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| 1 | 高血压患者肾素血管紧张素系统阻断的血浆分子标志:肾损害与初发蛋白尿的新预测指标显示文摘蛋白尿是一个与心血管病密切相关的危险因素,也是一般人群的首位死亡原因。虽然已经明确肾素血管紧张素系统(renin-angiotensin system,RAS)阻断剂能延缓高血压患者初发蛋白尿进展、减少蛋白尿排出,但仍不能忽视高血压患者发生初发蛋白尿的比例。 | Baldan-Martin M Mourino-Alvarez L Gonzalez-Calero L Moreno-Luna R Sastre-Oliva T Ruiz-Hurtado G Segura J Lopez JA Vazquez J Vivanco F Alvarez-Llamas G Ruilope LM de la Cuesta F Barderas MG 赵狄 练桂丽 | 2016 | 中华高血压杂志2016，24，6： | 2 |
| 2 | Rapid diagnosis of Entamoeba infection by using Entamoeba and Entamoeba histolytica stool antigen detection kits显示文摘 | Haque R Nevill LM Hahn P | 1995 | J Clin Microbiol1995，33，： | 2 |
| 3 | TSC1-mTOR-PLK轴以阶段特异性方式调节从施旺细胞增殖到髓鞘形成的内稳态开关显示文摘恰如其分的外周髓鞘形成取决于雪旺细胞增殖与分化进程间的平衡。丝氨酸/苏氨酸激酶(mTOR)整合多种环境因素,是细胞生长、代谢、发挥作用的中枢调节者。本文报道了一种mTOR的负性调节剂——结节性硬化复合体(TSC1),通过控制细胞增殖和髓鞘稳态,建立了雪旺细胞谱系进展和髓鞘形成的阶段依赖性程序。小鼠雪旺细胞祖细胞中TSC1的解离导致mTOR信号通路激活,继而导致雪旺细胞过量增殖,分化受阻,髓鞘形成减少。转录组分析显示,TSC1突变体中的mTOR活化使得polo样激酶(PLK)依赖性通路和细胞周期调节剂上调。弱化mTOR或者对PLK进行药理抑制部分挽救了因TSC1缺失导致的外周神经发育过程中的髓鞘形成减少。相较之下,成年小鼠成熟雪旺细胞中TSC1缺失可导致髓鞘的过度增殖和过度生长。本文的发现提示了TSC1-mTOR-PLK信号轴在控制雪旺细胞的发育过程中,从增殖到分化和髓鞘内稳态中起到的阶段特异性功能。 | Jiang M Rao R Wang J Wang J1 Xu L Wu LM Chan JR Wang H Lu QR 聂昊(编译) | 2018 | 神经损伤与功能重建2018，13，5： | 2 |
| 4 | Positional cloning of the gene for X-linked retinitis pigmentosa 3:homology with the guanine-nucleotide-exchange factor RCC1显示文摘 | Roepman R Van Duijnhoven G Rosenberg T Pinckers AJLG Bleeker-Wagemakers LM Bergen AAB | | 0，，： | 2 |
| 5 | Use of a geographic information system to identify and characterize areas with high proportions of distant stage breast cancer显示文摘 | Roche LM Skinner R Weinstein RB | 2002 | J Public Health Manag Pract2002，8，2： | 1 |
| 6 | Cerebrospinal fluid tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, and interleukin-8 as diagnostic markers of cerebrospinal fluid infection in neurosurgical patients显示文摘 | Lopez-Cortes LF Marquez-Arbizu R Jimenez-Jimenez LM | 2000 | Crit Care Med2000，28，1： | 1 |
| 7 | Nitric Oxide Signaling and Cellular Adaptations to Changes in Oxygenation显示文摘 | POSTOVIT LM SULLIVAN R ADAM MA | 2005 | Toxicology(S0915-9306)2005，208，2： | 1 |
| 8 | Pyonephrosis: diagno- sis and treatment显示文摘 | St LM Hofmann R Stoller ML | 1992 | Br J Urol1992，70，： | 1 |
| 9 | Maternal mortality in the United States: report from the matemal mortality collaborative 显示文摘 | Rochat R W Koofm LM Atrash H K | 1988 | Obstet Gynemol1988，72，1： | 1 |
| 10 | Plasma C-reactive protein levels among children with sleep-disordered breathing显示文摘 | Tauman R Ivanenko A O'Brien LM | 2004 | Pediatrics2004，113，6： | 1 |
| 11 | Epidemiology of ARDS and ALl 显示文摘 | Blank R Napolitano LM | 2011 | Crit Care Clin2011，27，3： | 1 |
| 12 | Nonarteritic anterior ischemic optic neuropathy显示文摘 | Buono LM Foroozan R Sergott RC | | 0，，05： | 1 |
| 13 | Relationship of parental trau-ma exposure and PTSD to PTSD,depressive and anxiety disordersin offspring显示文摘 | Yehuda R Halligan SL Bierer LM | 2001 | J Psychiatr Res2001，35，5： | 1 |
| 14 | Control of Toxoplasma re- activation by rescue of dysfunctional CD8 ~ T cell response via PD-1-PDL-1 blockade显示文摘 | Bhadra R Gigley JP Weiss LM | 2011 | Proc Natl Acad Sci USA2011，108，22： | 1 |
| 15 | A new classification system for facial paralysis in the clinical setting显示文摘 | Westin LM Zuker R | 2003 | J Craniofac Surg2003，14，5： | 1 |
| 16 | Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression显示文摘 | Le A Cooper CR Gouw AM Dinavahi R Maitra A Deck LM | 2010 | Proc Natl Acad Sci USA2010，107，5： | 1 |
| 17 | The assessment of nursing caries and its relationship to high caries in the permanent dentition显示文摘 | Kaste LM Marianos D Chang R | 1992 | J Public Health Dent1992，52，2： | 1 |
| 18 | 388 EKB-569: a new irreversible inhibitor of epidermal growth factor receptor tyrsine kinase for the treatment of cancer显示文摘 | Discafani C Wang YF Tsou HR Overbeek EG Nilakantan R | 2000 | Clin Cancer Res2000，，： | 1 |
| 19 | In vivo evidence that metabolic Cooperation is responsible for the bystander effect observed with Hsv tk retroviral gene therapy 显示文摘 | Parysek LM Waruick R | 1993 | Hum Gene Ther1993，4，： | 1 |
| 20 | The correlation between intraocular pressure and refractive status显示文摘 | David R Zangwill LM Tessler Z | 1985 | Arch Ophthalmol1985，103，12： | 1 |
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