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| 1 | Numerical Simulation of Thermal Stress of Shaped Casting Based on Rheological Model显示文摘In order to study the thermal stresses at the mushy zone, a three dimensional rheological model [H]-[H|N]-[N|S]including elastic, visco-elastic and visco-plastic elements was established, its al gorithm and codes for finite element method were also developed. A FDM/FEM integrated analysis system of thermal stresses was built based on the integration of this procedure with thermal analysis by finite difference method. A steel sample casting with a hot spot was simu lated in order to validate this system, and the calculated and experimental results were in good | Kang, JW Liu, BC Xiong, SM | 1999 | Journal of Materials Science & Technology1999，15，3： | 6 |
| 2 | 癫痫为首发症状的儿童甲状旁腺功能减退无需抗癫痫药物治疗显示文摘背景癫痫临床表现具有多样化,从不受控制的抽搐运动(强直-阵挛性发作)到瞬间失去知觉(失神发作)。大脑电脉冲传播到大脑相邻区域并产生不受控制的电活动风暴。癫痫发病机制可分为六类:代谢、结构、遗传、免疫、炎症、特发性。甲状旁腺功能减退是一种由于甲状旁腺激素(Parathyroid hormone,PTH)缺失或任何激素功能抵抗导致的内分泌疾病,表现主要包括低钙血症,高磷血症和异常PTH水平。 | 邹丽萍 Liu MJ Li JW Shi XY | 2017 | 癫痫杂志2017，3，2： | 5 |
| 3 | 异硫氰酸苯己酯调控肝癌细胞株SMMC-7721组蛋白乙酰化及诱导细胞凋亡显示文摘目的 研究异硫氰酸苯己酯(PHI)对肝癌SMMC-7721细胞组蛋白乙酰化调控及凋亡的影响.方法 采用台盼蓝拒染直接计数法观察PHI对SMMC-7721细胞增殖的影响,采用原位末端标记(TUNEL)法检测PHI对SMMC-7721细胞凋亡的影响,采用Western blot法检测PHI对SMMC-7721细胞组蛋白乙酰化及凋亡相关蛋白表达的影响.结果 PHI可抑制SMMC-7721细胞的增殖,与0 μmol/L作用组比较,5、10、20、40和80 μmol/L的PHI对SMMC-7721细胞均有不同程度的增殖抑制作用.PHI可诱导SMMC-7721细胞产生凋亡,PHI作用于SMMC-7721细胞7 h后,10、20和40 μmol/LPHI组的细胞凋亡率分别为6.9%±2.4%、17.5%±4.2%和54.5%±5.4%,明显高于0 μmol/L PHI组(4.5%±2.3%,P<0.05).PHI作用于SMMC-7721细胞3 h时,与0 μmol/L PHI组比较,10、20和40 μmol/L PHI组中Bcl-2、Procaspse-9和Procaspse-3的表达下降,caspase-9和caspase-3的表达上升,而Procaspase-8的表达未见明显变化;作用7 h时,这种变化趋势更加明显.PHI作用于SMMC-7721细胞3 h时,与0 μmol/L PHI组比较,10、20和40 μmol/L PHI组中组蛋白H3的乙酰化分别增加了1.87倍、2.43倍和3.67倍,组蛋白H4的乙酰化分别增加了1.29倍、1.45倍和2.25倍;作用7 h时,这种变化趋势更加明显.结论 PHI是一种组蛋白去乙酰化酶抑制剂,可调控组蛋白的乙酰化水平,影响其表观遗传学,并通过线粒体凋亡途径诱导细胞凋亡. | 赖亚栋 马旭东 黄轶群 许向农 王小众 Dicky JW Chiao Delong liu | 2010 | 中华肿瘤杂志2010，32，11： | 2 |
| 4 | Dissection of key events in tubular epithelial to myofibroblast transition and its implications in kenal interstitial fibrosis 显示文摘 | Yang JW Liu YH | 2001 | Am J Pathol2001，159，4： | 1 |
| 5 | Effect of ONO-1078, a leukotriene anagonist, on capsaicin and substance P-induced bronchoconstriction and airway microvascular leakage in guinea pigs显示文摘 | Wei EQ Liu JW Zhang LF | 1996 | Acta Pharmacol Sin1996，17，3： | 1 |
| 6 | Scheduling algorithms for multiprogramming in a hard-real-time environment显示文摘 | Liu CL Layland JW | 1973 | Journal of ACM1973，20，1： | 1 |
| 7 | Discovery of l-(4-(4-propio- nylpiperazin-I -yl) -3-( trifluoromethyl ) phenyl) -9-(quinolin-3-yl) benzol hi 显示文摘 | Liu Q Chang JW Wang J | 2010 | J Med Chem2010，53，19： | 1 |
| 8 | Evaluation of two polymeric blends (EVA/PLA and EVA/PEG) as coating film materials for paclitaxel-eluting stent application 显示文摘 | Liu X Lei L Hou JW | 2011 | J Mater Sci Mater Med2011，22，： | 1 |
| 9 | Neoengleromycin,a novel compound from Engleromyces goetzii显示文摘 | Liu JK Tan JW Dong ZJ | 2002 | Helv Chim Acta2002，85，： | 1 |
| 10 | Accuracy and Repeatability of a New Method for Measuring Scoliosis Curvature显示文摘 | He JW Yan ZH Liu J | 2009 | Spine2009，34，9： | 1 |
| 11 | Hepatitis B virus X protein pro- motes cell migration by inducing matrix metalloproteinase -3 显示文摘 | Yu FL Liu H J Lee JW | 2005 | J Hepatol2005，42，4： | 1 |
| 12 | Telomerase activation causes vascular smooth muscle cell proliferation in genetic hypertension显示文摘 | Cao Y Li H Mu FT Ebisui O Funder JW Liu JP | 2002 | FASEB2002，16，1： | 1 |
| 13 | Gene expression networks underlying retinoie acid-induced differentiation of acute promyelocytic leukemia cells 显示文摘 | Liu TX Zhang JW Tao J | 2000 | Blood2000，96，4： | 1 |
| 14 | Clinicopathological characteristics and prognosis of breast cancer patients with type 2 diabetes melli- tus显示文摘 | He DE Bai JW Liu J | 2015 | Mol Clin Oncol2015，3，3： | 1 |
| 15 | Powder Microelectrodes Applied to NO2- Detection显示文摘TheelectrochemicalbehaviorsandthedetectionofNO2-haveattractedincreasingattentionrecentlybecauseoftheimportantrolesplayedbyNO2-inenvironmentandlifeprocesses.Thus,advancedtechniquesforthedetermination,especiallyon-sitedetermination,ofthenitriteinfoods... | Yan, JW Lu, JT Liu, PF | 1999 | Chinese Chemical Letters1999，10，1： | 1 |
| 16 | Proinflammatory chemokine induction in keratocytes and inflammatory cell infiltration into the cornea显示文摘 | Hong JW Liu JJ Lee JS Mohan RR Mohan RR Woods DJ | 2001 | Investi Ophthalmol Vis Sci2001，42，： | 1 |
| 17 | Acute respiratory distress syndrome in scrub typhus 显示文摘 | Wang CC Liu SF Liu JW | 2007 | Am J Trop Med Hyg2007，76，6： | 1 |
| 18 | Inhibitory effect of medroxyprogesterone acetate on human liver cytochrome P450 enzymes显示文摘 | Zhang JW Liu Y Li W Hao DC Yang L | 2006 | Eur J Clin Pharmacol2006，62，7： | 1 |
| 19 | Purification and characterization of L-amino acid oxidase from Agkistrodon halys pallas venom显示文摘 | Liu JW Chai MQ Du XY | 2002 | Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao2002，34，3： | 1 |
| 20 | Transplanted embryonic stem cells survive,differentiated and promote recovery in injured rat spinal cord显示文摘 | McDonald JW Liu XZ Qu Y | 1999 | Nat Med1999，5，12： | 1 |
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