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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | What have we learned from 15 years of free-air CO2 enrichment(FACE)?A meta-analytic review of the responses of photosynthesis,canopy properties and plant production to rising CO2显示文摘 | AINSWORTH E A LONG S P | 2005 | New Phytologist2005，165，2： | 1 |
| 3 | Effects of rising CO2concentration on expression of photosynthrtic protein显示文摘 | Webber A N Nie G Y Long S P | 1994 | Photosynth Res1994，39，： | 1 |
| 4 | Animal model of simulated mierogravity : a comparative study of hindlimb unloading via tail ver- sus pelvic suspension显示文摘 | Chowdhury P Long A Harris G | 2013 | Physiol Rep2013，1，00： | 1 |
| 5 | Monitoring electrical resistance of concretes containing alternative cementitious materials to assess their resistance to chloride penetration显示文摘 | Basheer P A M Gilleece P R V Long A E | 2002 | Cement and Concrete Composites2002，24，5： | 1 |
| 6 | Acclimation of photosynthetic proteins to rising atmospheric CO2显示文摘 | Webber A N Nie G Long S P | 1994 | Photosynthesis Res1994，39，： | 1 |
| 7 | Group 4 metal olefin polymerization catalysts stabilized by bidentate O,Pligands显示文摘 | Long R J Gibson V C White A J P | | 0，，： | 1 |
| 8 | More efficient plants:A consequence of rising atmospheric CO2?显示文摘 | Drake B G Gonzalez-Meler M A Long S P | 1997 | Annu Rev Plant Physiol Plant Mol Biol1997，48，： | 1 |
| 9 | The relationship of the degree of interconnection to permeability in fractured networks显示文摘 | Long J C S Witherspoon P A | 1985 | Journal of Geophysical Research1985，90，4： | 1 |
| 10 | Porous media equivalents for networks of discontinuous fractures显示文摘 | Long J C S Remer J S Wilson C R Witherspoon P A | 1982 | Water Resources Research1982，18，3： | 1 |
| 11 | Seasonal changes in weight of above-ground and below-ground vegetation and dead plant material in a salt marsh at Colne point,Essex显示文摘 | Hussey A Long S P | | 0，，： | 1 |
| 12 | Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4 CD25 regulatory T- cells of type 1 diabetic subjects 显示文摘 | LONG S A CEROSALET'FI K BOLLYKY P L | 2010 | Diabetes2010，59，2： | 1 |
| 13 | Analyzing the responses of photosynthetic CO2 assimilation to long-term elevation of atmospheric CO2 concentration显示文摘 | LONG S P BAKER N R RAINES C A | 1993 | Vegetation1993，，： | 1 |
| 14 | Heat flux measurement techniques显示文摘 | Childs P R N Greenwood J R Long C A | 1999 | Pro Instn Mech Engrs1999，213，： | 1 |
| 15 | Introduction of senseconstructs of cinnamate4-hydroxylase (CYP73A24) in transgenic tomato plants shows oppositeeffects on flux into stemlignin and fruitflavonoids显示文摘 | Millar D J Long M Donovan G Fraser P D Boudet A M Danoun S Bramley M and Bolwell G P | | 0，，11： | 1 |
| 16 | A Bayesian framework for the analysis of microarray expression data: regularized t-test and statistical inferences of gene changes 显示文摘 | Baldi P Long A D | 2001 | Bio-informatics2001，17，6： | 1 |
| 17 | Influence of coarse ag- gregate on the permeation, durability and the microstructure character- istics of ordinary Portland cement concrete显示文摘 | BASHEER L BASHEER P A M LONG A E | 2005 | Construction and Build- ing Materials2005，，19： | 1 |
| 18 | Deposition of gold films and nanostructures from supercritieal carbon dioxide 显示文摘 | Cabanas A Long D P Watkins J J | 2004 | Chem Mater2004，16，10： | 1 |
| 19 | The composite genome of the legume symbiont Sinorhizobium meliloti显示文摘 | Finan TM Long SR Puhler A Abola P | 2001 | Science2001，293，： | 1 |
| 20 | Effects of three durability enhancing products on some physical proper- ties of near surface concrete显示文摘 | Nolan E Basheer P A M Long A E | 1995 | Construction and Build- ing Materials1995，9，5： | 1 |
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