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| 1 | In vivo radiometric analysis of glucose uptake and distribution in mouse bone显示文摘Bone formation and remodeling occurs throughout life and requires the sustained activity of osteoblasts and osteoclasts,particularly during periods of rapid bone growth.Despite increasing evidence linking bone cell activity to global energy homeostasis,little is known about the relative energy requirements or substrate utilization of bone cells.In these studies,we measured the uptake and distribution of glucose in the skeleton in vivo using positron-emitting^(18)F-fluorodeoxyglucose([^(18)F]-FDG) and non-invasive,high-resolution positron emission tomography/computed tomography(PET/CT) imaging and ex vivo autoradiography.Assessment of [^(18)F]-FDG uptake demonstrated that relative to other tissues bone accumulated a significant fraction of the total dose of the glucose analog.Skeletal accumulation was greatest in young mice undergoing the rapid bone formation that characterizes early development.PET/CT imaging revealed that [^(18)F]-FDG uptake was greatest in the epiphyseal and metaphyseal regions of long bones,which accords with the increased osteoblast numbers and activity at this skeletal site.Insulin administration significantly increased skeletal accumulation of [^(18)F]-FDG,while uptake was reduced in mice lacking the insulin receptor specifically in osteoblasts or fed a high-fat diet.Our results indicated that the skeleton is a site of significant glucose uptake and that its consumption by bone cells is subject to regulation by insulin and disturbances in whole-body metabolism. | Meredith L Zoch Diane S Abou Thomas L Clemens Daniel LJ Thorek Ryan C Riddle | 2016 | Bone Research2016，4，1： | 9 |
| 2 | 男性迟发性性腺功能减退症的检查、治疗和监测:国际男科学会(ISA)、国际老年男性研究会(ISSAM)、欧洲泌尿外科学会(EAU)、欧洲泌尿外科学院(EAA)和美国男科学会(ASA)联合推荐显示文摘简介
人口学资料明确显示:老年人口占总人口的百分率正逐年增加。当前,有关老年男性雄激素缺乏的问题逐渐成为令人感兴趣、但又充满争议的世界性话题。已经有横向和纵向的研究资料表明,随着年龄增大,成年男子的雄激素水平逐渐降低, | Wang C Nieschlage E Swerdloff R Behre HM Hellstrom WJ Gooren LJ Kaufman JM Legros JJ Lunenfeld B Morales A Morley JE Schulman C Thompson IM Weidner W Wu FCW 伍学焱(翻译) | 2011 | 国际生殖健康/计划生育杂志2011，30，1： | 8 |
| 3 | 超重和正常体质量患者的心力衰竭新发率的荟萃分析显示文摘肥胖和新发心力衰竭之间的关系已经反复确立,关于超重与心力衰竭发展风险知之甚少。该系统回顾和荟萃分析旨在探讨超重、肥胖与新发心力衰竭发生率的关系。在该研究中,研究者从数据库创建开始到2017年6月,系统检索了MEDLINE,Medline InProcess and Other Non-Indexed Citations,EMBASE,Scopus和Cochrane对照试验中心登记册。 | Krittanawong C Tunhasiriwet A Wang Z Zhang H Prokop LJ Chirapongsathorn S Sun T Kitai T Tang WHW 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，4： | 4 |
| 4 | 育龄期妊娠和非妊娠女性的初次脑卒中发生率比较:以英国人口为基础的队列研究显示文摘与相似年龄的非妊娠女性相比,妊娠女性的脑卒中风险可能增加,但这种风险的严重程度和影响时机尚不清楚。该研究调查了育龄女性初次发生脑卒中事件的风险,并比较了在妊娠期间与产后早期与平时的风险差异。 | 刘莉 叶鹏 Ban L Sprigg N Abdul Sultan A Nelson-Piercy C Bath PM Ludvigsson JF Stephansson O Tata LJ | 2017 | 中华高血压杂志2017，25，5： | 2 |
| 5 | Geographic distribution of vacA allelic types of Helicobacter pylori 显示文摘 | VanDoorn LJ Figueiredo C Megraud F | 1999 | Gastroenterology1999，116，4： | 1 |
| 6 | Guidelines for preventing health-care-associated pneumonia,2003:recommendations of CDC and the Healthcare Infection Control Practices Advisory Committee显示文摘 | Tablan OC Anderson LJ Besser R Bridges C Hajjeh R | 2004 | Mmwr Recomm Rep2004，53，： | 1 |
| 7 | Endovascular aneurysm repair in nonagenarians is safe and effective显示文摘 | Goldstein LJ Halpern JA Rezayat C | 2010 | J Vasc Surg2010，52，5： | 1 |
| 8 | Needlestick and adverse outcomes in office-based allergy practices显示文摘 | Kanter LJ Siegel C | 2003 | Annals of Allergy Asthma and Immunology2003，90，4： | 1 |
| 9 | c-KIT mutation analy- sis for diagnosis of gastrointestinal stromal tumours in fine needle aspiration specimens显示文摘 | Willmore-Payne C Layfield LJ Holden JA | 2005 | Cancer2005，105，3： | 1 |
| 10 | A bone structural basis for fracture risk in diabetes显示文摘 | Melton LJ Riggs BL Leibson C | 2008 | J Clin Endocrinol Metab2008，93，： | 1 |
| 11 | Eurolight steering committee prevalence of headache in Europe: a review for the Eurolight project 显示文摘 | Stovner LJ Andree C | 2010 | J Headache Pain2010，11，4： | 1 |
| 12 | CD4-regulatory cells in COPD patients 显示文摘 | Smyth LJ Starkey C Vestho J | 2007 | Chest2007，132，： | 1 |
| 13 | Thediagnosis of osteoporosis显示文摘 | Kanis JA Melton LJ Christiansen C | 1994 | J Bone Miner Res1994，9，8： | 1 |
| 14 | Energy Absorbed by Longitudinally Splitting a Tibialis Anterior Allograft:Implications for Double-Bundle Anterior Cruciate Ligament Reconstruction显示文摘 | Clark L Howard C Bisso LJ | 2010 | The Journal of Arthroscopic&Related Surgery2010，26，9： | 1 |
| 15 | Assessment of NMYC amplification : a comparison of FISH, quantitative PCR monoplexing and traditional blotting methods used with formalin-fixed, paraffin-embed- ded neuroblastomas显示文摘 | Layfield LJ Willmore-Payne C Shimada H | 2005 | Anal Quant Cytol Histol2005，27，1： | 1 |
| 16 | Radial head subluxation:comparing two methods of reduction显示文摘 | Mc Donald J Whitelaw C Goldsmith LJ | 1999 | Acad Emerg Med1999，6，7： | 1 |
| 17 | Deficiency of mannose- binding lectin-associated serine protease-2 associated with increased risk of fever and neutropenia in pediatric cancer patients 显示文摘 | Schlapbach LJ Aebi C OtthM | 2007 | Pediatr Infect Dis J2007，26，11： | 1 |
| 18 | Medication events:The experience of the Taiwan patient -safety reporting system (TPR) 显示文摘 | Huang LJ Wung C Shih CL | 2009 | World Hosp Health Serv2009，45，4： | 1 |
| 19 | An overview of the features influencing pain after inguinal hernia repair 显示文摘 | Nienhuijs SW Rosman C Strobbe LJ | 2008 | Int J Surg2008，6，4： | 1 |
| 20 | Stretch-induced paracrine hypertrophic stimuli increase TGF-beta1 expression in cardiomyocytes显示文摘 | van Wamel AJ Ruwhof C van der Valk-Kokshoom LJ | 2002 | Mol Cell Biochem2002，236，12： | 1 |
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