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| 1 | Endocrine radionuclide scintigraphy with fusion single photon emission computed tomography/computed tomography显示文摘AIM: To review the benefits of single photon emission computed tomography(SPECT)/computed tomography(CT) hybrid imaging for diagnosis of various endocrine disorders.METHODS: We performed MEDLINE and Pub Med searches using the terms: 'SPECT/CT'; 'functional anatomic mapping'; 'transmission emission tomography'; 'parathyroid adenoma'; 'thyroid cancer'; 'neuroendocrine tumor'; 'adrenal'; 'pheochromocytoma'; 'paraganglioma'; in order to identify relevant articles published in English during the years 2003 to 2015. Reference lists from the articles were reviewed to identify additional pertinent articles. Retrieved manuscripts(case reports, reviews, meta-analyses and abstracts) concerning the application of SPECT/CT to endocrine imaging were analyzed to provide a descriptive synthesis of the utility of this technology.RESULTS: The emergence of hybrid SPECT/CT camera technology now allows simultaneous acquisition of combined multi-modality imaging, with seamless fusion of three-dimensional volume datasets. The usefulness of combining functional information to depict the biodistribution of radiotracers that map cellular processes of the endocrine system and tumors of endocrine origin, with anatomy derived from CT, has improved the diagnostic capability of scintigraphy for a range of disorders of endocrine gland function. The literature describes benefits of SPECT/CT for ^(99m)Tc-sestamibi parathyroid scintigraphy and ^(99m)Tc-pertechnetate thyroid scintigraphy, ^(123)I- or ^(131)I-radioiodine for staging of differentiated thyroid carcinoma, ^(111)In- and ^(99m)Tclabeled somatostatin receptor analogues for detection of neuroendocrine tumors, ^(131)I-norcholesterol(NP-59) scans for assessment of adrenal cortical hyperfunction, and ^(123)I- or ^(131)I-metaiodobenzylguanidine imaging for evaluation of pheochromocytoma and paraganglioma.CONCLUSION: SPECT/CT exploits the synergism between the functional information from radiopharmaceutical imaging and anatomy from CT, translating to improved diagnostic accuracy and meaningful impact on patient care. | Ka-Kit Wong Arpit Gandhi Benjamin L Viglianti Lorraine M Fig Domenico Rubello Milton D Gross | 2016 | World Journal of Radiology2016，8，6： | 3 |
| 2 | Downscaling future climate scenarios to fine scales for hydrologic and ecological modeling and analysis显示文摘Introduction:Evaluating the environmental impacts of climate change on water resources and biological components of the landscape is an integral part of hydrologic and ecological investigations,and the resultant land and resource management in the twenty-first century.Impacts of both climate and simulated hydrologic parameters on ecological processes are relevant at scales that reflect the heterogeneity and complexity of landscapes.At present,simulations of climate change available from global climate models[GCMs]require downscaling for hydrologic or ecological applications.Methods:Using statistically downscaled future climate projections developed using constructed analogues,a methodology was developed to further downscale the projections spatially using a gradient-inverse-distancesquared approach for application to hydrologic modeling at 270-m spatial resolution.Results:This paper illustrates a methodology to downscale and bias-correct national GCMs to subkilometer scales that are applicable to fine-scale environmental processes.Four scenarios were chosen to bracket the range of future emissions put forth by the Intergovernmental Panel on Climate Change.Fine-scale applications of downscaled datasets of ecological and hydrologic correlations to variation in climate are illustrated.Conclusions:The methodology,which includes a sequence of rigorous analyses and calculations,is intended to reduce the addition of uncertainty to the climate data as a result of the downscaling while providing the fine-scale climate information necessary for ecological analyses.It results in new but consistent data sets for the US at 4 km,the southwest US at 270 m,and California at 90 m and illustrates the utility of fine-scale downscaling to analyses of ecological processes influenced by topographic complexity. | Lorraine E Flint Alan L Flint | 2012 | Ecological Processes2012，1，1： | 2 |
| 3 | Impact of machine perfusion of the liver on post-transplant biliary complications: A systematic review显示文摘AIM To review the clinical impact of machine perfusion(MP) of the liver on biliary complications post-transplantation, particularly ischaemic-type biliary lesions(ITBL). METHODS This systematic review was performed in accordance with the Preferred Reporting Systematic Reviews and MetaAnalysis(PRISMA) protocol. The following databases were searched: PubMed, MEDLINE and Scopus. The keyword 'liver transplantation' was used in combination with the free term 'machine perfusion'. Clinical studies reporting results of transplantation of donor human livers following ex situ or in situ MP were analysed. Details relating to donor characteristics, recipients, technique of MP performed and post-operative biliary complications(ITBL, bile leak and anastomotic strictures) were critically analysed.RESULTS Fifteen articles were considered to fit the criteria for this review. Ex situ normothermic MP was used in 6 studies, ex situ hypothermic MP in 5 studies and the other 4 studies investigated in situ normothermic regional perfusion(NRP) and controlled oxygenated rewarming. MP techniques which have per se the potential to alleviate ischaemia-reperfusion injury: Such as hypothermic MP and NRP, have also reported lower rates of ITBL. Other biliary complications, such as biliary leak and anastomotic biliary strictures, are reported with similar incidences with all MP techniques. There is currently less clinical evidence available to support normothermic MP as a mitigator of biliary complications following liver transplantation. On the other hand, restoration of organ to full metabolism during normothermic MP allows assessment of hepatobiliary function before transplantation, although universally accepted criteria have yet to be validated.CONCLUSION MP of the liver has the potential to have a positive impact on post-transplant biliary complications, specifically ITBL, and expand extended criteria donor livers utilisation. | Yuri L Boteon Amanda PCS Boteon Joseph Attard Lorraine Wallace Ricky H Bhogal Simon C Afford | 2018 | World Journal of Transplantation2018，8，6： | 2 |
| 4 | Personalising pancreas cancer treatment:When tissue is the issue显示文摘The treatment of advanced pancreatic cancer has not moved much beyond single agent gemcitabine until recently when protocols such as FOLFIRINOX(fluorouracil,leucovorin,irinotecan and oxaliplatin)and nab-paclitaxelgemcitabine have demonstrated some improved outcomes.Advances in technology especially in massively parallel genome sequencing has progressed our understanding of the biology of pancreatic cancer especially the candidate signalling pathways that are involved in tumourogenesis and disease course.This has allowed identification of potentially actionable mutations that may be targeted by new biological agents.The heterogeneity of pancreatic cancer makes tumour tissue collection important with the aim of being able to personalise therapies for the individual as opposed to a one size fits all approach to treatment of the condition.This paper reviews the developments in this area of translational research and the ongoing clinical studies that will attempt to move this into the everyday oncology practice. | Katrin M Sjoquist Venessa T Chin Lorraine A Chantrill Chelsie O'Connor Chris Hemmings David K Chang Angela Chou Marina Pajic Amber L Johns Adnan M Nagrial Andrew V Biankin Desmond Yip | 2014 | World Journal of Gastroenterology2014，20，24： | 2 |
| 5 | High-throughput phenotyping in cotton:a review显示文摘Recent technological advances in cotton(Gossypium hirsutum L.) phenotyping have offered tools to improve the efficiency of data collection and analysis.High-throughput phenotyping(HTP) is a non-destructive and rapid approach of monitoring and measuring multiple phenotypic traits related to the growth,yield,and adaptation to biotic or abiotic stress.Researchers have conducted extensive experiments on HTP and developed techniques including spectral,fluorescence,thermal,and three-dimensional imaging to measure the morphological,physiological,and pathological resistance traits of cotton.In addition,ground-based and aerial-based platforms were also developed to aid in the implementation of these HTP systems.This review paper highlights the techniques and recent developments for HTP in cotton,reviews the potential applications according to morphological and physiological traits of cotton,and compares the advantages and limitations of these HTP systems when used in cotton cropping systems.Overall,the use of HTP has generated many opportunities to accurately and efficiently measure and analyze diverse traits of cotton.However,because of its relative novelty,HTP has some limitations that constrains the ability to take full advantage of what it can offer.These challenges need to be addressed to increase the accuracy and utility of HTP,which can be done by integrating analytical techniques for big data and continuous advances in imaging. | PABUAYON Irish Lorraine B SUN Yazhou GUO Wenxuan RITCHIE Glen L | 2019 | Journal of Cotton Research2019，2，3： | 1 |
| 6 | A frame- work for assessing ecological quality based on ecosystem services 显示文摘 | Achim Paetzold Philip H Warren Lorraine L Mahby | 2010 | Ecological Complexity2010，7，3： | 1 |
| 7 | Membrane-bound Fas ligand only is es- sential for Fas-induced apoptosis 显示文摘 | Lorraine A Lin T Lily L | 2009 | Nature2009，461，7264： | 1 |
| 8 | Kinetics and formation mechanisms of the nanocomposite powder AgSnO2 prepared by reactive milling显示文摘 | Lorrain N Chaffron L Carry C | 2004 | Mater Sei Eng A2004，367，12： | 1 |
| 9 | Mammary Gland Immunity and Mastitis Susceptibility显示文摘 | Lorraine M Sordillo Katie L S | 2002 | Journal of Mammary Gland Biology and Neoplasia2002，，7： | 1 |
| 10 | Global epidemiological study of variation of premenstrual symptoms with age and sociodemo- graphic factors显示文摘 | LORRAINE D PHILIPPE L KLAAS H | 2011 | Menopause Int2011，17，3： | 1 |
| 11 | Resistant starch: a potential functional food ingredient显示文摘 | Lorraine L Niba | 2002 | Nutrition and Food Science2002，32，23： | 1 |
| 12 | Phenotypic and molecular characterisation of Brucella isolates from marine mammals显示文摘 | Claire E Dawson Emma J Stubberfield Lorraine L Perrett | 2008 | BMC Microbiology2008，8，： | 1 |
| 13 | plasma cortisol and B-endorphin concentrations in trained and over-trained standardbred racehorses 显示文摘 | Lorraine C Goll David L Evans Grant M Store | 1999 | European Journal Applied Physiology1999，79，： | 1 |
| 14 | Resistant starch: A potential functional food ingredient 显示文摘 | LORRAINE L NIBA | 2002 | Nutrition Food Science2002，32，2： | 1 |
| 15 | Vertical and lateral fluid flow related to a large growth fault, South Eugene Island Block 330 field, Offshore Louisiana 显示文摘 | Steven L Lorraine B E | 1999 | AAPG Bulletin1999，83，2： | 1 |
| 16 | Plasma cortisol and B - endorphin concentrations in trainedand over- trained standardbred racehorses 显示文摘 | Lorraine C Goll David L Evans Grant M Store | 1999 | European Journal Applied Physiology1999，，79： | 1 |
| 17 | Kinetics and formarion mechanisms of the manocomposite powder Ag-SnO2 prepared by reactive milling显示文摘 | Lorrain N Chaffion L Carry C | 2004 | Materials Science and Engineering2004，，367： | 1 |
| 18 | Phenolic composition of Merlot and Cabernet-Sauvignon grapes from Bordeaux vineyard for the 2009-vintage:Comparison to 2006,2007 and 2008 vintages 显示文摘 | Lorrain B Chira K Teissedre P L | 2011 | Food Chemistry2011，126，4： | 1 |
| 19 | Structural recognition and functional activation of fcγr by innate pentraxins显示文摘 | Jinghua Lu Lorraine L Marnell Kristopher D Marjon | 2008 | Nature2008，456，7224： | 1 |
| 20 | Damage evolution and infrared thermography in woven composite laminates under fatigue loading 显示文摘 | Toubal L Karama M Lorrain B | 2006 | International Journal of Fatigue2006，28，12： | 1 |
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