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| 1 | 肠道菌群在功能性便秘中的作用显示文摘功能性便秘非常常见,但其发病机制尚不明了。越来越多的证据显示,功能性便秘与肠道微生态失调有关,而肠道微生态与肠道转运之间很可能存在相互影响。本文对功能性便秘发生过程中肠道微生态所发挥作用的证据进行了总结。肠道微生态通过胆酸、短链脂肪酸、5-羟色胺和甲烷等相关微生物代谢活动调控结肠动力、结肠黏膜分泌和吸收,进而促使功能性便秘的发生。作为肠道微生态影响功能性便秘的证据支持,用益生菌、益生元、合生元和中药治疗功能性便秘时,常可观察到患者肠道微生态在菌种组成和功能上的改变。深入研究功能性便秘的病理发生,阐明微生态制剂治疗功能性便秘的药理机制,将为功能性便秘的新型治疗方法提供理论基础。 | Shengsheng Zhang Ruixin Wang Danyan Li Luqing Zhao Lixin Zhu | 2021 | Gastroenterology Report2021，9，5： | 13 |
| 2 | Levels of Metabolic Enzymes and Nitrogenous Compounds in the Swimming Crab Portunus trituberculatus Exposed to Elevated Ambient Ammonia-N显示文摘This study investigated the effects of ammonia-N(control and 1 and 5 mg L^(-1)) on the changes of metabolic enzymes activities and nitrogenous compounds levels in the gills, hepatopancreas, muscles, and hemolymph of the swimming crab Portunus trituberculatus. Results showed that the levels of hemolymph ammonia increased significantly at 6 h and then decreased to control level at 12 h. The activities of key enzymes involved in biosynthesis pathways of glutamine(Gln) and urea, such as glutamate dehydrogenase(GDH), glutamine synthetase(GS), and arginase(ARG), increased remarkably in different tissues of P. trituberculatus. Gln level was the highest in muscles, while urea content was the largest in hepatopancreas. The m RNA expression level of xanthine dehydrogenase(XDH) was downregulated sharply in gills but upregulated in the hepatopancreas and muscles. A small amount of uric acid was detected in the hemolymph. This result suggests that Gln in muscles may be used as an intermediary nitrogen repository, while urea may be primarily synthesized in the hepatopancreas and then transferred to other tissues via the hemolymph. Uric acid could be synthesized by the anabolism of purine nucleotides, in additon to the inhibitory activities of gills. In addition, the levels of Gln, urea and uric acid exhibited dose-and time-dependent effects with ammonia content. Therefore, P. trituberculatus could possibly convert ammonia into Gln, urea, or uric acid to detoxify ammonia during high ambient ammonia-N stress. | PAN Luqing SI Lingjun LIU Shengnan LIU Maoqi WANG Guohui | 2018 | Journal of Ocean University of China2018，17，4： | 5 |
| 3 | Effects of Heavy Metal Ions (Cu^(2+), Pb^(2+) and Cd^(2+)) on DNA Damage of the Gills, Hemocytes and Hepatopancreas of Marine Crab, Charybdis japonica显示文摘There are rising concerns about the hazardous effects of heavy metals on the environment. In this study, comet assay and DNA alkaline unwinding assay were conducted on the tissues (gills, hepatopancreas, and hemocytes) of Charybdis japonica in order to illustrate genotoxicity of three heavy metal ions (Cu2+, Pb2+, and Cd2+) on the marine crabs C. japonica. The crabs were exposed to Cu2+ (10, 50, and 100 ?g.L?1), Pb2+ (50, 250, and 500 ?g L?1) and Cd2+ (5, 25, and 50 ?g L?1), and the tissues were sampled at days 0.5, 1, 3, 6, 9, and 15. DNA alkaline unwinding assay was used for testing the DNA single strand break in gills and hepatopancreas and comet assay was employed for testing the DNA damage in hemocytes. The results showed that the DNA damage (F-value) of gills in the crabs exposed to the three heavy metals was decreased gradually during the exposure periods and there was a dose-time response relationship in certain time, suggesting that the levels of DNA single strand break in all the experimental groups increased significantly compared to the controls. Changes of F-value in hepatopancreas of the crabs exposed to the three heavy metals were similar to those in gills except that the peak values were found in the 500 ?g L?1 Pb2+ treatment group at day 3 and the 50 ?g L?1 Cd2+ treatment group at day 9. The ranks of DNA damage in gills and hepatopancreas induced by the three heavy metal ions (50 ?g L?1, day 15) were Cd2+ >Pb2+ >Cu2+ and Pb2+ >Cu2+ >Cd2+. The levels of DNA damage in gills were higher than those in hepatopancreas in the same experimental group. It can be concluded that indices of DNA damage can be used as the potential biomarkers of heavy metal pollution in marine environment. | PAN Luqing LIU Na ZHANG Hongxia WANG Jing MIAO Jingjing | 2011 | Journal of Ocean University of China2011，10，2： | 4 |
| 4 | The effect of oxidation on physicochemical properties and aqueous stabilization of multiwalled carbon nanotubes:comparison of multiple analysis methods显示文摘Surface oxidation can alter physicochemical properties of multiwalled carbon nanotubes(MWCNTs) and influence their aqueous stabilization.Many techniques have been used to characterize the physicochemical properties and aqueous stabilization of MWCNTs.However,the relationship between the change in physicochemical property and the aqueous stabilization of MWCNTs merits more studies,and the multiple characterization techniques have not been well compared.This study systematically and comparatively investigated the effect of oxidation on the physicochemical properties and aqueous stabilization of MWCNTs using multiple analysis methods.Increased surface area,disclosed tube ends,defects on the sidewalls,disruption of the electronic structure,and removal of metal catalysts and amorphous carbon were observed for the oxidized MWCNTs(o-MWCNTs) using the multipoint Brunauer-Emmett-Teller(BET) method,transmission electron microscope observation,Raman spectroscopy,UV-Vis spectroscopy,and thermogravimetric analysis.An oxidation-time-dependent increase in oxygen content of the MWCNTs was verified by the methods of elemental analysis,mass difference calculation,and X-ray photoelectron spectroscopy(XPS).Fourier transform infrared spectroscopy,XPS,and the Boehm titration were employed to study the functionalities on the MWCNT surfaces.Despite the limitations of these techniques,the results indicated that the dramatic increase in carboxyl groups was mainly responsible for the significant increase in oxygen content after the oxidation.The dissociation of the grafted functional groups increased electronegativity of the o-MWCNTs and facilitated the aqueous stabilization of o-MWCNTs through electrostatic repulsions.The oxidation affected the UV-Vis absorbance of MWCNT suspensions.The absorbances at 800 nm of the stabilized MWCNT suspensions had a good correlation with the MWCNT concentrations and could be used to quantify the MWCNT suspensions.The findings of this work are expected to boost the research on carbon nanotubes and their environmental behaviors. | Luqing Zhang Minhao Wang Jing Fang Kun Yang Daohui Lin | 2016 | Science China Chemistry2016，59，11： | 2 |
| 5 | Interaction among inflammasome,autophagy and non-coding RNAs:new horizons for drug显示文摘Autophagy and inflammasomes are shown to interact in various situations including infectious disease,cancer,diabetes and neurodegeneration.Since multiple layers of molecular regulators contribute to the interplay between autophagy and inflammasome activation,the detail of such interplay remains largely unknown.Non-coding RNAs(ncRNAs),which have been implicated in regulating an expanding list of cellular processes including immune defense against pathogens and inflammatory response in cancer and metabolic diseases,may join in the crosstalk between inflammasomes and autophagy in physiological or disease conditions.In this review,we summarize the latest research on the interlink among ncRNAs,inflammasomes and autophagy and discuss the emerging role of these three in multiple signaling transduction pathways involved in clinical conditions.By analyzing these intriguing interconnections,we hope to unveil the mechanism inter-regulating these multiple processes and ultimately discover potential drug targets for some refractory diseases. | Qinqin Pu Ping Lin Zhihan Wang Pan Gao Shugang Qin Luqing Cui Min Wu | 2019 | Precision Clinical Medicine2019，2，3： | 1 |
| 6 | Back-analysis of viscoelastic displacements in a soft rock road tunnel显示文摘 | Yang Zhifa Wang Zhiyin Zhang Luqing Zhou Ruiguang Xing Nianxing | 2001 | International Journal of Rock Mechanics and Mining Sciences2001，，3： | 1 |
| 7 | Cloning, characterization and tissue distribution of a pi-class glutathione S-transferase from clam ( Venerupis philippinarum ): Response to benzo[α]pyrene exposure显示文摘 | Chaoqun Xu Luqing Pan Na Liu Lin Wang Jingjing Miao | 2010 | Comparative Biochemistry and Physiology Part C2010，，2： | 1 |
| 8 | Back-analysis of viscoelastic displacements in a soft rock road tunnel显示文摘 | Yang Zhifa Wang Zhiyin Zhang Luqing | 2001 | International Journal of Rock Mechanics and Mining Sciences2001，38，3： | 1 |
| 9 | A simplified clipping and filtering technique for PAR reduction in OFDM systems 显示文摘 | WANG Luqing TELLAMBURA C | 2005 | IEEE Signal Processing Letters2005，12，6： | 1 |
| 10 | Control maintenance strategy for fault tolerant mode and reliability analysis of hydro power stations显示文摘 | WANG Shengtie | 2001 | IEEE Transactions on Power Systems2001，16，3： | 1 |
| 11 | Back-analysis of viscoelastic displacements in a soft rock road tunnel显示文摘 | Yang Zhifa Wang Zhiyin Zhang Luqing | 2001 | Int J Rock Mech Min2001，38，3： | 1 |
| 12 | Analysis of Clipping Noise and Tone - Reservation Algorithms for Peak Reduction in OFDM Systems 显示文摘 | Wang Luqing Tellambura C | 2008 | IEEE Transactions on Vehicular Technology2008，3，： | 1 |
| 13 | Metabolic enzyme activities, metabolism-related genes expression and bioaccumulation in juvenile white shrimp Litopenaeus vannamei exposed to benzo pyrene显示文摘 | Ren Xianyun Pan Luqing Wang Lin | 2014 | Ecotoxicol Environm Saf2014，104，： | 1 |
| 14 | A simplified clipping and filtering technique for PAR reduction in OFDM systems显示文摘 | WANG Luqing Tellambura C | 2005 | IEEE Signal Processing Letters2005，12，6： | 1 |
| 15 | Back-analysis of viscoelastic displacements in a soft rock road tunnel 显示文摘 | Yang Zhifa Wang Zhiyin Zhang Luqing | 2001 | International Journal of Rock Mechanics & Mining Sci ences2001，38，3： | 1 |
| 16 | Coupling of biological methods with membrane filtration using ozone as pre-treatment for water reuse显示文摘 | Qi Luqing Wang Xiaojun Xu Qikun | 2011 | Desalination2011，270，123： | 1 |
| 17 | An ethical solution to the challenges in teaching anatomy with disseetion in the Chinese cuhure显示文摘 | Luqing Zhang Yunfeng Wang Ming Xiao | 2008 | Anat Sci Ed2008，，1： | 1 |
| 18 | Control Maintenance Strategy for Fault Tolerant Mode and Reliability Analysis of Hydro Power Stations显示文摘 | Wang Shengtie | 2001 | Transactions on Power Engineering2001，，： | 1 |
| 19 | A simplified clipping and filtering technique for PAR reduction in OFDM systems 显示文摘 | Wang Luqing Tellambura C | 2005 | IEEE Signal Processing Letters2005，12，6： | 1 |
| 20 | Back-analysis of Viscoelastic Displacements in a Soft Rock Road Tunnel 显示文摘 | Yang Zhifa Wang Zhiyin Zhang Luqing Zhou Ruiguang Xing Nianxing | 2001 | International Journal of Rock Mechanics & Mining Sciences2001，，38： | 1 |
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