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| 1 | Laparoscopic vs open approach to resection of hepatocellular carcinoma in patients with known cirrhosis:Systematic review and meta-analysis显示文摘AIM: To review the currently available literature comparing laparoscopic to open resection of hepatocellular carcinoma(HCC) in patients with known liver cirrhosis.METHODS: A literature search of MEDLINE, EMBASE, and Cochrane databases was conducted. The search terms used included(laparoscopic OR laparoscopy) AND(hepatic or liver) AND(surgery or resection) AND 'hepatocellular carcinoma' AND(cirrhosis or cirrhotic). Furthermore, to widen the search, we also used the 'related articles' section. Studies reporting a comparison of outcomes and methods of open vs laparoscopic hepatic resection for HCC in patients with liver cirrhosis were included. Meta-analysis of results was performed using a random effects model to compute relative risk(RR) and for dichotomous variablesand standard mean differences(SMD) for continuous variables.RESULTS: A total of 420 patients from 4 cohort studies were included in final analysis. Patients undergoing laparoscopic procedures had statistically less blood loss compared to the open cohort, SMD of-1.01(95%CI:-1.23-0.79), P < 0.001, with a reduced risk of transfusion, RR = 0.19(95%CI: 0.09-0.38), P < 0.001. A wider clearance at tumour resection margins was achieved following a laparoscopic approach, SMD of 0.34(95%CI: 0.08-0.60), P = 0.011. No significant difference was noted between laparoscopic and open resection operative times, SMD of-0.15(95%CI: 0.35-0.05), P = 0.142. The overall RR of suffering from postoperative morbidity is 0.25 in favour of the open surgery cohort(95%CI: 0.17-0.37), P < 0.001. Patients under-going laparoscopic surgery had significantly shorter length of stays in hospital compared to the open cohort, SMD of-0.53(95%CI:-0.73 to-0.32), P < 0.001.CONCLUSION: This review suggests that laparoscopic resection of hepatocellular carcinoma in patients with cirrhosis is safe and may provide improved patient outcomes when compared to the open technique. | Ahmed Twaij Philip H Pucher Mikael H Sodergren Tamara Gall Ara Darzi Long R Jiao | 2014 | World Journal of Gastroenterology2014，20，25： | 16 |
| 2 | No difference in mortality among ALPPS,two-staged hepatectomy,and portal vein embolization/ligation:A systematic review by updated traditional and network meta-analyses显示文摘Background:There is an ongoing debate on the feasibility,safety,and oncological efficacy of the associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)technique.The aim of this study was to compare ALPPS,two-staged hepatectomy(TSH),and portal vein embolization(PVE)/ligation(PVL)using updated traditional meta-analysis and network meta-analysis(NMA).Data sources:Electronic databases were used in a systematic literature search.Updated traditional metaanalysis and NMA were performed and compared.Mortality and major morbidity were selected as primary outcomes.Results:Nineteen studies including 1200 patients were selected from the pool of 436 studies.Of these patients,315(31%)and 702(69%)underwent ALPPS and portal vein occlusion(PVO),respectively.Ninetyday mortality based on updated traditional meta-analysis,subgroup analysis of the randomized controlled trials(RCTs),and both Bayesian and frequentist NMA did not demonstrate significant differences between the ALPPS cohort and the PVE,PVL,and TSH cohorts.Moreover,analysis of RCTs did not demonstrate significant differences of major morbidity between the ALPPS and PVO cohorts.The ALPPS cohort demonstrated significantly more favorable outcomes in hypertrophy parameters,time to operation,definitive hepatectomy,and R0 margins rates compared with the PVO cohort.In contrast,1-year disease-free survival was significantly higher in the PVO cohort compared to the ALPPS cohort.Conclusions:This study is the first to use updated traditional meta-analysis and both Bayesian and frequentist NMA and demonstrated no significant differences in 90-day mortality between the ALPPS and other hepatic hypertrophy approaches.Furthermore,two high quality RCTs including 147 patients demonstrated no significant differences in major morbidity between the ALPPS and PVO cohorts. | Paschalis Gavriilidis Robert P Sutcliffe Keith J Roberts Madhava Pai Duncan Spalding Nagy Habib Long R Jiao Mikael H Sodergren | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，5： | 6 |
| 3 | Genetic polymorphism of Malus sieversii populations in Xinjiang, China 显示文摘 | Yan G R Long H Song W Q | 2008 | Genet Resour Crop Evol2008，，55： | 1 |
| 4 | Formation causes and recovery of the 'Black Soil Type' degraded alpine grassland in Qinghai-Ti- betan Plateau显示文摘 | Shang Z H Long R J | 2007 | Frontiers of Agrieuhure in China2007，1，2： | 1 |
| 5 | Radiation characteristics of thin-wire ternary fractal trees 显示文摘 | Werner D H Rubio B A Long B R | 1996 | Electronics Letters1996，35，8： | 1 |
| 6 | Kondo Resonance in a Single-molecule Transistor显示文摘 | LIANG W SHORES M P BOCKRATH M LONG J R PARK H | 2002 | Nature (London)2002，417，： | 1 |
| 7 | Implications of Land-use Change in Rural China:A Case Study of Yucheng, Shan- dong Province显示文摘 | Liu Y S Yang R Long H L | 2014 | Land Use Policy2014，40，： | 1 |
| 8 | The empirical mode decomposition and the Hilbert spectrum for nonlinear and non-stationary time series analysis显示文摘 | Shen Z Long S R | 1998 | Proceedings of the Royal Society A:Mathematical Physical and Engineering Sciences1998，454，： | 1 |
| 9 | Accelerated Restructu- ring in Rural China Fueled by ' Increasing vs Decreasing Balance' Land-use Policy for Dealing with Hollowed Vil- lages 显示文摘 | Long H L Li Y R Liu Y S | 2012 | Land Use Policy2012，29，1： | 1 |
| 10 | Variation in availability of emergency contraception in pharmacies显示文摘 | SHACTER H E GEE R E LONG J A | 2007 | Contraception2007，75，3： | 1 |
| 11 | The empirical mode decomposition and the Hilbert spectrum for nonlinear and non-stationary time series analysis显示文摘 | Norden E H Zheng Shen Steven R Long | 1998 | Mathematical Physical and Engineering Sciences1998，454，1971： | 1 |
| 12 | Chlorophyll fluorescence as a probe of the photosynthetic competence of leaves in the field:a review of current instrumentation显示文摘 | Bolhar-Nordenkampf H R Long S P Baker N R | 1989 | Funct Ecol1989，3，： | 1 |
| 13 | Television based bistafic radar显示文摘 | GRIFFITHS H D LONG N R W | 1986 | IEE Proc F Commun Radar1986，133，7： | 1 |
| 14 | Comparison of methanogen diversity of yak (Bos grunniens) and cattle (Bos taurus ) from the Qinghai-Tibetan Plateau, China显示文摘 | HUANG X D TAN H Y LONG R J | 2012 | BMC Microbiology2012，12，： | 1 |
| 15 | Rural Resident's Attitudes Toward Recreation and Tourism Development显示文摘 | ALLEN L R H R HAFER P T LONG | 1993 | Ournal of Travel Research1993，21，4： | 1 |
| 16 | An Integrative Approach to Assessing the Potential Impacts of Climate Change on the Yunnan Snub - nosed Monkey 显示文摘 | Wong M H G Li R Xu M Long Y | 2013 | Biological Conservation2013，，158： | 1 |
| 17 | Laspeyres Decomposition of Energy Intensity Including Household-energy Factors 显示文摘 | Dong F Li X H Long R Y | 2011 | Energy Procedia2011，，5： | 1 |
| 18 | Rural Residents' Attitudes toward Recreation and Tourism Development 显示文摘 | ALLEN L HAFER H LONG R | 1993 | Journal of Travel Research1993，31，4： | 1 |
| 19 | Weighted composition followed and proceeded by differentiation operator from Zygmund spaces to Bloch-type显示文摘 | LONG J R QIU C H WU P C | 2014 | Inequal Appl2014，，： | 1 |
| 20 | Structure of 1-ethyl-3-methyl imidazoliu hexafluorophosphate: model for room temperature molten salts显示文摘 | Carlin R T De Long H C | 1994 | J Chem Soc Chem Commun1994，，3： | 1 |
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