhood and adolescence:A longitudinal cohort study显示文摘 | Hagen CP Lise A Kaspar S | 2012 | Human Reproduction2012，27，3： | 1 |
| 5 | Low level of p27kip1 protein expression in gastric adenocarcinoma is associated with disease progression and poor ont-come显示文摘 | Nitti D Belluco C Mammano E Marchet A Ambrosi A Mencarelle R Segato P Lise M | 2002 | J Surg Oncol2002，81，： | 1 |
| 6 | Renoprotective effects of angiotensin Ⅱ receptor blockade in type Ⅰ diabetic patients with diabetic nephropathy显示文摘 | Steen A Lise T Peter R | 2000 | Kidney Int2000，57，： | 1 |
| 7 | The neuroligin and neurexin families: from structure to function at the synapse显示文摘 | Lise MF El Husseini A | 2006 | Cellular and Molecular Life Sciences2006，63，： | 1 |
| 8 | Emission of PAH and mutagenic activity from furnaces fueled with cereal streal of wood chips显示文摘 | Preben A N Lise J | 1991 | Chemosphere1991，23，6： | 1 |
| 9 | Low iron stores are related to higher blood concentrations of manganese, cobalt and cadmium in non - smoking, Norwegian women in the HUNT 2 study 显示文摘 | Margrete M H Lise B A Berit B I | 2010 | Environl Res2010，110，5： | 1 |
| 10 | Stimulation of protein synthesis and expansion of pig blastocysts by insulin in vitro显示文摘 | LEWIS A M KAYE P L LISING R | 1992 | Reprod Fertil Dev1992，4，1： | 1 |
| 11 | Negative affect, risk perception,and adolescent risk behavior显示文摘 | Laura A Curry Lise M Youngblade | 2006 | Journal of Applied Developmental Psychology2006，27，： | 1 |
| 12 | Bromohydration and bromination of the pendant vinylbenzene groups of commercial poly ( divinylbenzene-co-ethylvinylbenzene) resins with subsequent modifications of the (1,2-dibromoethyl) benzene groups: thiol-containing styrenic resins 显示文摘 | Lise Hubbard K Finch James A Darling Graham D | 1999 | Reactive & Functional Polymers1999，39，： | 1 |
| 13 | Longterm effects of poly-acrylam hydrogel on human breast tissue显示文摘 | Lise HC Vibeke BB Annet A | 2003 | Plast Reconst Surg2003，111，6： | 1 |
| 14 | Ureteroduodenalfistula显示文摘 | INFANTINO A DODI G LISE M | 1987 | Br J Surg1987，74，： | 1 |
| 15 | Critical review of health effects of soyabean phyto-oestrogens in post-menopausal women 显示文摘 | Cassidy A Albertazzi P Lise NI | 2006 | Proc Nutr Soc2006，65，： | 1 |
| 16 | Critical review of health effects of soyabean phyto-oestrogens in post-menopausal women显示文摘 | Cassidy A Albertazzi P Lise Nielsen I | 2006 | Proc Nutr Soc2006，65，1： | 1 |
| 17 | Critical review of health effects of soyabean phyto-oestrogens in postmenopausal women显示文摘 | Cassidy A Albertazzi P Lise Nielsen I | 2006 | Proc Nutr Soc2006，65，1： | 1 |
| 18 | The Alstrue homogenization model for industrial aluminum alloys显示文摘 | Lise Dons A | 2001 | Journal of Light Metals2001，1，2： | 1 |
| 19 | Exuda rive epidermitis in pigs caused by toxigenic Staphylococcus chromogenes显示文摘 | Lars O A Peter Ahrens Lise Daugaard | 2005 | Vet Microhiol2005，105，： | 1 |
| 20 | Impact of metformin versus repaglinide on non-glycaemic cardiovascular risk markers related to inflammation and endothelial dysfunction in non-obese patients with type 2 diabetes 显示文摘 | Soren S Lund Lise Tarnow Coen D A Stehouwer | 2008 | European Journal of Endocrinology2008，158，： | 1 |
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