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| 1 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 2 | Uncoupling of metabolism to reduce biomass production in the activated sludge process 显示文摘 | Low E W Chase H A Milner M G | 2000 | Water Res2000，34，12： | 1 |
| 3 | Pediatric ethmoidectomy显示文摘 | PRANSKY S M LOW W S | 1996 | Otolaryngol Clio North Am1996，29，1： | 1 |
| 4 | In-situ determination of thermal coefficients for electrical machines显示文摘 | Bousbaine A McCormick M Low W F | 1995 | IEEE Transactions of Energy Conversion1995，10，3： | 1 |
| 5 | A microprocessor based fully digital AC servo drive显示文摘 | LOW K S LIM K W RAHAMAN M F | 1997 | Microprocessors and Microsystems1997，20，3： | 1 |
| 6 | Imaging features of hepatic angiomyolipomas显示文摘 | Low S C Peh W C Muttarak M | 2008 | J Med Imaging Radiat Oncol2008，52，2： | 1 |
| 7 | Is there a potential therapeutic value of copper & zinc for osteopo- rosis显示文摘 | Lowe N M Fraser W D Jackson M J | 2002 | Proc Nutr Soc2002，61，： | 1 |
| 8 | Structural elucidation of a PDE-5 inhibitor detected as an adulterant in a health supplement 显示文摘 | GEA X W LOW M Y ZOU P | 2008 | J Pharm Biomed Anal2008，48，4： | 1 |
| 9 | Linking scales in stream ecol- ogy显示文摘 | Lowe W H Likens G E Power M E | 2006 | Bioscience2006，6，7： | 1 |
| 10 | A framework for intelligent medical diagnosis using the theory of evidence显示文摘 | Jones R W Lowe A Harrison M J | 2002 | Knowledge- Based Systems2002，15，： | 1 |
| 11 | Seismic design and performance of self-centering steel plate shear walls 显示文摘 | CLAYTON P M BERMAN J W LOWES L N | 2012 | Journal of Structural Engineering2012，138，1： | 1 |
| 12 | The spitzer space telescope mission 显示文摘 | M W Werner T L Roellig F J Low | 2004 | The Astrophysical Journal Supplement Series2004，154，： | 1 |
| 13 | Assessment of hub status among Asian ports from a network perspective 显示文摘 | Low J M W Lam S W Tang L C | 2009 | Transportation Research Part A2009，，43： | 1 |
| 14 | Abnormal glucose metabolism and pancreatic cancer mortality显示文摘 | GAPSTUR S M GANN P H LOWE W | 2000 | JA- MA2000，283，19： | 1 |
| 15 | Concentration and 13C records of atmospheric methane in New Zealand and Antarctica:Evidence for changes in methane sources显示文摘 | Lowe D C Brenninkmeijer C A M Brailsford G W | 1994 | Journal of Geophysical Research1994，99，16： | 1 |
| 16 | Total synthesis of cytochrome b562 by native chemical ligation using a removable auxiliary显示文摘 | Low D W Hill M G Carraso M R | | 0，，： | 1 |
| 17 | Compaction process in granular beds composed of different particle sizes显示文摘 | Low C A Greenaway M W | | 0，，12： | 1 |
| 18 | Family history, near work, outdoor activity, and myopia in Singapore Chinese preschool children 显示文摘 | LOW W DIRANI M GAZZARD G | 2010 | Br J Ophthalmol2010，94，8： | 1 |
| 19 | Detection of specific virus sequence and protein from lpox virus strains显示文摘 | Tadese T Reed reticuloendotheliosis REV-integrated low Virological Methods W M | 2003 | Journal of2003，110，1： | 1 |
| 20 | Cyclin E and survival in patients with breast cancer 显示文摘 | Knickerbocker C Toyofuku W Lowe M | 2002 | New Eng J2002，3，47： | 1 |
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